Brian DePasquale
@briandepasquale.bsky.social
science. https://briandepasquale.github.io
Reposted by Brian DePasquale
“The bad review will come from your list of suggested reviewers”
October 31, 2025 at 7:39 AM
“The bad review will come from your list of suggested reviewers”
Reposted by Brian DePasquale
What if we did a single run and declared victory
October 23, 2025 at 2:28 AM
What if we did a single run and declared victory
Reposted by Brian DePasquale
Ouch. This one cuts to the bone.
October 18, 2025 at 8:41 PM
Ouch. This one cuts to the bone.
Reposted by Brian DePasquale
Chemists call for ban on generative AI for chemical structures: "serious errors could damag[e] the next generation of scientists"
As ever, the problem seems to be not AI but lazy application of it and lack of checks. Whether _that_ problem is solvable...
www.chemistryworld.com/news/the-che...
As ever, the problem seems to be not AI but lazy application of it and lack of checks. Whether _that_ problem is solvable...
www.chemistryworld.com/news/the-che...
The chemistry community should ban drawing chemical structures with generative AI, chemists warn
AIs like Microsoft's Copilot, Google's Gemini and OpenAI's ChatGPT still make serious errors rendering structural formulae
www.chemistryworld.com
October 16, 2025 at 12:10 PM
Chemists call for ban on generative AI for chemical structures: "serious errors could damag[e] the next generation of scientists"
As ever, the problem seems to be not AI but lazy application of it and lack of checks. Whether _that_ problem is solvable...
www.chemistryworld.com/news/the-che...
As ever, the problem seems to be not AI but lazy application of it and lack of checks. Whether _that_ problem is solvable...
www.chemistryworld.com/news/the-che...
Reposted by Brian DePasquale
Reposted by Brian DePasquale
"the quickest way to get a collaborator to return edits on your manuscript is to write down their affiliation wrong" (ancient academic proverb)
October 6, 2025 at 3:21 AM
"the quickest way to get a collaborator to return edits on your manuscript is to write down their affiliation wrong" (ancient academic proverb)
Reposted by Brian DePasquale
Can one bring together Reinforcement learning and Drift Diffusion models to understand collective foraging ?
Congrads to Jonathan Marienhagen , Lisa Blum Moyse and Dominik Deffner on this new study. Very happy that I was part of this collaboration.
Preprint here: osf.io/preprints/ps...
Congrads to Jonathan Marienhagen , Lisa Blum Moyse and Dominik Deffner on this new study. Very happy that I was part of this collaboration.
Preprint here: osf.io/preprints/ps...
September 16, 2025 at 10:14 AM
Can one bring together Reinforcement learning and Drift Diffusion models to understand collective foraging ?
Congrads to Jonathan Marienhagen , Lisa Blum Moyse and Dominik Deffner on this new study. Very happy that I was part of this collaboration.
Preprint here: osf.io/preprints/ps...
Congrads to Jonathan Marienhagen , Lisa Blum Moyse and Dominik Deffner on this new study. Very happy that I was part of this collaboration.
Preprint here: osf.io/preprints/ps...
Reposted by Brian DePasquale
PLOS Comput. Biol.: Stochastic activity in low-rank recurrent neural networks
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1013371
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1013371
August 20, 2025 at 1:03 PM
PLOS Comput. Biol.: Stochastic activity in low-rank recurrent neural networks
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1013371
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1013371
Reposted by Brian DePasquale
“NeuroAI should not remain limited to learning statistical relationships, but should also help in building mechanistic and causal models of neural activity. These models will incorporate biological properties of neural circuits, including cellular characteristics and network properties.”
💯💯💯
💯💯💯
We were asked to write a commentary on NeuroAI for Nat. Rev. Neuro. with Sadra Sadeh, so here it is: www.nature.com/articles/s41...
www.nature.com
August 8, 2025 at 12:43 PM
“NeuroAI should not remain limited to learning statistical relationships, but should also help in building mechanistic and causal models of neural activity. These models will incorporate biological properties of neural circuits, including cellular characteristics and network properties.”
💯💯💯
💯💯💯
Reposted by Brian DePasquale
New preprint from @darbly.bsky.social @briandepasquale.bsky.social and my labs! If you love (or hate) mosquitoes, have a look:
doi.org/10.1101/2025...
We used TEM to describe the circuitry used for CO2 detection by mosquitoes. As usual with mosquitoes, nothing is as expected! 🌬️🦟
doi.org/10.1101/2025...
