Riyue Sunny Bao , PhD
@riyuesunnybao.bsky.social
Multiomics • Spatial imaging • I-O • AI. Asso Prof #Medicine. PI @ImmunoTiil . Director #Bioinfo @UPMCHillmanCC. Co-Chair #COWG. Lab: http://tiilab.org
🥳 We’re #hiring! 🎉 🎉 🎉 tiilab.org
#Computational #postdoc scholar position open - focusing on leveraging #singlecell, #spatial, #imaging, and #AI to uncover mechanisms and therapeutic targets on overcoming resistance to #immunotherapy.
Position is hybrid. DM or Email baor AT upmc DOT edu w CV :)
#Computational #postdoc scholar position open - focusing on leveraging #singlecell, #spatial, #imaging, and #AI to uncover mechanisms and therapeutic targets on overcoming resistance to #immunotherapy.
Position is hybrid. DM or Email baor AT upmc DOT edu w CV :)
TII Laboratory
tiilab.org
October 30, 2025 at 4:10 PM
🥳 We’re #hiring! 🎉 🎉 🎉 tiilab.org
#Computational #postdoc scholar position open - focusing on leveraging #singlecell, #spatial, #imaging, and #AI to uncover mechanisms and therapeutic targets on overcoming resistance to #immunotherapy.
Position is hybrid. DM or Email baor AT upmc DOT edu w CV :)
#Computational #postdoc scholar position open - focusing on leveraging #singlecell, #spatial, #imaging, and #AI to uncover mechanisms and therapeutic targets on overcoming resistance to #immunotherapy.
Position is hybrid. DM or Email baor AT upmc DOT edu w CV :)
Reposted by Riyue Sunny Bao , PhD
The UK's Medicine & Healthcare products Regulatory Agency (MHRA) became the 1st regulator globally to approve the new oral women's health drug by Bayer (originally through KaNDy Therapeutics acquisition) #biosky
Bayer bought a UK-based women's health-focused biotech in Phase 2b clinical trials, KaNDy Therapeutics, for $425M upfront in '20. VCs incl Forbion, OrbiMed, Advent & Fountain. Lynkuet for menopause & perimenopause symptoms received UK reg approval last wk www.gov.uk/government/n... #biosky
July 15, 2025 at 4:55 PM
The UK's Medicine & Healthcare products Regulatory Agency (MHRA) became the 1st regulator globally to approve the new oral women's health drug by Bayer (originally through KaNDy Therapeutics acquisition) #biosky
Neoadjuvant and Adjuvant Pembrolizumab in Locally Advanced Head and Neck Cancer | New England Journal of Medicine nejm.org/doi/abs/10.105…
https://nejm.org/doi/abs/10.105…
July 15, 2025 at 9:56 PM
Neoadjuvant and Adjuvant Pembrolizumab in Locally Advanced Head and Neck Cancer | New England Journal of Medicine nejm.org/doi/abs/10.105…
Great new work from #TRACERx team: Subclonal immune evasion in non-small cell lung cancer!
First study ex vivo #NSCLC demonstrating #PDOs are an excellent technology on #subclonal tumor evolution affecting #immuneescape.
t.co/1YUzihcY2H
#nonanimal #alternative #methods #cancer #immunotherapy
First study ex vivo #NSCLC demonstrating #PDOs are an excellent technology on #subclonal tumor evolution affecting #immuneescape.
t.co/1YUzihcY2H
#nonanimal #alternative #methods #cancer #immunotherapy
July 14, 2025 at 4:02 PM
Great new work from #TRACERx team: Subclonal immune evasion in non-small cell lung cancer!
First study ex vivo #NSCLC demonstrating #PDOs are an excellent technology on #subclonal tumor evolution affecting #immuneescape.
t.co/1YUzihcY2H
#nonanimal #alternative #methods #cancer #immunotherapy
First study ex vivo #NSCLC demonstrating #PDOs are an excellent technology on #subclonal tumor evolution affecting #immuneescape.
t.co/1YUzihcY2H
#nonanimal #alternative #methods #cancer #immunotherapy
Reposted by Riyue Sunny Bao , PhD
A high proportion of CD38 (high) CD16 (low) NK cells in tumor patients can interrupt immune surveillance and favor tumor growth
link.springer.com/article/10.1...
link.springer.com/article/10.1...
