Róża Przanowska
@rprzanowska.bsky.social
NCI K00 Fellow in Janes Lab at U of Virginia BME (USA) working on ncRNAs in breast cancer. PhD on ncRNAs in myogenesis in Dutta lab at UVA BMG. MSc from U of Warsaw (Poland). Mom of three and wife of Dr. Piotr Przanowski, scientist and HEMA fighter.
Pinned
Patient-derived response estimates from zero-passage organoids of luminal breast cancer - Breast Cancer Research
Background Primary luminal breast cancer cells lose their identity rapidly in standard tissue culture, which is problematic for testing hormone interventions and molecular pathways specific to the lum...
breast-cancer-research.biomedcentral.com
Thrilled to share my first-author postdoc paper, "Patient-derived response estimates from zero-passage organoids of luminal breast cancer," just published in Breast Cancer Research! This project brings us closer to personalized treatments for #BreastCancer patients. 🧵(1/5)
Reposted by Róża Przanowska
Exciting news for the RNA research community!
The Human RNome Project has been launched: a global effort to map all human RNAs and their chemical modifications. Proud to support it and contribute to the article in Genome Biology doi.org/10.1186/s130...
#RNA #bioinformatics #RNAstructure #modomics
The Human RNome Project has been launched: a global effort to map all human RNAs and their chemical modifications. Proud to support it and contribute to the article in Genome Biology doi.org/10.1186/s130...
#RNA #bioinformatics #RNAstructure #modomics
Unlocking the regulatory code of RNA: launching the Human RNome Project - Genome Biology
The human RNome, the complete set of RNA molecules in human cells, arises through complex processing and includes diverse molecular species. While research traditionally focuses on four canonical nucl...
genomebiology.biomedcentral.com
October 25, 2025 at 10:27 PM
Exciting news for the RNA research community!
The Human RNome Project has been launched: a global effort to map all human RNAs and their chemical modifications. Proud to support it and contribute to the article in Genome Biology doi.org/10.1186/s130...
#RNA #bioinformatics #RNAstructure #modomics
The Human RNome Project has been launched: a global effort to map all human RNAs and their chemical modifications. Proud to support it and contribute to the article in Genome Biology doi.org/10.1186/s130...
#RNA #bioinformatics #RNAstructure #modomics
Excited to share one of the first papers to link #lncRNA #structure to its function in #cancer!
We mapped the structure of a tumor-suppressive DRAIC lncRNA and identified a 36-nucleotide hairpin as necessary and sufficient for its #anti-oncogenic function.
www.sciencedirect.com/science/arti...
We mapped the structure of a tumor-suppressive DRAIC lncRNA and identified a 36-nucleotide hairpin as necessary and sufficient for its #anti-oncogenic function.
www.sciencedirect.com/science/arti...
July 25, 2025 at 7:52 PM
Excited to share one of the first papers to link #lncRNA #structure to its function in #cancer!
We mapped the structure of a tumor-suppressive DRAIC lncRNA and identified a 36-nucleotide hairpin as necessary and sufficient for its #anti-oncogenic function.
www.sciencedirect.com/science/arti...
We mapped the structure of a tumor-suppressive DRAIC lncRNA and identified a 36-nucleotide hairpin as necessary and sufficient for its #anti-oncogenic function.
www.sciencedirect.com/science/arti...
It’s interesting how an offside project can bring so much value. Working on ORCs gave me new experiences, deeper insights into #DNAreplication, and some of the most fun I have had giving talks. #Orc #LOTR
Read more in @elife.bsky.social Version of Record:
elifesciences.org/articles/102...
Read more in @elife.bsky.social Version of Record:
elifesciences.org/articles/102...
July 25, 2025 at 7:39 PM
It’s interesting how an offside project can bring so much value. Working on ORCs gave me new experiences, deeper insights into #DNAreplication, and some of the most fun I have had giving talks. #Orc #LOTR
Read more in @elife.bsky.social Version of Record:
elifesciences.org/articles/102...
Read more in @elife.bsky.social Version of Record:
elifesciences.org/articles/102...
Reposted by Róża Przanowska
Excited to share Benson’s and Maria’s work in collab w/Kostas Tzelepis: we found the nucleolar protein NPM1 is a marker of AML and can be targeted therapeutically
connecting ‘cell surface RNA biology’ to cancer biology
@natbiotech.nature.com
www.nature.com/articles/s41...
connecting ‘cell surface RNA biology’ to cancer biology
@natbiotech.nature.com
www.nature.com/articles/s41...
April 23, 2025 at 11:44 AM
Excited to share Benson’s and Maria’s work in collab w/Kostas Tzelepis: we found the nucleolar protein NPM1 is a marker of AML and can be targeted therapeutically
connecting ‘cell surface RNA biology’ to cancer biology
@natbiotech.nature.com
www.nature.com/articles/s41...
connecting ‘cell surface RNA biology’ to cancer biology
@natbiotech.nature.com
www.nature.com/articles/s41...