We used TEM to describe the circuitry used for CO2 detection by mosquitoes. As usual with mosquitoes, nothing is as expected! 🌬️🦟
Recurrent connectivity supports carbon dioxide sensitivity in Aedes aegypti mosquitoes
The mosquito Aedes aegypti′s human host-seeking behavior depends on the integration of multiple sensory cues. One of these cues, carbon dioxide (CO2), gates odorant and heat pathways and activates hos...
doi.org
July 31, 2025 at 12:28 PM
New preprint from @darbly.bsky.social @briandepasquale.bsky.social and my labs! If you love (or hate) mosquitoes, have a look:
doi.org/10.1101/2025...
We used TEM to describe the circuitry used for CO2 detection by mosquitoes. As usual with mosquitoes, nothing is as expected! 🌬️🦟
doi.org/10.1101/2025...
We used TEM to describe the circuitry used for CO2 detection by mosquitoes. As usual with mosquitoes, nothing is as expected! 🌬️🦟
Reposted by Brian DePasquale
June 19, 2025 at 4:31 PM
Reposted by Brian DePasquale
How do brain circuits evolve? We started looking for some answers by using synapse-resolution cross-species comparative connectomics on an entire olfactory circuit 👇
bit.ly/44aVm9E
bit.ly/44aVm9E
June 12, 2025 at 11:04 AM
How do brain circuits evolve? We started looking for some answers by using synapse-resolution cross-species comparative connectomics on an entire olfactory circuit 👇
bit.ly/44aVm9E
bit.ly/44aVm9E
Reposted by Brian DePasquale
Can #AI become a true scientist? @ninamiolane.bsky.social explores how new technologies are reshaping scientific discovery, and why human expertise remains essential as we enter a new era of research powered by intelligent algorithms. 🧪
plos.io/4kZi0aB
plos.io/4kZi0aB
The fifth era of science: Artificial scientific intelligence
Can AI become a true scientist? This Perspective explores how new technologies are reshaping scientific discovery, and why human expertise remains essential as we enter a new era of research powered b...
plos.io
June 11, 2025 at 11:46 AM
Can #AI become a true scientist? @ninamiolane.bsky.social explores how new technologies are reshaping scientific discovery, and why human expertise remains essential as we enter a new era of research powered by intelligent algorithms. 🧪
plos.io/4kZi0aB
plos.io/4kZi0aB
Tired of your boring old DDM? Check out recent work by grad student @ryguy.io that introduces a *state-dependent* DDM using an underlying HMM. We find mice change their speed-accuracy strategy from trial to trial! Code provided! (in Julia of course!)
🚨PREPRINT ALERT🚨
"A State–Dependent Drift Diffusion Model Reveals Mice Actively Explore A Speed–Accuracy Continuum During Decision-Making" is now available on biorxiv! Check it out below 👇
www.biorxiv.org/content/10.1...
In this work we find that mice are not just static mindless decision makers.
"A State–Dependent Drift Diffusion Model Reveals Mice Actively Explore A Speed–Accuracy Continuum During Decision-Making" is now available on biorxiv! Check it out below 👇
www.biorxiv.org/content/10.1...
In this work we find that mice are not just static mindless decision makers.
A State-Dependent Drift Diffusion Model Reveals Mice Actively Explore A Speed–Accuracy Continuum During Decision-Making
Understanding how animals shift between different decision-making strategies is critical for bridging normative models with naturalistic behavior. While drift diffusion models (DDMs) provide a powerfu...
www.biorxiv.org
June 10, 2025 at 6:48 PM
Tired of your boring old DDM? Check out recent work by grad student @ryguy.io that introduces a *state-dependent* DDM using an underlying HMM. We find mice change their speed-accuracy strategy from trial to trial! Code provided! (in Julia of course!)
Reposted by Brian DePasquale
90% of doing science is being open to new ideas.
May 31, 2025 at 6:14 PM
90% of doing science is being open to new ideas.
Reposted by Brian DePasquale
Unsurprising, but nevertheless tragic. Makes it very hard for integrators and multidisciplinarians to exist in academia. #academicsky
The further a researcher or inventor moves from their previous work, the less cited their latest work will be
https://go.nature.com/44VjEW9
https://go.nature.com/44VjEW9
Shifting research focus comes with the risk of reduced impact
An analysis of millions of scientific papers and patents shows that the further a researcher or inventor moves from their previous work, the less cited their latest work will be.
go.nature.com
June 1, 2025 at 2:43 AM
Unsurprising, but nevertheless tragic. Makes it very hard for integrators and multidisciplinarians to exist in academia. #academicsky
Reposted by Brian DePasquale
Hivemind, what's the best approach/tool to aggregate neural data across sessions (and animals) in dimensionality reduction analyses, particularly when it's not known how overlapping the pool of neurons are over different sessions?
