Nicolas Panayotis
@npanayotis.bsky.social
Group Leader @sppin-cnrs.bsky.social | @cnrs.fr & @upcite.bsky.social / Weizmann Institute of Science & Aix-Marseille Université alumnus.
Pinned
Subcellular depletion of importin β1 impairs presynaptic local translation and spatial memory
Axonal localization of importin β1 is required for presynaptic functions that support spatial memory tasks.
www.science.org
Very happy to share our new paper in #ScienceSignaling revealing that importin β1 isn’t just important for nuclear transport or neuronal growth.
We now show it is key for presynaptic plasticity in the hippocampus, local translation, and memory!
www.science.org/doi/10.1126/...
We now show it is key for presynaptic plasticity in the hippocampus, local translation, and memory!
www.science.org/doi/10.1126/...
Huge energy today at "Les 12h30 de la recherche" !
From ~20 participants to 60+ today. Amazing to see such growing interest in conversations bridging clinical practice and basic science.
Thank you to our speakers and everyone. The dialogue between bench and bedside is clearly alive and thriving.
From ~20 participants to 60+ today. Amazing to see such growing interest in conversations bridging clinical practice and basic science.
Thank you to our speakers and everyone. The dialogue between bench and bedside is clearly alive and thriving.
February 17, 2026 at 2:05 PM
Huge energy today at "Les 12h30 de la recherche" !
From ~20 participants to 60+ today. Amazing to see such growing interest in conversations bridging clinical practice and basic science.
Thank you to our speakers and everyone. The dialogue between bench and bedside is clearly alive and thriving.
From ~20 participants to 60+ today. Amazing to see such growing interest in conversations bridging clinical practice and basic science.
Thank you to our speakers and everyone. The dialogue between bench and bedside is clearly alive and thriving.
Paris sous la pluie, Jussieu, 24e étage
February 13, 2026 at 6:27 PM
Paris sous la pluie, Jussieu, 24e étage
Reposted by Nicolas Panayotis
As a Humboldt Fellow, SPPIN’s director @martin-oheim.bsky.social can host a German researcher or a "Bildungsinländer" (M.Sc and PhD in 🇩🇪) for a multi-year postdoc or research stay in his lab.
Apps from outstanding candidates interested in developing an ambitious research in France are welcomed !
Apps from outstanding candidates interested in developing an ambitious research in France are welcomed !
February 12, 2026 at 8:15 AM
As a Humboldt Fellow, SPPIN’s director @martin-oheim.bsky.social can host a German researcher or a "Bildungsinländer" (M.Sc and PhD in 🇩🇪) for a multi-year postdoc or research stay in his lab.
Apps from outstanding candidates interested in developing an ambitious research in France are welcomed !
Apps from outstanding candidates interested in developing an ambitious research in France are welcomed !
Very important topic. IMO, it is not all academia who fails here but specific societies. We were lucky with my partner to do our research...and our kid in Israel where it is VERY common to see mothers at all training levels. The Weizmann is doing great to allow its researchers to be parents too !
"The academic structure … makes planning for a family feel like an impossible luxury."
In this #ScienceWorkingLife, two postdocs share how, as women in academia, having children can feel impossible—and how talking about it makes them feel less alone. https://scim.ag/46uBWgD #WomenInScienceDay
In this #ScienceWorkingLife, two postdocs share how, as women in academia, having children can feel impossible—and how talking about it makes them feel less alone. https://scim.ag/46uBWgD #WomenInScienceDay
February 12, 2026 at 8:41 AM
Very important topic. IMO, it is not all academia who fails here but specific societies. We were lucky with my partner to do our research...and our kid in Israel where it is VERY common to see mothers at all training levels. The Weizmann is doing great to allow its researchers to be parents too !
Just saw a review about using transcranial NIR (no optogenetics here) to treat Rett syndrome. Excuse my ignorance but apart from suggesting that photons will hit the mitochondria (and more), I see only wishful thinking here. Anyone here to tell if this is real ?
