Patrick Lewis
@patrickalfrynlewis.bsky.social
Biochemist and academic working to understand how cells go wrong in neurodegenerative disease.
https://orcid.org/0000-0003-4537-0489
https://orcid.org/0000-0003-4537-0489
Reposted by Patrick Lewis
Happy Valentine’s Day from your friends at the Parkinson’s Foundation! 🩵 Today and every day, we’re sending our love & support to the PD community: Parkinson.org/Resources
February 14, 2026 at 4:03 PM
Happy Valentine’s Day from your friends at the Parkinson’s Foundation! 🩵 Today and every day, we’re sending our love & support to the PD community: Parkinson.org/Resources
Reposted by Patrick Lewis
Our new paper's out: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity
With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule
rdcu.be/e3Ris
With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule
rdcu.be/e3Ris
February 13, 2026 at 4:04 PM
Our new paper's out: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity
With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule
rdcu.be/e3Ris
With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule
rdcu.be/e3Ris
Reposted by Patrick Lewis
📣 UK Proteostasis Meeting 2026 – Registration Now Open!
I’m delighted to share that registration is now open for the UK Proteostasis Meeting 2026, hosted by The Francis Crick Institute on 20–21 July 2026 .
Please register here(lnkd.in/ervXMzWN) and through Eventbrite for payment (lnkd.in/eTxqjnQy)
I’m delighted to share that registration is now open for the UK Proteostasis Meeting 2026, hosted by The Francis Crick Institute on 20–21 July 2026 .
Please register here(lnkd.in/ervXMzWN) and through Eventbrite for payment (lnkd.in/eTxqjnQy)
February 13, 2026 at 1:25 PM
📣 UK Proteostasis Meeting 2026 – Registration Now Open!
I’m delighted to share that registration is now open for the UK Proteostasis Meeting 2026, hosted by The Francis Crick Institute on 20–21 July 2026 .
Please register here(lnkd.in/ervXMzWN) and through Eventbrite for payment (lnkd.in/eTxqjnQy)
I’m delighted to share that registration is now open for the UK Proteostasis Meeting 2026, hosted by The Francis Crick Institute on 20–21 July 2026 .
Please register here(lnkd.in/ervXMzWN) and through Eventbrite for payment (lnkd.in/eTxqjnQy)
Reposted by Patrick Lewis
Reposted by Patrick Lewis
Reposted by Patrick Lewis
Exciting conference alert! The 93rd Biochemical Society Harden Conference will be on "Endosomal-lysosomal network dysfunction in neurodegeneration" on the South coast of England (1st to 4th of September 2026). Lots of speaker slots available from submitted abstracts so do come and join us!
February 6, 2026 at 2:46 PM
Exciting conference alert! The 93rd Biochemical Society Harden Conference will be on "Endosomal-lysosomal network dysfunction in neurodegeneration" on the South coast of England (1st to 4th of September 2026). Lots of speaker slots available from submitted abstracts so do come and join us!
Reposted by Patrick Lewis
I watched much of Ian Chapman's (Head of @ukri.org) appearance this morning at @ukparliament.parliament.uk Science, Innovation and Technology Committee..
A few points and new information that bioscientists may find interesting...
A 🧵
A few points and new information that bioscientists may find interesting...
A 🧵
February 3, 2026 at 1:57 PM
I watched much of Ian Chapman's (Head of @ukri.org) appearance this morning at @ukparliament.parliament.uk Science, Innovation and Technology Committee..
A few points and new information that bioscientists may find interesting...
A 🧵
A few points and new information that bioscientists may find interesting...
A 🧵
Reposted by Patrick Lewis
The pause of response mode funding will have a huge impact on ECRs who are not yet fellowship ready.When researchers leave academia they rarely return. Clarity on when RM will reopen is urgently needed & transitions to the new model need to avoid investment gaps that disproportionally affect ECRs
Open letter to the R&I community by @ukri.org CEO Ian Chapman:
www.ukri.org/news/open-le...
Reassuring to know that curiosity-driven research is protected over 4y *but* does not address concerns regarding the huge impact of the current pauses at MRC, BBSRC, EPSRC #UKsciencefundingcrisis
www.ukri.org/news/open-le...