July 13, 2025 at 4:23 PM
A high proportion of CD38 (high) CD16 (low) NK cells in tumor patients can interrupt immune surveillance and favor tumor growth
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Riyue Sunny Bao , PhD
New Journal for ImmunoTherapy of Cancer article: Multiomics identifies tumor-intrinsic SREBP1 driving immune exclusion in hepatocellular carcinoma bit.ly/4lcxHLC
@riyuesunnybao.bsky.social @pancpathologist.bsky.social
@zervanto.bsky.social @jasonlukemd.bsky.social
#JITC #cancer #MedSky
@riyuesunnybao.bsky.social @pancpathologist.bsky.social
@zervanto.bsky.social @jasonlukemd.bsky.social
#JITC #cancer #MedSky
June 24, 2025 at 6:32 PM
New Journal for ImmunoTherapy of Cancer article: Multiomics identifies tumor-intrinsic SREBP1 driving immune exclusion in hepatocellular carcinoma bit.ly/4lcxHLC
@riyuesunnybao.bsky.social @pancpathologist.bsky.social
@zervanto.bsky.social @jasonlukemd.bsky.social
#JITC #cancer #MedSky
@riyuesunnybao.bsky.social @pancpathologist.bsky.social
@zervanto.bsky.social @jasonlukemd.bsky.social
#JITC #cancer #MedSky
🚀First time joining #ENAR2025 and ✨Grateful to share our lab's work leveraging #singlecell #spatial #pathomics #radiomics to understand resistance/response in #cancer #immunotherapy.
Had a wonderful time discussing #statistics & #quantitative sciences for #biological #clinical impact w my peers!!
Had a wonderful time discussing #statistics & #quantitative sciences for #biological #clinical impact w my peers!!
March 27, 2025 at 3:29 PM
🚀First time joining #ENAR2025 and ✨Grateful to share our lab's work leveraging #singlecell #spatial #pathomics #radiomics to understand resistance/response in #cancer #immunotherapy.
Had a wonderful time discussing #statistics & #quantitative sciences for #biological #clinical impact w my peers!!
Had a wonderful time discussing #statistics & #quantitative sciences for #biological #clinical impact w my peers!!
Looking forward to #ENAR2025!! I will be discussing our lab's new work in using #singlecell omics and #radiomics to understand resistance and response in patients who received #immunotherapy.
Here we come - #music, #food, and GREAT #science 🚀💃 @enar-ibs.bsky.social
Here we come - #music, #food, and GREAT #science 🚀💃 @enar-ibs.bsky.social
March 22, 2025 at 7:19 PM
Looking forward to #ENAR2025!! I will be discussing our lab's new work in using #singlecell omics and #radiomics to understand resistance and response in patients who received #immunotherapy.
Here we come - #music, #food, and GREAT #science 🚀💃 @enar-ibs.bsky.social
Here we come - #music, #food, and GREAT #science 🚀💃 @enar-ibs.bsky.social
We have a #research tech job open 🤩 if you are interested in quickly gaining experience in #translational & #clinical space, DM /send me your CV.
#master #graduates who want to go to #PhD or #MD prog w strong motivation + #wetlab exp are welcome to apply!!
#standupForScience #standupAgainstCancer
#master #graduates who want to go to #PhD or #MD prog w strong motivation + #wetlab exp are welcome to apply!!
#standupForScience #standupAgainstCancer
a little girl wearing sunglasses and a blue dress is dancing on the floor .
ALT: a little girl wearing sunglasses and a blue dress is dancing on the floor .
media.tenor.com
March 5, 2025 at 10:20 PM
We have a #research tech job open 🤩 if you are interested in quickly gaining experience in #translational & #clinical space, DM /send me your CV.
#master #graduates who want to go to #PhD or #MD prog w strong motivation + #wetlab exp are welcome to apply!!
#standupForScience #standupAgainstCancer
#master #graduates who want to go to #PhD or #MD prog w strong motivation + #wetlab exp are welcome to apply!!
#standupForScience #standupAgainstCancer
Where are the #AI #Agents who can clean up/reformat all publication #figures and #deposit big data cuz I would like to buy one
Would even better if AI Agents take care of all the #paperwork and #administrative tasks so that I, a #human, can focus on #science and #curing human diseases
Would even better if AI Agents take care of all the #paperwork and #administrative tasks so that I, a #human, can focus on #science and #curing human diseases
a man in a suit sits at a desk with the words " these are busy times " written on the bottom
ALT: a man in a suit sits at a desk with the words " these are busy times " written on the bottom
media.tenor.com
March 5, 2025 at 9:56 PM
Where are the #AI #Agents who can clean up/reformat all publication #figures and #deposit big data cuz I would like to buy one
Would even better if AI Agents take care of all the #paperwork and #administrative tasks so that I, a #human, can focus on #science and #curing human diseases
Would even better if AI Agents take care of all the #paperwork and #administrative tasks so that I, a #human, can focus on #science and #curing human diseases
Back to #Nak #Won Garden and loving it!!! The best #authentic #korean food in the Burgh. Plus Friendly environment and super nice owners 😍
March 5, 2025 at 12:53 AM
Back to #Nak #Won Garden and loving it!!! The best #authentic #korean food in the Burgh. Plus Friendly environment and super nice owners 😍
Reposted by Riyue Sunny Bao , PhD
Human-relevant neuroscience research is everywhere, but so many many poorly translatable experiments on animals still get funded. Why?