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
February 10, 2026 at 12:20 PM
Just saw a review about using transcranial NIR (no optogenetics here) to treat Rett syndrome. Excuse my ignorance but apart from suggesting that photons will hit the mitochondria (and more), I see only wishful thinking here. Anyone here to tell if this is real ?
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
Reposted by Nicolas Panayotis
La @semaineducerveau.bsky.social arrive bientôt au SPPIN !
Nous avons le plaisir d’accueillir une conférence suivie d’une visite du laboratoire par @uligraupner.bsky.social dédié aux approches optogénétiques pour comprendre les circuits neuronaux et le comportement.
Nous avons le plaisir d’accueillir une conférence suivie d’une visite du laboratoire par @uligraupner.bsky.social dédié aux approches optogénétiques pour comprendre les circuits neuronaux et le comportement.
February 10, 2026 at 8:57 AM
La @semaineducerveau.bsky.social arrive bientôt au SPPIN !
Nous avons le plaisir d’accueillir une conférence suivie d’une visite du laboratoire par @uligraupner.bsky.social dédié aux approches optogénétiques pour comprendre les circuits neuronaux et le comportement.
Nous avons le plaisir d’accueillir une conférence suivie d’une visite du laboratoire par @uligraupner.bsky.social dédié aux approches optogénétiques pour comprendre les circuits neuronaux et le comportement.
Reposted by Nicolas Panayotis
New paper from the @nguerout.bsky.social team in Stem cell Research & Therapy:
"Spinal cord injury alters the therapeutic potential of olfactory ensheathing cells harvested in an autologous transplantation model"
rdcu.be/eRxxg
@sppin-cnrs.bsky.social @cnrs.fr @upcite.bsky.social
"Spinal cord injury alters the therapeutic potential of olfactory ensheathing cells harvested in an autologous transplantation model"
rdcu.be/eRxxg
@sppin-cnrs.bsky.social @cnrs.fr @upcite.bsky.social
Spinal cord injury alters the therapeutic potential of olfactory ensheathing cells harvested in an autologous transplantation model | Stem Cell Research & Therapy
rdcu.be
November 24, 2025 at 2:36 PM
New paper from the @nguerout.bsky.social team in Stem cell Research & Therapy:
"Spinal cord injury alters the therapeutic potential of olfactory ensheathing cells harvested in an autologous transplantation model"
rdcu.be/eRxxg
@sppin-cnrs.bsky.social @cnrs.fr @upcite.bsky.social
"Spinal cord injury alters the therapeutic potential of olfactory ensheathing cells harvested in an autologous transplantation model"
rdcu.be/eRxxg
@sppin-cnrs.bsky.social @cnrs.fr @upcite.bsky.social
Calling on my fellow Marseille PIs everywhere in the world.
Please send moral support as I face relentless trolling from my PhD student following OM’s collapse against PSG last night...
Please send moral support as I face relentless trolling from my PhD student following OM’s collapse against PSG last night...
February 9, 2026 at 1:34 PM
Calling on my fellow Marseille PIs everywhere in the world.
Please send moral support as I face relentless trolling from my PhD student following OM’s collapse against PSG last night...
Please send moral support as I face relentless trolling from my PhD student following OM’s collapse against PSG last night...
Reposted by Nicolas Panayotis
If one paper wasn’t enough for tissue clearing and 3D imaging enthusiasts, here’s another freshly published paper by Marwa Moulzir in #AnnalsofAnatomy, presenting a robust pipeline for high-resolution 3D imaging of cleared bird feathers 🪶🔬
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
February 9, 2026 at 11:00 AM
If one paper wasn’t enough for tissue clearing and 3D imaging enthusiasts, here’s another freshly published paper by Marwa Moulzir in #AnnalsofAnatomy, presenting a robust pipeline for high-resolution 3D imaging of cleared bird feathers 🪶🔬
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Nicolas Panayotis
New paper from Marwa Moulzir et al. (Oheim lab) in #Reproduction describing a fast, label-free, high-resolution method to image testes in 3D at micrometric scale opening new doors for histology and reproduction research ! Bravo Marwa and the team 🎉🧪🔬
academic.oup.com/reproduction...
academic.oup.com/reproduction...
