Pfliegler Lab at University of Debrecen
@pflieglerlab.bsky.social
Saccharomyces, yeasts, mycobiome, phylogenomics
My first ever English cask ale in London. We are visiting The Old Swan after Churchill Arms! Tasting an Old Golden Hen and an Abbot Ale!
October 29, 2025 at 7:48 PM
My first ever English cask ale in London. We are visiting The Old Swan after Churchill Arms! Tasting an Old Golden Hen and an Abbot Ale!
Reposted by Pfliegler Lab at University of Debrecen
The new issue of #Yeast is out ... with a surprise 😄! This issue marks the 40th anniversary of the creation of our journal, in 1985. To celebrate this achievement, we made a brand new cover with the most beautiful #Yeast front pages 😍
Happy birthday Yeast!!!
onlinelibrary.wiley.com/toc/10970061...
Happy birthday Yeast!!!
onlinelibrary.wiley.com/toc/10970061...
Happy 40th birthday Yeast: Yeast: Vol 42, No 8-10
Yeast is a microbiology journal for research in the rapidly moving field of yeast biology. We publish the most significant developments in unicellular fungi.
onlinelibrary.wiley.com
October 15, 2025 at 8:03 AM
The new issue of #Yeast is out ... with a surprise 😄! This issue marks the 40th anniversary of the creation of our journal, in 1985. To celebrate this achievement, we made a brand new cover with the most beautiful #Yeast front pages 😍
Happy birthday Yeast!!!
onlinelibrary.wiley.com/toc/10970061...
Happy birthday Yeast!!!
onlinelibrary.wiley.com/toc/10970061...
Reposted by Pfliegler Lab at University of Debrecen
#Fungi living in the body play an important role in #health ...
| #microbiome | #gut | #microbes | #mycobiome | #diet | Via @theconversation.com
| #microbiome | #gut | #microbes | #mycobiome | #diet | Via @theconversation.com
The fungi living in the body play an important role in health – here’s what you should know about the ‘mycobiome’
The ‘mycobiome’ refers to the hundreds of species of fungi that normally live on and in our body.
theconversation.com
October 19, 2025 at 5:02 PM
#Fungi living in the body play an important role in #health ...
| #microbiome | #gut | #microbes | #mycobiome | #diet | Via @theconversation.com
| #microbiome | #gut | #microbes | #mycobiome | #diet | Via @theconversation.com
Phylogenomic signatures of repeat-induced point mutations across the fungal kingdom #Fungalevolution
Fungal #GenomeSize variation is largely driven by TEs & lineage-specific genome defenses. @tbadet.bsky.social & @danielcroll.bsky.social show that presence/absence of RIP mutation systems influences #genome architecture, identifying a likely novel defense mechanism @plosbiology.org 🧪 plos.io/4hcC5tx
October 16, 2025 at 3:44 PM
Phylogenomic signatures of repeat-induced point mutations across the fungal kingdom #Fungalevolution
Wow! Massive new #Saccharomyces resource and super interesting paper "From genotype to phenotype with 1,086 near telomere-to-telomere #yeast genomes"
✨ Latest exciting story of the group in @nature.com. Here, we go beyond SNPs and built a species-wide atlas of genetic variants in yeast. With >1,000 near T2T genomes, we show how large genomic variations affect trait diversity.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes - Nature
A newly compiled atlas of species-wide structural variants and gene-based and graph pangenomes derived from highly complete assemblies of genomes from 1,086 natural isolates enable integrative genome-...
www.nature.com
October 16, 2025 at 9:41 AM
Wow! Massive new #Saccharomyces resource and super interesting paper "From genotype to phenotype with 1,086 near telomere-to-telomere #yeast genomes"
Oral Bacterial and Fungal Microbiome and Subsequent Risk for Pancreatic Cancer #mycobiome #yeast
Specific oral bacteria and fungi were risk factors for pancreatic cancer development, suggesting the potential use of oral microbiota as noninvasive biomarkers for identifying high-risk individuals.
ja.ma/4n9QpFm
ja.ma/4n9QpFm
October 5, 2025 at 7:48 AM
Oral Bacterial and Fungal Microbiome and Subsequent Risk for Pancreatic Cancer #mycobiome #yeast
Reposted by Pfliegler Lab at University of Debrecen
May she journey forever amongst the imperishable stars.
October 1, 2025 at 6:18 PM
May she journey forever amongst the imperishable stars.
Recently I revived my experimental sourdough culture from the -80C freezer and started refreshing it every day. The khachapuri made with it tonight looks quite good:) #yeast
September 29, 2025 at 7:37 PM
Recently I revived my experimental sourdough culture from the -80C freezer and started refreshing it every day. The khachapuri made with it tonight looks quite good:) #yeast
The emerging roles of non-Saccharomyces #yeasts in fermented foods and human health - new minireview from @alexandraimre.bsky.social !