One reason: Grant reviewers are mostly animal experimenters themselves.
New preprint from @katherineroe.bsky.social & me 🧵 🧪
www.biorxiv.org/content/10.1...
One reason: Grant reviewers are mostly animal experimenters themselves.
New preprint from @katherineroe.bsky.social & me 🧵 🧪
www.biorxiv.org/content/10.1...
March 3, 2025 at 7:17 PM
Human-relevant neuroscience research is everywhere, but so many many poorly translatable experiments on animals still get funded. Why?
One reason: Grant reviewers are mostly animal experimenters themselves.
New preprint from @katherineroe.bsky.social & me 🧵 🧪
www.biorxiv.org/content/10.1...
One reason: Grant reviewers are mostly animal experimenters themselves.
New preprint from @katherineroe.bsky.social & me 🧵 🧪
www.biorxiv.org/content/10.1...
Respect 🫡
Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter
www.nytimes.com/2025/03/01/u...
www.nytimes.com/2025/03/01/u...
March 2, 2025 at 3:46 PM
Respect 🫡
March 2, 2025 at 3:44 PM
Here is a growing list of #universities and #programs that have to reduce or pause graduate admission as a consequence of indirect cuts, and funding freeze.
We are witnessing an entire generational loss of #science.
We are witnessing an entire generational loss of #science.
I created a brief spreadsheet of reductions I've heard of so far. Any additions you know of (especially if you have the links/receipts) would be great: docs.google.com/spreadsheets...
Graduate Reductions Across Biomedical Sciences (2025)
docs.google.com
February 23, 2025 at 7:37 PM
Here is a growing list of #universities and #programs that have to reduce or pause graduate admission as a consequence of indirect cuts, and funding freeze.
We are witnessing an entire generational loss of #science.
We are witnessing an entire generational loss of #science.
February 20, 2025 at 10:39 PM
Dr Rose Doerfler from our lab #ImmunoTiil presenting her work in #headNeck #cancer patient derived #organoids #TRCCC2025.
Looking forward to further developing this scalable ex vivo technology for rapid #oncology #immunooncology #therapeutic #HNSCC!!!
Check Rose poster #62 tonight to learn more!
Looking forward to further developing this scalable ex vivo technology for rapid #oncology #immunooncology #therapeutic #HNSCC!!!
Check Rose poster #62 tonight to learn more!
February 20, 2025 at 10:38 PM
Dr Rose Doerfler from our lab #ImmunoTiil presenting her work in #headNeck #cancer patient derived #organoids #TRCCC2025.
Looking forward to further developing this scalable ex vivo technology for rapid #oncology #immunooncology #therapeutic #HNSCC!!!
Check Rose poster #62 tonight to learn more!
Looking forward to further developing this scalable ex vivo technology for rapid #oncology #immunooncology #therapeutic #HNSCC!!!
Check Rose poster #62 tonight to learn more!
Dr Alan Hutson, Chair of Biostats and Bioinfo Dept #RoswellPark Cancer center giving keynote #immunoOncology translational network #IOTNmoonshot at #TRCCC2025 annual meeting !!!
🚀Especially important for today’s scientific landscape
🚀Especially important for today’s scientific landscape
February 19, 2025 at 10:23 PM
Dr Alan Hutson, Chair of Biostats and Bioinfo Dept #RoswellPark Cancer center giving keynote #immunoOncology translational network #IOTNmoonshot at #TRCCC2025 annual meeting !!!
