Supramolecular chemistry is a rapidly evolving field that has focused on building a foundation of fundamental understanding in controlling molecular self-assembly, through the use of non-covalent inte...

A potent squaramide-based anion transporter was used to evaluate how vesicles prepared with tailored lipid compositions, which mimic organelle membranes, can impact transmembrane transport. Using…

A potent squaramide-based anion transporter was used to evaluate how vesicles prepared with tailored lipid compositions, which mimic organelle membranes, can impact transmembrane transport. Using HPTS...

PhD Project - PhD in Chemistry - Designing and exploiting peptide nanotubes at University of Glasgow, listed on FindAPhD.com

An early love of construction toys led the Scottish chemist to thread molecules together, opening up a new field of chemistry.

Find out more about working for us and view all vacancies including. We continue to ensure an inclusive workplace where opportunities are open to all, and where everyone can belong and bring their tru...

Designing molecular receptors that bind anions in water is a significant challenge, and an even greater difficulty lies in using these receptors to remove anions from water without resorting to the ha...

The struggle to fill places on a major Parkinson's trial

Ryder et al. report the first subcellular targeted anion transporters that accumulate in specific membrane-bound organelles to bias their natural propensity to depolarize lysosomes. Confocal microscopy revealed the ability of the naphthalimide-based transporters to localize within their intended organelles. Analogs that contained endoplasmic reticulum (ER) and lysosomal targeting motifs showed an enhanced H+/Cl− transport ability and cytotoxicity compared with non-targeted analogs. Moreover, lysosomal accumulation improved cancer cell selectivity, while ER and mitochondrial localization enhanced apoptosis in cancerous cells.