May 10, 2025 at 3:30 PM
Hivemind, what's the best approach/tool to aggregate neural data across sessions (and animals) in dimensionality reduction analyses, particularly when it's not known how overlapping the pool of neurons are over different sessions?
Reposted by Brian DePasquale
"The core strategy is to slow NIH spending to generate surpluses...then use surpluses as justification for slashing the budget...unspent [$] won’t be because NIH doesn’t have good science to spend on [but] because the administration has blocked spending" donmoynihan.substack.com/p/the-nih-bu...
donmoynihan.substack.com
April 29, 2025 at 5:53 PM
"The core strategy is to slow NIH spending to generate surpluses...then use surpluses as justification for slashing the budget...unspent [$] won’t be because NIH doesn’t have good science to spend on [but] because the administration has blocked spending" donmoynihan.substack.com/p/the-nih-bu...
Reposted by Brian DePasquale
Using pretrained vision-language models to align neural signals from different modalities:
arxiv.org/pdf/2407.14020
Cool stuff, though I would still love to see if we could align different neural modalities without the pretrained VLMs...
🧠📈 🧪 #NeuroAI
arxiv.org/pdf/2407.14020
Cool stuff, though I would still love to see if we could align different neural modalities without the pretrained VLMs...
🧠📈 🧪 #NeuroAI
arxiv.org
April 29, 2025 at 6:40 PM
Using pretrained vision-language models to align neural signals from different modalities:
arxiv.org/pdf/2407.14020
Cool stuff, though I would still love to see if we could align different neural modalities without the pretrained VLMs...
🧠📈 🧪 #NeuroAI
arxiv.org/pdf/2407.14020
Cool stuff, though I would still love to see if we could align different neural modalities without the pretrained VLMs...
🧠📈 🧪 #NeuroAI
Reposted by Brian DePasquale
“Science is a smart, low cost investment. The costs of not investing in it are higher than the risk of doing so… talk to people about science.” - @kevinochsner.bsky.social makes his case to the field #sans2025
April 26, 2025 at 9:03 PM
“Science is a smart, low cost investment. The costs of not investing in it are higher than the risk of doing so… talk to people about science.” - @kevinochsner.bsky.social makes his case to the field #sans2025
Reposted by Brian DePasquale
First big new @simonsfoundation.org neuroscience collaboration launches - exciting!! The product of a HUGE competition among the best minds and teams.
Congrats to this group:
www.simonsfoundation.org/neuroscience...
Congrats to this group:
www.simonsfoundation.org/neuroscience...
Simons Collaboration on Ecological Neuroscience
The mission of the Simons Collaboration on Ecological NEuroscience (SCENE) is to understand how affordances offered by the world shape representations in the mind and the brain.
www.simonsfoundation.org
April 24, 2025 at 6:52 PM
First big new @simonsfoundation.org neuroscience collaboration launches - exciting!! The product of a HUGE competition among the best minds and teams.
Congrats to this group:
www.simonsfoundation.org/neuroscience...
Congrats to this group:
www.simonsfoundation.org/neuroscience...
Reposted by Brian DePasquale
Olfactory neuroscientists have known for a while that their stimuli stink. A new analysis illuminates the extent of the problem.
By @callimcflurry.bsky.social
#neuroskyence
www.thetransmitter.org/olfaction/sm...
By @callimcflurry.bsky.social
#neuroskyence
www.thetransmitter.org/olfaction/sm...
Smell studies often use unnaturally high odor concentrations, analysis reveals
It’s time to fashion olfactory neuroscience stimuli based on odor concentrations in the wild, say study investigators Elizabeth Hong and Matt Wachowiak.
www.thetransmitter.org
April 16, 2025 at 2:26 PM
Olfactory neuroscientists have known for a while that their stimuli stink. A new analysis illuminates the extent of the problem.
By @callimcflurry.bsky.social
#neuroskyence
www.thetransmitter.org/olfaction/sm...
By @callimcflurry.bsky.social
#neuroskyence
www.thetransmitter.org/olfaction/sm...
Reposted by Brian DePasquale
Cool project led by Victor Geadah, fitting smoothly time-varying (and condition-varying) linear dynamical systems to neural activity.
arxiv.org/abs/2502.18347
arxiv.org/abs/2502.18347
April 11, 2025 at 3:56 PM
Cool project led by Victor Geadah, fitting smoothly time-varying (and condition-varying) linear dynamical systems to neural activity.
arxiv.org/abs/2502.18347
arxiv.org/abs/2502.18347