Stefan Emming
@semming.bsky.social
He/him, based in Meanjin
Immunologist interested in all things inflammation and T-cells
Cyclist @ one of my bicycles
Immunologist interested in all things inflammation and T-cells
Cyclist @ one of my bicycles
Don't see this too much around here yet but Bluesky supports labels to add to your posts, similar to the flairs on reddit and it's an easy way to display pronouns with your posts:
bsky.app/profile/pron...
bsky.app/profile/pron...
bsky.app
February 1, 2025 at 12:08 PM
Don't see this too much around here yet but Bluesky supports labels to add to your posts, similar to the flairs on reddit and it's an easy way to display pronouns with your posts:
bsky.app/profile/pron...
bsky.app/profile/pron...
Reposted by Stefan Emming
Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies!
Link: rdcu.be/d2mjm
Link: rdcu.be/d2mjm
Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells
Nature Immunology - Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate...
rdcu.be
December 9, 2024 at 1:39 AM
Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies!
Link: rdcu.be/d2mjm
Link: rdcu.be/d2mjm
Getting busy here... hope soon a critical mass is reached.
November 18, 2024 at 9:05 PM
Getting busy here... hope soon a critical mass is reached.
Quite a quick turnaround for this small story from us: Turns out that messing up septins activates NLRP3.
www.cell.com/cell-chemica...
www.cell.com/cell-chemica...
The septin modifier, forchlorfenuron, activates NLRP3 via a potassium-independent mitochondrial axis
NLRP3 is widely regarded as a sensor for ionic flux because most NLRP3 activators
do so via potassium efflux. Holley, Emming et al. report that the septin modifier
FCF induces septin-2 rearrangement a...
www.cell.com
May 16, 2024 at 10:58 PM
Quite a quick turnaround for this small story from us: Turns out that messing up septins activates NLRP3.
www.cell.com/cell-chemica...
www.cell.com/cell-chemica...
That story took a looong time spanning multiple Honours and PhD projects, but finally here we are (and it even made the cover!:
NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome
www.science.org/doi/10.1126/...
NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome
www.science.org/doi/10.1126/...
January 24, 2024 at 10:01 PM
That story took a looong time spanning multiple Honours and PhD projects, but finally here we are (and it even made the cover!:
NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome
www.science.org/doi/10.1126/...
NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome
www.science.org/doi/10.1126/...
Reposted by Stefan Emming
Do all the reviews you want, but the bottom line has been obvious for 10+ years.
"We urgently need publicly funded scientists doing essential research for overall public benefit & a nice social media strategy doesn’t make that happen – funding does."
www.theguardian.com/business/202...
"We urgently need publicly funded scientists doing essential research for overall public benefit & a nice social media strategy doesn’t make that happen – funding does."
www.theguardian.com/business/202...
Australia being ‘left behind’ as federal research and development funding sinks to 30-year low
Technology experts sound the alarm as authorities try to encourage private investment
www.theguardian.com
January 23, 2024 at 11:04 PM
Do all the reviews you want, but the bottom line has been obvious for 10+ years.
"We urgently need publicly funded scientists doing essential research for overall public benefit & a nice social media strategy doesn’t make that happen – funding does."
www.theguardian.com/business/202...
"We urgently need publicly funded scientists doing essential research for overall public benefit & a nice social media strategy doesn’t make that happen – funding does."
www.theguardian.com/business/202...
Australia being ‘left behind’ as federal research and development funding sinks to 30-year low
www.theguardian.com/business/202...
www.theguardian.com/business/202...
January 22, 2024 at 3:58 AM
Australia being ‘left behind’ as federal research and development funding sinks to 30-year low
www.theguardian.com/business/202...
www.theguardian.com/business/202...
Reposted by Stefan Emming
Biology is never simple ! I’m happy to share our new publication on the role of HDAC6 on inflammasome. We used several methods (KO mouse, inhibitors, DARPIN…) to show that HDAC6 is NOT always driving the inflammasome and is context-dependent. DOI:https://doi.org/10.1016/j.jbc.2024.105638
January 14, 2024 at 5:05 PM
Biology is never simple ! I’m happy to share our new publication on the role of HDAC6 on inflammasome. We used several methods (KO mouse, inhibitors, DARPIN…) to show that HDAC6 is NOT always driving the inflammasome and is context-dependent. DOI:https://doi.org/10.1016/j.jbc.2024.105638
Reposted by Stefan Emming
#DiscoveryProjects
For those who missed the ARC's (technically challenged) presentation about the EOI stage of #DP25 yesterday, the recording is at youtu.be/gEFrZABjVPQ
For those who missed the ARC's (technically challenged) presentation about the EOI stage of #DP25 yesterday, the recording is at youtu.be/gEFrZABjVPQ
November 30, 2023 at 12:36 AM
#DiscoveryProjects
For those who missed the ARC's (technically challenged) presentation about the EOI stage of #DP25 yesterday, the recording is at youtu.be/gEFrZABjVPQ
For those who missed the ARC's (technically challenged) presentation about the EOI stage of #DP25 yesterday, the recording is at youtu.be/gEFrZABjVPQ
link.springer.com/article/10.1...
"The “Free lunches” index for assessing academics: a not entirely serious proposal"
Love this one, I feel some basic researchers would also be quite high up on the list.
"The “Free lunches” index for assessing academics: a not entirely serious proposal"
Love this one, I feel some basic researchers would also be quite high up on the list.
November 8, 2023 at 11:11 PM
link.springer.com/article/10.1...
"The “Free lunches” index for assessing academics: a not entirely serious proposal"
Love this one, I feel some basic researchers would also be quite high up on the list.
"The “Free lunches” index for assessing academics: a not entirely serious proposal"
Love this one, I feel some basic researchers would also be quite high up on the list.
There is so much coming out on NLRP1 and I still have a lot of questionmarks on how this all is regulated 😵💫
Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome
Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome - Nature
Structural and mutational studies and cellular assays show that the inflammasome sensor NLRP1 forms a complex with thioredoxin, which acts as a negative regulator of inflammasome activity.
www.nature.com
October 7, 2023 at 6:58 AM
There is so much coming out on NLRP1 and I still have a lot of questionmarks on how this all is regulated 😵💫
Don't think bluesky made it down under yet, but better get started:
I am a postdoc in Kates Inflammasomelab @IMB @University of Queensland and interested in all inflammasomey things especially NLRP3 and novel inhibitors
I am a postdoc in Kates Inflammasomelab @IMB @University of Queensland and interested in all inflammasomey things especially NLRP3 and novel inhibitors
October 7, 2023 at 6:56 AM
Don't think bluesky made it down under yet, but better get started:
I am a postdoc in Kates Inflammasomelab @IMB @University of Queensland and interested in all inflammasomey things especially NLRP3 and novel inhibitors
I am a postdoc in Kates Inflammasomelab @IMB @University of Queensland and interested in all inflammasomey things especially NLRP3 and novel inhibitors