Ryan Senne (he/him)
@ryguy.io
Computational Neuroscience Ph.D. Student @ Boston University. Labs of Dr. Brian DePasquale, Ben Scott, & Steve Ramirez. #JuliaLang stan.
Reposted by Ryan Senne (he/him)
The woman killed by ICE was Renee Nicole Good, a 37-year old who was the mother of a 4-year old child whose father already died a few years ago.
The Star Tribune talked to her mother. www.startribune.com/she-was-an-a...
The Star Tribune talked to her mother. www.startribune.com/she-was-an-a...
January 7, 2026 at 10:38 PM
The woman killed by ICE was Renee Nicole Good, a 37-year old who was the mother of a 4-year old child whose father already died a few years ago.
The Star Tribune talked to her mother. www.startribune.com/she-was-an-a...
The Star Tribune talked to her mother. www.startribune.com/she-was-an-a...
Reposted by Ryan Senne (he/him)
BBC is reporting that the same ICE officer who murdered Renee Good was involved in another violent incident in June.
January 7, 2026 at 11:46 PM
BBC is reporting that the same ICE officer who murdered Renee Good was involved in another violent incident in June.
Reposted by Ryan Senne (he/him)
NOW: Crowd continues to grow in Minneapolis at a vigil where a federal agent shot and killed Renee Good this morning.
“SAY HER NAME!”
“RENEE GOOD!”
“SAY HER NAME!”
“RENEE GOOD!”
January 7, 2026 at 11:22 PM
NOW: Crowd continues to grow in Minneapolis at a vigil where a federal agent shot and killed Renee Good this morning.
“SAY HER NAME!”
“RENEE GOOD!”
“SAY HER NAME!”
“RENEE GOOD!”
Reposted by Ryan Senne (he/him)
If you knew Renee Nicole Good - the 37 year old killed by ICE in Minneapolis today - please text me at 202-510-1268. You can remain anonymous
January 7, 2026 at 11:50 PM
If you knew Renee Nicole Good - the 37 year old killed by ICE in Minneapolis today - please text me at 202-510-1268. You can remain anonymous
Reposted by Ryan Senne (he/him)
A meta-analysis of studies using Tolman’s sunburst maze suggests poor replicability and little evidence for shortcutting. Ouch! Definitely relevant reading for anyone interested in cognitive maps! 👇
Can humans & animals really use internal maps to take shortcuts?
Tolman famously said yes - based largely on his Sunburst maze.
Our new review & meta-analysis suggests evidence is far weaker than you might think.
🧵👇 doi.org/10.1111/ejn....
@uofgpsychneuro.bsky.social @ejneuroscience.bsky.social
Tolman famously said yes - based largely on his Sunburst maze.
Our new review & meta-analysis suggests evidence is far weaker than you might think.
🧵👇 doi.org/10.1111/ejn....
@uofgpsychneuro.bsky.social @ejneuroscience.bsky.social
Tolman's Sunburst Maze 80 Years on: A Meta‐Analysis Reveals Poor Replicability and Little Evidence for Shortcutting
In 1946, Tolman et al. reported that rats could take a novel shortcut to a goal after training on an indirect route, supporting the Cognitive Map theory. However, a review of subsequent Sunburst maze...
doi.org
January 6, 2026 at 11:26 AM
A meta-analysis of studies using Tolman’s sunburst maze suggests poor replicability and little evidence for shortcutting. Ouch! Definitely relevant reading for anyone interested in cognitive maps! 👇
Reposted by Ryan Senne (he/him)
Given the popularity and centrality of neuronal calcium imaging to systems and cellular neuroscience, it is shockingly under-modelled. Makes me nervous about the conclusions from those studies.
At least the fMRI BOLD interpretation gets routinely debated...
At least the fMRI BOLD interpretation gets routinely debated...
the dendritic computation field are historically great at using biophysical NEURON simulations to think about their ephys experiments.
But the dendritic calcium modelling is way less developed, less rigorous, and as a result way less used than dendritic imaging physiologists
Modellers need to help
But the dendritic calcium modelling is way less developed, less rigorous, and as a result way less used than dendritic imaging physiologists
Modellers need to help
January 5, 2026 at 8:07 PM
Given the popularity and centrality of neuronal calcium imaging to systems and cellular neuroscience, it is shockingly under-modelled. Makes me nervous about the conclusions from those studies.
At least the fMRI BOLD interpretation gets routinely debated...
At least the fMRI BOLD interpretation gets routinely debated...
