Sean Piantadosi
@piantadosisean.bsky.social
Post-doctoral fellow in the Bruchas lab at the University of Washington.
cool new work from @ppiantad.bsky.social and the Holmes laboratory looking at how BLA neurons encode risk using a variety of approaches. check it out!
for anyone interested in the amygdala and risky decision-making, check out our new preprint: biorxiv.org/content/10.1...
amygdala neurons track reward-seeking actions, and punishment risk dramatically alters this function. lots of other (BLA-accumbens!) data included.
amygdala neurons track reward-seeking actions, and punishment risk dramatically alters this function. lots of other (BLA-accumbens!) data included.
Risk reshapes amygdala representation of choice
Modifying behavior in response to changing environmental conditions is a crucial adaptive function. This capacity is exemplified when animals curtail pursuit of a valued outcome that risks being punis...
biorxiv.org
October 9, 2025 at 7:28 PM
cool new work from @ppiantad.bsky.social and the Holmes laboratory looking at how BLA neurons encode risk using a variety of approaches. check it out!
Reposted by Sean Piantadosi
UW folks, don't miss @ishmailsaboor.bsky.social's seminar tomorrow.
April 7, 2025 at 4:51 PM
UW folks, don't miss @ishmailsaboor.bsky.social's seminar tomorrow.
Reposted by Sean Piantadosi
Our work, lead by former graduate student Olivia Hon on the BNST, CRF and regulation of different types of fear is finalized as an elife reviewed preprint.
elifesciences.org/reviewed-pre...
elifesciences.org/reviewed-pre...
Sex Differences in BNST Signaling and BNST CRF in Fear Processing: Implications for Unpredictable Threat in Sustained Fear
elifesciences.org
April 7, 2025 at 9:52 PM
Our work, lead by former graduate student Olivia Hon on the BNST, CRF and regulation of different types of fear is finalized as an elife reviewed preprint.
elifesciences.org/reviewed-pre...
elifesciences.org/reviewed-pre...
Reposted by Sean Piantadosi
How do we associate the flavors we experience during a meal 🍽️😋 with postingestive effects like food poisoning 🤢🤮 that arise much later?
Our answer in @nature.com this week: Illness signals from the gut reactivate and strengthen flavor representations in the amygdala.
📄: nature.com/articles/s41...
Our answer in @nature.com this week: Illness signals from the gut reactivate and strengthen flavor representations in the amygdala.
📄: nature.com/articles/s41...
A neural mechanism for learning from delayed postingestive feedback - Nature
Illness signals from the gut reactivate and strengthen flavour representations in the amygdala to support learning from delayed postingestive feedback.
www.nature.com
April 3, 2025 at 6:34 PM
How do we associate the flavors we experience during a meal 🍽️😋 with postingestive effects like food poisoning 🤢🤮 that arise much later?
Our answer in @nature.com this week: Illness signals from the gut reactivate and strengthen flavor representations in the amygdala.
📄: nature.com/articles/s41...
Our answer in @nature.com this week: Illness signals from the gut reactivate and strengthen flavor representations in the amygdala.
📄: nature.com/articles/s41...
Reposted by Sean Piantadosi
Our latest study identifies a specific cell type and receptor essential for psilocybin’s long-lasting neural and behavioral effects 🍄🔬🧠🧪
Led by Ling-Xiao Shao and @ItsClaraLiao
Funded by @NIH @NIMHgov
📄 Read in @nature.com - www.nature.com/articles/s41...
1/12
Led by Ling-Xiao Shao and @ItsClaraLiao
Funded by @NIH @NIMHgov
📄 Read in @nature.com - www.nature.com/articles/s41...
1/12
Psilocybin’s lasting action requires pyramidal cell types and 5-HT2A receptors - Nature
A pyramidal cell type and the 5-HT2A receptor in the medial frontal cortex have essential roles in psilocybin’s long-term drug action.
www.nature.com
April 2, 2025 at 4:09 PM
Our latest study identifies a specific cell type and receptor essential for psilocybin’s long-lasting neural and behavioral effects 🍄🔬🧠🧪
Led by Ling-Xiao Shao and @ItsClaraLiao
Funded by @NIH @NIMHgov
📄 Read in @nature.com - www.nature.com/articles/s41...
