Roberto J. Brea
@robertojbrea.bsky.social
Ramón y Cajal Assistant Professor at @CICAUDC.bsky.social @udc.gal | Research group leader of @BioNanoChem.bsky.social | #chemicalbiology #supramolecular #lipid #syntheticcell
Reposted by Roberto J. Brea
Researchers in Itay Budin's lab, incl. William Moore, have created a tool with the power to see lipid movement inside cells in unprecedented detail. The tool uses fluorogens to illuminate certain lipids while other remain dark. Their work appears in Nature Chemical Biology. https://bit.ly/4hnDFZG
The Many FACES of Lipid Research
Scientists have long wanted to get a closer look at the movement of lipids around a cell, but it’s tough to visualize with traditional light microscopy. UC San Diego researchers have unveiled a new technology with the power to see cells in unprecedented detail.
bit.ly
October 17, 2025 at 6:01 PM
Researchers in Itay Budin's lab, incl. William Moore, have created a tool with the power to see lipid movement inside cells in unprecedented detail. The tool uses fluorogens to illuminate certain lipids while other remain dark. Their work appears in Nature Chemical Biology. https://bit.ly/4hnDFZG
Reposted by Roberto J. Brea
Lipid imaging on the cover of @nature.com! Great times for lipid cell biology indeed. And a fantastic recognition of all the hard work by the team, especially Juan M. Iglesias-Artola and Kristin Böhlig (who made the cover). Link to article: www.nature.com/articles/s41...
October 9, 2025 at 9:01 AM
Lipid imaging on the cover of @nature.com! Great times for lipid cell biology indeed. And a fantastic recognition of all the hard work by the team, especially Juan M. Iglesias-Artola and Kristin Böhlig (who made the cover). Link to article: www.nature.com/articles/s41...
Reposted by Roberto J. Brea
Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...
Leaflet-specific phospholipid imaging using genetically encoded proximity sensors - Nature Chemical Biology
An approach combining bioorthogonal chemistry with genetically encoded fluorogen-activating proteins enables subcellular imaging of phospholipids and glycans, as well as the visualization of lipid tra...
www.nature.com
September 15, 2025 at 6:03 PM
Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...
Reposted by Roberto J. Brea
We have developed an entirely new mechanism of action for gene knockdown -> trafficking of targeted mRNAs to the lysosomal, using lysosomal trafficking oligonucleotides (LyTONs)!
Published in @chemicalscience.rsc.org
Led by Disha Kashyap
#chemsky 🧪
pubs.rsc.org/en/content/a...
Published in @chemicalscience.rsc.org
Led by Disha Kashyap
#chemsky 🧪
pubs.rsc.org/en/content/a...
Engineering antisense oligonucleotides for targeted mRNA degradation through lysosomal trafficking
Antisense oligonucleotides (ASOs) can modulate gene expression at the mRNA level, providing the ability to tackle conventionally undruggable targets and usher in an era of personalized medicine. A key...
pubs.rsc.org
June 23, 2025 at 8:01 AM
We have developed an entirely new mechanism of action for gene knockdown -> trafficking of targeted mRNAs to the lysosomal, using lysosomal trafficking oligonucleotides (LyTONs)!
Published in @chemicalscience.rsc.org
Led by Disha Kashyap
#chemsky 🧪
pubs.rsc.org/en/content/a...
Published in @chemicalscience.rsc.org
Led by Disha Kashyap
#chemsky 🧪
pubs.rsc.org/en/content/a...
Reposted by Roberto J. Brea
Extremadamente orgulloso de Xoán, Lucía e Andrés, estudantes STEMbach do IES Eusebio da Guarda tutorizados no meu laboratorio @bionanochem.bsky.social @udc.gal @cicaudc.bsky.social, polo seu premio no acto de recoñecemento dos proxectos STEMbach da Xunta de Galicia.
www.xunta.gal/notas-de-pre...
www.xunta.gal/notas-de-pre...
June 20, 2025 at 1:50 PM
Reposted by Roberto J. Brea
🌟 Noraboa aos 63 centros e alumnado participante nunha nova convocatoria #Stembach. Desde a #UDC codiriximos 14 proxectos, sendo o de Células sintéticas disipativas moduladas mediante combustibles químicos, do Instituto IES Plurilingüe Eusebio de A Guarda (A Coruña); un dos permiados.🔝 Parabéns!!👏👏
June 20, 2025 at 8:28 AM
🌟 Noraboa aos 63 centros e alumnado participante nunha nova convocatoria #Stembach. Desde a #UDC codiriximos 14 proxectos, sendo o de Células sintéticas disipativas moduladas mediante combustibles químicos, do Instituto IES Plurilingüe Eusebio de A Guarda (A Coruña); un dos permiados.🔝 Parabéns!!👏👏
Extremadamente orgulloso de Xoán, Lucía e Andrés, estudantes STEMbach do IES Eusebio da Guarda tutorizados no meu laboratorio @bionanochem.bsky.social @udc.gal @cicaudc.bsky.social, polo seu premio no acto de recoñecemento dos proxectos STEMbach da Xunta de Galicia.
www.xunta.gal/notas-de-pre...
www.xunta.gal/notas-de-pre...