Reposted by Ryan Senne (he/him)
New paper drop! 🧠💊 Our new paper out in Molecular Psychiatry shows that the serotonin 1B receptor is important for the neural and antidepressant/anxiolytic behavioral responses to psilocybin in mice.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The serotonin 1B receptor is required for some of the behavioral effects of psilocybin in mice - Molecular Psychiatry
Molecular Psychiatry - The serotonin 1B receptor is required for some of the behavioral effects of psilocybin in mice
www.nature.com
December 21, 2025 at 7:50 PM
New paper drop! 🧠💊 Our new paper out in Molecular Psychiatry shows that the serotonin 1B receptor is important for the neural and antidepressant/anxiolytic behavioral responses to psilocybin in mice.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The reviewer 2 special I see
December 22, 2025 at 1:58 AM
The reviewer 2 special I see
Well that’s just absurd…
December 22, 2025 at 1:55 AM
Well that’s just absurd…
Reposted by Ryan Senne (he/him)
🚨 We are recruiting a full-time Research Programmer to push forward several exciting machine learning projects in the lab!
Work on computational behavior and joint neural/behavior models. Start date flexible, can be a pre-grad-school position or longer term.
recruiting2.ultipro.com/SCR1003TSRI/...
Work on computational behavior and joint neural/behavior models. Start date flexible, can be a pre-grad-school position or longer term.
recruiting2.ultipro.com/SCR1003TSRI/...
recruiting2.ultipro.com
December 10, 2025 at 4:40 PM
🚨 We are recruiting a full-time Research Programmer to push forward several exciting machine learning projects in the lab!
Work on computational behavior and joint neural/behavior models. Start date flexible, can be a pre-grad-school position or longer term.
recruiting2.ultipro.com/SCR1003TSRI/...
Work on computational behavior and joint neural/behavior models. Start date flexible, can be a pre-grad-school position or longer term.
recruiting2.ultipro.com/SCR1003TSRI/...
Reposted by Ryan Senne (he/him)
Are manifolds real?
Are latent circuits real?
Tatiana @engeltatiana.bsky.social uses one, infers the other, and says yes to both.
Also, how timescales are different and the same across the entire brain...
braininspired.co/podcast/226/
Are latent circuits real?
Tatiana @engeltatiana.bsky.social uses one, infers the other, and says yes to both.
Also, how timescales are different and the same across the entire brain...
braininspired.co/podcast/226/
December 4, 2025 at 6:52 PM
Are manifolds real?
Are latent circuits real?
Tatiana @engeltatiana.bsky.social uses one, infers the other, and says yes to both.
Also, how timescales are different and the same across the entire brain...
braininspired.co/podcast/226/
Are latent circuits real?
Tatiana @engeltatiana.bsky.social uses one, infers the other, and says yes to both.
Also, how timescales are different and the same across the entire brain...
braininspired.co/podcast/226/
Reposted by Ryan Senne (he/him)
My baby #JuliaLang package got an award!
DifferentiationInterface.jl just received a national prize for open-source research software and I couldn't be prouder. We started this from a vague dream with @adrianhill.de, and reached 1000 dependents and 100k downloads last month.
Research != just papers.
DifferentiationInterface.jl just received a national prize for open-source research software and I couldn't be prouder. We started this from a vague dream with @adrianhill.de, and reached 1000 dependents and 100k downloads last month.
Research != just papers.
December 2, 2025 at 9:55 AM
My baby #JuliaLang package got an award!
DifferentiationInterface.jl just received a national prize for open-source research software and I couldn't be prouder. We started this from a vague dream with @adrianhill.de, and reached 1000 dependents and 100k downloads last month.
Research != just papers.
DifferentiationInterface.jl just received a national prize for open-source research software and I couldn't be prouder. We started this from a vague dream with @adrianhill.de, and reached 1000 dependents and 100k downloads last month.
Research != just papers.
Reposted by Ryan Senne (he/him)
Awesome to see the French government recognize our work on open-source software! @ouvrirlascience.bsky.social
My baby #JuliaLang package got an award!
DifferentiationInterface.jl just received a national prize for open-source research software and I couldn't be prouder. We started this from a vague dream with @adrianhill.de, and reached 1000 dependents and 100k downloads last month.
Research != just papers.
DifferentiationInterface.jl just received a national prize for open-source research software and I couldn't be prouder. We started this from a vague dream with @adrianhill.de, and reached 1000 dependents and 100k downloads last month.
Research != just papers.
