Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...

Wang et al. reveal a role of DNMT1, traditionally known for DNA methylation, in regulating mitochondrial health through RNA modification. Their findings explain how the mutation in DNMT1 disrupts cellular energy metabolism, contributing to neurological disorders, and suggest therapeutic potential targeting RNA methylation in neurodegenerative diseases.

The actin cytoskeleton is crucial for cell and organelle motility. Here, the authors show that actin acts upstream of the mitochondrial fusion machinery to bridge two fusing mitochondria.

Endogenous mitochondrial NAD(P)H fluorescence enables label-free and subcellular resolution quantification of aging, prediction of remaining lifespan and tracking of age-dependent changes to mitochond...