Noonan Lab
@noonanlab.bsky.social
Laboratory of Professor James Noonan | Department of Genetics at Yale University. Science is a team sport. Reposts are not necessarily endorsements. We speak only for ourselves. Website: noonanlab.org
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Noonan Lab
@noonanlab.bsky.social
· Aug 13
Human Genome Sciences
The overall goal of the Human Genome Sciences (HGS) track is to train the next generation of scientists in the areas of human genomics, genetics, and
medicine.yale.edu
Yale has established a new PhD program in Human Genome Sciences and will be accepting applications this fall. We are also searching for an Associate Director of Student Services (a PhD-level position).
Learn more here:
medicine.yale.edu/bbs/tracks/h...
careers.yale.edu/us/en/job/YU...
Learn more here:
medicine.yale.edu/bbs/tracks/h...
careers.yale.edu/us/en/job/YU...
Out in Cell Genomics: A comprehensive analysis of the cell-type-specific effects of CHD8 loss of function on gene expression in the embryonic and juvenile mouse cortex. Thread 🧵:
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
Cell-type-specific dysregulation of gene expression due to Chd8 haploinsufficiency during mouse cortical development
Yim et al. use single-cell transcriptomics to elucidate the molecular outcomes of
Chd8 haploinsufficiency in the mouse cortex. Their results provide insight into dynamic,
cell-type-biased transcriptio...
www.cell.com
September 23, 2025 at 5:18 PM
Out in Cell Genomics: A comprehensive analysis of the cell-type-specific effects of CHD8 loss of function on gene expression in the embryonic and juvenile mouse cortex. Thread 🧵:
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
Reposted by Noonan Lab
Most neurodevelopmental disorders are caused by having 1 functional gene copy. Using SCN2A, we show that upregulating the functional copy rescues neuronal phenotypes. Amazing work with @neurobender.bsky.social led by Serena Tamura, Andrew Nelson, Perry Spratt & others.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CRISPR activation for SCN2A-related neurodevelopmental disorders | Nature
www.nature.com
September 17, 2025 at 3:13 PM
Most neurodevelopmental disorders are caused by having 1 functional gene copy. Using SCN2A, we show that upregulating the functional copy rescues neuronal phenotypes. Amazing work with @neurobender.bsky.social led by Serena Tamura, Andrew Nelson, Perry Spratt & others.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Yale has established a new PhD program in Human Genome Sciences and will be accepting applications this fall. We are also searching for an Associate Director of Student Services (a PhD-level position).
Learn more here:
medicine.yale.edu/bbs/tracks/h...
careers.yale.edu/us/en/job/YU...
Learn more here:
medicine.yale.edu/bbs/tracks/h...
careers.yale.edu/us/en/job/YU...
Human Genome Sciences
The overall goal of the Human Genome Sciences (HGS) track is to train the next generation of scientists in the areas of human genomics, genetics, and
medicine.yale.edu
August 13, 2025 at 3:18 PM
Yale has established a new PhD program in Human Genome Sciences and will be accepting applications this fall. We are also searching for an Associate Director of Student Services (a PhD-level position).
Learn more here:
medicine.yale.edu/bbs/tracks/h...
careers.yale.edu/us/en/job/YU...
Learn more here:
medicine.yale.edu/bbs/tracks/h...
careers.yale.edu/us/en/job/YU...
Reposted by Noonan Lab
Check out our latest work co-led by @dcsoto.bsky.social and @jmuribescr.bsky.social identifying hundreds of human duplicated gene families using the new T2T-CHM13 assembly, with a focus on those potentially contributing to brain evolution 🧪: authors.elsevier.com/a/1lTQtL7PXu...
authors.elsevier.com
July 21, 2025 at 4:26 PM
Check out our latest work co-led by @dcsoto.bsky.social and @jmuribescr.bsky.social identifying hundreds of human duplicated gene families using the new T2T-CHM13 assembly, with a focus on those potentially contributing to brain evolution 🧪: authors.elsevier.com/a/1lTQtL7PXu...
So NIMH is no longer supporting F31s, but is still supporting F30s and F32s? I initially thought this might be an error in the FOA (there are a lot more errors popping up now), but it's in the Guide too:
grants.nih.gov/funding/nih-...
grants.nih.gov/funding/nih-...