December 2, 2025 at 7:03 PM
Awesome to see the French government recognize our work on open-source software! @ouvrirlascience.bsky.social
Reposted by Ryan Senne (he/him)
Simulation-based inference has really become a commonly used tool for parameter inference across many fields and applications. We (finally...) got together to write a tutorial introduction and guide to (hopefully) help users get started and navigate the different methods and diagnostics!
Simulation-based inference (SBI) has transformed parameter inference across a wide range of domains. To help practitioners get started and make the most of these methods, we joined forces with researchers from many institutions and wrote a practical guide to SBI.
📄 Paper: arxiv.org/abs/2508.12939
📄 Paper: arxiv.org/abs/2508.12939
Simulation-Based Inference: A Practical Guide
A central challenge in many areas of science and engineering is to identify model parameters that are consistent with prior knowledge and empirical data. Bayesian inference offers a principled framewo...
arxiv.org
November 21, 2025 at 3:34 PM
Simulation-based inference has really become a commonly used tool for parameter inference across many fields and applications. We (finally...) got together to write a tutorial introduction and guide to (hopefully) help users get started and navigate the different methods and diagnostics!
Check out cool new work from the DePaq lab!
🔔 NEW PREPRINT FROM THE LAB ‼️
We introduce a new ML model, LoRAX, for predicting olfactory responses from chemical features, a tricky problem that benefits from progress in ML for biochem. We combine LoRA fine-tuning with protein and chemical foundation models, www.biorxiv.org/content/10.1...
We introduce a new ML model, LoRAX, for predicting olfactory responses from chemical features, a tricky problem that benefits from progress in ML for biochem. We combine LoRA fine-tuning with protein and chemical foundation models, www.biorxiv.org/content/10.1...
Low rank adaptation of chemical foundation models generate effective odorant representations
Featurizing odorants to enable robust prediction of their properties is difficult due to the complex activation patterns that odorants evoke in the olfactory system. Structurally similar odorants can ...
www.biorxiv.org
November 20, 2025 at 4:13 PM
Check out cool new work from the DePaq lab!
Reposted by Ryan Senne (he/him)
check out the @okaysteve.bsky.social lab’s posters (for both neuron and glia enthusiasts) at #SfN2025 on Saturday PM! especially say hello to @siriacoello.bsky.social who is applying to grad school this cycle✨
November 14, 2025 at 7:10 PM
check out the @okaysteve.bsky.social lab’s posters (for both neuron and glia enthusiasts) at #SfN2025 on Saturday PM! especially say hello to @siriacoello.bsky.social who is applying to grad school this cycle✨
And also thanks to @zachloschin.bsky.social and fellow bluesky-less authors for making this happen with me! Of course also a huge shout out to the @julialang.org, the friendliest OSS community ever created. Our GitHub: github.com/depasquale-l...
GitHub - depasquale-lab/StateSpaceDynamics.jl: Julia library for fitting and analyzing state space models. Provides efficient implementations of various SSMs including the canonical Gaussian LDS (Kalm...
Julia library for fitting and analyzing state space models. Provides efficient implementations of various SSMs including the canonical Gaussian LDS (Kalman Filter/Smoother), Poisson LDS, HMMs, etc....
github.com
November 14, 2025 at 4:29 PM
And also thanks to @zachloschin.bsky.social and fellow bluesky-less authors for making this happen with me! Of course also a huge shout out to the @julialang.org, the friendliest OSS community ever created. Our GitHub: github.com/depasquale-l...
but Julia has not...until now! This project was incredibly fun and really was a labor of love. Please check us out on GitHub! We are still in active development so the model offerings are only bigger! Special thanks to @briandepasquale.bsky.social for being a phenomenal mentor for this project!
November 14, 2025 at 4:29 PM
but Julia has not...until now! This project was incredibly fun and really was a labor of love. Please check us out on GitHub! We are still in active development so the model offerings are only bigger! Special thanks to @briandepasquale.bsky.social for being a phenomenal mentor for this project!
🚨🚨🚨NEW PAPER ALERT🚨🚨🚨
We present StateSpaceDynamics.jl, an open-source Julia package for fitting probabilistic state-space models (SSMs)—including non-conjugate models like Poisson LDS and switching variants (SLDS). Python has had existing packages that have given this functionality...
We present StateSpaceDynamics.jl, an open-source Julia package for fitting probabilistic state-space models (SSMs)—including non-conjugate models like Poisson LDS and switching variants (SLDS). Python has had existing packages that have given this functionality...