New minireview on non-Saccharomyces yeasts and their contribution to 🍺🍷🍞🧀 fermentations and human health 💊⚕️. With Dr. Nathan Crook we summarized some recent trends in this field that could be of interest to folks in the yeast community.
academic.oup.com/femsyr/advan...
academic.oup.com/femsyr/advan...
The emerging roles of non-Saccharomyces yeasts in fermented foods and human health
Abstract. Yeasts play a crucial role in the maturation of fermented foods, with Saccharomyces cerevisiae standing out as the most prominent among them. How
academic.oup.com
September 26, 2025 at 1:04 PM
The emerging roles of non-Saccharomyces #yeasts in fermented foods and human health - new minireview from @alexandraimre.bsky.social !
Reproductive Isolation due to Divergent Ecological Selection Is Accompanied by Vast Genomic Instability in Experimentally Evolved #Yeast Populations! #fungalevolution #Saccharomyces new paper from @stelkens.bsky.social
We have a new paper out in Molecular Ecology, led by @devinbendixsen.bsky.social ! Reproductive isolation due to divergent ecological selection is accompanied by vast genomic instability in experimentally evolved yeast populations onlinelibrary.wiley.com/doi/10.1111/...
September 19, 2025 at 5:24 AM
Reproductive Isolation due to Divergent Ecological Selection Is Accompanied by Vast Genomic Instability in Experimentally Evolved #Yeast Populations! #fungalevolution #Saccharomyces new paper from @stelkens.bsky.social
Reposted by Pfliegler Lab at University of Debrecen
Another traditional brewer has left us. Harald Storli died earlier this week. I visited the family in 2014 and it was an unforgettable experience. Harald is a great loss not just for family and friends, but also for Norwegian brewing culture.
www.garshol.priv.no/blog/297.html
www.garshol.priv.no/blog/297.html
Storli Gard: Norway's oldest beer? | Larsblog
Personal blog of Lars Marius Garshol.
www.garshol.priv.no
September 18, 2025 at 5:04 PM
Another traditional brewer has left us. Harald Storli died earlier this week. I visited the family in 2014 and it was an unforgettable experience. Harald is a great loss not just for family and friends, but also for Norwegian brewing culture.
www.garshol.priv.no/blog/297.html
www.garshol.priv.no/blog/297.html
Repeated losses of self-fertility shaped heterozygosity and polyploidy in #yeast evolution! #Saccharomyces
New preprint from the lab: we show that the ability to switch mating type was lost at least 13 times independently in the evolution of S. cerevisiae. At least 27% of isolates are heterothallic with a strong association with polyploidy and heterozygosity
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Repeated losses of self-fertility shaped heterozygosity and polyploidy in yeast evolution
Evolutionary transitions in mating strategy have profound consequences for genetic variation and adaptation. In Saccharomyces cerevisiae, mating-type switching is a central feature of the life cycle t...
www.biorxiv.org
September 17, 2025 at 4:11 AM
Repeated losses of self-fertility shaped heterozygosity and polyploidy in #yeast evolution! #Saccharomyces
Checkout our new preprint with the @rokaslab.bsky.social!:
www.biorxiv.org/content/10.1...
doi: doi.org/10.1101/2025...
www.biorxiv.org/content/10.1...
doi: doi.org/10.1101/2025...
Discovery of additional ancient genome duplications in yeasts
Whole genome duplication (WGD) has had profound macroevolutionary impacts on diverse lineages[1][1],[2][2], preceding adaptive radiations in vertebrates[3][3]–[5][4], teleost fish[6][5],[7][6], and an...
www.biorxiv.org
September 17, 2025 at 4:07 AM
Long-term monitoring of a North American cheese cave reveals mechanisms and consequences of fungal adaptation #Fungalevolution
Long-term monitoring of a North American cheese cave reveals mechanisms and consequences of fungal adaptation
Penicillium solitum over 8 years in a cheese cave => green-to-white shift
@currentbiology.bsky.social from @benwolfe.bsky.social with @kellerlab.bsky.social
www.cell.com/current-biol...
Penicillium solitum over 8 years in a cheese cave => green-to-white shift
@currentbiology.bsky.social from @benwolfe.bsky.social with @kellerlab.bsky.social
www.cell.com/current-biol...
Long-term monitoring of a North American cheese cave reveals mechanisms and consequences of fungal adaptation
Using a unique longitudinal sampling approach, Louw et al. demonstrate how a cheese-associated
Penicillium population has adapted in an artisan cheese production facility in Vermont,
USA. Adaptation i...
www.cell.com
September 15, 2025 at 9:07 AM
Long-term monitoring of a North American cheese cave reveals mechanisms and consequences of fungal adaptation #Fungalevolution
Reposted by Pfliegler Lab at University of Debrecen
Our latest review on the effect of tyrosol in yeast has just been published. 🔥🔥🔥🍄
link.springer.com/10.1007/s002...
link.springer.com/10.1007/s002...
