Krishanu Saha
@sahakris.bsky.social
Professor at Univ. of Wisconsin-Madison (@WIDiscovery @HoltzCenter @Forward_BIO @UWMadGIE) + Genome Editor (@somaticediting) + Cell Bioengineer (@CMaT_ERC)
Thrilled to highlight the brilliant work by Mandana Arbab, Zaneta Matuszek, with the Mouro Pinto and Liu labs — another major leap forward for somatic cell gene editing. 👏🧬
Base editing as a therapeutic strategy for repeat expansion diseases
@NatureGenet
nature.com/articles/s41...
Base editing as a therapeutic strategy for repeat expansion diseases
@NatureGenet
nature.com/articles/s41...
https://nature.com/articles/s41588-025-02201-6…
May 29, 2025 at 3:48 AM
Thrilled to highlight the brilliant work by Mandana Arbab, Zaneta Matuszek, with the Mouro Pinto and Liu labs — another major leap forward for somatic cell gene editing. 👏🧬
Base editing as a therapeutic strategy for repeat expansion diseases
@NatureGenet
nature.com/articles/s41...
Base editing as a therapeutic strategy for repeat expansion diseases
@NatureGenet
nature.com/articles/s41...
At a major genome editing summit, spotlight turns to the value of human life www.statnews.com/2025/05/27/g... via @statnews.com
At a major genome editing summit, spotlight turns to the value of human life
Earlier gatherings focused on gaining public acceptance for what scientists want to do with CRISPR. This meeting flipped that on its head.
www.statnews.com
May 27, 2025 at 1:13 PM
At a major genome editing summit, spotlight turns to the value of human life www.statnews.com/2025/05/27/g... via @statnews.com
@laurensarko.bsky.social gave a great talk at #ASGCT2025:
CRISPR-engineered CAR T cells targeting senescence-associated uPAR
Clear, compelling science—and a great discussion that followed. Exciting to see where this work is headed.
#CRISPR #CellTherapy
@warfnews.bsky.social
CRISPR-engineered CAR T cells targeting senescence-associated uPAR
Clear, compelling science—and a great discussion that followed. Exciting to see where this work is headed.
#CRISPR #CellTherapy
@warfnews.bsky.social
May 16, 2025 at 5:32 PM
@laurensarko.bsky.social gave a great talk at #ASGCT2025:
CRISPR-engineered CAR T cells targeting senescence-associated uPAR
Clear, compelling science—and a great discussion that followed. Exciting to see where this work is headed.
#CRISPR #CellTherapy
@warfnews.bsky.social
CRISPR-engineered CAR T cells targeting senescence-associated uPAR
Clear, compelling science—and a great discussion that followed. Exciting to see where this work is headed.
#CRISPR #CellTherapy
@warfnews.bsky.social
Looking forward to this timely Scientific Symposium and conversation on #CRISPR #GeneEditing at #ASGCT2025!
“Who’s Afraid of Off-Target Editing?”
1:30–3:15 PM CT (Room 293–296)
With Claire Clelland (UCSF) & Kiran Musunuru (Penn) of
@somaticediting Join us! #GenomicMedicine
“Who’s Afraid of Off-Target Editing?”
1:30–3:15 PM CT (Room 293–296)
With Claire Clelland (UCSF) & Kiran Musunuru (Penn) of
@somaticediting Join us! #GenomicMedicine
May 13, 2025 at 1:20 PM
Looking forward to this timely Scientific Symposium and conversation on #CRISPR #GeneEditing at #ASGCT2025!
“Who’s Afraid of Off-Target Editing?”
1:30–3:15 PM CT (Room 293–296)
With Claire Clelland (UCSF) & Kiran Musunuru (Penn) of
@somaticediting Join us! #GenomicMedicine
“Who’s Afraid of Off-Target Editing?”
1:30–3:15 PM CT (Room 293–296)
With Claire Clelland (UCSF) & Kiran Musunuru (Penn) of
@somaticediting Join us! #GenomicMedicine
Reposted by Krishanu Saha
Virus-free CRISPR knock-in of a chimeric antigen receptor into KLRC1 generates potent GD2-specific NK cells @sahakris.bsky.social
www.cell.com/molecular-th...
www.cell.com/molecular-th...
