Pedro Vélez Pardo BPsy MSc
LightNews LightNews
banner
pedrovelezpardo.bsky.social
Pedro Vélez Pardo BPsy MSc
@pedrovelezpardo.bsky.social
40 followers 100 following 24 posts
Clinical Psychologist | Psychobiologist | MSc in Biosciences | Microbiome, Microalgae and Mental Health Research | Diversity and Inclusion Consultant in 1976.group | Professor at Universidad CES | Medellín, Colombia
Posts Replies Media Videos
Reposted by Pedro Vélez Pardo BPsy MSc
natmetabolism.nature.com
The cyclic metabolic switching theory of intermittent fasting
Nature Metabolism, Published online: 14 March 2025; doi:10.1038/s42255-025-01254-5The cyclic metabolic switching theory of intermittent fasting
bit.ly
March 14, 2025 at 2:10 PM
Reposted by Pedro Vélez Pardo BPsy MSc
natmetabolism.nature.com
SIRT5 slows skeletal muscle ageing by alleviating inflammation
Nature Metabolism, Published online: 14 March 2025; doi:10.1038/s42255-025-01228-7Sarcopenia is one of the main contributors to the loss of independence in older adults. A study in primates demonstrates that SIRT5-mediated desuccinylation of TBK1 at…
bit.ly
March 14, 2025 at 2:10 PM
Reposted by Pedro Vélez Pardo BPsy MSc
natmetabolism.nature.com
Regulation of mammalian cellular metabolism by endogenous cyanide production
Nature Metabolism, Published online: 03 March 2025; doi:10.1038/s42255-025-01225-wZuhra and Petrosino et al. report evidence that cyanide acts as a regulatory gasotransmitter in mammalian cells, where it is shown to affect cellular bioenergetics, most…
bit.ly
March 10, 2025 at 11:39 AM
Reposted by Pedro Vélez Pardo BPsy MSc
natmetabolism.nature.com
Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation
Nature Metabolism, Published online: 19 February 2025; doi:10.1038/s42255-025-01224-xCasey et al. explore the basic mechanisms of mitochondrial superoxide production and its impact on interleukin-1β production in LPS-treated macrophages.
bit.ly
February 26, 2025 at 4:26 PM
Reposted by Pedro Vélez Pardo BPsy MSc
natmetabolism.nature.com
Querying stool for dietary information
Nature Metabolism, Published online: 18 February 2025; doi:10.1038/s42255-025-01219-8Accurately determining food intake remains a substantial challenge in nutrition research. This issue of Nature Metabolism introduces a methodology for assessing dietary…
bit.ly
February 25, 2025 at 3:39 PM
Reposted by Pedro Vélez Pardo BPsy MSc
natmetabolism.nature.com
Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation
Nature Metabolism, Published online: 19 February 2025; doi:10.1038/s42255-025-01224-xCasey et al. explore the basic mechanisms of mitochondrial superoxide production and its impact on interleukin-1β production in LPS-treated macrophages.
bit.ly
February 19, 2025 at 4:25 PM
Reposted by Pedro Vélez Pardo BPsy MSc
natmetabolism.nature.com
Metagenomic estimation of dietary intake from human stool
Nature Metabolism, Published online: 18 February 2025; doi:10.1038/s42255-025-01220-1Diener et al. present a method that allows the estimation of dietary intake from human stool by detecting food-derived DNA in faecal metagenomes.
bit.ly
February 18, 2025 at 3:38 PM
Reposted by Pedro Vélez Pardo BPsy MSc
vjsanchez.bsky.social
1️⃣ We are super happy to announce our latest paper in Nature Communications! 🚀

We show how targeting ELOVL6 disrupts c-MYC-driven lipid metabolism in PDAC, enhancing chemosensitivity.

📄 Read more: doi.org/10.1038/s414...

