Susan Gregurick
@sgregurick.bsky.social
I’m the Associate Director for Data Science at the NIH. All views, posts, and retweets are my own.
cdt.amegroups.org/article/view... 🧪.
A thoughtful article on the need for policies regarding AI use for manuscript writing assistance.
A thoughtful article on the need for policies regarding AI use for manuscript writing assistance.
Artificial intelligence for manuscript writing: policies and implementation in cardiovascular journals
Artificial intelligence for manuscript writing: policies and implementation in cardiovascular journals
cdt.amegroups.org
November 11, 2025 at 12:00 PM
cdt.amegroups.org/article/view... 🧪.
A thoughtful article on the need for policies regarding AI use for manuscript writing assistance.
A thoughtful article on the need for policies regarding AI use for manuscript writing assistance.
Excited and grateful to be awarded HPCwire 35 legends this year. Bittersweet as I am unlikely to be able to attend SC25 due to the furlough. Congratulations to my esteemed colleagues and wishing you a great conference. #SC25
www.hpcwire.com/35-hpc-legen...
www.hpcwire.com/35-hpc-legen...
35 HPC Legends - HPCwire
We are proud to announce the HPCwire 35 Legends Class of 2025. Our second annual list recognizes 35 luminaries who have made HPC what it is today. The High Performance Computing (HPC) market is distin...
www.hpcwire.com
November 10, 2025 at 5:05 PM
Excited and grateful to be awarded HPCwire 35 legends this year. Bittersweet as I am unlikely to be able to attend SC25 due to the furlough. Congratulations to my esteemed colleagues and wishing you a great conference. #SC25
www.hpcwire.com/35-hpc-legen...
www.hpcwire.com/35-hpc-legen...
Beyond the Secretory Pathway: New Insights Into Protein Release - Chen - 2025 - Traffic - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/.... Thank you all for publishing a wonderful scientific summary on inaugural conference on Molecular Mechanisms & Physiology of Unconventional Secretion
Beyond the Secretory Pathway: New Insights Into Protein Release
While proteins bearing N-terminal signal or leader sequences are secreted via the ER-Golgi-plasma membrane axis of the conventional secretion pathway, many cytosolic proteins lacking signaling sequen...
onlinelibrary.wiley.com
November 7, 2025 at 1:28 PM
Beyond the Secretory Pathway: New Insights Into Protein Release - Chen - 2025 - Traffic - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/.... Thank you all for publishing a wonderful scientific summary on inaugural conference on Molecular Mechanisms & Physiology of Unconventional Secretion
Reposted by Susan Gregurick
Long-term monitoring tells a story of change. For 80 years scientists have monitored Windermere and nearby lakes in Cumbria, tracking how climate change and pollution are reshaping our freshwater ecosystems.
It’s one of the longest lake datasets anywhere in the world! 🌎
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It’s one of the longest lake datasets anywhere in the world! 🌎
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November 6, 2025 at 12:02 PM
Long-term monitoring tells a story of change. For 80 years scientists have monitored Windermere and nearby lakes in Cumbria, tracking how climate change and pollution are reshaping our freshwater ecosystems.
It’s one of the longest lake datasets anywhere in the world! 🌎
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It’s one of the longest lake datasets anywhere in the world! 🌎
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The updated Global Naturalized Alien Flora (GloNAF 2.0) database - Davis - 2025 - Ecology - Wiley Online Library esajournals.onlinelibrary.wiley.com/doi/10.1002/... nice to see updates improving accessibility, standards and support for data reuse in GloNAF 2.0 a resource for invasive vascular plants
The updated Global Naturalized Alien Flora (GloNAF 2.0) database
GloNAF is a continuously updated, curated compilation of alien naturalized vascular plant inventories for geographic regions worldwide. Building on its predecessor, GloNAF 2.0 now contains 16,429 tax....
esajournals.onlinelibrary.wiley.com
November 6, 2025 at 12:47 PM
The updated Global Naturalized Alien Flora (GloNAF 2.0) database - Davis - 2025 - Ecology - Wiley Online Library esajournals.onlinelibrary.wiley.com/doi/10.1002/... nice to see updates improving accessibility, standards and support for data reuse in GloNAF 2.0 a resource for invasive vascular plants
Artificial Intelligence Networks Combining Histopathology and Machine Learning Can Extract Axon Pathology in Autism Spectrum Disorder . Authors developed custom transfer learning processes and protocols to distinguishing high-resolution microscopic images of myelinated axons in white matter pathways
Artificial Intelligence Networks Combining Histopathology and Machine Learning Can Extract Axon Pathology in Autism Spectrum Disorder
Axon features that underlie the structural and functional organization of cortical pathways have distinct patterns in the brains of neurotypical controls (CTR) compared to individuals with Autism Spe....
onlinelibrary.wiley.com
November 3, 2025 at 12:00 PM
Artificial Intelligence Networks Combining Histopathology and Machine Learning Can Extract Axon Pathology in Autism Spectrum Disorder . Authors developed custom transfer learning processes and protocols to distinguishing high-resolution microscopic images of myelinated axons in white matter pathways
The relationship between obesity and chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference - Kidney International www.kidney-international.org/article/S008... 🧪 just out and worth reading.