🚀Especially important for today’s scientific landscape
🚀Especially important for today’s scientific landscape
#Glioblastoma #Cortical #Organoids Recapitulate Cell-State Heterogeneity and Intercellular Transfer #precisionOncology #PDO
scRNAseq revealing endogenous #malignant #transcripts transfer #EV from malignant to nonmalignant cells, toward #GBM cell states + #astroglia cell types!
tinyurl.com/5h2v8tak
scRNAseq revealing endogenous #malignant #transcripts transfer #EV from malignant to nonmalignant cells, toward #GBM cell states + #astroglia cell types!
tinyurl.com/5h2v8tak
February 18, 2025 at 4:47 PM
#Glioblastoma #Cortical #Organoids Recapitulate Cell-State Heterogeneity and Intercellular Transfer #precisionOncology #PDO
scRNAseq revealing endogenous #malignant #transcripts transfer #EV from malignant to nonmalignant cells, toward #GBM cell states + #astroglia cell types!
tinyurl.com/5h2v8tak
scRNAseq revealing endogenous #malignant #transcripts transfer #EV from malignant to nonmalignant cells, toward #GBM cell states + #astroglia cell types!
tinyurl.com/5h2v8tak
Has it occur to anybody that a non-profit initiative should be put together to #backup all #US #government funded #data #repositories, such as GEO, SRA, GDC, among many others?
It could be just all gov funded resources is gone overnight?! Not saying it is happening, but it could.
It could be just all gov funded resources is gone overnight?! Not saying it is happening, but it could.
February 14, 2025 at 3:41 PM
Has it occur to anybody that a non-profit initiative should be put together to #backup all #US #government funded #data #repositories, such as GEO, SRA, GDC, among many others?
It could be just all gov funded resources is gone overnight?! Not saying it is happening, but it could.
It could be just all gov funded resources is gone overnight?! Not saying it is happening, but it could.
Reposted by Riyue Sunny Bao , PhD
At these bleak times when the intent seems to be to cripple NIH-funded research, a reminder that NIH funding sustains the economy and creates jobs “In fiscal year 2023, NIH funding generated an estimated $92.89 billion in economic activity.”
www.nih.gov/about-nih/wh...
www.nih.gov/about-nih/wh...
Direct Economic Contributions
NIH directly supports the economy through investments in research institutions and job formation.
www.nih.gov
February 8, 2025 at 4:32 AM
At these bleak times when the intent seems to be to cripple NIH-funded research, a reminder that NIH funding sustains the economy and creates jobs “In fiscal year 2023, NIH funding generated an estimated $92.89 billion in economic activity.”
www.nih.gov/about-nih/wh...
www.nih.gov/about-nih/wh...
#pathology #AI twitter - recommendations on a reliable predictor of #HPV status directly from #HE images in #HNSCC, that has been validated in large datasets across sites #opensource? We could build our own models but do not wish to reinvent the wheel if great tools already exists.
Thank you !!
Thank you !!
February 7, 2025 at 4:40 AM
#pathology #AI twitter - recommendations on a reliable predictor of #HPV status directly from #HE images in #HNSCC, that has been validated in large datasets across sites #opensource? We could build our own models but do not wish to reinvent the wheel if great tools already exists.
Thank you !!
Thank you !!
🚀 Exciting news! The brand-new #Y2025 #SITC
#CompIO Webinar Series is here!!! 🎉
Ten courses focusing on advanced methods and clinical utility for #biomarker #development in IO @sitcancer.bsky.social @roswellpark.bsky.social #NCI 👏
✨ FREE registration: tinyurl.com/3863jp9t
Let's spread the word!🚀
#CompIO Webinar Series is here!!! 🎉
Ten courses focusing on advanced methods and clinical utility for #biomarker #development in IO @sitcancer.bsky.social @roswellpark.bsky.social #NCI 👏
✨ FREE registration: tinyurl.com/3863jp9t
Let's spread the word!🚀
February 4, 2025 at 7:09 PM
🚀 Exciting news! The brand-new #Y2025 #SITC
#CompIO Webinar Series is here!!! 🎉
Ten courses focusing on advanced methods and clinical utility for #biomarker #development in IO @sitcancer.bsky.social @roswellpark.bsky.social #NCI 👏
✨ FREE registration: tinyurl.com/3863jp9t
Let's spread the word!🚀
#CompIO Webinar Series is here!!! 🎉
Ten courses focusing on advanced methods and clinical utility for #biomarker #development in IO @sitcancer.bsky.social @roswellpark.bsky.social #NCI 👏
✨ FREE registration: tinyurl.com/3863jp9t
Let's spread the word!🚀
Reposted by Riyue Sunny Bao , PhD
An update with latest data available for graph of life expectancy vs health care expenditures per capita for 20 countries and one outlier.
February 3, 2025 at 3:19 PM
An update with latest data available for graph of life expectancy vs health care expenditures per capita for 20 countries and one outlier.