Schrader Lab
@schraderlab.bsky.social
Schraderlab.org - Enjoying all things related to RNA, RNPs, biomolecular condensates, and bacteriology. IU micro.
Reposted by Schrader Lab
Now in print: @lortzrodz.bsky.social with @schraderlab.bsky.social found that the stress-induced transition of the material properties of bacterial ribonucleoprotein bodies repurposes them from sites of mRNA decay to reservoirs for mRNA storage.
@natcomms.nature.com
www.nature.com/articles/s41...
@natcomms.nature.com
www.nature.com/articles/s41...
Stress changes the material state of a bacterial biomolecular condensate and shifts its function from mRNA decay to storage - Nature Communications
Bacterial ribonucleoprotein bodies are dynamic biomolecular condensates that play roles in RNA metabolism. Here, Ortiz-Rodríguez et al. show that, under stress, these condensates shift from a liquid s...
www.nature.com
November 14, 2025 at 4:32 PM
Now in print: @lortzrodz.bsky.social with @schraderlab.bsky.social found that the stress-induced transition of the material properties of bacterial ribonucleoprotein bodies repurposes them from sites of mRNA decay to reservoirs for mRNA storage.
@natcomms.nature.com
www.nature.com/articles/s41...
@natcomms.nature.com
www.nature.com/articles/s41...
Reposted by Schrader Lab
Thrilled to share our multidisiplinary work on how genome-wide DNA bridging by H-NS reshapes the stationary phase bacterial nucleoid and affects the transcriptional landscape. With Xindan Wang and @meyerroc.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 21, 2025 at 10:01 AM
Thrilled to share our multidisiplinary work on how genome-wide DNA bridging by H-NS reshapes the stationary phase bacterial nucleoid and affects the transcriptional landscape. With Xindan Wang and @meyerroc.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Schrader Lab
Caulophiles take note 👇
#MicroSky
#MicroSky
🚨🚨🚨Calling all Caulophiles and Alpha aficionados - stayed tuned for a virtual CauloCon in early 2026. And HOPEFULLY an in person alpha meeting in 2027!! DM me or @chienlab.bsky.social w questions or to stay in the know.
two men are standing next to each other and one of them is saying `` you wanna hang out shoot the breeze ''
ALT: two men are standing next to each other and one of them is saying `` you wanna hang out shoot the breeze ''
media.tenor.com
September 19, 2025 at 11:56 PM
Caulophiles take note 👇
#MicroSky
#MicroSky
Reposted by Schrader Lab
So proud to have trained with Lucy. She is an exceptional scientist, exceptional person, and exceptional mentor. Huge congrats and so well-deserved. laskerfoundation.org/winners/pion...
Pioneering approach to bacterial cell biology & national leadership - Lasker Foundation
Lucy Shapiro
laskerfoundation.org
September 11, 2025 at 11:42 PM
So proud to have trained with Lucy. She is an exceptional scientist, exceptional person, and exceptional mentor. Huge congrats and so well-deserved. laskerfoundation.org/winners/pion...
Reposted by Schrader Lab
Reposted by Schrader Lab
*** Only a few days left to apply ***
Postdoc position at the University of Marburg (Germany), funded within our ERC Advanced Grant "C-SWITCH"
Spatiotemporal regulation of cellular processes by CTP-switches in bacteria
Apply by 04 May: stellenangebote.uni-marburg.de/jobposting/2...
Postdoc position at the University of Marburg (Germany), funded within our ERC Advanced Grant "C-SWITCH"
Spatiotemporal regulation of cellular processes by CTP-switches in bacteria
Apply by 04 May: stellenangebote.uni-marburg.de/jobposting/2...
May 1, 2025 at 11:17 AM
*** Only a few days left to apply ***
Postdoc position at the University of Marburg (Germany), funded within our ERC Advanced Grant "C-SWITCH"
Spatiotemporal regulation of cellular processes by CTP-switches in bacteria
Apply by 04 May: stellenangebote.uni-marburg.de/jobposting/2...
Postdoc position at the University of Marburg (Germany), funded within our ERC Advanced Grant "C-SWITCH"
Spatiotemporal regulation of cellular processes by CTP-switches in bacteria
Apply by 04 May: stellenangebote.uni-marburg.de/jobposting/2...