Just published in JOSS: 'StateSpaceDynamics.jl: A Julia package for probabilistic state space models (SSMs)' https://doi.org/10.21105/joss.08077
November 14, 2025 at 4:29 PM
🚨🚨🚨NEW PAPER ALERT🚨🚨🚨
We present StateSpaceDynamics.jl, an open-source Julia package for fitting probabilistic state-space models (SSMs)—including non-conjugate models like Poisson LDS and switching variants (SLDS). Python has had existing packages that have given this functionality...
We present StateSpaceDynamics.jl, an open-source Julia package for fitting probabilistic state-space models (SSMs)—including non-conjugate models like Poisson LDS and switching variants (SLDS). Python has had existing packages that have given this functionality...
Reposted by Ryan Senne (he/him)
Boulder friends: if you’re into animal behavior or vision, come to The Language of Light: Bioluminescence in the Deep Sea with Sönke Johnsen (Duke)!
Fri Nov 14, 4-5:30 pm, Benson Earth Sciences Auditorium, Room 180. Reception 5:30-6:30 at the Earth Sciences & Map Library
Free and open to all!
Fri Nov 14, 4-5:30 pm, Benson Earth Sciences Auditorium, Room 180. Reception 5:30-6:30 at the Earth Sciences & Map Library
Free and open to all!
November 9, 2025 at 8:54 PM
Boulder friends: if you’re into animal behavior or vision, come to The Language of Light: Bioluminescence in the Deep Sea with Sönke Johnsen (Duke)!
Fri Nov 14, 4-5:30 pm, Benson Earth Sciences Auditorium, Room 180. Reception 5:30-6:30 at the Earth Sciences & Map Library
Free and open to all!
Fri Nov 14, 4-5:30 pm, Benson Earth Sciences Auditorium, Room 180. Reception 5:30-6:30 at the Earth Sciences & Map Library
Free and open to all!
Great gerbil content Estelle!
October 31, 2025 at 5:23 PM
Great gerbil content Estelle!
Reposted by Ryan Senne (he/him)
Super excited to share the first part of my thesis work!
Perhaps how you might be able to both recognize someone’s voice *and* understand what they’re saying, we find that both social identity and vocalization category can be decoded from gerbil auditory cortex activity👂🧠
tinyurl.com/4fba6wk4
Perhaps how you might be able to both recognize someone’s voice *and* understand what they’re saying, we find that both social identity and vocalization category can be decoded from gerbil auditory cortex activity👂🧠
tinyurl.com/4fba6wk4
October 27, 2025 at 10:03 PM
Super excited to share the first part of my thesis work!
Perhaps how you might be able to both recognize someone’s voice *and* understand what they’re saying, we find that both social identity and vocalization category can be decoded from gerbil auditory cortex activity👂🧠
tinyurl.com/4fba6wk4
Perhaps how you might be able to both recognize someone’s voice *and* understand what they’re saying, we find that both social identity and vocalization category can be decoded from gerbil auditory cortex activity👂🧠
tinyurl.com/4fba6wk4
Reposted by Ryan Senne (he/him)
On November 7th, DON'T MISS @bostonu.bsky.social's Dr. Rebecca Suthard when she JOINS #MSNSeminars. Hosted by Drs. Brian Kipp, Chloe Lopez-Lee and Rimjhim Tomar, Dr. Suthard will present “A hippocampal astrocytic sequence emerges during learning and memory". @mountsinainyc.bsky.social
October 27, 2025 at 1:26 PM
On November 7th, DON'T MISS @bostonu.bsky.social's Dr. Rebecca Suthard when she JOINS #MSNSeminars. Hosted by Drs. Brian Kipp, Chloe Lopez-Lee and Rimjhim Tomar, Dr. Suthard will present “A hippocampal astrocytic sequence emerges during learning and memory". @mountsinainyc.bsky.social
Reposted by Ryan Senne (he/him)
I’m recruiting a postdoctoral researcher on a fully funded 2-year contract. The topic is developing and implementing new parallel graph algorithms, with applications to data-driven transportation and logistics.
Details and application procedure below ⬇️ Reach out if you have any questions!
Details and application procedure below ⬇️ Reach out if you have any questions!
acme-mobidec.github.io
October 27, 2025 at 5:43 PM
I’m recruiting a postdoctoral researcher on a fully funded 2-year contract. The topic is developing and implementing new parallel graph algorithms, with applications to data-driven transportation and logistics.
Details and application procedure below ⬇️ Reach out if you have any questions!
Details and application procedure below ⬇️ Reach out if you have any questions!