Sebastian
@sebastianuitbe.bsky.social
Chemistry postdoc, TU Delft
Reading this week’s most important research 🐈⬛ www.science.org/doi/10.1126/...
The dispersal of domestic cats from North Africa to Europe around 2000 years ago
The domestic cat (Felis catus) descends from the African wildcat Felis lybica lybica. Its global distribution alongside humans testifies to its successful adaptation to anthropogenic environments. Unc...
www.science.org
November 29, 2025 at 9:56 AM
Reading this week’s most important research 🐈⬛ www.science.org/doi/10.1126/...
Reposted by Sebastian
View of Rome https://clevelandart.org/art/1970.55
August 1, 2025 at 6:47 PM
View of Rome https://clevelandart.org/art/1970.55
Reposted by Sebastian
Behold the double-edged sword of natural product medicinal chemistry! On the one hand, doing the SAR is such a pain that industry has largely given up. On the other, look what we haven’t tapped into: a one-atom change to morphine, never before made in the 73 years since the first total synthesis!
Total synthesis and biological activity of “carbamorphine”: O-to-CH2 replacement in the E-ring of the morphine core structure | PNAS
Morphine is a µ-opioid receptor (MOR) agonist and potent analgesic. However, it displays
several side effects including respiratory depression and ...
www.pnas.org
August 1, 2025 at 9:07 PM
Behold the double-edged sword of natural product medicinal chemistry! On the one hand, doing the SAR is such a pain that industry has largely given up. On the other, look what we haven’t tapped into: a one-atom change to morphine, never before made in the 73 years since the first total synthesis!
Reposted by Sebastian
The Kitchen Garden, Yerres https://www.wikiart.org/en/gustave-caillebotte/the-kitchen-garden-yerres
July 19, 2025 at 7:50 AM
The Kitchen Garden, Yerres https://www.wikiart.org/en/gustave-caillebotte/the-kitchen-garden-yerres
Reposted by Sebastian
"..you have to talk to the people who are doing the killing if you want peace. Talking to them does not mean agreeing with them."
fivebooks.com/best-books/n...
fivebooks.com/best-books/n...
Negotiation
The former chief of staff to Tony Blair, Jonathan Powell, tells us about his experience of negotiating in Northern Ireland, and explains why it's important never to lose your temper except on purpose
fivebooks.com
July 19, 2025 at 8:00 AM
"..you have to talk to the people who are doing the killing if you want peace. Talking to them does not mean agreeing with them."
fivebooks.com/best-books/n...
fivebooks.com/best-books/n...
Reposted by Sebastian
Y’en a-t-il un plus beau ?!
June 7, 2025 at 8:45 AM
Y’en a-t-il un plus beau ?!
if the FDA prefers it, this means I can autoclave sorbitol? 😎
June 2, 2025 at 9:35 AM
if the FDA prefers it, this means I can autoclave sorbitol? 😎
Reposted by Sebastian
Incredibly proud to finally see @sebastianuitbe.bsky.social first corresponding author paper online! Congrats to Jan (worked on this during MSc thesis) and Mohit for helping to get it done. I must say, I really enjoyed working on this paper!
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Synthesis and Nucleophilic Ring-Opening of 1,1-Dicyanocyclopropanes: Accessing β-Aminocarbonyl Derivatives from Olefins
We report an atom-transfer radical addition-ring closure sequence for the preparation of 1,1-dicyanocyclopropane electrophiles and demonstrate their nucleophilic ring-opening with alkyl amines under mild conditions. The resulting aminomalononitrile products were converted to complex β-aminocarbonyl derivatives in one pot under aerobic conditions.
pubs.acs.org
May 28, 2025 at 12:51 PM
Incredibly proud to finally see @sebastianuitbe.bsky.social first corresponding author paper online! Congrats to Jan (worked on this during MSc thesis) and Mohit for helping to get it done. I must say, I really enjoyed working on this paper!
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Reposted by Sebastian
It’s weird because for my whole career I was assured that a rising anti-intellectual fringe wasn’t really a problem because those people had no power to make any decisions that impacted my life
Huh
Huh
Couched in all those sciencey sounding words is that the people who believe the Earth is 6k years old will be appointing officers at each agency to evaluate if research is “Gold Standard Science” or not. They will have the power to call anything fraud.
www.whitehouse.gov/presidential...
www.whitehouse.gov/presidential...
