Pau Pascual
@paupascual.bsky.social
Love to see cells under a microscope | researcher @CRG.eu | @UPenn | 🏳️🌈
POM121 is one of the transmembrane nucleoporins that anchors the Nuclear Pore to the nuclear envelope. The Rodriguez-Bravo+labs identified a nuclear-soluble pool of POM121 that enhances the aggressiveness of prostate cancer, offering new therapeutic opportunities for this disease. shorturl.at/Z2Ked
Off-pore Nucleoporin sPOM121 Transcriptionally Propels β-Catenin–driven Tumor Progression and Immune Escape in Prostate Cancer
Transcriptional reprogramming, mediated by off-pore, nucleoplasm-localized sPOM121, leads to therapy resistance and immune evasion and represents a vulnerability to β-catenin inhibition in prostate ca...
aacrjournals.org
November 4, 2025 at 10:47 AM
POM121 is one of the transmembrane nucleoporins that anchors the Nuclear Pore to the nuclear envelope. The Rodriguez-Bravo+labs identified a nuclear-soluble pool of POM121 that enhances the aggressiveness of prostate cancer, offering new therapeutic opportunities for this disease. shorturl.at/Z2Ked
Reposted by Pau Pascual
Are you looking for a PhD? Join us in Barcelona! You'll dive into a community of >100 PhD students from 30 countries exploring the frontiers of biology. You can also join an online workshop on 6 November (15:00 CET) to learn how to find the right lab for you.
More info: www.crg.eu/en/content/t...
More info: www.crg.eu/en/content/t...
October 23, 2025 at 7:56 AM
Are you looking for a PhD? Join us in Barcelona! You'll dive into a community of >100 PhD students from 30 countries exploring the frontiers of biology. You can also join an online workshop on 6 November (15:00 CET) to learn how to find the right lab for you.
More info: www.crg.eu/en/content/t...
More info: www.crg.eu/en/content/t...
Really cool read - 'New generation of cancer-preventing vaccines could wipe out tumors before they form | Science | AAAS' www.science.org/content/arti...
New generation of cancer-preventing vaccines could wipe out tumors before they form
Shots enter early clinical trials for healthy people at high risk for disease
www.science.org
September 28, 2025 at 10:37 PM
Really cool read - 'New generation of cancer-preventing vaccines could wipe out tumors before they form | Science | AAAS' www.science.org/content/arti...
Reposted by Pau Pascual
Whitehead Institute honors the life and legacy of Nobel Laureate David Baltimore (1938–2025), its Founding Director and a globally revered scientific leader. 1/4
lnkd.in/eUKd4zxh
lnkd.in/eUKd4zxh
September 8, 2025 at 7:40 PM
Whitehead Institute honors the life and legacy of Nobel Laureate David Baltimore (1938–2025), its Founding Director and a globally revered scientific leader. 1/4
lnkd.in/eUKd4zxh
lnkd.in/eUKd4zxh
Great news, providing access to CRISPR therapy for rare diseases in children is giving hope to many families
chanzuckerberg.com/newsroom/cen...
chanzuckerberg.com/newsroom/cen...
Advancing Cures for Rare Diseases
With the launch of the new center, we're one step closer to making personalized CRISPR cures a reality for children born with rare genetic diseases.
chanzuckerberg.com
July 9, 2025 at 8:26 PM
Great news, providing access to CRISPR therapy for rare diseases in children is giving hope to many families
chanzuckerberg.com/newsroom/cen...
chanzuckerberg.com/newsroom/cen...
How are some enhancers able to regulate genes over megabase distances when they usually act in genes over kilobase distances? This is about a cis-element that helps enhancers to increase substantially their genomic interaction capacity.. Cool! www.nature.com/articles/s41...
Range extender mediates long-distance enhancer activity - Nature
The REX element is associated with long-range enhancer–promoter interactions.
www.nature.com
July 6, 2025 at 9:56 PM
How are some enhancers able to regulate genes over megabase distances when they usually act in genes over kilobase distances? This is about a cis-element that helps enhancers to increase substantially their genomic interaction capacity.. Cool! www.nature.com/articles/s41...
Reposted by Pau Pascual
Introducing Arc Institute’s first virtual cell model: STATE
June 23, 2025 at 5:28 PM
Introducing Arc Institute’s first virtual cell model: STATE
Reposted by Pau Pascual
💜Feliz #11F y #DíadelaMujeryNiñaEnLaCiencia💜
El 8-M de las científicas: miles de mujeres se vuelcan para despertar vocaciones en la niñas
Un movimiento imparable ha arrancado con fuerza: es el sigiloso 8-M de las científicas. Mujeres determinadas a enseñar a las chicas que pueden ser profesionales capaces
www.lavanguardia.com
February 11, 2025 at 8:42 AM
💜Feliz #11F y #DíadelaMujeryNiñaEnLaCiencia💜
Today is #WorldCancerDay, a time to support those impacted, honor the memories of loved ones we've lost, and reflect on the important work we, as scientists, do.
This year's message, #CloseTheCareGap," reminds us that equitable access to cancer care is not just a goal; it's a necessity.
This year's message, #CloseTheCareGap," reminds us that equitable access to cancer care is not just a goal; it's a necessity.
February 4, 2025 at 10:33 PM
Today is #WorldCancerDay, a time to support those impacted, honor the memories of loved ones we've lost, and reflect on the important work we, as scientists, do.
This year's message, #CloseTheCareGap," reminds us that equitable access to cancer care is not just a goal; it's a necessity.
This year's message, #CloseTheCareGap," reminds us that equitable access to cancer care is not just a goal; it's a necessity.
This is such a step forward! Kudos to the authors. KRAS is mutated in around 25% of cancers and was considered “undruggable”, being this a good example of how the drug discovery field is being changed quickly with new computing tools and power. Hopefully the impact to patients arrives also soon! 🚀
Excited to share our latest work, published this morning in Nature Biotechnology! 🎉 We developed a hybrid quantum computing-enhanced generative model to design KRAS inhibitors. Check it out here: rdcu.be/d68Fs.
Some fascinating insights along the way:
Some fascinating insights along the way:
January 26, 2025 at 8:22 PM
This is such a step forward! Kudos to the authors. KRAS is mutated in around 25% of cancers and was considered “undruggable”, being this a good example of how the drug discovery field is being changed quickly with new computing tools and power. Hopefully the impact to patients arrives also soon! 🚀