Reassuring to know that curiosity-driven research is protected over 4y *but* does not address concerns regarding the huge impact of the current pauses at MRC, BBSRC, EPSRC #UKsciencefundingcrisis
Open letter from Ian Chapman to research and innovation community
UKRI Chief Executive outlines changes to UKRI investment approach, addressing concerns about research funding and the financial position of STFC.
www.ukri.org
February 1, 2026 at 6:31 PM
The pause of response mode funding will have a huge impact on ECRs who are not yet fellowship ready.When researchers leave academia they rarely return. Clarity on when RM will reopen is urgently needed & transitions to the new model need to avoid investment gaps that disproportionally affect ECRs
Reposted by Patrick Lewis
Explore some scintillating scotomas (which are much less pleasant than they sound) and illustrations of migraine auras from the work of 19th century physician Hubert Airy from the archives of the Philosophical Transactions: https://royalsociety.org/blog/2026/01/visual-disturbances/
Visual disturbances | Royal Society
Katharine Marshall looks at the work of physician Hubert Airy on migraine auras, or scintillating scotomas.
royalsociety.org
January 29, 2026 at 11:56 AM
Explore some scintillating scotomas (which are much less pleasant than they sound) and illustrations of migraine auras from the work of 19th century physician Hubert Airy from the archives of the Philosophical Transactions: https://royalsociety.org/blog/2026/01/visual-disturbances/
Reposted by Patrick Lewis
January 27, 2026 at 11:17 AM
Reposted by Patrick Lewis
Hey, it’s me! Very happy to chat about how to use flies to address biomedical questions.
Our Best Models Working Group can offer advice on the use of a range of model systems.
The next in our series of posts highlighting our diverse expertise features Dr Alex Whitworth, whose group uses Drosophila models of neurodegenerative diseases.
nmgn.mrc.ukri.org/working-grou...
The next in our series of posts highlighting our diverse expertise features Dr Alex Whitworth, whose group uses Drosophila models of neurodegenerative diseases.
nmgn.mrc.ukri.org/working-grou...
January 27, 2026 at 9:53 PM
Hey, it’s me! Very happy to chat about how to use flies to address biomedical questions.
Reposted by Patrick Lewis
The Royal Society's International Exchanges are now open for applications. These grants are for scientists based in the UK who want to stimulate new research collaborations with leading scientists overseas. Find out more and apply: #RSGrants https://royalsociety.org/grants/international-exchanges/
International Exchanges | Royal Society
These schemes are for scientists based in the UK who want to stimulate collaborations with leading scientists overseas through either a one-off visit or bilateral travel
royalsociety.org
January 27, 2026 at 4:56 PM
The Royal Society's International Exchanges are now open for applications. These grants are for scientists based in the UK who want to stimulate new research collaborations with leading scientists overseas. Find out more and apply: #RSGrants https://royalsociety.org/grants/international-exchanges/
Reposted by Patrick Lewis
This is wonderful news and a reflection of the work of so many ppl to make the institute a fair and inclusive place to work, particularly Prof Hélène Plun-Favreau, Deputy Director for EDI, EDI project manager Dimitrios Zachos and Athena SWAN leads Prof Gabriele Lignani and Laura Allum.
We are proud to share that ION has been awarded an Athena SWAN Gold Award. Awarded in January 2026 and valid until January 2031, this recognises our sustained, evidence‑based commitment to gender equality and inclusive culture across staff and students.
www.ucl.ac.uk/brain-scienc...
www.ucl.ac.uk/brain-scienc...
UCL Queen Square Institute of Neurology awarded Athena SWAN Gold
The UCL Queen Square Institute of Neurology (IoN) has been awarded the Athena SWAN Gold Award, recognising its sustained and sector‑leading commitment to gender equality and inclusive culture.
www.ucl.ac.uk
January 27, 2026 at 11:15 AM
This is wonderful news and a reflection of the work of so many ppl to make the institute a fair and inclusive place to work, particularly Prof Hélène Plun-Favreau, Deputy Director for EDI, EDI project manager Dimitrios Zachos and Athena SWAN leads Prof Gabriele Lignani and Laura Allum.
Reposted by Patrick Lewis
CRN Team Hardy found that a splice variant of PMCA2 localizes to the lysosome and helps regulate lysosomal calcium. Disruption of this pathway contributes to both Niemann-Pick disease type C and #ParkinsonsDisease 🧪
🔗 Read the full #preprint: bit.ly/4jOyOSl
🔗 Read the full #preprint: bit.ly/4jOyOSl
January 26, 2026 at 4:14 PM
CRN Team Hardy found that a splice variant of PMCA2 localizes to the lysosome and helps regulate lysosomal calcium. Disruption of this pathway contributes to both Niemann-Pick disease type C and #ParkinsonsDisease 🧪
🔗 Read the full #preprint: bit.ly/4jOyOSl
🔗 Read the full #preprint: bit.ly/4jOyOSl
Reposted by Patrick Lewis
Wilma van de Berg, PhD, a Parkinson's Foundation 2025 Trailblazer Awardee, is rethinking Lewy Bodies and cellular traffic in Parkinson’s disease.