#PDAC #CancerResearch #ELOVL6 🧪
Targeting ELOVL6 to disrupt c-MYC driven lipid metabolism in pancreatic cancer enhances chemosensitivity - Nature Communications
Overexpression of c-MYC regulates tumor metabolism in pancreatic ductal adenocarcinoma (PDAC). Here the authors identify ELOVL6, a fatty acid elongase regulated by c-MYC, as a potential therapeutic ta...
doi.org
February 16, 2025 at 3:55 PM
pedrovelezpardo.bsky.social
“Mapping Lesions That Cause Psychosis to a Human Brain Circuit and Proposed Stimulation Target”. #Neurobiology #Psychobiology #Psychiatry

jamanetwork.com/journals/jam...
Mapping Lesions That Cause Psychosis
This case-control study analyzes published cases of lesion-induced psychosisTo assess whether lesions that cause secondary psychosis have functional connections to a common brain circuit
jamanetwork.com
February 14, 2025 at 5:11 PM
pedrovelezpardo.bsky.social
"Connecting genomic results for psychiatric disorders to human brain cell types and regions reveals convergence with functional connectivity" #Neuroscience #Neurobiology #Psychobiology #Genomics #Metabolomics #TheScienceHusbands

www.nature.com/articles/s41...
Connecting genomic results for psychiatric disorders to human brain cell types and regions reveals convergence with functional connectivity - Nature Communications
Circuit and cell type prioritization for complex disorders is crucial to direct future efforts. Here the authors integrate GWAS, human single-cell RNA-seq and fMRI analysis suggesting multi-modality c...
www.nature.com
February 14, 2025 at 3:50 PM
pedrovelezpardo.bsky.social
"The person-to-person transmission landscape of the gut and oral microbiomes". #Microbiome #Psychobiology #TheScienceHusbands

www.nature.com/articles/s41...
The person-to-person transmission landscape of the gut and oral microbiomes - Nature
Data from more than 9,700 human stool and oral metagenomes has been used to decipher the strain transmission patterns of the human microbiome from mother to infant, within households and within p...
www.nature.com
February 13, 2025 at 10:24 PM
pedrovelezpardo.bsky.social
"Direct conversion of human umbilical cord mesenchymal stem cells into dopaminergic neurons for Parkinson's disease treatment". #Neurobiology #Psychobiology #TheScienceHusbands

www.sciencedirect.com/science/arti...
Direct conversion of human umbilical cord mesenchymal stem cells into dopaminergic neurons for Parkinson's disease treatment
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor deficits due to the depletion of nigrostriatal dopamine. Stem cell dif…
www.sciencedirect.com
February 13, 2025 at 10:22 PM
Reposted by Pedro Vélez Pardo BPsy MSc
natmetabolism.nature.com
Translocation renal cell carcinoma says no to the Warburg effect
Nature Metabolism, Published online: 06 February 2025; doi:10.1038/s42255-025-01216-xA new study reveals that in drastic contrast to other cancer types, translocation renal cell carcinoma (tRCC) is transcriptionally rewired towards an oxidative…
bit.ly
February 13, 2025 at 1:03 PM
Reposted by Pedro Vélez Pardo BPsy MSc
multicellgenome.bsky.social
Cool! A burst of genome evolution (HGT, new genes, expansion of gene families) on their origin. The study also highlights the important role of viruses in shaping brown algae evolution. Congrats to all authors! #multicellularity #brownalgae #protistsonSky