June 19, 2025 at 10:02 PM
Extremadamente orgulloso de Xoán, Lucía e Andrés, estudantes STEMbach do IES Eusebio da Guarda tutorizados no meu laboratorio @bionanochem.bsky.social @udc.gal @cicaudc.bsky.social, polo seu premio no acto de recoñecemento dos proxectos STEMbach da Xunta de Galicia.
www.xunta.gal/notas-de-pre...
www.xunta.gal/notas-de-pre...
Reposted by Roberto J. Brea
Excited to share that our latest work “Abiotic lipid metabolism enables membrane plasticity in artificial cells” has been featured on the cover of @natchem.nature.com. @cicaudc.bsky.social @robertojbrea.bsky.social
www.nature.com/nchem/volume...
doi.org/10.1038/s415...
www.nature.com/nchem/volume...
doi.org/10.1038/s415...
Nature Chemistry - Membrane metabolism
Complex metabolic networks control membrane properties such as lipid composition and morphological plasticity in living cells, but regulating these features...
www.nature.com
June 6, 2025 at 7:32 AM
Excited to share that our latest work “Abiotic lipid metabolism enables membrane plasticity in artificial cells” has been featured on the cover of @natchem.nature.com. @cicaudc.bsky.social @robertojbrea.bsky.social
www.nature.com/nchem/volume...
doi.org/10.1038/s415...
www.nature.com/nchem/volume...
doi.org/10.1038/s415...
Reposted by Roberto J. Brea
Limited spots available, register by May 12! The registration fee (450 €) covers lectures, hands-on tutorials, accommodation (3 nights), meals / coffee breaks.
bit.ly/4j1jL5V
bit.ly/4j1jL5V
EuChemS Chemical Biology School in Madrid - Register - EuChemS
1st EuChemS Chemical Biology School on COMPUTATIONAL CHEMICAL BIOLOGY 8-11 July, 2025 Miraflores de la Sierra (Madrid), Spain
bit.ly
May 9, 2025 at 5:57 PM
Limited spots available, register by May 12! The registration fee (450 €) covers lectures, hands-on tutorials, accommodation (3 nights), meals / coffee breaks.
bit.ly/4j1jL5V
bit.ly/4j1jL5V
Reposted by Roberto J. Brea
🧬 Mark your calendars! The 1st EuChemS School on Computational Chemical Biology will take place in Madrid, from 8-11 July 2025! #ChemSky
💻 Bring your laptop-this is all about hands-on learning with leading European experts in ML, MD, QM/MM, Cheminformatics, Coarse-Grain & Digital Visualization...
💻 Bring your laptop-this is all about hands-on learning with leading European experts in ML, MD, QM/MM, Cheminformatics, Coarse-Grain & Digital Visualization...
May 9, 2025 at 5:57 PM
🧬 Mark your calendars! The 1st EuChemS School on Computational Chemical Biology will take place in Madrid, from 8-11 July 2025! #ChemSky
💻 Bring your laptop-this is all about hands-on learning with leading European experts in ML, MD, QM/MM, Cheminformatics, Coarse-Grain & Digital Visualization...
💻 Bring your laptop-this is all about hands-on learning with leading European experts in ML, MD, QM/MM, Cheminformatics, Coarse-Grain & Digital Visualization...
Reposted by Roberto J. Brea
✨🔬Carla Fernández, e Joel García, alumnos do CIFP Ánxel Casal; Miguel Vázquez, do IES Menéndez Pidal; e Sofía Carou, do IES Rafael Dieste; os catro gañadores do Congreso Científico Incrustado do @cicaudc.bsky.social.
🔗+info: https://bit.ly/CICACCK
🔗+info: https://bit.ly/CICACCK
April 29, 2025 at 8:58 AM
✨🔬Carla Fernández, e Joel García, alumnos do CIFP Ánxel Casal; Miguel Vázquez, do IES Menéndez Pidal; e Sofía Carou, do IES Rafael Dieste; os catro gañadores do Congreso Científico Incrustado do @cicaudc.bsky.social.