Virus-free CRISPR knock-in of a chimeric antigen receptor into KLRC1 generates potent GD2-specific natural killer cells
Saha and colleagues report an improved method to genetically engineer human primary
natural killer (NK) cells using a virus-free CRISPR strategy, yielding high editing
outcomes with minimal off-target...
www.cell.com
January 19, 2025 at 3:30 AM
Virus-free CRISPR knock-in of a chimeric antigen receptor into KLRC1 generates potent GD2-specific NK cells @sahakris.bsky.social
www.cell.com/molecular-th...
www.cell.com/molecular-th...
Reposted by Krishanu Saha
Proud to have you represent!
🌍 Excited to join the @UWMadison delegation in India for Badger Utsav II! We'll celebrate the opening of @BharatBiotech’s new gene & cell therapy facility. Grateful for this opportunity to connect & collaborate.
#CRISPR
ghi.wisc.edu/science-is-g...
#CRISPR
ghi.wisc.edu/science-is-g...
Science is Global: Building Bridges with Dr. Kris Saha – Global Health Institute
ghi.wisc.edu
March 13, 2025 at 8:19 PM
Proud to have you represent!
Reposted by Krishanu Saha
Congrats to Giulia Scimonelli from the @sahakris.bsky.social Lab. The research award, funded by grants from Brittingham Wisconsin Trust, Knapp Bequest, and UW Division for Teaching and Learning, allows her to study T Cell Phenotype Enrichment Through mRNA Delivery for Enhanced CAR-T Manufacturing.
May 6, 2025 at 4:21 PM
Congrats to Giulia Scimonelli from the @sahakris.bsky.social Lab. The research award, funded by grants from Brittingham Wisconsin Trust, Knapp Bequest, and UW Division for Teaching and Learning, allows her to study T Cell Phenotype Enrichment Through mRNA Delivery for Enhanced CAR-T Manufacturing.
🌍 Excited to join the @UWMadison delegation in India for Badger Utsav II! We'll celebrate the opening of @BharatBiotech’s new gene & cell therapy facility. Grateful for this opportunity to connect & collaborate.
#CRISPR
ghi.wisc.edu/science-is-g...
#CRISPR
ghi.wisc.edu/science-is-g...
Science is Global: Building Bridges with Dr. Kris Saha – Global Health Institute
ghi.wisc.edu
March 12, 2025 at 4:17 AM
🌍 Excited to join the @UWMadison delegation in India for Badger Utsav II! We'll celebrate the opening of @BharatBiotech’s new gene & cell therapy facility. Grateful for this opportunity to connect & collaborate.
#CRISPR
ghi.wisc.edu/science-is-g...
#CRISPR
ghi.wisc.edu/science-is-g...
🎉 Huge congrats to our newest PhD, Dr. Khajanchi (@omgitsnamita), on her stellar defense! 🌟 She delivered an outstanding presentation on her groundbreaking work developing a tunable #CRISPR genome editing system in human cells. Stay tuned for the preprint! 📄👏
November 14, 2024 at 4:46 AM
🎉 Huge congrats to our newest PhD, Dr. Khajanchi (@omgitsnamita), on her stellar defense! 🌟 She delivered an outstanding presentation on her groundbreaking work developing a tunable #CRISPR genome editing system in human cells. Stay tuned for the preprint! 📄👏
🎓 Today at 10 am CT, join us at the DeLuca Forum or online for @omgitsnamita’s PhD defense on “Regulating Cas9 Genome Editor with Small Molecule Drugs.” 🌟
📍 @DiscoveryBldg
🔗 DM for Zoom link!
#CRISPR
📍 @DiscoveryBldg
🔗 DM for Zoom link!
#CRISPR
November 14, 2024 at 4:46 AM
🎓 Today at 10 am CT, join us at the DeLuca Forum or online for @omgitsnamita’s PhD defense on “Regulating Cas9 Genome Editor with Small Molecule Drugs.” 🌟
📍 @DiscoveryBldg
🔗 DM for Zoom link!
#CRISPR
📍 @DiscoveryBldg
🔗 DM for Zoom link!