www.cell.com/cell/fulltex...
Evolutionary genomics of the emergence of brown algae as key components of coastal ecosystems
Comparative genomics charts the evolutionary history of the brown algal lineage, identifying an early period of accelerated genome evolution followed by diversification of the major orders, and a majo...
www.cell.com
February 10, 2025 at 8:29 AM
Reposted by Pedro Vélez Pardo BPsy MSc
natmetabolism.nature.com
Subcutaneous depth-selective spectral imaging with mμSORS enables noninvasive glucose monitoring
Nature Metabolism, Published online: 05 February 2025; doi:10.1038/s42255-025-01217-wIn this study, multiple μ-spatially offset Raman spectroscopy is used to determine blood glucose levels noninvasively in humans, achieving comparatively high accuracy in…
bit.ly
February 5, 2025 at 11:46 AM
pedrovelezpardo.bsky.social
“In this review, we discuss 3 genetic variants of CAMK4 found in individuals with hyperkinetic movement disorder and comorbid neurological symptoms including autism spectrum disorder that are likely pathogenic with monogenic effect”. #MentalHealth #Autism #TheScienceHusbands
Convergence on CaMK4: A Key Modulator of Autism-Associated Signaling Pathways in Neurons
Although the precise underlying cause(s) of autism spectrum disorder remain unclear, more than 1000 rare genetic variations are associated with the condition. For many people living with profound auti...
id.elsevier.com
February 5, 2025 at 12:26 PM
Reposted by Pedro Vélez Pardo BPsy MSc
biorxiv-neursci.bsky.social
AAV serotype PHP.eB achieves superior neuronal transduction efficiency compared to AAV9 in pigtail macaques following intracerebroventricular administration https://www.biorxiv.org/content/10.1101/2025.02.04.636515v1
February 5, 2025 at 3:15 AM
Reposted by Pedro Vélez Pardo BPsy MSc
biorxiv-microbiol.bsky.social
DNA repair functions are essential for bacterial stress defense but render antibiotic tolerant sub-populations susceptible to ciprofloxacin and gentamicin upon prolonged treatment https://www.biorxiv.org/content/10.1101/2025.02.03.636342v1
February 5, 2025 at 3:19 AM
pedrovelezpardo.bsky.social
“These findings indicate that glutamatergic medications may be effective in treating OCRDs, particularly OCD. However, high heterogeneity and potential publication bias necessitate cautious interpretation”. #MentalHealth #TheScienceHusbands

jamanetwork.com/journals/jam...
Glutamatergic Medications for Obsessive-Compulsive and Related Disorders
This systematic review and meta-analysis evaluates the association of glutamatergic medications with symptoms of obsessive-compulsive and related disorders as monotherapy or as augmentation to selecti...
jamanetwork.com
February 3, 2025 at 1:14 AM
Reposted by Pedro Vélez Pardo BPsy MSc
biorxiv-microbiol.bsky.social
Pectobacterium versatile beta-lactamase, a common good of the soft rot Pectobacteriaceae (SRP) species complex https://www.biorxiv.org/content/10.1101/2025.01.30.635659v1
January 31, 2025 at 4:17 AM
Reposted by Pedro Vélez Pardo BPsy MSc
krelllaboratory.bsky.social
Very pleased to see that out in PNAS: Bacterial sensor evolved by decreasing complexity. Evolution is not always towards complexity. Yet another wonderful collaboration with @zhulinlab @gavirius and @miguel_matilla, @BLASTMeetings @SEMicrobiologia
www.pnas.org/doi/10.1073/...
January 30, 2025 at 8:11 AM
pedrovelezpardo.bsky.social
Estudio genético gigantesco en pacientes con trastorno bipolar. #Genomics #BipolarDisorder #TheScienceHusbands

www.nature.com/articles/s41...
Genomics yields biological and phenotypic insights into bipolar disorder - Nature
Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.
www.nature.com
January 29, 2025 at 4:32 PM
pedrovelezpardo.bsky.social
Interesante meta-análisis relacionando filos, familias y géneros de bacterias presentes en la microbiota intestinal con diferentes trastornos psiquiátricos. #TheScienceHusbands

jamanetwork.com/journals/jam...
Perturbations in Gut Microbiota Composition in Psychiatric Disorders
This systematic review and meta-analysis reviews gut microbiota alterations in general adult psychiatric populations and performs a within- and between-diagnostic comparison.
jamanetwork.com
January 29, 2025 at 1:16 AM
pedrovelezpardo.bsky.social
Mi esposo y yo en El Río Hotel en Doradal, Antioquia - Colombia #TheScienceHusbands
January 29, 2025 at 1:09 AM
pedrovelezpardo.bsky.social
Mi esposo y yo en un atardecer de Santa Marta - Colombia. #TheScienceHusbands
January 29, 2025 at 1:07 AM