🔬 Learn more about Dr. van de Berg and her research: Parkinson.org/living-with-parkinsons/stories/wilma-van-de-berg
🔬 Learn more about Dr. van de Berg and her research: Parkinson.org/living-with-parkinsons/stories/wilma-van-de-berg
January 26, 2026 at 8:02 PM
Wilma van de Berg, PhD, a Parkinson's Foundation 2025 Trailblazer Awardee, is rethinking Lewy Bodies and cellular traffic in Parkinson’s disease.
🔬 Learn more about Dr. van de Berg and her research: Parkinson.org/living-with-parkinsons/stories/wilma-van-de-berg
🔬 Learn more about Dr. van de Berg and her research: Parkinson.org/living-with-parkinsons/stories/wilma-van-de-berg
Reposted by Patrick Lewis
Clinical Research Manager role at Cure Parkinsons providing strategic leadership across clinical trial development and treatment selection.
www.dementiaresearcher.nihr.ac.uk/job/clinical...
www.dementiaresearcher.nihr.ac.uk/job/clinical...
Clinical Research Manager - DEMENTIA RESEARCHER
Cure Parkinsons seeks a Clinical Research Manager to lead clinical development and support disease modifying trials in Parkinsons research.
www.dementiaresearcher.nihr.ac.uk
January 22, 2026 at 11:47 PM
Clinical Research Manager role at Cure Parkinsons providing strategic leadership across clinical trial development and treatment selection.
www.dementiaresearcher.nihr.ac.uk/job/clinical...
www.dementiaresearcher.nihr.ac.uk/job/clinical...
Reposted by Patrick Lewis
Do you enjoy photography whilst engaging in dementia research?
If so, we’d love to see your work at our photo contest! Show us your science through your lens, with merch prizes up for grabs. Launching soon - watch this space!
If so, we’d love to see your work at our photo contest! Show us your science through your lens, with merch prizes up for grabs. Launching soon - watch this space!
January 19, 2026 at 2:47 PM
Do you enjoy photography whilst engaging in dementia research?
If so, we’d love to see your work at our photo contest! Show us your science through your lens, with merch prizes up for grabs. Launching soon - watch this space!
If so, we’d love to see your work at our photo contest! Show us your science through your lens, with merch prizes up for grabs. Launching soon - watch this space!
Reposted by Patrick Lewis
The Michael J Fox Foundation is hosting an online town hall on endolysosomal targets in Parkinson disease on 25 March at 12.30pm EST. Registration now open.
www.dementiaresearcher.nihr.ac.uk/event/mjff-t...
www.dementiaresearcher.nihr.ac.uk/event/mjff-t...
MJFF Town Hall on Endolysosomal Targets - DEMENTIA RESEARCHER
Michael J Fox Foundation hosts an online town hall on endolysosomal targets in Parkinson disease on 25 March at 12.30pm EST. Register to attend.
www.dementiaresearcher.nihr.ac.uk
January 18, 2026 at 12:34 PM
The Michael J Fox Foundation is hosting an online town hall on endolysosomal targets in Parkinson disease on 25 March at 12.30pm EST. Registration now open.
www.dementiaresearcher.nihr.ac.uk/event/mjff-t...
www.dementiaresearcher.nihr.ac.uk/event/mjff-t...
Reposted by Patrick Lewis
Did the new Greenwich Peninsula Parkrun this morning (lovely event!) then over to the London stadium for a talk to this years cohort of runners for Alzheimer’s Research UK 🥳 🏃🏼♀️
January 17, 2026 at 1:33 PM
Did the new Greenwich Peninsula Parkrun this morning (lovely event!) then over to the London stadium for a talk to this years cohort of runners for Alzheimer’s Research UK 🥳 🏃🏼♀️
Reposted by Patrick Lewis
Have you read our annual research recap yet? 👩🔬
Catch up now with our exciting research developments from 2025 and discover what’s in store for 2026 – from the launch of SLEIPNIR to recruitment for DAPA-PD.