#CRISPR
Please join me in congratulating @Shankar_K2, Ph.D. on her thesis defense! 🎓 By integrating #CRISPR genome editing w/ cell engineering, Dr. Shankar has crafted programmable cell therapies that are foundational to our lab’s new directions. @CMaT_ERC @UWCarbone @UWMadison_BME
November 14, 2024 at 4:46 AM
Please join me in congratulating @Shankar_K2, Ph.D. on her thesis defense! 🎓 By integrating #CRISPR genome editing w/ cell engineering, Dr. Shankar has crafted programmable cell therapies that are foundational to our lab’s new directions. @CMaT_ERC @UWCarbone @UWMadison_BME
Two PhD defenses this week: Join us! Orchard View, 3280, @WIDiscovery:
@dcapps123 5/14: 2pm, Towards Efficient and Scalable Manufacturing of Genome-Edited CRISPR CAR T Cells
@Shankar_K2 5/16: 2pm, Development of human natural killer cell-based immunotherapies via genome eng.
@dcapps123 5/14: 2pm, Towards Efficient and Scalable Manufacturing of Genome-Edited CRISPR CAR T Cells
@Shankar_K2 5/16: 2pm, Development of human natural killer cell-based immunotherapies via genome eng.
November 14, 2024 at 4:46 AM
Two PhD defenses this week: Join us! Orchard View, 3280, @WIDiscovery:
@dcapps123 5/14: 2pm, Towards Efficient and Scalable Manufacturing of Genome-Edited CRISPR CAR T Cells
@Shankar_K2 5/16: 2pm, Development of human natural killer cell-based immunotherapies via genome eng.
@dcapps123 5/14: 2pm, Towards Efficient and Scalable Manufacturing of Genome-Edited CRISPR CAR T Cells
@Shankar_K2 5/16: 2pm, Development of human natural killer cell-based immunotherapies via genome eng.
At #ASGCT2024, we're showcasing advances in non-viral gene editing, CAR T cell therapies, & high-throughput screening. Explore our work on vision restoration, cancer therapy, and ethical challenges in the field. Join us to learn about the latest progress in #GeneTherapy research
November 14, 2024 at 4:46 AM
At #ASGCT2024, we're showcasing advances in non-viral gene editing, CAR T cell therapies, & high-throughput screening. Explore our work on vision restoration, cancer therapy, and ethical challenges in the field. Join us to learn about the latest progress in #GeneTherapy research
Join us this Thursday, Mar 21!
A Question of Beginnings: Lab Embryos Between Nature and Synthesis
with @jacob_hanna, @cartersnead, @ArnoldEisen, @SJasanoff, @JudyNorsigian, @jdhardin1959 + many more.
@GenomeObserv
Registration:
A Question of Beginnings: Lab Embryos Between Nature and Synthesis
with @jacob_hanna, @cartersnead, @ArnoldEisen, @SJasanoff, @JudyNorsigian, @jdhardin1959 + many more.
@GenomeObserv
Registration:
November 14, 2024 at 4:46 AM
Join us this Thursday, Mar 21!
A Question of Beginnings: Lab Embryos Between Nature and Synthesis
with @jacob_hanna, @cartersnead, @ArnoldEisen, @SJasanoff, @JudyNorsigian, @jdhardin1959 + many more.
@GenomeObserv
Registration:
A Question of Beginnings: Lab Embryos Between Nature and Synthesis
with @jacob_hanna, @cartersnead, @ArnoldEisen, @SJasanoff, @JudyNorsigian, @jdhardin1959 + many more.
@GenomeObserv
Registration:
More momentum for CRISPR drugs! This time, it’s through direct injection of nanoparticles into the body.
November 14, 2024 at 4:45 AM
More momentum for CRISPR drugs! This time, it’s through direct injection of nanoparticles into the body.
Learn about the first approved #CRISPR drug and our own efforts to build on this breakthrough...tomorrow morning @WPR at 7:30am Central. Call in with your questions: 800-642-1234 @WIDiscovery @uwsmph @UWMadEngr @somaticediting @CMaT_ERC
November 14, 2024 at 4:45 AM
Learn about the first approved #CRISPR drug and our own efforts to build on this breakthrough...tomorrow morning @WPR at 7:30am Central. Call in with your questions: 800-642-1234 @WIDiscovery @uwsmph @UWMadEngr @somaticediting @CMaT_ERC
The first authorized medicine for the #CRISPR field! The US FDA decision is likely to come next month. We are all hoping that post-market/approval data is shared and the durability of efficacy is at least many years, as seen in the clinical trials.