Reposted by Róża Przanowska
🎉 Incredibly proud to share my first-author paper in
@nature.com! Heartfelt thanks to my mentor @andrzejdziembowski.bsky.social and the brilliant team at DziembowskiLab at @iimcb.bsky.social. More details in the 🧵below ⬇️
@nature.com! Heartfelt thanks to my mentor @andrzejdziembowski.bsky.social and the brilliant team at DziembowskiLab at @iimcb.bsky.social. More details in the 🧵below ⬇️
April 17, 2025 at 12:15 PM
🎉 Incredibly proud to share my first-author paper in
@nature.com! Heartfelt thanks to my mentor @andrzejdziembowski.bsky.social and the brilliant team at DziembowskiLab at @iimcb.bsky.social. More details in the 🧵below ⬇️
@nature.com! Heartfelt thanks to my mentor @andrzejdziembowski.bsky.social and the brilliant team at DziembowskiLab at @iimcb.bsky.social. More details in the 🧵below ⬇️
Reposted by Róża Przanowska
🌐Our @nature.com paper is out! Researchers from IIMCB and other Polish institutions show how TENT5A boosts mRNA vaccine efficacy by stabilizing therapeutic mRNAs and enhancing antigen production. A step toward better therapies for cancer and beyond! 🧬
👉Read the story: bit.ly/3XYvQkI
#Nature #mRNA
👉Read the story: bit.ly/3XYvQkI
#Nature #mRNA
IIMCB
bit.ly
April 16, 2025 at 6:00 PM
🌐Our @nature.com paper is out! Researchers from IIMCB and other Polish institutions show how TENT5A boosts mRNA vaccine efficacy by stabilizing therapeutic mRNAs and enhancing antigen production. A step toward better therapies for cancer and beyond! 🧬
👉Read the story: bit.ly/3XYvQkI
#Nature #mRNA
👉Read the story: bit.ly/3XYvQkI
#Nature #mRNA
Reposted by Róża Przanowska
Urgently reposting! University leadership need to actively check the SEVIS database every day (studyinthestates.dhs.gov/sevis-help-hub). Ask your chair to commit to it.
Yesterday, UW discovered 9 visa cancellations & only found out b/c they ran a status check. www.seattletimes.com/seattle-news...
Yesterday, UW discovered 9 visa cancellations & only found out b/c they ran a status check. www.seattletimes.com/seattle-news...
April 8, 2025 at 4:16 PM
Urgently reposting! University leadership need to actively check the SEVIS database every day (studyinthestates.dhs.gov/sevis-help-hub). Ask your chair to commit to it.
Yesterday, UW discovered 9 visa cancellations & only found out b/c they ran a status check. www.seattletimes.com/seattle-news...
Yesterday, UW discovered 9 visa cancellations & only found out b/c they ran a status check. www.seattletimes.com/seattle-news...
Reposted by Róża Przanowska
A nearly 9 year effort to design and implement new CLIP-based technologies to define multimeric protein assemblies on RNA.
Enables ‘watching’ of RNP assemblies inside living cells
Special congrats to Luca Ducoli, Brian Zarnegar, and Paul Khavari @nature.com
www.nature.com/articles/s41...
Enables ‘watching’ of RNP assemblies inside living cells
Special congrats to Luca Ducoli, Brian Zarnegar, and Paul Khavari @nature.com
www.nature.com/articles/s41...
March 26, 2025 at 5:40 PM
A nearly 9 year effort to design and implement new CLIP-based technologies to define multimeric protein assemblies on RNA.
Enables ‘watching’ of RNP assemblies inside living cells
Special congrats to Luca Ducoli, Brian Zarnegar, and Paul Khavari @nature.com
www.nature.com/articles/s41...
Enables ‘watching’ of RNP assemblies inside living cells
Special congrats to Luca Ducoli, Brian Zarnegar, and Paul Khavari @nature.com
www.nature.com/articles/s41...
Congratulations to all authors, especially Natalia! Great work!
#ninetails #nanopore #polyA #mRNA #vaccines
#ninetails #nanopore #polyA #mRNA #vaccines
Direct profiling of non-adenosines in poly(A) tails of endogenous and therapeutic mRNAs with Ninetails - Nature Communications
Ninetails, a neural network that uses Nanopore Direct RNA sequencing data to identify non-A residues in mRNA poly(A) tails is presented. Particularly non-A of therapeutic, mitochondrial, and TENT5A/C ...
www.nature.com
March 18, 2025 at 9:22 PM
Congratulations to all authors, especially Natalia! Great work!