NIH Guide for Grants and Contracts | Grants & Funding
grants.nih.gov
June 13, 2025 at 8:53 PM
So NIMH is no longer supporting F31s, but is still supporting F30s and F32s? I initially thought this might be an error in the FOA (there are a lot more errors popping up now), but it's in the Guide too:
grants.nih.gov/funding/nih-...
grants.nih.gov/funding/nih-...
Reposted by Noonan Lab
After spending tons of time rebutting our trainee's grant termination.. this response doesn't suggest a 'careful assessment'
There aren't mechanisms that support mid-PhD trainees, so theres nothing to apply to, even though it scored in the top % of all apps.
Not to mention the demotivation.
Ugh.
There aren't mechanisms that support mid-PhD trainees, so theres nothing to apply to, even though it scored in the top % of all apps.
Not to mention the demotivation.
Ugh.
June 10, 2025 at 4:01 PM
After spending tons of time rebutting our trainee's grant termination.. this response doesn't suggest a 'careful assessment'
There aren't mechanisms that support mid-PhD trainees, so theres nothing to apply to, even though it scored in the top % of all apps.
Not to mention the demotivation.
Ugh.
There aren't mechanisms that support mid-PhD trainees, so theres nothing to apply to, even though it scored in the top % of all apps.
Not to mention the demotivation.
Ugh.
Reposted by Noonan Lab
I'm proud of Yale for doing this
Yale backing Harvard in lawsuit against government
In a joint motion with 17 other universities, Yale argues that cutting federal funds to Harvard endangers the nation.
yaledailynews.com
June 6, 2025 at 10:42 PM
I'm proud of Yale for doing this
Reposted by Noonan Lab
Hey BlueSky! Want to learn more about some almost literally mind-bending brain research being done by @noonanlab.bsky.social?
Check out the story below for one scientist's perspective on the importance of basic scientific research and the pursuit of open-ended questions about what makes us human.
Check out the story below for one scientist's perspective on the importance of basic scientific research and the pursuit of open-ended questions about what makes us human.
Hybrid brains and the search for what makes us human - the Node
It lives. It lives! What lives, you may ask? Well, somewhere in a lab at Yale University, one young scientist has stuck human brain cells and chimp brain
thenode.biologists.com
May 28, 2025 at 10:27 PM
Hey BlueSky! Want to learn more about some almost literally mind-bending brain research being done by @noonanlab.bsky.social?
Check out the story below for one scientist's perspective on the importance of basic scientific research and the pursuit of open-ended questions about what makes us human.
Check out the story below for one scientist's perspective on the importance of basic scientific research and the pursuit of open-ended questions about what makes us human.
Reposted by Noonan Lab
Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...
A human-specific enhancer fine-tunes radial glia potency and corticogenesis - Nature
HARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence betw...
www.nature.com
May 14, 2025 at 4:09 PM
Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...
Despite the Times trying to spin this as “Harvard should quit,” the article really (and likely unintentionally) conveys the message “Harvard should absolutely keep fighting.”
www.nytimes.com/2025/05/08/u...
www.nytimes.com/2025/05/08/u...
Harvard Leaders See Only Bad Outcomes Ahead as They Battle Trump
www.nytimes.com
May 8, 2025 at 11:35 PM
Despite the Times trying to spin this as “Harvard should quit,” the article really (and likely unintentionally) conveys the message “Harvard should absolutely keep fighting.”
www.nytimes.com/2025/05/08/u...
www.nytimes.com/2025/05/08/u...
For #FluorescenceFriday, here's a human-chimpanzee iPSC-derived chimeric somitoid, with human cells shown in red and chimpanzee cells shown in green, made by our student Je Won Yang (1/2):
May 2, 2025 at 7:52 PM
For #FluorescenceFriday, here's a human-chimpanzee iPSC-derived chimeric somitoid, with human cells shown in red and chimpanzee cells shown in green, made by our student Je Won Yang (1/2):
Reposted by Noonan Lab
Yes, this... 👇
Read this first, then read this piece from an anonymous NIH employee at @donmoyn.bsky.social's Substack. Everything falling into place for Congress to go through rescission to make NIH cuts in a way that's both more politically palatable and more enduring.
donmoynihan.substack.com/p/the-nih-bu...
donmoynihan.substack.com/p/the-nih-bu...