1/12
Led by Ling-Xiao Shao and @ItsClaraLiao
Funded by @NIH @NIMHgov
📄 Read in @nature.com - www.nature.com/articles/s41...
1/12
Reposted by Sean Piantadosi
Thrilled to share our latest work🚀! Interested in corticostriatal circuits and genetics of anorexia nervosa? Check out our preprint on bioRxiv! www.biorxiv.org/content/10.1...
March 12, 2025 at 10:25 AM
Thrilled to share our latest work🚀! Interested in corticostriatal circuits and genetics of anorexia nervosa? Check out our preprint on bioRxiv! www.biorxiv.org/content/10.1...
Reposted by Sean Piantadosi
🚨Amidst all the uncertainty at NIH Welcome Leap just launched an important new $50M program in Women’s Health👩🏻🔬🧠
CARE focuses on the link between Alzheimer’s and perimenopausal hormonal changes wellcomeleap.org/care/
Note: full indirects!
Please share widely to support women’s health 🙏🏼
CARE focuses on the link between Alzheimer’s and perimenopausal hormonal changes wellcomeleap.org/care/
Note: full indirects!
Please share widely to support women’s health 🙏🏼
CARE Program Details | Wellcome Leap: Unconventional Projects. Funded at Scale.
NEW $50M Program in Women's Health care Cutting Alzheimer's Risk through EndocrinologyWe are pleased to announce the selected performers.Sabine Vollstädt-Klein, Central Institute of Mental Health ...
wellcomeleap.org
February 14, 2025 at 12:11 AM
🚨Amidst all the uncertainty at NIH Welcome Leap just launched an important new $50M program in Women’s Health👩🏻🔬🧠
CARE focuses on the link between Alzheimer’s and perimenopausal hormonal changes wellcomeleap.org/care/
Note: full indirects!
Please share widely to support women’s health 🙏🏼
CARE focuses on the link between Alzheimer’s and perimenopausal hormonal changes wellcomeleap.org/care/
Note: full indirects!
Please share widely to support women’s health 🙏🏼
Reposted by Sean Piantadosi
Feels odd to post in a normal way about science right now, but I am REALLY proud of this work from the amazing @victoriacorbit.bsky.social from her grad student days in my lab 💪🧠💗 Huge congrats to her, @piantadosisean.bsky.social, & the whole team on this tour-de-force!🎊🎊🎊
Bluetorial on the way...
Bluetorial on the way...
It's a little surreal that this paper is finally out. My last paper from my PhD and likely my last mouse neuro publication ever!
Ft. @ahmarilab.bsky.social @piantadosisean.bsky.social
If you're into mouse behavior, optogenetics, and calcium imaging, here's this 🐀🔦🔬
www.cell.com/cell-reports...
Ft. @ahmarilab.bsky.social @piantadosisean.bsky.social
If you're into mouse behavior, optogenetics, and calcium imaging, here's this 🐀🔦🔬
www.cell.com/cell-reports...
Dissociable roles of central striatum and anterior lateral motor area in initiating and sustaining naturalistic behavior
Corbit et al. studied patterns of activity in corticostriatal circuits during naturally
occurring complex behavior in mice. In contrast to models in which cortex leads striatum,
these findings suggest...
www.cell.com
January 31, 2025 at 8:31 PM
Feels odd to post in a normal way about science right now, but I am REALLY proud of this work from the amazing @victoriacorbit.bsky.social from her grad student days in my lab 💪🧠💗 Huge congrats to her, @piantadosisean.bsky.social, & the whole team on this tour-de-force!🎊🎊🎊
Bluetorial on the way...
Bluetorial on the way...
Reposted by Sean Piantadosi
The NIH BRAIN Initiatives Impacts in Systems and Computational Neuroscience, 2014-2023 https://www.biorxiv.org/content/10.1101/2025.01.30.635684v1
February 1, 2025 at 1:15 PM
The NIH BRAIN Initiatives Impacts in Systems and Computational Neuroscience, 2014-2023 https://www.biorxiv.org/content/10.1101/2025.01.30.635684v1
Reposted by Sean Piantadosi
FYI @ahmarilab.bsky.social is still following up on this work if any trainees are interested 👀
Great opportunity to study behavior relevant for OCD🐀🧠 use cutting edge techniques🔬🧬 and have a supportive and encouraging mentor 🫶
Not to mention, Pittsburgh is the best 💛🖤
Great opportunity to study behavior relevant for OCD🐀🧠 use cutting edge techniques🔬🧬 and have a supportive and encouraging mentor 🫶
Not to mention, Pittsburgh is the best 💛🖤
It's a little surreal that this paper is finally out. My last paper from my PhD and likely my last mouse neuro publication ever!