Reposted by Schrader Lab
Interesting study shows CsrA forms a dynamic, membraneless compartment with sRNAs, mRNAs & the degradosome in E. coli, flipping its role between activating and repressing virulence. A new layer of RNA-based regulation! #microbiology #RNA #CsrA
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Formation of a membraneless compartment regulates bacterial virulence - Nature Communications
The RNA-binding protein CsrA switches from upregulation to downregulation of virulence genes in bacteria through unclear mechanisms. Here, the authors show that the switch between promoting and repres...
www.nature.com
April 25, 2025 at 9:10 AM
Interesting study shows CsrA forms a dynamic, membraneless compartment with sRNAs, mRNAs & the degradosome in E. coli, flipping its role between activating and repressing virulence. A new layer of RNA-based regulation! #microbiology #RNA #CsrA
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Schrader Lab
Registration is open, look forward to seeing you!
microbialrnameeting.com
microbialrnameeting.com
April 15, 2025 at 10:49 AM
Registration is open, look forward to seeing you!
microbialrnameeting.com
microbialrnameeting.com
Reposted by Schrader Lab
Striking new study from @archaeon-alex.bsky.social's lab just out in @science.org on multicellular development induced by compression in Archaea: www.science.org/doi/10.1126/...
Tissue-like multicellular development triggered by mechanical compression in archaea
The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes, rarely in bacteria, and only once in archaea. We show that uniaxial compression induces clonal mul...
www.science.org
April 3, 2025 at 6:24 PM
Striking new study from @archaeon-alex.bsky.social's lab just out in @science.org on multicellular development induced by compression in Archaea: www.science.org/doi/10.1126/...
Reposted by Schrader Lab
Spread the word to support science communication through illustrated storytelling. And if you want your own copy of this microbial adventure comic, 5 days remain at 20% off. www.lulu.com/shop/james-m...
March 26, 2025 at 6:46 PM
Spread the word to support science communication through illustrated storytelling. And if you want your own copy of this microbial adventure comic, 5 days remain at 20% off. www.lulu.com/shop/james-m...
Our team found the N-terminal IDR of bacterial translation initiation factor 2 promotes condensation with RNA that is stimulated in the cold. We think these cold-stimulated IF2 condensates likely explain why the IDR's deletion in E. coli is unable to grow in the cold. www.biorxiv.org/content/10.1...
Bacterial IF2’s N-terminal IDR drives cold-induced phase separation and promotes fitness during cold stress
Translation initiation factor 2 (IF2) plays an essential role in bacterial cells by delivering the fMet-tRNAfMet to the ribosome pre-initiation complex. IF2 is known to have an N-terminal disordered r...
www.biorxiv.org
February 13, 2025 at 2:42 PM
Our team found the N-terminal IDR of bacterial translation initiation factor 2 promotes condensation with RNA that is stimulated in the cold. We think these cold-stimulated IF2 condensates likely explain why the IDR's deletion in E. coli is unable to grow in the cold. www.biorxiv.org/content/10.1...
Reposted by Schrader Lab
1/ 🚨We’re thrilled to share our latest study:
"Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟
www.biorxiv.org/content/10.1...
How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️
"Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟
www.biorxiv.org/content/10.1...
How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️
Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure
Biomolecular condensates play key roles in the spatiotemporal regulation of cellular processes. Yet, the relationship between atomic features and condensate function remains poorly understood. We stud...
www.biorxiv.org
December 30, 2024 at 9:01 PM
1/ 🚨We’re thrilled to share our latest study:
"Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟
www.biorxiv.org/content/10.1...
How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️
"Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟
www.biorxiv.org/content/10.1...
How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️
One year ago today my lab was destroyed in a fire. Nobody was hurt and our key freezer samples survived. My colleague Tamara Hendrickson has graciously hosted all my trainees in her lab since. In January, the Schrader Lab will be officially reopening at Indiana University.
November 24, 2024 at 4:16 AM
One year ago today my lab was destroyed in a fire. Nobody was hurt and our key freezer samples survived. My colleague Tamara Hendrickson has graciously hosted all my trainees in her lab since. In January, the Schrader Lab will be officially reopening at Indiana University.
Reposted by Schrader Lab
Thrilled to share Luis' manuscript showing how bacterial ribonucleoprotein bodies (BR-bodies) control RNA metabolism: stress changes the bacterial biomolecular condensate material state *and* shifts function from mRNA decay to storage. #LiveCell #SingleMolecule #Microscopy @schraderlab.bsky.social
November 13, 2024 at 10:35 PM
Thrilled to share Luis' manuscript showing how bacterial ribonucleoprotein bodies (BR-bodies) control RNA metabolism: stress changes the bacterial biomolecular condensate material state *and* shifts function from mRNA decay to storage. #LiveCell #SingleMolecule #Microscopy @schraderlab.bsky.social
We're very excited about the new preprint from @juliebiteenlab.bsky.social and our lab. We found that upon stress, BR-bodies material state becomes more solid/gel-like, changing their activity from mRNA decay to mRNA storage. Check it out here: www.biorxiv.org/content/10.1...