The relationship between obesity and chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference
Obesity and chronic kidney disease (CKD) are complex diseases that are interlinked
directly and indirectly. In October 2024, Kidney Disease: Improving Global Outcomes
(KDIGO) held a Controversies Conf...
www.kidney-international.org
November 3, 2025 at 11:40 AM
The relationship between obesity and chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference - Kidney International www.kidney-international.org/article/S008... 🧪 just out and worth reading.
pubs.acs.org/doi/10.1021/... neat work on a probabilistic machine learning framework to estimate total or partial RDFs with uncertainty quantification from background and inelastic corrected scattering data. The results could help with folks interested in molecular force field optimization.
Physics-Informed Gaussian Process Inference of Liquid Structure from Scattering Data
We present a nonparametric Bayesian framework to infer radial distribution functions from experimental scattering measurements with uncertainty quantification using nonstationary Gaussian processes. The Gaussian process prior mean and kernel functions are designed to mitigate well-known numerical challenges with the Fourier transform, including discrete measurement binning and detector windowing, while encoding fundamental yet minimal physical knowledge of the liquid structure. We demonstrate uncertainty propagation of the Gaussian process posterior to unmeasured quantities of interest. Experimental radial distribution functions of liquid argon and water with uncertainty quantification are provided as both a proof of principle for the method and a benchmark for molecular models.
pubs.acs.org
October 31, 2025 at 12:25 PM
pubs.acs.org/doi/10.1021/... neat work on a probabilistic machine learning framework to estimate total or partial RDFs with uncertainty quantification from background and inelastic corrected scattering data. The results could help with folks interested in molecular force field optimization.
Paratyphoid fever and relapsing fever in 1812 Napoleon's devastated army: Current Biology www.cell.com/current-biol... new meta genomics study reveal pathogens that contributed to the devastation of Napoleon's Grande Armée during its disastrous retreat from Russia in 1812.
Paratyphoid fever and relapsing fever in 1812 Napoleon's devastated army
By implementing a phylogeny-driven approach for authenticating ultra-low-coverage
pathogen aDNA, Barbieri et al. detect Salmonella enterica Paratyphi C and Borrelia
recurrentis, agents of paratyphoid ...
www.cell.com
October 26, 2025 at 11:51 AM
Paratyphoid fever and relapsing fever in 1812 Napoleon's devastated army: Current Biology www.cell.com/current-biol... new meta genomics study reveal pathogens that contributed to the devastation of Napoleon's Grande Armée during its disastrous retreat from Russia in 1812.
link.springer.com/article/10.1.... study analyzes feature extraction methods, including morphological gray matter, structural connectivity and functional connectivity to investigate neurodegenerative diseases. It’s a good analysis of graph methodologies to characterize individual brain networks.🧪
Evaluating topological and graph-theoretical approaches to extract complex multimodal brain connectivity patterns in multiple sclerosis - Health Information Science and Systems
Brain networks, or graphs, derived from magnetic resonance imaging (MRI) offer a powerful framework for representing the structural, morphological, and functional organization of the brain. Graph-theo...
link.springer.com
October 22, 2025 at 10:48 AM
link.springer.com/article/10.1.... study analyzes feature extraction methods, including morphological gray matter, structural connectivity and functional connectivity to investigate neurodegenerative diseases. It’s a good analysis of graph methodologies to characterize individual brain networks.🧪
advanced.onlinelibrary.wiley.com/doi/10.1002/... cool printable sweat sensor for metabolomics biomarkers measurements 🧪🧪
Printed Wearable Sweat Rate Sensor for Continuous In Situ Perspiration Measurement
A wireless wearable sweat rate sensor system is presented, featuring digital 3D direct-write printing on a flexible substrate with microfluidic layers for continuous, real-time monitoring. Printed en....
advanced.onlinelibrary.wiley.com
October 22, 2025 at 10:34 AM
advanced.onlinelibrary.wiley.com/doi/10.1002/... cool printable sweat sensor for metabolomics biomarkers measurements 🧪🧪
www.nature.com/articles/s41...