February 9, 2026 at 10:43 AM
New paper from Marwa Moulzir et al. (Oheim lab) in #Reproduction describing a fast, label-free, high-resolution method to image testes in 3D at micrometric scale opening new doors for histology and reproduction research ! Bravo Marwa and the team 🎉🧪🔬
academic.oup.com/reproduction...
academic.oup.com/reproduction...
New in #ScienceSignaling 👉Importin β1 has an unexpected role in presynaptic long-term plasticity and spatial memory, by regulating local protein synthesis at hippocampal synapses.
#neuroscience #cellbiology #synapticplasticity #memory
www.science.org/doi/10.1126/...
#neuroscience #cellbiology #synapticplasticity #memory
www.science.org/doi/10.1126/...
February 3, 2026 at 4:30 PM
New in #ScienceSignaling 👉Importin β1 has an unexpected role in presynaptic long-term plasticity and spatial memory, by regulating local protein synthesis at hippocampal synapses.
#neuroscience #cellbiology #synapticplasticity #memory
www.science.org/doi/10.1126/...
#neuroscience #cellbiology #synapticplasticity #memory
www.science.org/doi/10.1126/...
January 31, 2026 at 4:53 PM
Reposted by Nicolas Panayotis
Schwarz lab @bostonchildrens.bsky.social identify a mechanism coupling mitochondrial movement to energy demand. When energy levels are low, the energy-sensing kinase AMPK phosphorylates the motor/adaptor protein TRAK1, arresting #mitochondria via the #actin #cytoskeleton. rupress.org/jcb/article/...
January 30, 2026 at 5:00 PM
Schwarz lab @bostonchildrens.bsky.social identify a mechanism coupling mitochondrial movement to energy demand. When energy levels are low, the energy-sensing kinase AMPK phosphorylates the motor/adaptor protein TRAK1, arresting #mitochondria via the #actin #cytoskeleton. rupress.org/jcb/article/...
January 25, 2026 at 5:05 PM
Reposted by Nicolas Panayotis
There may not be much translation in axons compared to the soma, but what does go on there is important: "Axonal localization of importin β1–encoding mRNA is required to shape the presynapse, and disruption of this mechanism causes memory deficits."
Scientists have mapped out an importin-based pathway that enables neurons to maintain synaptic plasticity and spatial memory despite their unusually elongated shape.
Learn more in #ScienceSignaling: https://scim.ag/4qIJWTi
Learn more in #ScienceSignaling: https://scim.ag/4qIJWTi
Subcellular depletion of importin β1 impairs presynaptic local translation and spatial memory
Axonal localization of importin β1 is required for presynaptic functions that support spatial memory tasks.
scim.ag
January 22, 2026 at 11:45 PM
There may not be much translation in axons compared to the soma, but what does go on there is important: "Axonal localization of importin β1–encoding mRNA is required to shape the presynapse, and disruption of this mechanism causes memory deficits."
January Blues?
Nah.. let's have publication celebration cakes !!
Shout out to Maison Mulot www.maison-mulot.com in Saint-Germain-des-Prés for the contribution ;-)
Nah.. let's have publication celebration cakes !!
Shout out to Maison Mulot www.maison-mulot.com in Saint-Germain-des-Prés for the contribution ;-)
January 22, 2026 at 2:46 PM
January Blues?
Nah.. let's have publication celebration cakes !!
Shout out to Maison Mulot www.maison-mulot.com in Saint-Germain-des-Prés for the contribution ;-)
Nah.. let's have publication celebration cakes !!
Shout out to Maison Mulot www.maison-mulot.com in Saint-Germain-des-Prés for the contribution ;-)
Reposted by Nicolas Panayotis
This week’s new issue of #ScienceSignaling has arrived!
