PLOS Medicine
@plosmedicine.org
Leading open access health science journal publishing impactful research that transforms global healthcare and advances clinical understanding.
🔗 https://journals.plos.org/plosmedicine
🔗 https://journals.plos.org/plosmedicine
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PLOS Medicine
@plosmedicine.org
· Nov 20
We are thrilled to now be on BlueSky!
We prioritize studies addressing critical health challenges—from major diseases to health equity—that bridge scientific rigor with real-world impact, connecting researchers, clinicians, and policymakers to advance global health 🧬🧪
#OpenScience #MedSky
We prioritize studies addressing critical health challenges—from major diseases to health equity—that bridge scientific rigor with real-world impact, connecting researchers, clinicians, and policymakers to advance global health 🧬🧪
#OpenScience #MedSky
Over the festive period, we will be giving staff, editors, and reviewers a well-deserved break! The journal office will be closed from Monday 22nd December, and will reopen Monday 5th January. To those who celebrate, we wish everyone happy holidays, and see you in 2026! 🎄
December 19, 2025 at 6:02 PM
Over the festive period, we will be giving staff, editors, and reviewers a well-deserved break! The journal office will be closed from Monday 22nd December, and will reopen Monday 5th January. To those who celebrate, we wish everyone happy holidays, and see you in 2026! 🎄
In a retrospective analysis of US FDA records of novel, approved drugs with pediatric study requirements, Rylee McGonigle and colleagues report that less than 60% of requirements were met a decade post-approval, and labeling changes were substantially delayed. 🧪 #MedSky
Pediatric studies and labeling additions required by the U.S. FDA for novel drugs approved from 2011 to 2023: A retrospective cohort study
In a retrospective analysis of US FDA records of novel, approved drugs with pediatric study requirements, Rylee McGonigle and colleagues report that less than 60% of requirements were met a decade…
plos.io
December 19, 2025 at 5:15 PM
In a retrospective analysis of US FDA records of novel, approved drugs with pediatric study requirements, Rylee McGonigle and colleagues report that less than 60% of requirements were met a decade post-approval, and labeling changes were substantially delayed. 🧪 #MedSky
In this follow-up of a randomized controlled trial, Fahmida Tofail, Helen Pitchik & colleagues assess the long-term effects of early water, sanitation, handwashing and nutrition interventions on child development in rural Bangladesh🧪 #MedSky
Effects of early water, sanitation, handwashing, and nutrition interventions on child development at school age: a follow-on study of a cluster-randomized trial in rural Bangladesh
In this follow-up of a randomized controlled trial, Fahmida Tofail, Helen Pitchik and colleagues assess the long-term effects of early water, sanitation, handwashing and nutrition interventions on…
plos.io
December 19, 2025 at 1:15 PM
In this follow-up of a randomized controlled trial, Fahmida Tofail, Helen Pitchik & colleagues assess the long-term effects of early water, sanitation, handwashing and nutrition interventions on child development in rural Bangladesh🧪 #MedSky
Females & males often experience different health outcomes, but it is unclear which sex is more disadvantaged overall. In this study, Angela Chang et al. define a metric to assess sex inequalities in health outcomes, using countries with the highest life expectancy as benchmarks.🧪
From sex differences to sex inequalities in life expectancy: A cross-country observational benchmarking analysis
In a proof-of-concept study, Angela Chang and colleagues defined a metric to assess sex inequalities in health outcomes, using countries with the highest life expectancy as bench marks.
