Rene Sugar
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renesugar.bsky.social
Rene Sugar
@renesugar.bsky.social
1K followers 3.2K following 3.1K posts
https://renesugar.substack.com/
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renesugar.bsky.social
Wistar Scientists Find FDA-Approved Drug Halts EBV-Driven Lymphoma by Disrupting a Key Cancer Pathway #EBV #MECFS #LongCovid

www.wistar.org/press-releas...
Wistar Scientists Find FDA-Approved Drug Halts EBV-Driven Lymphoma by Disrupting a Key Cancer Pathway
Wistar Scientists Find FDA-Approved Drug Halts EBV-Driven Lymphoma by Disrupting a Key Cancer Pathway Press Releases
www.wistar.org
January 28, 2026 at 9:30 PM
renesugar.bsky.social
#SARSCoV2 peptide fragments selectively dysregulate specific immune cell populations via Gaussian curvature targeting #MECFS #LongCovid

www.pnas.org/doi/10.1073/....
SARS-CoV-2 peptide fragments selectively dysregulate specific immune cell populations via Gaussian curvature targeting | PNAS
Immune cell populations are dysregulated in COVID-19 for currently unknown reasons: Plasmacytoid dendritic cell (pDC) populations are reduced, thus...
www.pnas.org
January 28, 2026 at 6:52 PM
renesugar.bsky.social
Inherited Disorders of the Complement System Precision Panel

Inherited Disorders of the Complement System are rare disorders that predispose to bacterial infections and/or systemic lupus erythematosus (SLE). #MECFS #LongCovid

www.igenomix.eu/genomics-pre...

www.igenomix.co.uk/wp-content/u...
January 27, 2026 at 4:16 PM
renesugar.bsky.social
Tilly Rose was a ‘medical mystery’ patient and spent two decades in and out of medical care.

www.goodhousekeeping.com/uk/lifestyle...
“I spent 20 years in hospital - here are the horrifying things I saw”: A medical mystery patient on what life's really like on NHS wards
Tilly Rose was a ‘medical mystery’ patient and spent two decades in and out of medical care. Here, she tells Bethan Rose Jenkins what she experienced and how she’s now advocating for others
www.goodhousekeeping.com
January 27, 2026 at 1:20 AM
renesugar.bsky.social
α-Ketoglutarate for Preventing and Managing Intestinal Epithelial Dysfunction #MECFS #LongCovid

www.sciencedirect.com/science/arti...
January 26, 2026 at 9:13 PM
renesugar.bsky.social
The Antioxidative Function of Alpha-Ketoglutarate and Its Applications #MECFS #LongCovid

onlinelibrary.wiley.com/doi/10.1155/...
The Antioxidative Function of Alpha‐Ketoglutarate and Its Applications
Alpha-ketoglutarate (AKG) is a crucial intermediate of the Krebs cycle and plays a critical role in multiple metabolic processes in animals and humans. Of note, AKG contributes to the oxidation of nu....
onlinelibrary.wiley.com
January 25, 2026 at 4:03 PM
renesugar.bsky.social
Combined C-Reactive Protein and Novel Inflammatory Parameters as a Predictor in Cancer—What Can We Learn from the Hematological Experience? #GMCSF #CRP #MECFS #LongCovid

pmc.ncbi.nlm.nih.gov/articles/PMC...
January 22, 2026 at 5:40 AM
renesugar.bsky.social
Pheochromocytoma: Pitfalls in the biochemical evaluation #MECFS #LongCovid

www.researchgate.net/publication/...
January 21, 2026 at 3:45 PM
renesugar.bsky.social
Human natural killer cell deficiencies and susceptibility to infection #MECFS #LongCovid

www.sciencedirect.com/science/arti...
January 19, 2026 at 5:57 AM
renesugar.bsky.social
Systematic evaluation of 640 FDA drugs for their effect on CD4⁺Foxp3⁺ regulatory T cells using a novel cell-based high throughput screening assay #MECFS #LongCovid