Restoring Gold Standard Science
By the authority vested in me as President by the Constitution and the laws of the United States of America, including section 7301 of title 5, United
www.whitehouse.gov
May 24, 2025 at 12:45 PM
It’s weird because for my whole career I was assured that a rising anti-intellectual fringe wasn’t really a problem because those people had no power to make any decisions that impacted my life
Huh
Huh
Reposted by Sebastian
It’s 45 years today that Ian Curtis tragically died. I took this photo in Hulme, Manchester on 06.01.79. Walk in Silence… #IanCurtis #joydivision
May 18, 2025 at 11:20 AM
It’s 45 years today that Ian Curtis tragically died. I took this photo in Hulme, Manchester on 06.01.79. Walk in Silence… #IanCurtis #joydivision
Reposted by Sebastian
🔴 BREAKING - India carried out strikes on Pakistan, which vows to retaliate: Follow our live coverage
Live: India carries out strikes on nine sites in Pakistan and Pakistani Kashmir
Multiple loud explosions were heard in the mountains around the city of Muzaffarabad, capital of Pakistani Kashmir, as well as in two other places in the region, Reuters witnesses and a Pakistani TV…
f24.my
May 6, 2025 at 8:58 PM
🔴 BREAKING - India carried out strikes on Pakistan, which vows to retaliate: Follow our live coverage
Reposted by Sebastian
In May 1944, during World War II, artist Atie Siegenbeek van Heukelom was arrested for her resistance activities. While imprisoned in Amsterdam, she embroidered small scenes onto a handkerchief, capturing her daily hardships.
May 4, 2025 at 2:02 PM
In May 1944, during World War II, artist Atie Siegenbeek van Heukelom was arrested for her resistance activities. While imprisoned in Amsterdam, she embroidered small scenes onto a handkerchief, capturing her daily hardships.
Reposted by Sebastian
A reminder that this Administration's allies in the EU are the AfD, Orban, Fico, Kickl, Le Pen et al
May 3, 2025 at 9:08 AM
A reminder that this Administration's allies in the EU are the AfD, Orban, Fico, Kickl, Le Pen et al
Reposted by Sebastian
Hoi @nu.nl, ik heb jullie kop even verbeterd, ik hoop dat dat ok is 🙂
@woinactie.bsky.social @minocw.bsky.social
@woinactie.bsky.social @minocw.bsky.social
April 25, 2025 at 8:29 PM
Hoi @nu.nl, ik heb jullie kop even verbeterd, ik hoop dat dat ok is 🙂
@woinactie.bsky.social @minocw.bsky.social
@woinactie.bsky.social @minocw.bsky.social
Reposted by Sebastian
Reposted by Sebastian
Adriaen Coorte mainly created small still lifes with an intimate atmosphere. His paintings, often featuring simple subjects like asparagus or berries, stand in sharp contrast to the large, sumptuous still lifes that were popular at the time.
https://id.rijksmuseum.nl/200109193.
https://id.rijksmuseum.nl/200109193.
April 24, 2025 at 2:02 PM
Adriaen Coorte mainly created small still lifes with an intimate atmosphere. His paintings, often featuring simple subjects like asparagus or berries, stand in sharp contrast to the large, sumptuous still lifes that were popular at the time.
https://id.rijksmuseum.nl/200109193.
https://id.rijksmuseum.nl/200109193.
Reposted by Sebastian
Pope Francis's dream for Europe 🇪🇺
"I dream of a Europe that promotes and protects the rights of everyone, without neglecting its duties towards all.
I dream of a Europe of which it will not be said that its commitment to human rights was its last utopia"
Charlemagne Prize 2016.
"I dream of a Europe that promotes and protects the rights of everyone, without neglecting its duties towards all.
I dream of a Europe of which it will not be said that its commitment to human rights was its last utopia"
Charlemagne Prize 2016.
April 21, 2025 at 9:29 AM
Pope Francis's dream for Europe 🇪🇺
"I dream of a Europe that promotes and protects the rights of everyone, without neglecting its duties towards all.
I dream of a Europe of which it will not be said that its commitment to human rights was its last utopia"
Charlemagne Prize 2016.
"I dream of a Europe that promotes and protects the rights of everyone, without neglecting its duties towards all.
I dream of a Europe of which it will not be said that its commitment to human rights was its last utopia"
Charlemagne Prize 2016.