May 2, 2025 at 6:40 PM
Yes, this... 👇
Reposted by Noonan Lab
As a rare bit of good news, a huge congratulations to @jkpritch.bsky.social who was just elected to the National Academy of Sciences.
Here's the full list.
Here's the full list.
National Academy of Sciences Elects Members and International Members - NAS
WASHINGTON — The National Academy of Sciences announced today the election of 120 members and 30 international members in recognition of their distinguished and continuing achievements in original res...
www.nasonline.org
April 29, 2025 at 9:38 PM
As a rare bit of good news, a huge congratulations to @jkpritch.bsky.social who was just elected to the National Academy of Sciences.
Here's the full list.
Here's the full list.
Reposted by Noonan Lab
I'm honoured to have been elected as a member of the American Academy of Arts and Sciences. It's a wonderful recognition of all the hard work by the amazing folks in the lab over the years. A huge thanks to them all.
April 24, 2025 at 5:48 PM
I'm honoured to have been elected as a member of the American Academy of Arts and Sciences. It's a wonderful recognition of all the hard work by the amazing folks in the lab over the years. A huge thanks to them all.
Reposted by Noonan Lab
ACTION ITEM-----ACTION ITEM
Implementation of Schedule F
This is what a lot of us have been worried about.
This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.
BUT THERE IS A COMMENT PERIOD...
1/n
Implementation of Schedule F
This is what a lot of us have been worried about.
This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.
BUT THERE IS A COMMENT PERIOD...
1/n
the word alert is in a purple circle
ALT: the word alert is in a purple circle
media.tenor.com
April 23, 2025 at 6:03 PM
ACTION ITEM-----ACTION ITEM
Implementation of Schedule F
This is what a lot of us have been worried about.
This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.
BUT THERE IS A COMMENT PERIOD...
1/n
Implementation of Schedule F
This is what a lot of us have been worried about.
This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.
BUT THERE IS A COMMENT PERIOD...
1/n
Glad to see that Yale has co-signed this statement.
bsky.app/profile/cant...
bsky.app/profile/cant...
“We must reject the coercive use of public research funding.” Over 150 college & university leaders from big and small institutions have signed a joint statement defending the right to speak “without fear of retribution, censorship, or deportation.” 🇺🇸
www.aacu.org/newsroom/a-c...
www.aacu.org/newsroom/a-c...
A Call for Constructive Engagement | AAC&U
A Call for Constructive Engagement
www.aacu.org
April 22, 2025 at 7:45 PM
Glad to see that Yale has co-signed this statement.
bsky.app/profile/cant...
bsky.app/profile/cant...
Our own Paschal candle. Happy Easter, everyone.
April 21, 2025 at 12:41 AM
Our own Paschal candle. Happy Easter, everyone.
Reposted by Noonan Lab
Today the NY Times posted an interview with Chris Rufo that anyone associated with universities — or anyone who benefits from advances in health care or any other aspect of the research taking place there — should listen to or read in transcript.
www.nytimes.com/2025/04/11/p...?
www.nytimes.com/2025/04/11/p...?
The Conservative Activist Pushing Trump to Attack U.S. Colleges
Christopher Rufo has helped inspire Republican messaging and bills on hot-button issues.
www.nytimes.com
April 11, 2025 at 7:38 PM
Today the NY Times posted an interview with Chris Rufo that anyone associated with universities — or anyone who benefits from advances in health care or any other aspect of the research taking place there — should listen to or read in transcript.
www.nytimes.com/2025/04/11/p...?
www.nytimes.com/2025/04/11/p...?
On the futility of collaboration, from Tom Scocca. I'd also like to point out that trust in higher ed and institutional expertise is so low right now in large part because of a decades-long right wing propaganda campaign to achieve exactly that end.
defector.com/the-bargain-...
defector.com/the-bargain-...