pubmed.ncbi.nlm.nih.gov/23537702/
January 17, 2026 at 5:00 PM
renesugar.bsky.social
Repurposing Licensed Drugs with Activity Against Epstein-Barr Virus for Treatment of Multiple Sclerosis: ... #EBV #MECFS #LongCovid

pubmed.ncbi.nlm.nih.gov/39792343/

"expert panel shortlisted four drugs (famciclovir, tenofovir alafenamide, maribavir and spironolactone) ... for use in MS."
Repurposing Licensed Drugs with Activity Against Epstein-Barr Virus for Treatment of Multiple Sclerosis: A Systematic Approach - PubMed
Scientific and lived experience expert panel review of anti-EBV therapies selected four candidates with evidence for efficacy against EBV and acceptable safety and tolerability for potential use in phase III clinical trials for MS.
pubmed.ncbi.nlm.nih.gov
January 17, 2026 at 2:18 AM
Reposted by Rene Sugar
natcomms.nature.com
#Virology

Herpesviruses exploit a cellular membrane protein, once thought to transport chloride, to escape the nucleus by tapping into an ancient membrane fusion process
ER protein CLCC1 promotes nuclear envelope fusion in herpesviral and host processes - Nature Communications
Herpesvirales utilize a unique nuclear egress route for capsid export. Here the authors show that herpesviruses exploit a cellular membrane protein, once thought to transport chloride, to facilitate membrane fusion and egress from the nucleus.
dlvr.it
January 16, 2026 at 4:47 PM
Reposted by Rene Sugar
natmicrobiol.nature.com
A phage protein screen identifies triggers of the bacterial innate immune system
Nature Microbiology, Published online: 16 January 2026; doi:10.1038/s41564-025-02239-6A library of 400 phage protein-coding genes is used to find a trove of antiphage systems, revealing systems that target tail fibre and major capsid proteins.
go.nature.com
January 16, 2026 at 4:53 PM
renesugar.bsky.social
A clot to uncover: #SARSCoV2 nucleocapsid can outcompete the FOXP3 forkhead domain for DNA binding in vitro #MECFS #LongCovid

pubmed.ncbi.nlm.nih.gov/40783127/
A clot to uncover: SARS-CoV-2 nucleocapsid can outcompete the FOXP3 forkhead domain for DNA binding in vitro - PubMed
During COVID-19, systemic coagulopathy can lead to strokes and embolisms and may also contribute to long COVID. This coagulopathy is the result of overactivated platelets in circulation that lead to inappropriate clot formation. FOXP3 is a transcription factor involved in platelet development. Loss …
pubmed.ncbi.nlm.nih.gov
January 6, 2026 at 1:36 PM
Reposted by Rene Sugar
pluchinolab.bsky.social
Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology

www.nature.com/articles/s42...
Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology - Nature Metabolism
Barnett et al. disentangle the differential contribution of mitochondrial complex I- and complex III-derived ROS to astrocytic function, with CIII-derived ROS being a major driver of neuroinflammatory...
www.nature.com
November 5, 2025 at 8:40 AM
Reposted by Rene Sugar
lukensjohnr.bsky.social
TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration www.nature.com/articles/s41...
TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration - Nature Neuroscience
Zhu et al. find that aging causes region-specific myelin damage in the spinal cord, which is counteracted by enhanced TGFβ signaling in microglia, revealing a protective mechanism for healthy aging.
www.nature.com
January 2, 2026 at 3:24 PM
renesugar.bsky.social
Proximal renal tubular acidosis: a not so rare disorder of multiple etiologies #MECFS #LongCovid

academic.oup.com/ndt/article/...

