Failing to mix reactions in heterogeneous or industrial systems could cause numerous issues and might even be dangerous, preprint claims

Recent years have witnessed growing interest in integrating enabling technologies into synthetic organic chemistry to address long-standing challenges in reproducibility, sustainability, and scalability. This perspective showcases how modern tools, ranging from continuous-flow reactors and electrochemical cells to photochemical technologies, biocatalysis, mechanochemistry, and self-driving laboratories, are reshaping the way chemists design, perform, and optimize reactions. Through selected case studies, we highlight how these technologies not only solve specific reactivity and process issues but also open new avenues for reactivity discovery and chemical innovation. Rather than viewing technology as a complication, we advocate for its adoption as a natural extension of synthetic creativity, capable of enhancing safety, reducing waste, and expanding accessible chemical space. Our aim is to inspire broader implementation and interdisciplinary training to equip the next generation of chemists with the tools to rethink how synthesis is performed in the 21st century.

Recent years have witnessed growing interest in integrating enabling technologies into synthetic organic chemistry to address long-standing challenges in reproducibility, sustainability, and scalability. This perspective showcases how modern tools, ranging from continuous-flow reactors and electrochemical cells to photochemical technologies, biocatalysis, mechanochemistry, and self-driving laboratories, are reshaping the way chemists design, perform, and optimize reactions. Through selected case studies, we highlight how these technologies not only solve specific reactivity and process issues but also open new avenues for reactivity discovery and chemical innovation. Rather than viewing technology as a complication, we advocate for its adoption as a natural extension of synthetic creativity, capable of enhancing safety, reducing waste, and expanding accessible chemical space. Our aim is to inspire broader implementation and interdisciplinary training to equip the next generation of chemists with the tools to rethink how synthesis is performed in the 21st century.