Stress Changes the Bacterial Biomolecular Condensate Material State and Shifts Function from mRNA Decay to Storage
Bacterial ribonucleoprotein bodies (BR-bodies) are dynamic biomolecular condensates that play a pivotal role in RNA metabolism. We investigated how BR-bodies significantly influence mRNA fate by trans...
www.biorxiv.org
November 13, 2024 at 1:46 PM
We're very excited about the new preprint from @juliebiteenlab.bsky.social and our lab. We found that upon stress, BR-bodies material state becomes more solid/gel-like, changing their activity from mRNA decay to mRNA storage. Check it out here: www.biorxiv.org/content/10.1...
Reposted by Schrader Lab
Stress Changes the Bacterial Biomolecular Condensate Material State and Shifts Function from mRNA Decay to Storage https://www.biorxiv.org/content/10.1101/2024.11.12.623272v1
Stress Changes the Bacterial Biomolecular Condensate Material State and Shifts Function from mRNA Decay to Storage https://www.biorxiv.org/content/10.1101/2024.11.12.623272v1
Bacterial ribonucleoprotein bodies (BR-bodies) are dynamic biomolecular condensates that play a pivo
www.biorxiv.org
November 13, 2024 at 2:49 AM
Stress Changes the Bacterial Biomolecular Condensate Material State and Shifts Function from mRNA Decay to Storage https://www.biorxiv.org/content/10.1101/2024.11.12.623272v1
Reposted by Schrader Lab
Microbial reaction rate estimation using proteins and proteomes https://www.biorxiv.org/content/10.1101/2024.08.13.607198v1
Microbial reaction rate estimation using proteins and proteomes https://www.biorxiv.org/content/10.1101/2024.08.13.607198v1
Microbes transform their environments using diverse enzymatic reactions. However, it remains challen
www.biorxiv.org
August 17, 2024 at 1:04 AM
Microbial reaction rate estimation using proteins and proteomes https://www.biorxiv.org/content/10.1101/2024.08.13.607198v1
Reposted by Schrader Lab
Formylation facilitates the reduction of oxidized initiator methionines https://www.biorxiv.org/content/10.1101/2024.02.06.579201v1
Formylation facilitates the reduction of oxidized initiator methionines https://www.biorxiv.org/content/10.1101/2024.02.06.579201v1
Within a cell, protein-bound methionines can be oxidized by reactive oxygen species (ROS) or monooxy
www.biorxiv.org
February 8, 2024 at 10:46 AM
Formylation facilitates the reduction of oxidized initiator methionines https://www.biorxiv.org/content/10.1101/2024.02.06.579201v1
Reposted by Schrader Lab
We have a new story out at BiorXiv! Amazing work led by
Zach Curtis (Bisson), Pedro Escudeiro (Alva) and John Mallon (Bisson). Great collaboration with @vikramalva.bsky.social (Max Planck) and Mecky Pohlschroder (UPenn).
t.co/qGvuQ7mwO1
Zach Curtis (Bisson), Pedro Escudeiro (Alva) and John Mallon (Bisson). Great collaboration with @vikramalva.bsky.social (Max Planck) and Mecky Pohlschroder (UPenn).
t.co/qGvuQ7mwO1
Halofilins as Emerging Bactofilin Families of Archaeal Cell Shape Plasticity Orchestrators
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
t.co
January 23, 2024 at 5:02 PM
We have a new story out at BiorXiv! Amazing work led by
Zach Curtis (Bisson), Pedro Escudeiro (Alva) and John Mallon (Bisson). Great collaboration with @vikramalva.bsky.social (Max Planck) and Mecky Pohlschroder (UPenn).
t.co/qGvuQ7mwO1
Zach Curtis (Bisson), Pedro Escudeiro (Alva) and John Mallon (Bisson). Great collaboration with @vikramalva.bsky.social (Max Planck) and Mecky Pohlschroder (UPenn).
t.co/qGvuQ7mwO1
Reposted by Schrader Lab
Late consolidation of rRNA structure during co-transcriptional assembly in E. coli by time-resolved DMS footprinting https://www.biorxiv.org/content/10.1101/2024.01.10.574868v1
Late consolidation of rRNA structure during co-transcriptional assembly in E. coli by time-resolved DMS footprinting https://www.biorxiv.org/content/10.1101/2024.01.10.574868v1
The production of new ribosomes requires proper folding of the rRNA and the addition of more than 50
www.biorxiv.org
January 11, 2024 at 2:46 AM
Late consolidation of rRNA structure during co-transcriptional assembly in E. coli by time-resolved DMS footprinting https://www.biorxiv.org/content/10.1101/2024.01.10.574868v1