The effects of tyrosol on yeasts: an overview of current knowledge - Applied Microbiology and Biotechnology
Abstract Quorum sensing is a cell density-dependent microbial communication form, which can regulate several microbial properties, including virulence, biofilm formation and cell–cell competence. The ...
link.springer.com
September 12, 2025 at 8:34 PM
Our latest review on the effect of tyrosol in yeast has just been published. 🔥🔥🔥🍄
link.springer.com/10.1007/s002...
link.springer.com/10.1007/s002...
Congratulations to @balintnemeth.bsky.social on his talk on thousands and thousands of #Saccharomyces genomes!
September 12, 2025 at 1:56 PM
Congratulations to @balintnemeth.bsky.social on his talk on thousands and thousands of #Saccharomyces genomes!
We arrived in Szeged for the annual miniconference of the Hungarian Genetics Society! My PhD student @balintnemeth.bsky.social will present about the #Saccharomyces Compendium and I have a poster about integrating #yeast research into BSc lab classes at the University of Debrecen :)
September 12, 2025 at 10:19 AM
We arrived in Szeged for the annual miniconference of the Hungarian Genetics Society! My PhD student @balintnemeth.bsky.social will present about the #Saccharomyces Compendium and I have a poster about integrating #yeast research into BSc lab classes at the University of Debrecen :)
This is going to be a very nice hop harvest:)
September 7, 2025 at 5:02 PM
This is going to be a very nice hop harvest:)
Wow! Very interesting new analysis on #mycobiome. #yeast Kazachstania forms a causal relationship with cardiovascular disease risk in a mendelian two-sample randomization analysis!
We published a new lane of research today on human gut fungi. Shout out to 1st author @emilyvansyoc.bsky.social sky.social & @erdavenport.bsky.social For 20 years, bacteria received the lion's share of interest in the human gut. Yet we know little about the gut mycobiome. doi.org/10.1371/jour...
Gut fungi are associated with human genetic variation and disease risk
In contrast to decades of research on gut bacteria, human genetic determinants of the gut fungal community (mycobiome) remain understudied. This investigation presents the first GWAS on the number and...
doi.org
September 3, 2025 at 5:55 AM
Wow! Very interesting new analysis on #mycobiome. #yeast Kazachstania forms a causal relationship with cardiovascular disease risk in a mendelian two-sample randomization analysis!
"Did alcohol facilitate the evolution of complex societies?" Very interesting thread on a new paper!
Many researchers have suggested that alcohol may have been an important factor in developing early states. Basically, it's supposed to have helped social cohesion, improved cooperation, and reduced friction among people living cramped together.
Well, did it? New research on the subject out now.
Well, did it? New research on the subject out now.
September 1, 2025 at 5:50 PM
"Did alcohol facilitate the evolution of complex societies?" Very interesting thread on a new paper!
Finishing up two manuscripts while brewing a gruit with smoked malts and some fresh hops. Most of the hops I will harvest a few days later :)
August 31, 2025 at 2:51 PM
Finishing up two manuscripts while brewing a gruit with smoked malts and some fresh hops. Most of the hops I will harvest a few days later :)
Finally, our new -80°C freezer arrived! This is our #yeast lab now, two small rooms for my research group (one half-time and one full-time PhD-student, @balintnemeth.bsky.social, many BSc and MSc-students, and me). Looking forward to start the new semester with them very soon!
August 25, 2025 at 3:10 PM
Finally, our new -80°C freezer arrived! This is our #yeast lab now, two small rooms for my research group (one half-time and one full-time PhD-student, @balintnemeth.bsky.social, many BSc and MSc-students, and me). Looking forward to start the new semester with them very soon!
Reposted by Pfliegler Lab at University of Debrecen
Thrilled to share that the final chapter of my PhD with @rokaslab.bsky.social is now out in @natcomms.nature.com 🎉
Read it to find out how population structure impacts pathogenicity in Aspergillus flavus, a fungus that infects humans 🧪
rdcu.be/eAToj
Read it to find out how population structure impacts pathogenicity in Aspergillus flavus, a fungus that infects humans 🧪
rdcu.be/eAToj
Population structure in a fungal human pathogen is potentially linked to pathogenicity
Nature Communications - Genetic diversity between clinical and environmental fungal isolates of Aspergillus flavus is poorly studied. Here, the authors analysed genomic data from a global set of...
rdcu.be
August 18, 2025 at 9:48 PM
Thrilled to share that the final chapter of my PhD with @rokaslab.bsky.social is now out in @natcomms.nature.com 🎉
Read it to find out how population structure impacts pathogenicity in Aspergillus flavus, a fungus that infects humans 🧪
rdcu.be/eAToj
Read it to find out how population structure impacts pathogenicity in Aspergillus flavus, a fungus that infects humans 🧪
rdcu.be/eAToj