Chris McMaster
@rheumai.com
Rheumatologist, builder of AI things. Carbon over silicon.
Pinned
Chris McMaster
@rheumai.com
· Mar 17
The modern internet penalises anyone who thinks for more than 3 seconds before forming a strong opinion. You’ll be happy to know that I only thought for 2 seconds before typing this.
LLMs become much less useful the moment you dismantle bureaucracy.
March 24, 2025 at 10:00 PM
LLMs become much less useful the moment you dismantle bureaucracy.
The modern internet penalises anyone who thinks for more than 3 seconds before forming a strong opinion. You’ll be happy to know that I only thought for 2 seconds before typing this.
March 17, 2025 at 10:20 PM
The modern internet penalises anyone who thinks for more than 3 seconds before forming a strong opinion. You’ll be happy to know that I only thought for 2 seconds before typing this.
The idea that scaling up LLMs on human data will produce superhuman performance is magical thinking. The highest attainable performance in any given domain is simply the best human performance. Yes, maybe some insights span across domains, but I don’t think there’s actually evidence for that.
February 28, 2025 at 11:05 PM
The idea that scaling up LLMs on human data will produce superhuman performance is magical thinking. The highest attainable performance in any given domain is simply the best human performance. Yes, maybe some insights span across domains, but I don’t think there’s actually evidence for that.
The people who laugh about hacky “vibe coding” with LLMs are the same people who think that grok 3 is better than a doctor. Absolutely nuts.
"One doctor at a public hospital in Hubei province in central China said the institution’s leadership had issued a directive that DeepSeek should be used as a third-party arbiter if two doctors have differing views on a patient’s treatment"
on.ft.com/4bis0bm
on.ft.com/4bis0bm
DeepSeek spreads across China with Beijing’s backing
The AI start-up’s models are being rapidly adopted by state-owned enterprises, hospitals and local governments
on.ft.com
February 27, 2025 at 9:35 AM
The people who laugh about hacky “vibe coding” with LLMs are the same people who think that grok 3 is better than a doctor. Absolutely nuts.
“Below is the updated code” followed by absolutely no code is such an o3-mini thing to do that at this point I don’t really understand why this model exists.
February 24, 2025 at 2:14 AM
“Below is the updated code” followed by absolutely no code is such an o3-mini thing to do that at this point I don’t really understand why this model exists.
After much time spent looking at reasoning traces from DeepSeek R1 for medical cases, I have to conclude that there isn’t a strong correlation between good reasoning and a good answer.
January 31, 2025 at 11:15 AM
After much time spent looking at reasoning traces from DeepSeek R1 for medical cases, I have to conclude that there isn’t a strong correlation between good reasoning and a good answer.
These R1 distilled models are absolutely amazing on a single turn, but truly horrible on multi-turn conversations.
January 20, 2025 at 11:11 PM
These R1 distilled models are absolutely amazing on a single turn, but truly horrible on multi-turn conversations.
Meta’s new response to the Rohingya genocide.
a cartoon dog is sitting at a table with a cup of coffee in front of a fire with the words this is fine .
ALT: a cartoon dog is sitting at a table with a cup of coffee in front of a fire with the words this is fine .
media.tenor.com
January 15, 2025 at 7:19 AM
Meta’s new response to the Rohingya genocide.
"Mildly elevated rheumatoid factor has a very low positive predictive value that is completely overwhelmed in magnitude by the negative predictive value of not having any signs or symptoms of rheumatoid arthritis."
January 15, 2025 at 12:40 AM
"Mildly elevated rheumatoid factor has a very low positive predictive value that is completely overwhelmed in magnitude by the negative predictive value of not having any signs or symptoms of rheumatoid arthritis."
My 2 year old has 3 adjectives for the size of things. In increasing order: small, mummy, big.
January 13, 2025 at 9:38 PM
My 2 year old has 3 adjectives for the size of things. In increasing order: small, mummy, big.
Reposted by Chris McMaster
Reposted by Chris McMaster
Releasing Jupyter Agents - LLMs running data analysis directly in a notebook!
The agent can load data, execute code, plot results and following your guidance and ideas!
A very natural way to collaborate with an LLM over data and it's just scratching the surface of what's possible soon!
The agent can load data, execute code, plot results and following your guidance and ideas!
A very natural way to collaborate with an LLM over data and it's just scratching the surface of what's possible soon!
December 19, 2024 at 6:56 PM
Releasing Jupyter Agents - LLMs running data analysis directly in a notebook!
The agent can load data, execute code, plot results and following your guidance and ideas!
A very natural way to collaborate with an LLM over data and it's just scratching the surface of what's possible soon!
The agent can load data, execute code, plot results and following your guidance and ideas!
A very natural way to collaborate with an LLM over data and it's just scratching the surface of what's possible soon!
What percentage of “rhupus” is just misdiagnosed Sjögren?