🔗+info: https://bit.ly/CICACCK
🔗+info: https://bit.ly/CICACCK
Reposted by Roberto J. Brea
The QUIMBIO research group (www.epazoslab.es) at CICA @cicaudc.bsky.social from the UDC @udc.gal is looking for talented postdoctoral researchers interested in applying for a Marie Skłodowska-Curie Postdoctoral Fellowship.
www.epazoslab.es
April 28, 2025 at 6:11 AM
The QUIMBIO research group (www.epazoslab.es) at CICA @cicaudc.bsky.social from the UDC @udc.gal is looking for talented postdoctoral researchers interested in applying for a Marie Skłodowska-Curie Postdoctoral Fellowship.
Reposted by Roberto J. Brea
#CICAnews
🗞️Esta fin de semana a @vozdegalicia.bsky.social faise eco do traballo do grupo @bionanochem.bsky.social, liderado por Paco Fernández Trillo e @robertojbrea.bsky.social
🗞️Last weekend, @vozdegalicia.bsky.social released an article about the work of @bionanochem.bsky.social group
🗞️Esta fin de semana a @vozdegalicia.bsky.social faise eco do traballo do grupo @bionanochem.bsky.social, liderado por Paco Fernández Trillo e @robertojbrea.bsky.social
🗞️Last weekend, @vozdegalicia.bsky.social released an article about the work of @bionanochem.bsky.social group
April 1, 2025 at 9:18 AM
#CICAnews
🗞️Esta fin de semana a @vozdegalicia.bsky.social faise eco do traballo do grupo @bionanochem.bsky.social, liderado por Paco Fernández Trillo e @robertojbrea.bsky.social
🗞️Last weekend, @vozdegalicia.bsky.social released an article about the work of @bionanochem.bsky.social group
🗞️Esta fin de semana a @vozdegalicia.bsky.social faise eco do traballo do grupo @bionanochem.bsky.social, liderado por Paco Fernández Trillo e @robertojbrea.bsky.social
🗞️Last weekend, @vozdegalicia.bsky.social released an article about the work of @bionanochem.bsky.social group
Reposted by Roberto J. Brea
Interested in #BatteryInnovation ?
PhD studentship available at @cambridgeuni.bsky.social with Clare Grey and myself funded by #ALISTORE-ERI in collaboration with Arnaud Demortière at #LRCS and Elixabete Ayerbe at #CIDETEC !
Apply here: www.jobs.cam.ac.uk/job/50602/ !!
PhD studentship available at @cambridgeuni.bsky.social with Clare Grey and myself funded by #ALISTORE-ERI in collaboration with Arnaud Demortière at #LRCS and Elixabete Ayerbe at #CIDETEC !
Apply here: www.jobs.cam.ac.uk/job/50602/ !!
March 21, 2025 at 1:44 PM
Interested in #BatteryInnovation ?
PhD studentship available at @cambridgeuni.bsky.social with Clare Grey and myself funded by #ALISTORE-ERI in collaboration with Arnaud Demortière at #LRCS and Elixabete Ayerbe at #CIDETEC !
Apply here: www.jobs.cam.ac.uk/job/50602/ !!
PhD studentship available at @cambridgeuni.bsky.social with Clare Grey and myself funded by #ALISTORE-ERI in collaboration with Arnaud Demortière at #LRCS and Elixabete Ayerbe at #CIDETEC !
Apply here: www.jobs.cam.ac.uk/job/50602/ !!
Reposted by Roberto J. Brea
Join our Team (G-CEL & BioNanoChem research groups) at @cicaudc.bsky.social! We are currently seeking a passionate and dedicated individual to fill an open PhD position in gene delivery systems. @areyric.bsky.social @robertojbrea.bsky.social
March 17, 2025 at 12:09 PM
Join our Team (G-CEL & BioNanoChem research groups) at @cicaudc.bsky.social! We are currently seeking a passionate and dedicated individual to fill an open PhD position in gene delivery systems. @areyric.bsky.social @robertojbrea.bsky.social
Reposted by Roberto J. Brea
It’s out!😃
2 years ago, I organized a workshop with @WebersGroup and @KGoepfrich on how to build Life.
We discussed with leading scientists by day and wrote up our discussions in the eves.
The "Roadmap Towards Synthetic Life" is now out in Chem!
www.sciencedirect.com/science/arti...
2 years ago, I organized a workshop with @WebersGroup and @KGoepfrich on how to build Life.
We discussed with leading scientists by day and wrote up our discussions in the eves.
The "Roadmap Towards Synthetic Life" is now out in Chem!
www.sciencedirect.com/science/arti...
