#RésultatScientifique🔎 La force cachée des cellules

@bladoux.bsky.social et @rmmege.bsky.social et leurs collaborateurs révèlent que l’adhésion intercellulaire joue un rôle clé dans la compétition cellulaire, influençant le développement et la lutte contre le cancer.

✍️ The @bladoux.bsky.social / @rmmege.bsky.social Lab published a new article

📖 Nature materials
📃 Force transmission is a master regulator of mechanical cell competition
🔗 www.nature.com/articles/s41...

Happy to share our new publication in
@naturematerials.bsky.social
on mechanical cell competition! Great collaboration between our CAM team, Chavrier's and Doostmohammadi's. Special congrats
@luanger.bsky.social, @andreasschoenit.bsky.social, Siavash Monfared! 🎉
www.nature.com/articles/s41...

A stress describes forces applied in a given location regarding all the directions of space. As a tensor, it consists of several components expressing different deformations. Its isotropic part (pressure) creates compressive (shrinkage) or tensile (expansion) stresses describing the mechanical state

Tissues are dynamic and investigating cellular mechanical states can be crucial for understanding biological processes. But how to do it?

We are @andreasschoenit.bsky.social and @luanger.bsky.social from @bladoux.bsky.social / @rmmege.bsky.social lab highlighting ways to assess tissue stresses.

Shared link to our paper:
Dynamic forces shape the survival fate of eliminated cells
rdcu.be/d5AD6

Happy to share our new publication in @naturephysics.bsky.social on life and death of eliminated cells! Great collaboration between our CAM team and Doostmohammadi's. Special congrats @lakshmib02.bsky.social and Siavash Monfared! 🎉
www.nature.com/articles/s41...

So happy to share at the start of 2025 our publication in
@naturephysics.bsky.social with
@bladoux.bsky.social and Amin Doostmohammadion on the impact of E-cadherin adhesion on live-dead cell extrusion; first authors @lakshmib02.bsky.social and S. Monfared.
see www.nature.com/articles/s41...

Multiple groups have reported that losing cells are eliminated through being compressed by the winners. Directly measuring these forces, we confirmed this for most experimental conditions. Surprisingly, however, in the case of MDCK WT competing against E-cad KO cells, we observed the opposite!

Exerting high forces, losing E-cad KO cells compress the winning WT cells, but are eliminated anyway. But why?
Combining simulations and experiments, we found that E-cad KO elimination occurrs at the mechanically highly active interface between the tissues, due to large stress fluctuations

We show that cells with increased cell-cell adhesion benefit from increased force transmission capabilities and exhibit a higher resistance to these stress fluctuations, while the opposing cells are removed.
Thus, force transmission can provide the crucial advantage in mechanical cell competition