plos.io
December 18, 2025 at 4:25 PM
Females & males often experience different health outcomes, but it is unclear which sex is more disadvantaged overall. In this study, Angela Chang et al. define a metric to assess sex inequalities in health outcomes, using countries with the highest life expectancy as benchmarks.🧪
Open research & data transparency protect against unethical activities, but can also introduce integrity risks. In this Perspective, @dmaupin.bsky.social, Matt Spick & Nophar Geifman set out the case for the use of safeguarding practices to protect against data exploitation🧪 #MedSky
Safeguarding Open Science from exploitative practices
Open research and data transparency are a bulwark against unethical activities, but can also introduce integrity risks. In this Perspective, Danny Maupin, Matt Spick and Nophar Geifman argue that…
plos.io
December 18, 2025 at 2:34 PM
Open research & data transparency protect against unethical activities, but can also introduce integrity risks. In this Perspective, @dmaupin.bsky.social, Matt Spick & Nophar Geifman set out the case for the use of safeguarding practices to protect against data exploitation🧪 #MedSky
Next up in our "meet the editors" is Academic Editor Pei Gao, Principal Investigator at Peking University, China. Pei's primary expertise lie in epidemiology and biostatistics, with a particular interest in cardiovascular disease risk prediction and decision modeling.🧪🫀 #MedSky #PLOSMedicine
December 18, 2025 at 10:23 AM
Next up in our "meet the editors" is Academic Editor Pei Gao, Principal Investigator at Peking University, China. Pei's primary expertise lie in epidemiology and biostatistics, with a particular interest in cardiovascular disease risk prediction and decision modeling.🧪🫀 #MedSky #PLOSMedicine
Controlling transmission of bacterial #STIs has proven difficult in recent years. In this Perspective, Sami Gottlieb & colleagues highlight the need for innovative research, expedited clinical development & increased investment in the development of #vaccines against bacterial STIs🧪🦠
plos.io/4j7PpjU
plos.io/4j7PpjU
Vaccines to prevent bacterial sexually transmitted infections: Promise, progress, and public health potential
Controlling transmission of the bacterial sexually transmitted infections (STIs) gonorrhoea, chlamydia and syphilis has proven difficult in recent years, and new solutions are needed. In this Perspect...
plos.io
December 17, 2025 at 12:52 PM
Controlling transmission of bacterial #STIs has proven difficult in recent years. In this Perspective, Sami Gottlieb & colleagues highlight the need for innovative research, expedited clinical development & increased investment in the development of #vaccines against bacterial STIs🧪🦠
plos.io/4j7PpjU
plos.io/4j7PpjU
Next up in our "meet the editors" is Academic Editor David Flood, Assistant Professor at the University of Michigan. David brings a wealth of expertise in internal medicine, including global non-communicable diseases such as cardiovascular disease and diabetes. 🧪 #MedSky #PLOSMedicine
December 16, 2025 at 4:31 PM
Next up in our "meet the editors" is Academic Editor David Flood, Assistant Professor at the University of Michigan. David brings a wealth of expertise in internal medicine, including global non-communicable diseases such as cardiovascular disease and diabetes. 🧪 #MedSky #PLOSMedicine
In this retrospective cohort study, Jeffrey Joy and colleagues examine frequencies of baseline antiretroviral drug resistance mutations and the heterogeneity of HIV transmission clusters associated with HIV pre-exposure prophylaxis 🧪 #MedSky #HIV #PrEP
Heterogeneous impacts of HIV pre-exposure prophylaxis (PrEP) on drug resistance and phylogenetic cluster transmission dynamics in British Columbia, Canada: A retrospective cohort and simulation study
Jeffrey Joy and colleagues examine frequencies of baseline antiretroviral drug resistance mutations and the heterogeneity of HIV transmission clusters associated with HIV pre-exposure prophylaxis in…
plos.io
December 16, 2025 at 2:45 PM
In this randomized controlled trial, Anuja Dokras and colleagues compare the effects of oral contraceptive pills, metformin, and a combination of both on metabolic syndrome prevalence in patients with high-risk hyperandrogenic polycystic ovary syndrome 🧪 #PCOS #MedSky
Impact of combined hormonal contraceptives and metformin on metabolic syndrome in women with hyperandrogenic polycystic ovary syndrome and obesity: The COMET-PCOS randomized clinical trial
Anuja Dokras and colleagues compare the effects of oral contraceptive pills, metformin, and a combination of both on metabolic syndrome prevalence in patients with high-risk hyperandrogenic…
plos.io
December 15, 2025 at 5:36 PM
Using a novel ultrasensitive assay, Miguel Á. González-Gay and colleagues perform a phenotypic characterization of patients with systemic lupus erythematosus, examining how serum levels of IFN-α and IFN-γ correlate with disease activity, organ damage, and remission status. 🧪 #MedSky
plos.io/4pCXGP0
plos.io/4pCXGP0
Ultrasensitive quantification of serum IFN-α and IFN-γ in systemic lupus erythematosus: A cross-sectional observational study
Using a new, sensitive test, Miguel Á. González-Gay and colleagues perform a phenotypic characterization of patients with systemic lupus erythematosus, examining how serum levels of IFN-α and IFN-γ co...
