@peterwlaird.bsky.social
Our paper on deep single-cell DNA methylation analysis is out in Nature Communications rdcu.be/evfJm. Super elegant work by Nathan Spix describing replication dynamics, X-inactivation, and cell lineage identification.
High-coverage allele-resolved single-cell DNA methylation profiling reveals cell lineage, X-inactivation state, and replication dynamics
Nature Communications - Here, the authors describe scDEEP-mC, an improved single-cell whole-genome bisulfite sequencing method for complex libraries and deep genomic coverage, and show advanced...
rdcu.be
July 8, 2025 at 9:46 AM
Our paper on deep single-cell DNA methylation analysis is out in Nature Communications rdcu.be/evfJm. Super elegant work by Nathan Spix describing replication dynamics, X-inactivation, and cell lineage identification.
Reposted
I can't believe we're still allowing completely inadequate and uninterpretable Epigenome-Wide Association Studies (EWAS) to be published.
I don't care that this study is probably well-intentioned, and probably trying to draw attention to awful events in Syria.
www.nature.com/articles/s41...
I don't care that this study is probably well-intentioned, and probably trying to draw attention to awful events in Syria.
www.nature.com/articles/s41...
Epigenetic signatures of intergenerational exposure to violence in three generations of Syrian refugees - Scientific Reports
Scientific Reports - Epigenetic signatures of intergenerational exposure to violence in three generations of Syrian refugees
www.nature.com
March 1, 2025 at 4:51 PM
I can't believe we're still allowing completely inadequate and uninterpretable Epigenome-Wide Association Studies (EWAS) to be published.
I don't care that this study is probably well-intentioned, and probably trying to draw attention to awful events in Syria.
www.nature.com/articles/s41...
I don't care that this study is probably well-intentioned, and probably trying to draw attention to awful events in Syria.
www.nature.com/articles/s41...
Reposted
AACR urges Congress to reaffirm its long history of steadfast and bipartisan support for medical research by ensuring that NIH has all of the resources needed to advance its lifesaving mission to prevent, diagnose, and treat cancer and other diseases: AACR.org/NIH
February 18, 2025 at 6:10 PM
AACR urges Congress to reaffirm its long history of steadfast and bipartisan support for medical research by ensuring that NIH has all of the resources needed to advance its lifesaving mission to prevent, diagnose, and treat cancer and other diseases: AACR.org/NIH
Reposted
In Stalin's USSR geneticists were, for political reasons, labelled "fly lovers who hate people" (мухолюбы-человеконенавистники). Soviet genetics died as a field.
A complementary way to kill biomedical research that yields lifesaving medicines is to defund it for equally political reasons:
A complementary way to kill biomedical research that yields lifesaving medicines is to defund it for equally political reasons:
February 8, 2025 at 12:51 AM
In Stalin's USSR geneticists were, for political reasons, labelled "fly lovers who hate people" (мухолюбы-человеконенавистники). Soviet genetics died as a field.
A complementary way to kill biomedical research that yields lifesaving medicines is to defund it for equally political reasons:
A complementary way to kill biomedical research that yields lifesaving medicines is to defund it for equally political reasons:
Reposted
Wondering whether your cancer risk might start before you are born? Our latest work published in #Nature Cancer suggests it does, through regulation by Trim28 and #epigenetic silencing. Congratulations to @ilariapanzeri.bsky.social for spearheading! Read it here: www.nature.com/articles/s43...
TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states - Nature Cancer
Panzeri et al. use a Trim28+/D9 mouse model with intrinsic developmental heterogeneity to show that ‘heavy’ and ‘light’ developmental morphs exhibit different timing, type and severity of cancer, link...
www.nature.com
January 27, 2025 at 6:41 PM
Wondering whether your cancer risk might start before you are born? Our latest work published in #Nature Cancer suggests it does, through regulation by Trim28 and #epigenetic silencing. Congratulations to @ilariapanzeri.bsky.social for spearheading! Read it here: www.nature.com/articles/s43...
Reposted
New pre-print alert 🚨 Interested in what @ikafetzo.bsky.social learned about DNA hypomethylation in cancer from investigating surprising gains DNA methylation in DNMT1 KO cells? Read all about it here: www.biorxiv.org/content/10.1...
For a quick summary see this 🧵 1/8 #epigenetics
For a quick summary see this 🧵 1/8 #epigenetics
DNMT1 loss leads to hypermethylation of a subset of late replicating domains by DNMT3A
Loss of DNA methylation is a hallmark of cancer that is proposed to promote carcinogenesis through gene expression alterations, retrotransposon activation and induction of genomic instability. Cancer-...
www.biorxiv.org
January 9, 2025 at 4:53 PM
New pre-print alert 🚨 Interested in what @ikafetzo.bsky.social learned about DNA hypomethylation in cancer from investigating surprising gains DNA methylation in DNMT1 KO cells? Read all about it here: www.biorxiv.org/content/10.1...
For a quick summary see this 🧵 1/8 #epigenetics
For a quick summary see this 🧵 1/8 #epigenetics
Thrilled to share the results in Cancer Cell of years of hard work to develop classifiers for all major TCGA cancer subtypes, enabling assessment of differential drug response among cancer subtypes in clinical trials. www.cell.com/cancer-cell/...
Classification of non-TCGA cancer samples to TCGA molecular subtypes using compact feature sets
Ellrott et al. provide a means to assign patient samples from clinical trials and other cancer genome studies to published TCGA molecular subtypes. Applying machine learning to data from five different molecular platforms for 8,791 TCGA tumor samples, they contribute a public resource of 737 top classifier models, which can form the foundation for clinical assay development.
www.cell.com
January 2, 2025 at 4:49 PM
Thrilled to share the results in Cancer Cell of years of hard work to develop classifiers for all major TCGA cancer subtypes, enabling assessment of differential drug response among cancer subtypes in clinical trials. www.cell.com/cancer-cell/...
Reposted
Congratulations to VAI's Dr. Russell Jones and Dr. @peterwlaird.bsky.social for being named to this year's Clarivate Highly Cited Researchers list — a distinction that marks them as leaders in their fields. #HighlyCited2024
Van Andel Institute scientists named to prestigious Highly Cited Researchers list – Van Andel Institute
VAI scientists Russell Jones, Ph.D., and Peter W. Laird, Ph.D., are included in this year’s Clarivate Highly Cited Researchers list, a distinction marking them as leaders in their fields.
www.vai.org
November 19, 2024 at 3:14 PM
Congratulations to VAI's Dr. Russell Jones and Dr. @peterwlaird.bsky.social for being named to this year's Clarivate Highly Cited Researchers list — a distinction that marks them as leaders in their fields. #HighlyCited2024