Ft. @ahmarilab.bsky.social @piantadosisean.bsky.social
If you're into mouse behavior, optogenetics, and calcium imaging, here's this 🐀🔦🔬
www.cell.com/cell-reports...
Ft. @ahmarilab.bsky.social @piantadosisean.bsky.social
If you're into mouse behavior, optogenetics, and calcium imaging, here's this 🐀🔦🔬
www.cell.com/cell-reports...
Dissociable roles of central striatum and anterior lateral motor area in initiating and sustaining naturalistic behavior
Corbit et al. studied patterns of activity in corticostriatal circuits during naturally
occurring complex behavior in mice. In contrast to models in which cortex leads striatum,
these findings suggest...
www.cell.com
January 31, 2025 at 12:30 AM
FYI @ahmarilab.bsky.social is still following up on this work if any trainees are interested 👀
Great opportunity to study behavior relevant for OCD🐀🧠 use cutting edge techniques🔬🧬 and have a supportive and encouraging mentor 🫶
Not to mention, Pittsburgh is the best 💛🖤
Great opportunity to study behavior relevant for OCD🐀🧠 use cutting edge techniques🔬🧬 and have a supportive and encouraging mentor 🫶
Not to mention, Pittsburgh is the best 💛🖤
So happy to see this paper out! Congrats @victoriacorbit.bsky.social and @ahmarilab.bsky.social! Lots of fond memories from running these experiments. The similarity in the behavioral and striatal neural response time course produced by driving M2 inputs was really striking.
It's a little surreal that this paper is finally out. My last paper from my PhD and likely my last mouse neuro publication ever!
Ft. @ahmarilab.bsky.social @piantadosisean.bsky.social
If you're into mouse behavior, optogenetics, and calcium imaging, here's this 🐀🔦🔬
www.cell.com/cell-reports...
Ft. @ahmarilab.bsky.social @piantadosisean.bsky.social
If you're into mouse behavior, optogenetics, and calcium imaging, here's this 🐀🔦🔬
www.cell.com/cell-reports...
Dissociable roles of central striatum and anterior lateral motor area in initiating and sustaining naturalistic behavior
Corbit et al. studied patterns of activity in corticostriatal circuits during naturally
occurring complex behavior in mice. In contrast to models in which cortex leads striatum,
these findings suggest...
www.cell.com
January 31, 2025 at 6:28 PM
So happy to see this paper out! Congrats @victoriacorbit.bsky.social and @ahmarilab.bsky.social! Lots of fond memories from running these experiments. The similarity in the behavioral and striatal neural response time course produced by driving M2 inputs was really striking.
Reposted by Sean Piantadosi
Folks at #wcbr- Come check out our symposium on lateral hypothalamus and addiction tomorrow (Wed), 4:30pm in Alpine B. Organised by @marcusweera.bsky.social! I’ll be presenting on #dopamine in lateral hypothalamus and how this changes after methamphetamine self-admin! 🧠 🧪 🧬
January 29, 2025 at 3:30 AM
Folks at #wcbr- Come check out our symposium on lateral hypothalamus and addiction tomorrow (Wed), 4:30pm in Alpine B. Organised by @marcusweera.bsky.social! I’ll be presenting on #dopamine in lateral hypothalamus and how this changes after methamphetamine self-admin! 🧠 🧪 🧬
Reposted by Sean Piantadosi
NIH memo addresses ‘confusion’ about restrictions imposed by Trump, easing some concerns | Science | AAAS www.science.org/content/arti...
January 28, 2025 at 1:52 AM
NIH memo addresses ‘confusion’ about restrictions imposed by Trump, easing some concerns | Science | AAAS www.science.org/content/arti...