plos.io
December 15, 2025 at 10:23 AM
Using a novel ultrasensitive assay, Miguel Á. González-Gay and colleagues perform a phenotypic characterization of patients with systemic lupus erythematosus, examining how serum levels of IFN-α and IFN-γ correlate with disease activity, organ damage, and remission status. 🧪 #MedSky
plos.io/4pCXGP0
plos.io/4pCXGP0
Next up in our "meet the editors", it's Editor-in-Chief of PLOS Medicine, Till Bärnighausen, Director of the Heidelberg Institute of Global Health and Alexander von Humboldt Professor at the University of Heidelberg. 🧪 #MedSky #PLOSMedicine
December 11, 2025 at 5:15 PM
Next up in our "meet the editors", it's Editor-in-Chief of PLOS Medicine, Till Bärnighausen, Director of the Heidelberg Institute of Global Health and Alexander von Humboldt Professor at the University of Heidelberg. 🧪 #MedSky #PLOSMedicine
In this retrospective analysis of national surveillance data in China, Li Chen & colleagues find that short-term exposure to wildfire-related fine particulate matter (PM2.5) was associated with a higher incidence of respiratory transmitted diseases than non-wildfire-related PM2.5.🧪
plos.io/4iRaPBn
plos.io/4iRaPBn
Wildfire-related PM2.5 and respiratory transmitted disease among Chinese children and adolescents from 2008 to 2019: A retrospective study
In a retrospective analysis of national surveillance data in China over a 12 year period, Li Chen and colleagues find that short-term exposure to wildfire-related fine particulate matter (PM2.5) was a...
plos.io
December 11, 2025 at 10:22 AM
In this retrospective analysis of national surveillance data in China, Li Chen & colleagues find that short-term exposure to wildfire-related fine particulate matter (PM2.5) was associated with a higher incidence of respiratory transmitted diseases than non-wildfire-related PM2.5.🧪
plos.io/4iRaPBn
plos.io/4iRaPBn
Analyses of open health datasets can offer valuable contributions to health & medicine, but recent years have seen a proliferation of papers lacking robust or novel findings. In this Editorial, we provide guidance for conducting & reporting high-quality analyses using open datasets🧪
plos.io/4poBmZo
plos.io/4poBmZo
Setting the standard for high-quality studies using open health datasets
Large open health datasets present unique opportunities for studies that when well-designed, conducted, and reported, can offer valuable contributions to health and medicine. However, recent years hav...
plos.io
December 10, 2025 at 2:21 PM
Analyses of open health datasets can offer valuable contributions to health & medicine, but recent years have seen a proliferation of papers lacking robust or novel findings. In this Editorial, we provide guidance for conducting & reporting high-quality analyses using open datasets🧪
plos.io/4poBmZo
plos.io/4poBmZo
Next up in our 'meet the editors' is Academic Editor Brooke Nichols (@brookeenichols.bsky.social), Associate Professor of Global Health at Boston University School of Public Health (@busph.bsky.social). Brooke specializes in infectious disease modeling and health economics. 🧪 #MedSky #PLOSMedicine
December 9, 2025 at 5:22 PM
Next up in our 'meet the editors' is Academic Editor Brooke Nichols (@brookeenichols.bsky.social), Associate Professor of Global Health at Boston University School of Public Health (@busph.bsky.social). Brooke specializes in infectious disease modeling and health economics. 🧪 #MedSky #PLOSMedicine
In this population health estimates analysis, Xiaojing Zeng and colleagues explore the distinct factors associated with declines in maternal mortality in Eastern and Western China, which may help inform efforts to reach global reduction targets 🧪 #MedSky
plos.io/44YcdfP
plos.io/44YcdfP
Social and health system factors associated with maternal mortality in Eastern and Western China: Population health estimates using provincial-level data
Xiaojing Zeng and colleagues, in a population health estimates analysis, explore the distinct factors associated with declines in maternal mortality in Eastern and Western China, which may help inform...