Scientists map out how an importin-based pathway in neurons supports spatial memory and plasticity, a new study reveals the pervasive and unintended effects of pervanadate, and more. https://scim.ag/4qGVrus
Scientists map out how an importin-based pathway in neurons supports spatial memory and plasticity, a new study reveals the pervasive and unintended effects of pervanadate, and more. https://scim.ag/4qGVrus
January 20, 2026 at 10:00 PM
This week’s new issue of #ScienceSignaling has arrived!
Scientists map out how an importin-based pathway in neurons supports spatial memory and plasticity, a new study reveals the pervasive and unintended effects of pervanadate, and more. https://scim.ag/4qGVrus
Scientists map out how an importin-based pathway in neurons supports spatial memory and plasticity, a new study reveals the pervasive and unintended effects of pervanadate, and more. https://scim.ag/4qGVrus
Reposted by Nicolas Panayotis
🧠 New in #ScienceSignaling
A collaborative study involving @npanayotis.bsky.social show that Importin β1, best known for nuclear transport or peripheral nerve growth is essential for presynaptic plasticity, local translation, and memory formation in the hippocampus.
🧵 Read the thread by Nicolas 👇
A collaborative study involving @npanayotis.bsky.social show that Importin β1, best known for nuclear transport or peripheral nerve growth is essential for presynaptic plasticity, local translation, and memory formation in the hippocampus.
🧵 Read the thread by Nicolas 👇
Very happy to share our new paper in #ScienceSignaling revealing that importin β1 isn’t just important for nuclear transport or neuronal growth.
We now show it is key for presynaptic plasticity in the hippocampus, local translation, and memory!
www.science.org/doi/10.1126/...
We now show it is key for presynaptic plasticity in the hippocampus, local translation, and memory!
www.science.org/doi/10.1126/...
Subcellular depletion of importin β1 impairs presynaptic local translation and spatial memory
Axonal localization of importin β1 is required for presynaptic functions that support spatial memory tasks.
www.science.org
January 21, 2026 at 11:01 AM
🧠 New in #ScienceSignaling
A collaborative study involving @npanayotis.bsky.social show that Importin β1, best known for nuclear transport or peripheral nerve growth is essential for presynaptic plasticity, local translation, and memory formation in the hippocampus.
🧵 Read the thread by Nicolas 👇
A collaborative study involving @npanayotis.bsky.social show that Importin β1, best known for nuclear transport or peripheral nerve growth is essential for presynaptic plasticity, local translation, and memory formation in the hippocampus.
🧵 Read the thread by Nicolas 👇
Reposted by Nicolas Panayotis
#ResultatScientifique🔎| Quand le transport subcellulaire façonne la mémoire
✍️ @npanayotis.bsky.social
🤝 @cnrs-idf-villejuif.bsky.social @upcite.bsky.social @sppin-cnrs.bsky.social
📕 buff.ly/WEafAex
✍️ @npanayotis.bsky.social
🤝 @cnrs-idf-villejuif.bsky.social @upcite.bsky.social @sppin-cnrs.bsky.social
📕 buff.ly/WEafAex
Le transport subcellulaire au service de la mémoire
Dans une étude publiée dans Science Signaling, des scientifiques mettent en lumière un rôle inattendu d’une protéine
buff.ly
January 21, 2026 at 11:00 AM
#ResultatScientifique🔎| Quand le transport subcellulaire façonne la mémoire
✍️ @npanayotis.bsky.social
🤝 @cnrs-idf-villejuif.bsky.social @upcite.bsky.social @sppin-cnrs.bsky.social
📕 buff.ly/WEafAex
✍️ @npanayotis.bsky.social
🤝 @cnrs-idf-villejuif.bsky.social @upcite.bsky.social @sppin-cnrs.bsky.social
📕 buff.ly/WEafAex
Reposted by Nicolas Panayotis
Axonal importin β1 regulates the presynapse. See thread 🧪
Very happy to share our new paper in #ScienceSignaling revealing that importin β1 isn’t just important for nuclear transport or neuronal growth.