Reposted by Sean Piantadosi
Early start (7:30am symposium) in Grand Ballroom C, for WinterBrain
❄️🧠
I’ll be talking about translational approaches to paranoia, and consilience across rodents, primates, and humans
❄️🧠
I’ll be talking about translational approaches to paranoia, and consilience across rodents, primates, and humans
January 27, 2025 at 2:27 PM
Early start (7:30am symposium) in Grand Ballroom C, for WinterBrain
❄️🧠
I’ll be talking about translational approaches to paranoia, and consilience across rodents, primates, and humans
❄️🧠
I’ll be talking about translational approaches to paranoia, and consilience across rodents, primates, and humans
Reposted by Sean Piantadosi
Registrations are open for the 2nd "Beginners training school on the use of home-cage technologies to monitor rodents".
If you are working or interested in working in animal behaviour using home-cage systems, you need to sign up! All costs covered!
17-20 June Bratislava
https://buff.ly/3E7MiaW
If you are working or interested in working in animal behaviour using home-cage systems, you need to sign up! All costs covered!
17-20 June Bratislava
https://buff.ly/3E7MiaW
January 20, 2025 at 7:39 AM
Registrations are open for the 2nd "Beginners training school on the use of home-cage technologies to monitor rodents".
If you are working or interested in working in animal behaviour using home-cage systems, you need to sign up! All costs covered!
17-20 June Bratislava
https://buff.ly/3E7MiaW
If you are working or interested in working in animal behaviour using home-cage systems, you need to sign up! All costs covered!
17-20 June Bratislava
https://buff.ly/3E7MiaW
Reposted by Sean Piantadosi
@kurtfraser.bsky.social and I just had our paper on dopamine, salience, and psychosis accepted @ Am J Psychiatry. We review the history of aberrant salience and the data gathered since: osf.io/preprints/ps...
January 14, 2025 at 12:15 PM
@kurtfraser.bsky.social and I just had our paper on dopamine, salience, and psychosis accepted @ Am J Psychiatry. We review the history of aberrant salience and the data gathered since: osf.io/preprints/ps...
Be sure to check out new Bruchas lab work from @davidjmarcus.bsky.social and co-authors! An exciting and nuanced story unraveling how endocannabinoid signaling influences behavioral engagement. Make sure to dive into the Supplemental Figures which describes the circuit's role in aversive behavior.
I’m excited to share the most recent study from the Bruchas
lab, which represents the culmination of my postdoctoral work, and serves as the platform for my future research programs investigating the in vivo role of the endocannabinoid signaling system!
www.biorxiv.org/content/10.1...
lab, which represents the culmination of my postdoctoral work, and serves as the platform for my future research programs investigating the in vivo role of the endocannabinoid signaling system!
www.biorxiv.org/content/10.1...
Endocannabinoids facilitate transitory reward engagement through retrograde gain-control
Neuromodulatory signaling is poised to serve as a neural mechanism for gain control, acting as a crucial tuning factor to influence neuronal activity by dynamically shaping excitatory and inhibitory f...
www.biorxiv.org
January 14, 2025 at 7:56 PM
Be sure to check out new Bruchas lab work from @davidjmarcus.bsky.social and co-authors! An exciting and nuanced story unraveling how endocannabinoid signaling influences behavioral engagement. Make sure to dive into the Supplemental Figures which describes the circuit's role in aversive behavior.
Reposted by Sean Piantadosi
A reminder about our position at SickKids/U of T. Accepting applications until February 15th. Please share widely.
can-acn.org/scientist-se...
can-acn.org/scientist-se...
Scientist/Senior Scientist – Research Institute, Hospital for Sick Children, University of Toronto – Canadian Association for Neuroscience
can-acn.org
January 10, 2025 at 2:13 PM
A reminder about our position at SickKids/U of T. Accepting applications until February 15th. Please share widely.
can-acn.org/scientist-se...
can-acn.org/scientist-se...
Very excited for this! Abstract submission is open now and the due date is Februrary 14th, 2025!
Announcing the 2025 "Engram and Ensembles in Learning and Memory" meeting, at @tcddublin.bsky.social
Half of speakers will be selected from abstracts submitted by trainees. Registration is open below, with discounted rates available until January 31st.
event.fourwaves.com/engramsensem...
Half of speakers will be selected from abstracts submitted by trainees. Registration is open below, with discounted rates available until January 31st.
event.fourwaves.com/engramsensem...