plos.io
December 9, 2025 at 4:59 PM
In this population health estimates analysis, Xiaojing Zeng and colleagues explore the distinct factors associated with declines in maternal mortality in Eastern and Western China, which may help inform efforts to reach global reduction targets 🧪 #MedSky
plos.io/44YcdfP
plos.io/44YcdfP
High blood pressure is recognized as a risk factor associated with the development of blood cancers. Here, the authors analyzed whether continuous use of the antihypertensive agent hydralazine is associated with a lower risk of hematologic neoplasms compared to other treatments 🧪
plos.io/48rqCDx
plos.io/48rqCDx
Association of hydralazine use with risk of hematologic neoplasms in patients with hypertension: A nationwide population-based cohort study in Taiwan
Li-Tzu Wang, Wu-Chien Chien and colleagues analyzed the association between long-term hydralazine use and the risk of hematologic neoplasms in patients with hypertension.
plos.io
December 9, 2025 at 10:39 AM
High blood pressure is recognized as a risk factor associated with the development of blood cancers. Here, the authors analyzed whether continuous use of the antihypertensive agent hydralazine is associated with a lower risk of hematologic neoplasms compared to other treatments 🧪
plos.io/48rqCDx
plos.io/48rqCDx
In this population-based cohort study, Daniel Myran and colleagues report that emergency or hospital care after hallucinogen use was associated with an increased risk of incident mania or bipolar disorder diagnosis 🏥🧪 #MedSky
plos.io/48nPZGq
plos.io/48nPZGq
Hospital-based care for hallucinogens and risk of mania and bipolar disorder: A population-based cohort study
Using a population-based cohort study, Daniel Myran and colleagues report that emergency or hospital care after hallucinogen use was associated with an increased risk of incident mania or bipolar diso...
plos.io
December 8, 2025 at 2:47 PM
In this population-based cohort study, Daniel Myran and colleagues report that emergency or hospital care after hallucinogen use was associated with an increased risk of incident mania or bipolar disorder diagnosis 🏥🧪 #MedSky
plos.io/48nPZGq
plos.io/48nPZGq
In this Editorial, Zulfiqar Bhutta discusses the Global Burden of Disease 2023 report, outlining why, alongside improved data acquisition & analysis, its continued expansion creates new challenges & opportunities for improving its accuracy, completeness & policy relevance 🌏🧪 #GBD2023
plos.io/4rKtXVN
plos.io/4rKtXVN
Global Burden of Disease 2023: Challenges and opportunities for a growing collaboration
In this Editorial, Zulfiqar Bhutta discusses the Global Burden of Disease (GBD) 2023 report, outlining why, alongside improved health monitoring, data acquisition, and analytical methods, its continue...
plos.io
December 8, 2025 at 10:50 AM
In this Editorial, Zulfiqar Bhutta discusses the Global Burden of Disease 2023 report, outlining why, alongside improved data acquisition & analysis, its continued expansion creates new challenges & opportunities for improving its accuracy, completeness & policy relevance 🌏🧪 #GBD2023
plos.io/4rKtXVN
plos.io/4rKtXVN
Over the next few weeks, as our Bluesky community grows, we will be introducing some of the PLOS Medicine Staff and Academic Editors, so that you can learn about their roles, areas of expertise, and their hopes for the journal and community. 🧪 #MedSky #PLOSMedicine #editors
December 4, 2025 at 4:15 PM
Over the next few weeks, as our Bluesky community grows, we will be introducing some of the PLOS Medicine Staff and Academic Editors, so that you can learn about their roles, areas of expertise, and their hopes for the journal and community. 🧪 #MedSky #PLOSMedicine #editors
In this modeling study, Jiaxin Xie, Xuesi Dong, Zilin Luo and team use a multistate Markov model to quantify the long-term health and economic benefits of adhering to colorectal #cancer #screening, incorporating both traditional and biomarker-based initial screening methods 🧪 #MedSky
plos.io/4rB3nOT
plos.io/4rB3nOT
The impact of adherence on colorectal cancer screening cost-effectiveness: A modeling study
Jiaxin Xie, Xuesi Dong, Zilin Luo, and team use a multistate Markov model to quantify the long-term health and economic benefits of adhering to colorectal cancer screening, incorporating both traditio...
plos.io
December 4, 2025 at 10:49 AM
In this modeling study, Jiaxin Xie, Xuesi Dong, Zilin Luo and team use a multistate Markov model to quantify the long-term health and economic benefits of adhering to colorectal #cancer #screening, incorporating both traditional and biomarker-based initial screening methods 🧪 #MedSky
plos.io/4rB3nOT
plos.io/4rB3nOT
Did you know that you may be eligible to publish in PLOS Medicine without paying an APC? All PLOS journals offer several APC-alternative business agreements through institutional partnerships.📝🧪
To learn more and find out if your institution has an agreement, visit: plos.org/libraries/pa...