Study add to the growing body of evidence that links periodontitis to long-term cardiovascular consequences in T2D
Study add to the growing body of evidence that links periodontitis to long-term cardiovascular consequences in T2D
Increased cardiovascular risk in people with type 2 diabetes and periodontitis: an analysis from a global real-world federated database - British Dental Journal
British Dental Journal - Increased cardiovascular risk in people with type 2 diabetes and periodontitis: an analysis from a global real-world federated database
www.nature.com
October 22, 2025 at 10:27 AM
www.nature.com/articles/s41...
Study add to the growing body of evidence that links periodontitis to long-term cardiovascular consequences in T2D
Study add to the growing body of evidence that links periodontitis to long-term cardiovascular consequences in T2D
EndoCompass project: artificial intelligence in endocrinology url: academic.oup.com/ejendo/artic.... This is a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, to identify & promote research priorities in endocrine science.🧪
EndoCompass project: artificial intelligence in endocrinology
AbstractBackground. Endocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human
academic.oup.com
October 17, 2025 at 12:05 PM
EndoCompass project: artificial intelligence in endocrinology url: academic.oup.com/ejendo/artic.... This is a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, to identify & promote research priorities in endocrine science.🧪
PET-MRI biomarkers reveal efficacy of a novel NLRP3 inhibitor in Parkinson’s disease models url: academic.oup.com/brain/articl... nice work highlighting the highlight use of PET/MRI as a non-invasive tool to evaluate drug efficacy 🧪
PET-MRI biomarkers reveal efficacy of a novel NLRP3 inhibitor in Parkinson’s disease models
Albornoz et al. show using advanced imaging techniques that MCC7840—a novel NLRP3 inflammasome inhibitor—reduces neuroinflammation and protects dopaminergi
academic.oup.com
October 17, 2025 at 11:42 AM
PET-MRI biomarkers reveal efficacy of a novel NLRP3 inhibitor in Parkinson’s disease models url: academic.oup.com/brain/articl... nice work highlighting the highlight use of PET/MRI as a non-invasive tool to evaluate drug efficacy 🧪
www.ahajournals.org/doi/10.1161/.... Study finds ACE2 is causally protective for hypertension and diabetes. This suggests that ACE2 treatment may provide additional protection from these cardiovascular diseases.🧪
Circulating Cardiovascular Proteomic Associations With Genetics and Disease | Circulation: Genomic and Precision Medicine
BACKGROUND: The analysis of the circulating proteome can identify translational modifiers and
biomarkers of disease expressivity and severity at a given time point. Here, we explore
the relationships ...
www.ahajournals.org
October 8, 2025 at 11:34 AM
www.ahajournals.org/doi/10.1161/.... Study finds ACE2 is causally protective for hypertension and diabetes. This suggests that ACE2 treatment may provide additional protection from these cardiovascular diseases.🧪
www.frontiersin.org/journals/nut.... Really interesting review. 🧪
Frontiers | Immunomodulatory role of vitamin D and emerging immunotherapies in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most common cancers globally, with nearly 1 million new cases diagnosed annually. It is a complex disease, with ...
www.frontiersin.org
October 3, 2025 at 11:43 AM
www.frontiersin.org/journals/nut.... Really interesting review. 🧪
onlinelibrary.wiley.com/doi/10.1002/.... Nice study on a mobile health app for Chronic low back pain treatment 🧪
Mobile Health (mHealth) for Chronic Low Back Pain Assessment: Design, Development, and Usability Evaluation
This study introduces a mobile health (mHealth) system for chronic low back pain (cLBP) assessment, involving in-clinic and at-home apps to collect comprehensive data from 1000 individuals. Usability....
onlinelibrary.wiley.com
October 3, 2025 at 11:36 AM
onlinelibrary.wiley.com/doi/10.1002/.... Nice study on a mobile health app for Chronic low back pain treatment 🧪
www.jacc.org/doi/10.1016/.... Import results “the evidence linking inflammation with atherosclerotic CVD is no longer exploratory but is compelling and clinically actionable.” 🧪
Inflammation and Cardiovascular Disease: 2025 ACC Scientific Statement: A Report of the American College of Cardiology
www.jacc.org
September 30, 2025 at 10:18 AM
www.jacc.org/doi/10.1016/.... Import results “the evidence linking inflammation with atherosclerotic CVD is no longer exploratory but is compelling and clinically actionable.” 🧪
Allergen Chip Challenge: a nationwide open database supporting allergy prediction algorithms - Journal of Allergy and Clinical Immunology www.jacionline.org/article/S009.... nationwide, open database of allergen chip, demographic and clinical information
Allergen Chip Challenge: a nationwide open database supporting allergy prediction algorithms
Graphical abstract: 1
www.jacionline.org
September 29, 2025 at 10:21 AM
Allergen Chip Challenge: a nationwide open database supporting allergy prediction algorithms - Journal of Allergy and Clinical Immunology www.jacionline.org/article/S009.... nationwide, open database of allergen chip, demographic and clinical information
iopscience.iop.org/article/10.3... 🧪. Very exciting article on exoplanetary atmospheres
September 11, 2025 at 10:55 AM
iopscience.iop.org/article/10.3... 🧪. Very exciting article on exoplanetary atmospheres
www.nature.com/articles/s41... 🧪. Large study of over 1m quantifies the independent associations of albuminuria and eGFR with the incidence of overall cancer, and among selected site-specific cancers, using data from eligible cohorts in the Chronic Kidney Disease Prognosis Consortium (CKD-PC).