December 19, 2024 at 6:54 PM
Very excited for this! Abstract submission is open now and the due date is Februrary 14th, 2025!
Reposted by Sean Piantadosi
🎄PinkyCaMP- our christmas gift to you! 🎁: We are excited to present PinkyCaMP, the first mScarlet based calcium sensor with:
✨exceptional, brightness
✨phototability
✨and optogenetic compatability.
Check out our new preprint:
www.biorxiv.org/content/10.1...
✨exceptional, brightness
✨phototability
✨and optogenetic compatability.
Check out our new preprint:
www.biorxiv.org/content/10.1...
December 18, 2024 at 10:01 AM
🎄PinkyCaMP- our christmas gift to you! 🎁: We are excited to present PinkyCaMP, the first mScarlet based calcium sensor with:
✨exceptional, brightness
✨phototability
✨and optogenetic compatability.
Check out our new preprint:
www.biorxiv.org/content/10.1...
✨exceptional, brightness
✨phototability
✨and optogenetic compatability.
Check out our new preprint:
www.biorxiv.org/content/10.1...
Reposted by Sean Piantadosi
Saving the best for last! If you are still at #ACNP2024 stop by grad student Abby Galvez's poster (W48) describing mesolimbic dopamine dysfunction in a selectively bred rat model of bipolar disorder.
December 11, 2024 at 6:12 PM
Saving the best for last! If you are still at #ACNP2024 stop by grad student Abby Galvez's poster (W48) describing mesolimbic dopamine dysfunction in a selectively bred rat model of bipolar disorder.
If you are still at #ACNP2024 and are interested in the locus coeruleus and/or the amygdala, please stop by my poster from the @mbruchas lab examining how both nodes of this circuit mediate stress-induced anxiety-like behavior tonight (W169)!
December 11, 2024 at 9:16 PM
If you are still at #ACNP2024 and are interested in the locus coeruleus and/or the amygdala, please stop by my poster from the @mbruchas lab examining how both nodes of this circuit mediate stress-induced anxiety-like behavior tonight (W169)!
Reposted by Sean Piantadosi
Coming soon: We have a Scientist position in the Neuroscience & Mental Health Program at SickKids. Should post details later this week. Stay tuned.
December 11, 2024 at 2:27 PM
Coming soon: We have a Scientist position in the Neuroscience & Mental Health Program at SickKids. Should post details later this week. Stay tuned.
Reposted by Sean Piantadosi
If you’re still hanging around at #ACNP2024 tonight and you’re interested in the insular cortex, interoception, food intake or single-cell seq, stop by my poster (170)!
a girl wearing sunglasses with the words see you there on the bottom
ALT: a girl wearing sunglasses with the words see you there on the bottom
media.tenor.com
December 11, 2024 at 5:07 PM
If you’re still hanging around at #ACNP2024 tonight and you’re interested in the insular cortex, interoception, food intake or single-cell seq, stop by my poster (170)!
Reposted by Sean Piantadosi
Hello #ACNP2024
I’m Kasey Girven a Postdoc in the Bruchas Lab at The University of Washington.
I study how a neuropeptide S, peri-coerulear projection to the OFC is recruited during repeat exposure to high value rewards 🐭🧀💉
Come listen to my spiel this Wednesday at 3PM in the Grand Sonoran JK 🧠
I’m Kasey Girven a Postdoc in the Bruchas Lab at The University of Washington.
I study how a neuropeptide S, peri-coerulear projection to the OFC is recruited during repeat exposure to high value rewards 🐭🧀💉
Come listen to my spiel this Wednesday at 3PM in the Grand Sonoran JK 🧠
December 9, 2024 at 5:18 PM
Hello #ACNP2024
I’m Kasey Girven a Postdoc in the Bruchas Lab at The University of Washington.
I study how a neuropeptide S, peri-coerulear projection to the OFC is recruited during repeat exposure to high value rewards 🐭🧀💉
Come listen to my spiel this Wednesday at 3PM in the Grand Sonoran JK 🧠
I’m Kasey Girven a Postdoc in the Bruchas Lab at The University of Washington.
I study how a neuropeptide S, peri-coerulear projection to the OFC is recruited during repeat exposure to high value rewards 🐭🧀💉
Come listen to my spiel this Wednesday at 3PM in the Grand Sonoran JK 🧠