To learn more and find out if your institution has an agreement, visit: plos.org/libraries/pa...
Institutional Partners - PLOS
Institutional partners Open access is not truly open without equitable opportunities to publish. To support authors from diverse research communities, funding backgrounds…
plos.org
December 3, 2025 at 5:16 PM
Did you know that you may be eligible to publish in PLOS Medicine without paying an APC? All PLOS journals offer several APC-alternative business agreements through institutional partnerships.📝🧪
To learn more and find out if your institution has an agreement, visit: plos.org/libraries/pa...
To learn more and find out if your institution has an agreement, visit: plos.org/libraries/pa...
In this retrospective cohort study, Josh Lamb and colleagues estimate the cumulative incidence of first-time reoperation following primary total hip replacement, taking into consideration different age groups, sex, and implant types to help guide treatment decisions. 🧪🦴 #MedSky
plos.io/4ougtL6
plos.io/4ougtL6
The association between implant design, age, sex and the rate of major reoperation in patients undergoing primary total hip replacement: A retrospective study of UK National Joint Registry and Hospita...
Josh N Lamb and colleagues estimate the cumulative incidence of first-time reoperation following primary total hip replacement, including revision for any cause or fixation of the femur for postoperat...
journals.plos.org
December 3, 2025 at 10:25 AM
In this retrospective cohort study, Josh Lamb and colleagues estimate the cumulative incidence of first-time reoperation following primary total hip replacement, taking into consideration different age groups, sex, and implant types to help guide treatment decisions. 🧪🦴 #MedSky
plos.io/4ougtL6
plos.io/4ougtL6
What prospects are there for preventative & stem-cell based therapies for type 1 #diabetes? 💉
In this Perspective, Kevan Herold & colleagues highlight exciting therapeutic developments aimed at arresting or reversing T1D & discuss challenges they face in reaching the clinic🧪 #MedSky
plos.io/3XyyCwi
In this Perspective, Kevan Herold & colleagues highlight exciting therapeutic developments aimed at arresting or reversing T1D & discuss challenges they face in reaching the clinic🧪 #MedSky
plos.io/3XyyCwi
Towards insulin independence in type 1 diabetes: Prospects for prevention and cure
This Perspective highlights exciting developments in preventative treatments and stem cell-based therapies for type 1 diabetes, discussing the prospects and hurdles of arresting or reversing the disea...
plos.io
December 2, 2025 at 5:28 PM
What prospects are there for preventative & stem-cell based therapies for type 1 #diabetes? 💉
In this Perspective, Kevan Herold & colleagues highlight exciting therapeutic developments aimed at arresting or reversing T1D & discuss challenges they face in reaching the clinic🧪 #MedSky
plos.io/3XyyCwi
In this Perspective, Kevan Herold & colleagues highlight exciting therapeutic developments aimed at arresting or reversing T1D & discuss challenges they face in reaching the clinic🧪 #MedSky
plos.io/3XyyCwi
In recognition of World AIDS Day 2025, this Perspective by Gregory Folkers & Anthony Fauci reflects on progress made in #antiretroviral treatments & prevention of HIV/AIDS, highlighting promising therapeutic developments and looking ahead to what is needed to end the #AIDS epidemic 🧪
plos.io/48np3Fu
plos.io/48np3Fu
Treatment and prevention of HIV/AIDS: Unfinished business
In recognition of World AIDS Day 2025, this Perspective by Gregory Folkers and Anthony Fauci reflects on the progress made in antiretroviral treatments and prevention of HIV/AIDS, highlighting promisi...
plos.io
December 1, 2025 at 7:04 PM
In recognition of World AIDS Day 2025, this Perspective by Gregory Folkers & Anthony Fauci reflects on progress made in #antiretroviral treatments & prevention of HIV/AIDS, highlighting promising therapeutic developments and looking ahead to what is needed to end the #AIDS epidemic 🧪
plos.io/48np3Fu
plos.io/48np3Fu