"Proximal renal tubular acidosis (RTA) (Type II RTA) is characterized by a defect in the ability to reabsorb HCO3 in the proximal tubule."
December 31, 2025 at 5:16 PM
renesugar.bsky.social
A Case Report of Nearly Missed Renal Tubular Acidosis in the Setting of Sjögren’s Syndrome #MECFS #LongCovid

www.cureus.com/articles/138...

"This is an interesting case of a woman with probable chronic distal RTA that went undiagnosed for years prior to her admission."
A Case Report of Nearly Missed Renal Tubular Acidosis in the Setting of Sjögren’s Syndrome
The association of renal tubular acidosis (RTA) and Sjögren’s syndrome (SS) has been well-documented in the literature previously but is often undiagnosed in clinical practice. In this case report, we...
www.cureus.com
December 31, 2025 at 5:38 AM
renesugar.bsky.social
Varicella Zoster Virus disrupts MAIT cell polyfunctional effector responses #MECFS #LongCovid

pubmed.ncbi.nlm.nih.gov/39110717/
Varicella Zoster Virus disrupts MAIT cell polyfunctional effector responses - PubMed
Mucosal-associated invariant T (MAIT) cells are unconventional T cells that respond to riboflavin biosynthesis and cytokines through TCR-dependent and -independent pathways, respectively. MAIT cell activation plays an immunoprotective role against several pathogens, however the functional capacity o …
pubmed.ncbi.nlm.nih.gov
December 30, 2025 at 4:21 PM
Reposted by Rene Sugar
cp-cellmetabolism.bsky.social
Online now: Uridine depletion impairs CD8⁺ T cell antitumor activity through N-glycosylation
Uridine depletion impairs CD8⁺ T cell antitumor activity through N-glycosylation
Xiao et al. reveal that sorting nexin 17 (SNX17) promotes the synthesis of uridine phosphorylase 1 (UPP1) in tumor cells, leading to a decrease in uridine concentration within the tumor microenvironment (TME). This reduction subsequently impairs the antitumor efficacy of CD8⁺ T cells in the TME.
dlvr.it
December 29, 2025 at 4:42 PM
renesugar.bsky.social
Recent Advances on the Role of B Vitamins in Cancer Prevention and Progression #MECFS #LongCovid

www.mdpi.com/1422-0067/26...
December 28, 2025 at 5:11 PM
renesugar.bsky.social
More Than Just B12 Deficiency: The Hidden Chaos and Bizarre Symptoms of Pernicious Anaemia #MECFS #LongCovid

pernicious-anaemia-society.org/pernicious-a...
December 25, 2025 at 5:26 AM
Reposted by Rene Sugar
jem.org
Antibiotic use in early life impairs MAIT cell–mediated immunity in adulthood, say Gabrielle LeBlanc, Adam Sobel, Michael Constantinides (@mikerobe.bsky.social) and colleagues @scripps.edu: rupress.org/jem/article/...

#InfectiousDisease #HostDefense #MucosalImmunology #LymphocyteBiology #Microbiome
December 23, 2025 at 9:30 PM
renesugar.bsky.social
Breakthrough enables early detection of neurological diseases like Alzheimer's

Groundbreaking technique reveals brain's smallest blood vessels for the first time #MECFS #LongCovid

www.lumc.nl/en/news/2025...
Groundbreaking technique reveals brain's smallest blood vessels for the first time | LUMC
LUMC researchers, in collaboration with French colleagues, have developed a new technique that lets them to see and measure the tiniest blood vessels in the brain for the first time. This breakthrough...
www.lumc.nl
December 21, 2025 at 3:36 AM
Reposted by Rene Sugar
sciencex.bsky.social
RNA molecules have been found on the cell surface, where they help guide immune cell recognition, suggesting a previously unrecognized role for RNA in immune system regulation. doi.org/hbgbmj
RNA steps outside the cell to help guide immune responses, study suggests
RNA is usually portrayed as a molecule that works deep inside the cell, helping to turn genetic information into proteins.
medicalxpress.com
December 19, 2025 at 5:59 PM