Chronic kidney disease and incident cancer risk: an individual participant data meta-analysis - British Journal of Cancer
British Journal of Cancer - Chronic kidney disease and incident cancer risk: an individual participant data meta-analysis
www.nature.com
September 8, 2025 at 11:27 AM
www.nature.com/articles/s41... 🧪. Large study of over 1m quantifies the independent associations of albuminuria and eGFR with the incidence of overall cancer, and among selected site-specific cancers, using data from eligible cohorts in the Chronic Kidney Disease Prognosis Consortium (CKD-PC).
www.cell.com/biophysj/abs.... 🧪 nice work from Jeremey smith at ORNL discuss the role of MD and ML/AI to overcome lignocellulose recalcitrance by designing pretreatment methods to efficiently produce solubilized cellulose/lignin/hemicellulose, and improve energy-intensive manufacturing challenges.
Molecular Simulation and Artificial Intelligence for the Circular Economy of Bioenergy and Bioproducts
The concept of the circular bioeconomy is a carbon neutral, sustainable system with
zero waste. One vision for such an economy is based upon lignocellulosic biomass.
This lignocellulosic circular bioe...
www.cell.com
September 7, 2025 at 11:32 AM
www.cell.com/biophysj/abs.... 🧪 nice work from Jeremey smith at ORNL discuss the role of MD and ML/AI to overcome lignocellulose recalcitrance by designing pretreatment methods to efficiently produce solubilized cellulose/lignin/hemicellulose, and improve energy-intensive manufacturing challenges.
www.nature.com/articles/s41...
🧪. this study provides evidence indicating S. mutans can colonize the gut and affect PD pathology via microbial UrdA and its metabolite, imidazole propionate.
🧪. this study provides evidence indicating S. mutans can colonize the gut and affect PD pathology via microbial UrdA and its metabolite, imidazole propionate.
Gut microbial production of imidazole propionate drives Parkinson’s pathologies - Nature Communications
Here, the authors show that the oral microbe Streptococcus mutans, elevated in the gut microbiome of Parkinson’s patients, produces imidazole propionate via UrdA that in mice reaches the brain and tri...
www.nature.com
September 7, 2025 at 11:12 AM
www.nature.com/articles/s41...
🧪. this study provides evidence indicating S. mutans can colonize the gut and affect PD pathology via microbial UrdA and its metabolite, imidazole propionate.
🧪. this study provides evidence indicating S. mutans can colonize the gut and affect PD pathology via microbial UrdA and its metabolite, imidazole propionate.
Reposted by Susan Gregurick
Study reveals 90%^+ agreement between real-world amyloid-PET visual reads and quantification, aiding cognitive impairment diagnosis! 🧠 PMID:40720133, JAMA Neurol 2025, @JAMANeuro https://doi.org/10.1001/jamaneurol.2025.2218 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://doi.org/10.1001/jamaneurol.2025.2218
No description available
doi.org
September 5, 2025 at 10:10 AM
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link.springer.com/article/10.1...
Neat study finds that cholesterol metabolism was clearly altered in the TDP-43 proteinopathies of effected brains, pointing towards an accumulation of cholesterol esters and triglycerides in the form of lipid droplets
Neat study finds that cholesterol metabolism was clearly altered in the TDP-43 proteinopathies of effected brains, pointing towards an accumulation of cholesterol esters and triglycerides in the form of lipid droplets
TDP-43 dysregulation impairs cholesterol metabolism linked with myelination defects - Acta Neuropathologica
TDP-43 is a nuclear protein encoded by the TARDBP gene, which forms pathological aggregates in various neurodegenerative diseases, collectively known as TDP-43 proteinopathies, including amyotrophic l...
link.springer.com
September 5, 2025 at 10:46 AM
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