We now show it is key for presynaptic plasticity in the hippocampus, local translation, and memory!
www.science.org/doi/10.1126/...
We now show it is key for presynaptic plasticity in the hippocampus, local translation, and memory!
www.science.org/doi/10.1126/...
Subcellular depletion of importin β1 impairs presynaptic local translation and spatial memory
Axonal localization of importin β1 is required for presynaptic functions that support spatial memory tasks.
www.science.org
January 21, 2026 at 8:01 AM
Axonal importin β1 regulates the presynapse. See thread 🧪
Reposted by Nicolas Panayotis
New paper out. Intriguing impact of restricted importin β1 mRNA localization on synaptic local translation, plasticity, and spatial memory.
Very happy to share our new paper in #ScienceSignaling revealing that importin β1 isn’t just important for nuclear transport or neuronal growth.
We now show it is key for presynaptic plasticity in the hippocampus, local translation, and memory!
www.science.org/doi/10.1126/...
We now show it is key for presynaptic plasticity in the hippocampus, local translation, and memory!
www.science.org/doi/10.1126/...
Subcellular depletion of importin β1 impairs presynaptic local translation and spatial memory
Axonal localization of importin β1 is required for presynaptic functions that support spatial memory tasks.
www.science.org
January 21, 2026 at 5:07 AM
New paper out. Intriguing impact of restricted importin β1 mRNA localization on synaptic local translation, plasticity, and spatial memory.
Reposted by Nicolas Panayotis
For the French speakers, please find here a summary of our paper written by @upcite.bsky.social 👇
u-paris.fr/le-transport...
u-paris.fr/le-transport...
Le transport subcellulaire au service de la mémoire | Université Paris Cité
Image de microscopie électronique à transmission sur tranche d’hippocampe de souris, permettant l’analyse des synapses des fibres moussues.
u-paris.fr
January 20, 2026 at 7:27 PM
For the French speakers, please find here a summary of our paper written by @upcite.bsky.social 👇
u-paris.fr/le-transport...
u-paris.fr/le-transport...
Very happy to share our new paper in #ScienceSignaling revealing that importin β1 isn’t just important for nuclear transport or neuronal growth.
We now show it is key for presynaptic plasticity in the hippocampus, local translation, and memory!
www.science.org/doi/10.1126/...
We now show it is key for presynaptic plasticity in the hippocampus, local translation, and memory!
www.science.org/doi/10.1126/...
Subcellular depletion of importin β1 impairs presynaptic local translation and spatial memory
Axonal localization of importin β1 is required for presynaptic functions that support spatial memory tasks.
www.science.org
January 20, 2026 at 7:11 PM
Very happy to share our new paper in #ScienceSignaling revealing that importin β1 isn’t just important for nuclear transport or neuronal growth.
We now show it is key for presynaptic plasticity in the hippocampus, local translation, and memory!
www.science.org/doi/10.1126/...
We now show it is key for presynaptic plasticity in the hippocampus, local translation, and memory!
www.science.org/doi/10.1126/...
Reposted by Nicolas Panayotis
🧪 Interested in a Cutting-Edge Molecular Neuroscience Meeting at a dream location?
Join us at the EMBO | COB Workshop on Axonal degeneration and regeneration, 18 – 22 October 2026, Onna-son, Okinawa, Japan
meetings.embo.org/event/26-axo...
Join us at the EMBO | COB Workshop on Axonal degeneration and regeneration, 18 – 22 October 2026, Onna-son, Okinawa, Japan
meetings.embo.org/event/26-axo...
January 17, 2026 at 9:45 AM
🧪 Interested in a Cutting-Edge Molecular Neuroscience Meeting at a dream location?
Join us at the EMBO | COB Workshop on Axonal degeneration and regeneration, 18 – 22 October 2026, Onna-son, Okinawa, Japan
meetings.embo.org/event/26-axo...
Join us at the EMBO | COB Workshop on Axonal degeneration and regeneration, 18 – 22 October 2026, Onna-son, Okinawa, Japan
meetings.embo.org/event/26-axo...