41 "Rhupus" pts were compared to 160 SLE and 709 RA pts. Rhupus pts have a younger onset age than RA (P=0.032), but older than SLE (P=0.008). ~20% initially presented w/ SLE Sxs. Rhupus commonly has ILD, hyperglobulinemia & Lab abnormalities (61%), but seldom renal or CNS dz
Rhupus syndrome: a unique disease overlapping systemic lupus erythematosus and rheumatoid arthritis - Archives of Dermatological Research
Background though considered to have characteristics of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) theoretically, Rhupus Syndrome (RS) owns its unique clinical features. In this…
buff.ly
December 17, 2024 at 10:03 PM
What percentage of “rhupus” is just misdiagnosed Sjögren?
o1 is equal parts brilliant and boring. Very, very boring.
Inspired by another's idea, asking o1 this:
Basically, what are some scientific/technological insights that would have changed Rome.
Basically, what are some scientific/technological insights that would have changed Rome.
December 17, 2024 at 10:01 AM
o1 is equal parts brilliant and boring. Very, very boring.
Llamafile is a cheat code.
December 16, 2024 at 6:29 AM
Llamafile is a cheat code.
Reposted by Chris McMaster
"Zuckerberg's eyes brimmed with tears, and his heart felt full. He truly loved Big Brother!"
December 14, 2024 at 5:03 PM
"Zuckerberg's eyes brimmed with tears, and his heart felt full. He truly loved Big Brother!"
Sora’s idea of a hand exam. This 60 year-old rheumatologist is giving me very 2nd year medical student vibes with this bizarre technique. No synovitis was detected this day. #rheumsky
December 15, 2024 at 12:35 AM
Sora’s idea of a hand exam. This 60 year-old rheumatologist is giving me very 2nd year medical student vibes with this bizarre technique. No synovitis was detected this day. #rheumsky
So much delving
UnitedHealth CEO sent employees a memo yesterday (leaked to me) listing anonymous statements of support for the company.
December 13, 2024 at 6:01 AM
So much delving
Reposted by Chris McMaster
Four-year follow-up of patients with hand osteoarthritis found that the course of pain was variable. Changes in pain were associated with BMI, employment status, mental wellbeing, illness perceptions, and coping styles
In Arthritis Care & Research
doi.org/10.1002/acr....
In Arthritis Care & Research
doi.org/10.1002/acr....
Course of hand pain over four years in patients with hand osteoarthritis depends on BMI, employment and mental wellbeing: The Hand OSTeoArthritis in Secondary care cohort study
Objective We aimed to characterize hand osteoarthritis (OA) patients with deteriorating or improving hand pain, and to investigate patients achieving good clinical outcome after four years. Method...
doi.org
December 11, 2024 at 9:12 PM
Four-year follow-up of patients with hand osteoarthritis found that the course of pain was variable. Changes in pain were associated with BMI, employment status, mental wellbeing, illness perceptions, and coping styles
In Arthritis Care & Research
doi.org/10.1002/acr....
In Arthritis Care & Research
doi.org/10.1002/acr....
Reposted by Chris McMaster
Vlado Chernozemski, who assassinated King Alexander I of Yugoslavia, belonged in his youth to a club that was devoted to a game of regicide.
In the game, known as "chess," contestants subtly maneuver into a position that allows them to topple the opponent's monarch.
In the game, known as "chess," contestants subtly maneuver into a position that allows them to topple the opponent's monarch.
December 10, 2024 at 3:43 PM
Vlado Chernozemski, who assassinated King Alexander I of Yugoslavia, belonged in his youth to a club that was devoted to a game of regicide.
In the game, known as "chess," contestants subtly maneuver into a position that allows them to topple the opponent's monarch.
In the game, known as "chess," contestants subtly maneuver into a position that allows them to topple the opponent's monarch.
Reposted by Chris McMaster
For five years, I have been covering what is unquestionably the biggest criminal justice scandal in American history.
Today it ended when the most corrupt cop in history took his life.
But it's not over.
A thread.
Today it ended when the most corrupt cop in history took his life.
But it's not over.
A thread.
December 2, 2024 at 6:02 PM
For five years, I have been covering what is unquestionably the biggest criminal justice scandal in American history.
Today it ended when the most corrupt cop in history took his life.
But it's not over.
A thread.
Today it ended when the most corrupt cop in history took his life.
But it's not over.
A thread.
I love the fact that Wikipedia’s awful contributor guidelines have lead them to work on algorithms that force contributors to adhere to the guidelines, rather than just making better guidelines www.mediawiki.org/wiki/Edit_ch...
Edit check - MediaWiki
www.mediawiki.org
December 8, 2024 at 2:38 PM
I love the fact that Wikipedia’s awful contributor guidelines have lead them to work on algorithms that force contributors to adhere to the guidelines, rather than just making better guidelines www.mediawiki.org/wiki/Edit_ch...
Finally have COVID. 5 year streak comes to an end 😢
December 8, 2024 at 10:26 AM
Finally have COVID. 5 year streak comes to an end 😢
I think anthropic and pretty much anyone can beat o1 with better training data. I give o1 a complex problem, o1 thinks for 4 seconds, outputs a bad answer. Seriously, who trained this thing?
December 8, 2024 at 3:50 AM
I think anthropic and pretty much anyone can beat o1 with better training data. I give o1 a complex problem, o1 thinks for 4 seconds, outputs a bad answer. Seriously, who trained this thing?