A roadmap toward the synthesis of life
The synthesis of life from non-living matter has captivated and divided scientists for centuries. This bold goal aims at unraveling the fundamental pr…
www.sciencedirect.com
February 7, 2025 at 8:56 AM
It’s out!😃
2 years ago, I organized a workshop with @WebersGroup and @KGoepfrich on how to build Life.
We discussed with leading scientists by day and wrote up our discussions in the eves.
The "Roadmap Towards Synthetic Life" is now out in Chem!
www.sciencedirect.com/science/arti...
2 years ago, I organized a workshop with @WebersGroup and @KGoepfrich on how to build Life.
We discussed with leading scientists by day and wrote up our discussions in the eves.
The "Roadmap Towards Synthetic Life" is now out in Chem!
www.sciencedirect.com/science/arti...
Delighted to have been at CIFP Ánxel Casal in A Coruña to show its students the latest advancements in artificial cell research developed by @bionanochem.bsky.social at @cicaudc.bsky.social @udc.gal
January 30, 2025 at 7:56 AM
Delighted to have been at CIFP Ánxel Casal in A Coruña to show its students the latest advancements in artificial cell research developed by @bionanochem.bsky.social at @cicaudc.bsky.social @udc.gal
Reposted by Roberto J. Brea
‘Reactive’ coacervates out in @JACS"!! A molecular design enables complex coacervates which can be chemically triggered to react & transform into complex self-assemblies. These evolve to show life-like budding and membrane formation!! Super effort by stellar PhD Sudeep!!! more to follow 1/2
January 29, 2025 at 11:19 AM
‘Reactive’ coacervates out in @JACS"!! A molecular design enables complex coacervates which can be chemically triggered to react & transform into complex self-assemblies. These evolve to show life-like budding and membrane formation!! Super effort by stellar PhD Sudeep!!! more to follow 1/2
Reposted by Roberto J. Brea
🚀 We are excited to share our latest preprint on ChemRxiv that describes a simple approach using SPOT libraries to quickly identify metallopeptides for intracellular catalysis. #ChemSky
chemrxiv.org/engage/chemr...
chemrxiv.org/engage/chemr...
January 21, 2025 at 6:37 AM
🚀 We are excited to share our latest preprint on ChemRxiv that describes a simple approach using SPOT libraries to quickly identify metallopeptides for intracellular catalysis. #ChemSky
chemrxiv.org/engage/chemr...
chemrxiv.org/engage/chemr...
Reposted by Roberto J. Brea
Thrilled to share our latest work “Diacylation of Peptides Enables the Construction of Functional Vesicles for Drug-Carrying Liposomes” published in @angewandtechemie.bsky.social. @cicaudc.bsky.social @robertojbrea.bsky.social doi.org/10.1002/anie...
January 13, 2025 at 5:15 PM
Thrilled to share our latest work “Diacylation of Peptides Enables the Construction of Functional Vesicles for Drug-Carrying Liposomes” published in @angewandtechemie.bsky.social. @cicaudc.bsky.social @robertojbrea.bsky.social doi.org/10.1002/anie...
Reposted by Roberto J. Brea
Glad to share the work “Aqueous Synthesis of Membrane Lipids via Amide Formation between Amphiphilic Amines and Thioacids” published in ChemSystemsChem. @cicaudc.bsky.social @robertojbrea.bsky.social doi.org/10.1002/syst...
January 13, 2025 at 5:07 PM
Glad to share the work “Aqueous Synthesis of Membrane Lipids via Amide Formation between Amphiphilic Amines and Thioacids” published in ChemSystemsChem. @cicaudc.bsky.social @robertojbrea.bsky.social doi.org/10.1002/syst...
Reposted by Roberto J. Brea
I am excited to share our latest publication in JACS: "Chemically Driven Division of Protocells by Membrane Budding"
I am grateful to all my amazing coauthors for their incredible teamwork @boekhovenlab.bsky.social
Read it: pubs.acs.org/doi/10.1021/...
#protocells #chemistry #originoflife #JACS
I am grateful to all my amazing coauthors for their incredible teamwork @boekhovenlab.bsky.social
Read it: pubs.acs.org/doi/10.1021/...
#protocells #chemistry #originoflife #JACS
November 29, 2024 at 8:19 PM
I am excited to share our latest publication in JACS: "Chemically Driven Division of Protocells by Membrane Budding"
I am grateful to all my amazing coauthors for their incredible teamwork @boekhovenlab.bsky.social
Read it: pubs.acs.org/doi/10.1021/...
#protocells #chemistry #originoflife #JACS
I am grateful to all my amazing coauthors for their incredible teamwork @boekhovenlab.bsky.social
Read it: pubs.acs.org/doi/10.1021/...
#protocells #chemistry #originoflife #JACS