#ninetails #nanopore #polyA #mRNA #vaccines
#ninetails #nanopore #polyA #mRNA #vaccines
Reposted by Róża Przanowska
This is crazy shit. Here is early work on a very promising mRNA vaccine against pancreatic cancer.
Is cancer treatment anti-American now?
🧪
www.nature.com/articles/s41...
Is cancer treatment anti-American now?
🧪
www.nature.com/articles/s41...
March 17, 2025 at 1:13 AM
This is crazy shit. Here is early work on a very promising mRNA vaccine against pancreatic cancer.
Is cancer treatment anti-American now?
🧪
www.nature.com/articles/s41...
Is cancer treatment anti-American now?
🧪
www.nature.com/articles/s41...
Have you wondered what the @elife.bsky.social peer-review process looks like? Feel free to see our responses to the reviewer comments on our manuscript "DNA replication in primary hepatocytes without the six-subunit #ORC". I enjoyed the process and highly recommend it!
DNA replication in primary hepatocytes without the six-subunit ORC
elifesciences.org
March 11, 2025 at 2:59 PM
Have you wondered what the @elife.bsky.social peer-review process looks like? Feel free to see our responses to the reviewer comments on our manuscript "DNA replication in primary hepatocytes without the six-subunit #ORC". I enjoyed the process and highly recommend it!
Reposted by Róża Przanowska
One of the many, many “pauses” and cancellations devastating our next generation of researchers. “The NIH Intramural Program has paused the recruitment of IRTAs, CRTAs, and Visiting Fellows in all training programs pending guidance from Health and Human Services. Check back daily for updates.”
Postbac Program
www.training.nih.gov
February 18, 2025 at 2:03 AM
One of the many, many “pauses” and cancellations devastating our next generation of researchers. “The NIH Intramural Program has paused the recruitment of IRTAs, CRTAs, and Visiting Fellows in all training programs pending guidance from Health and Human Services. Check back daily for updates.”
This is an exciting piece of research that brings us closer to an informed choice of therapy for individual patients. I am grateful to my PI and all collaborators for letting me learn how to start a translational project and how far it can reach. Thanks to UVA Engineering for highlighting our work!
UVA Researchers Fast-Track Cancer Care with Patient-Specific Tumor Models | University of Virginia School of Engineering and Applied Science
What if doctors could predict a breast cancer patient’s response to treatment in just two weeks?
engineering.virginia.edu
January 30, 2025 at 7:39 PM
This is an exciting piece of research that brings us closer to an informed choice of therapy for individual patients. I am grateful to my PI and all collaborators for letting me learn how to start a translational project and how far it can reach. Thanks to UVA Engineering for highlighting our work!
Reposted by Róża Przanowska
#Rstats trick: use case_when(). I use it almost every week. No more nested if else
gist.github.com/crazyhottom...
gist.github.com/crazyhottom...
January 12, 2025 at 2:45 PM
#Rstats trick: use case_when(). I use it almost every week. No more nested if else
gist.github.com/crazyhottom...
gist.github.com/crazyhottom...
January 10, 2025 at 4:41 PM
Happy to close 2024 with my last first-author publication from PhD thesis: "DNA replication in primary hepatocytes without the six-subunit #ORC" in @elife.bsky.social. This study challenges existing paradigms in #DNAreplication. 🧵(1/4)
elifesciences.org/reviewed-pre...
elifesciences.org/reviewed-pre...
DNA replication in primary hepatocytes without the six-subunit ORC
elifesciences.org
January 1, 2025 at 8:57 PM
Happy to close 2024 with my last first-author publication from PhD thesis: "DNA replication in primary hepatocytes without the six-subunit #ORC" in @elife.bsky.social. This study challenges existing paradigms in #DNAreplication. 🧵(1/4)
elifesciences.org/reviewed-pre...
elifesciences.org/reviewed-pre...
Thrilled to share my first-author postdoc paper, "Patient-derived response estimates from zero-passage organoids of luminal breast cancer," just published in Breast Cancer Research! This project brings us closer to personalized treatments for #BreastCancer patients. 🧵(1/5)
Patient-derived response estimates from zero-passage organoids of luminal breast cancer - Breast Cancer Research
Background Primary luminal breast cancer cells lose their identity rapidly in standard tissue culture, which is problematic for testing hormone interventions and molecular pathways specific to the lum...
breast-cancer-research.biomedcentral.com
January 1, 2025 at 8:42 PM
Thrilled to share my first-author postdoc paper, "Patient-derived response estimates from zero-passage organoids of luminal breast cancer," just published in Breast Cancer Research! This project brings us closer to personalized treatments for #BreastCancer patients. 🧵(1/5)
Feeling so hopeful for 2025 after an amazing close to 2024! Grateful for a wonderful family vacation to recharge and thrilled to have two first-author papers published as a late birthday surprise on the very last day of the year. Wishing everyone a happy and fulfilling new year!