Read now: buff.ly/RnGgUqM
Catch up now with our exciting research developments from 2025 and discover what’s in store for 2026 – from the launch of SLEIPNIR to recruitment for DAPA-PD.
Read now: buff.ly/RnGgUqM
January 17, 2026 at 9:30 AM
Have you read our annual research recap yet? 👩🔬
Catch up now with our exciting research developments from 2025 and discover what’s in store for 2026 – from the launch of SLEIPNIR to recruitment for DAPA-PD.
Read now: buff.ly/RnGgUqM
Catch up now with our exciting research developments from 2025 and discover what’s in store for 2026 – from the launch of SLEIPNIR to recruitment for DAPA-PD.
Read now: buff.ly/RnGgUqM
Reposted by Patrick Lewis
Have a ballot place in the iconic London Marathon this year? Why not join #TeamCure and raise vital funds and awareness for Parkinson’s research!
At Cure Parkinson’s, our aim is to make sure your experience is truly unforgettable. Join the team: buff.ly/PkmHhml
At Cure Parkinson’s, our aim is to make sure your experience is truly unforgettable. Join the team: buff.ly/PkmHhml
January 16, 2026 at 4:02 PM
Have a ballot place in the iconic London Marathon this year? Why not join #TeamCure and raise vital funds and awareness for Parkinson’s research!
At Cure Parkinson’s, our aim is to make sure your experience is truly unforgettable. Join the team: buff.ly/PkmHhml
At Cure Parkinson’s, our aim is to make sure your experience is truly unforgettable. Join the team: buff.ly/PkmHhml
Reposted by Patrick Lewis
The WPC is proud to recognize our Double Platinum Champion Partner, The Michael J. Fox Foundation, for their continued support. MJFF is dedicated to advancing treatments and finding a cure for Parkinson’s. They’ll be at #wpc2026 in Phoenix—will you join us?
🔗 wpc2026.org
🔗 wpc2026.org
January 15, 2026 at 5:31 PM
The WPC is proud to recognize our Double Platinum Champion Partner, The Michael J. Fox Foundation, for their continued support. MJFF is dedicated to advancing treatments and finding a cure for Parkinson’s. They’ll be at #wpc2026 in Phoenix—will you join us?
🔗 wpc2026.org
🔗 wpc2026.org
Reposted by Patrick Lewis
Don't miss out. Apply to our 2026 Advanced Research Training Courses today!
January 15, 2026 at 1:46 PM
Don't miss out. Apply to our 2026 Advanced Research Training Courses today!
Reposted by Patrick Lewis
Our new white paper, Investing in Open Science, is out 📄 🧪
What does it really take to fund #OpenScience? We unpack our 5 policy requirements, along with key barriers and cost drivers, from data infrastructure to OA/APCs and compliance reviews.
🔗 bit.ly/4sxzIH2
What does it really take to fund #OpenScience? We unpack our 5 policy requirements, along with key barriers and cost drivers, from data infrastructure to OA/APCs and compliance reviews.
🔗 bit.ly/4sxzIH2
January 13, 2026 at 4:03 PM
Our new white paper, Investing in Open Science, is out 📄 🧪
What does it really take to fund #OpenScience? We unpack our 5 policy requirements, along with key barriers and cost drivers, from data infrastructure to OA/APCs and compliance reviews.
🔗 bit.ly/4sxzIH2
What does it really take to fund #OpenScience? We unpack our 5 policy requirements, along with key barriers and cost drivers, from data infrastructure to OA/APCs and compliance reviews.
🔗 bit.ly/4sxzIH2
Reposted by Patrick Lewis
Strengthen your ability to teach reproducible and open research practices by joining @irise-eu.bsky.social Train-the-Trainer workshops this February!
Live online, interactive, small-group activities and discussion. Free to attend. Places are limited.
#Training #Reproducibility #Preregistration
Live online, interactive, small-group activities and discussion. Free to attend. Places are limited.
#Training #Reproducibility #Preregistration
iRISE: News
iRise News
irise-project.eu
January 13, 2026 at 4:36 PM
Strengthen your ability to teach reproducible and open research practices by joining @irise-eu.bsky.social Train-the-Trainer workshops this February!
Live online, interactive, small-group activities and discussion. Free to attend. Places are limited.
#Training #Reproducibility #Preregistration
Live online, interactive, small-group activities and discussion. Free to attend. Places are limited.
#Training #Reproducibility #Preregistration