The Bargain Vs. The Boot | Defector
Welcome to Margin of Error, a politics column from Tom Scocca, editor of the Indignity newsletter. Gretchen Whitmer, the Democratic governor of Michigan, went to the White House on Wednesday hoping to...
defector.com
April 11, 2025 at 8:57 PM
On the futility of collaboration, from Tom Scocca. I'd also like to point out that trust in higher ed and institutional expertise is so low right now in large part because of a decades-long right wing propaganda campaign to achieve exactly that end.
defector.com/the-bargain-...
defector.com/the-bargain-...
Reposted by Noonan Lab
I greatly appreciate everything that Christopher Eisgruber says in this interview, but, more than that, it's increasingly a relief to hear someone in a position of authority willing to be sane in public. #academicSky #eduSky
www.nytimes.com/2025/04/09/p...
www.nytimes.com/2025/04/09/p...
The University President Willing to Fight Trump
Christopher L. Eisgruber of Princeton University talks about the administration’s move to freeze billions of dollars in funding to higher education institutions.
www.nytimes.com
April 9, 2025 at 2:34 PM
I greatly appreciate everything that Christopher Eisgruber says in this interview, but, more than that, it's increasingly a relief to hear someone in a position of authority willing to be sane in public. #academicSky #eduSky
www.nytimes.com/2025/04/09/p...
www.nytimes.com/2025/04/09/p...
Reposted by Noonan Lab
A project five years in the making, we've now published complete "T2T" genomes for six additional ape species! It turns out that finishing (and analyzing) six genomes is slightly more work than one... doi.org/10.1038/s415...
April 9, 2025 at 9:31 PM
A project five years in the making, we've now published complete "T2T" genomes for six additional ape species! It turns out that finishing (and analyzing) six genomes is slightly more work than one... doi.org/10.1038/s415...
Reposted by Noonan Lab
Exclusive: Weeks after President Donald Trump’s administration ordered NIH to pull $250 million in biomedical research grants to Columbia University, the agency is freezing all remaining grant money owed to the university until further notice. scim.ag/4if5Rg1
NIH freezes all research grants to Columbia University
Amid negotiations with Trump, the university could risk losing nearly $700 million
scim.ag
April 9, 2025 at 6:56 PM
Exclusive: Weeks after President Donald Trump’s administration ordered NIH to pull $250 million in biomedical research grants to Columbia University, the agency is freezing all remaining grant money owed to the university until further notice. scim.ag/4if5Rg1
Reposted by Noonan Lab
We're disappointed to see Ben Barres's powerful book "The Autobiography of a Transgender Scientist" among the ~400 titles removed from the Naval Academy Library. Needless to say, we're proud to have published his book and will keep it — and his memory — alive.
The Coming Out of a Transgender Scientist
"I know that I am making the right decision because whenever I think about changing my gender role, I am flooded with feelings of relief."
thereader.mitpress.mit.edu
April 8, 2025 at 8:24 PM
We're disappointed to see Ben Barres's powerful book "The Autobiography of a Transgender Scientist" among the ~400 titles removed from the Naval Academy Library. Needless to say, we're proud to have published his book and will keep it — and his memory — alive.
Cornell is unique among the Ivies in that many of its constituent colleges are effectively part of the SUNY system. Doesn't this give New York State standing to sue the federal government?
bsky.app/profile/deni...
bsky.app/profile/deni...
April 9, 2025 at 12:36 AM
Cornell is unique among the Ivies in that many of its constituent colleges are effectively part of the SUNY system. Doesn't this give New York State standing to sue the federal government?
bsky.app/profile/deni...
bsky.app/profile/deni...
Reposted by Noonan Lab
New preprint from my group! Here we studied the contribution of a subset of human- and hominoid-specific transposons (SVA, LTR5HS) to the evolution of human craniofacial development. We specifically focussed on cranial neural crest (CNCC) formation and migration 1/n
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Human-specific transposable elements shaped the evolution of craniofacial development through regulation of neural crest migration
Craniofacial development and neural crest specification are evolutionarily conserved processes, yet subtle modifications to their gene regulatory networks drive species-specific craniofacial diversity...
www.biorxiv.org
April 7, 2025 at 1:26 PM
New preprint from my group! Here we studied the contribution of a subset of human- and hominoid-specific transposons (SVA, LTR5HS) to the evolution of human craniofacial development. We specifically focussed on cranial neural crest (CNCC) formation and migration 1/n
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...