January 1, 2025 at 8:31 PM
Feeling so hopeful for 2025 after an amazing close to 2024! Grateful for a wonderful family vacation to recharge and thrilled to have two first-author papers published as a late birthday surprise on the very last day of the year. Wishing everyone a happy and fulfilling new year!
Reposted by Róża Przanowska
Bioart, courtesy of the NIH. All images are in the public domain and available for download as high-quality SVGs.
bioart.niaid.nih.gov
bioart.niaid.nih.gov
December 17, 2024 at 1:15 AM
Bioart, courtesy of the NIH. All images are in the public domain and available for download as high-quality SVGs.
bioart.niaid.nih.gov
bioart.niaid.nih.gov
Another beautiful example of #lncRNA #structure-function study from Dutta lab at UAB. Grateful to add a small puzzle piece to this work. Congratulations Xiaoxiao and all involved!
A 36-base hairpin within lncRNA DRAIC, which is modulated by alternative splicing, interacts with the IKKα coiled-coil domain and inhibits NF-kB and tumor cell phenotypes https://www.biorxiv.org/content/10.1101/2024.12.23.629241v1
December 26, 2024 at 3:20 PM
Another beautiful example of #lncRNA #structure-function study from Dutta lab at UAB. Grateful to add a small puzzle piece to this work. Congratulations Xiaoxiao and all involved!
Reposted by Róża Przanowska
A 36-base hairpin within lncRNA DRAIC, which is modulated by alternative splicing, interacts with the IKKα coiled-coil domain and inhibits NF-kB and tumor cell phenotypes https://www.biorxiv.org/content/10.1101/2024.12.23.629241v1
December 24, 2024 at 5:18 PM
A 36-base hairpin within lncRNA DRAIC, which is modulated by alternative splicing, interacts with the IKKα coiled-coil domain and inhibits NF-kB and tumor cell phenotypes https://www.biorxiv.org/content/10.1101/2024.12.23.629241v1
Reposted by Róża Przanowska
Many academics point to bioRxiv as “the one thing improving science publishing”.
If so, the one thing you all can do is persuade colleagues to submit and make this a norm. 1/2
If so, the one thing you all can do is persuade colleagues to submit and make this a norm. 1/2
December 21, 2024 at 2:01 PM
Many academics point to bioRxiv as “the one thing improving science publishing”.
If so, the one thing you all can do is persuade colleagues to submit and make this a norm. 1/2
If so, the one thing you all can do is persuade colleagues to submit and make this a norm. 1/2
Reposted by Róża Przanowska
Our recent preprint about using a custom chromatin capture assay, to identify potential target genes for cancer risk variants. For several variants, the target gene for cis regulation was ~ +/- 1Mb away, and we experimentally confirmed this for multiple targets.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Mapping chromatin interactions at melanoma susceptibility loci and cell-type specific dataset integration uncovers distant gene targets of cis-regulation
Genome-wide association studies (GWAS) of melanoma risk have identified 68 independent signals at 54 loci. For most loci, specific functional variants and their respective target genes remain to be es...
www.medrxiv.org
December 6, 2024 at 7:07 PM
Our recent preprint about using a custom chromatin capture assay, to identify potential target genes for cancer risk variants. For several variants, the target gene for cis regulation was ~ +/- 1Mb away, and we experimentally confirmed this for multiple targets.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Reposted by Róża Przanowska
We often hear that nutrition needs are dynamic over your life, that some things are more important as kids (calcium), that there are super foods.
If you are like me, these concepts can seem a bit vague.
This new @pnas.org paper is a great resource.
🧵
🧪
#PEDSky
#MEDSky
www.pnas.org/doi/full/10....
If you are like me, these concepts can seem a bit vague.
This new @pnas.org paper is a great resource.
🧵
🧪
#PEDSky
#MEDSky
www.pnas.org/doi/full/10....
Nutrient-dense foods and diverse diets are important for ensuring adequate nutrition across the life course | PNAS
The world faces a global challenge of how to meet the nutritional needs of a diverse
global population through diets. This paper defines the relati...
www.pnas.org
December 13, 2024 at 2:58 AM
We often hear that nutrition needs are dynamic over your life, that some things are more important as kids (calcium), that there are super foods.
If you are like me, these concepts can seem a bit vague.
This new @pnas.org paper is a great resource.
🧵
🧪
#PEDSky
#MEDSky
www.pnas.org/doi/full/10....
If you are like me, these concepts can seem a bit vague.
This new @pnas.org paper is a great resource.
🧵
🧪
#PEDSky
#MEDSky
www.pnas.org/doi/full/10....