November 14, 2024 at 4:45 AM
The first authorized medicine for the #CRISPR field! The US FDA decision is likely to come next month. We are all hoping that post-market/approval data is shared and the durability of efficacy is at least many years, as seen in the clinical trials.
Finding resonance with many others thinking about global governance of emerging tech here at the #ParisPeaceForum2023. Come see our roundtable discussion on #CRISPR genome editing tomorrow.
November 14, 2024 at 4:45 AM
Finding resonance with many others thinking about global governance of emerging tech here at the #ParisPeaceForum2023. Come see our roundtable discussion on #CRISPR genome editing tomorrow.
It’s been a joy to develop & teach this hands-on #CRISPR lab course for @UWMadEngr. Read about our journey here. Our teaching assistants - Jamie, Anna, and @smerchette - provided invaluable input, and the students are quickly becoming expert gene editors!
November 14, 2024 at 4:45 AM
It’s been a joy to develop & teach this hands-on #CRISPR lab course for @UWMadEngr. Read about our journey here. Our teaching assistants - Jamie, Anna, and @smerchette - provided invaluable input, and the students are quickly becoming expert gene editors!
Here is an excellent and ongoing discussion of a #CRISPR gene-edited cell therapy on the brink of approval. An important guidepost for our in vivo somatic editing efforts @somaticediting
November 14, 2024 at 4:45 AM
Here is an excellent and ongoing discussion of a #CRISPR gene-edited cell therapy on the brink of approval. An important guidepost for our in vivo somatic editing efforts @somaticediting
Congratulations to all the 2023 JITC Best Paper Award Recipients! Especially to former Ph.D. students in our @UWMadison lab: @kpmueller1 + @NicoleJPiscopo (w/@CapitiniMD @UWCarbone @CMaT_ERC) for Best Immune Cell Therapies & Immune Cell Engineering Paper
November 14, 2024 at 4:45 AM
Congratulations to all the 2023 JITC Best Paper Award Recipients! Especially to former Ph.D. students in our @UWMadison lab: @kpmueller1 + @NicoleJPiscopo (w/@CapitiniMD @UWCarbone @CMaT_ERC) for Best Immune Cell Therapies & Immune Cell Engineering Paper
We are hiring! Join the UW-Madison Biomedical Engineering department as a faculty member in a vibrant research community. 👇
November 14, 2024 at 4:45 AM
We are hiring! Join the UW-Madison Biomedical Engineering department as a faculty member in a vibrant research community. 👇
The ecosystem for biotech here in Madison and Wisconsin is on the rise… @UWCarbone @UWMadison @Forward_BIO
November 14, 2024 at 4:45 AM
The ecosystem for biotech here in Madison and Wisconsin is on the rise… @UWCarbone @UWMadison @Forward_BIO
Our new @somaticediting article describing an unexpected distribution of #CRISPR genome editing in the brain. These new delivery vectors can travel in surprising ways within tissues after injection. With Emborg, Levine, @GongShaoqin @uwsmph @UWMadEngr
November 14, 2024 at 4:45 AM
Our new @somaticediting article describing an unexpected distribution of #CRISPR genome editing in the brain. These new delivery vectors can travel in surprising ways within tissues after injection. With Emborg, Levine, @GongShaoqin @uwsmph @UWMadEngr
Happy to participate as an expert for this excellent @USGAO report on the applications, challenges, and policy options for regenerative medicine. Lots of exciting work ahead... #CellTherapy #GeneTherapy #CRISPR @NASEM_Health @CMaT_ERC @somaticediting
November 14, 2024 at 4:45 AM
Happy to participate as an expert for this excellent @USGAO report on the applications, challenges, and policy options for regenerative medicine. Lots of exciting work ahead... #CellTherapy #GeneTherapy #CRISPR @NASEM_Health @CMaT_ERC @somaticediting