Noel Research Group
@noelgroupuva.bsky.social
Our research focuses on the synergy between #Synthetic #OrganicChemistry and #Technology. #ChemSky
We built a machine learning–guided workflow to optimize reaction conditions for photochemical nickel-catalyzed cysteine arylation; no specialized robots or fancy HTE plates needed!
Check it out @chemrxiv.org : chemrxiv.org/engage/chemr...
#MachineLearning #ReactionOptimization
Check it out @chemrxiv.org : chemrxiv.org/engage/chemr...
#MachineLearning #ReactionOptimization
October 1, 2025 at 1:10 PM
We built a machine learning–guided workflow to optimize reaction conditions for photochemical nickel-catalyzed cysteine arylation; no specialized robots or fancy HTE plates needed!
Check it out @chemrxiv.org : chemrxiv.org/engage/chemr...
#MachineLearning #ReactionOptimization
Check it out @chemrxiv.org : chemrxiv.org/engage/chemr...
#MachineLearning #ReactionOptimization
We felt a sense of urgency to summarize why mixing matters in synthetic organic chemistry.
Our takeaway: don’t toss those stir bars yet!
The truth is more complex than it may seem.
Read our ChemRxiv preprint: chemrxiv.org/engage/chemr...
#Chemistry #Mixing #Reproducibility
Our takeaway: don’t toss those stir bars yet!
The truth is more complex than it may seem.
Read our ChemRxiv preprint: chemrxiv.org/engage/chemr...
#Chemistry #Mixing #Reproducibility
September 22, 2025 at 11:49 AM
We felt a sense of urgency to summarize why mixing matters in synthetic organic chemistry.
Our takeaway: don’t toss those stir bars yet!
The truth is more complex than it may seem.
Read our ChemRxiv preprint: chemrxiv.org/engage/chemr...
#Chemistry #Mixing #Reproducibility
Our takeaway: don’t toss those stir bars yet!
The truth is more complex than it may seem.
Read our ChemRxiv preprint: chemrxiv.org/engage/chemr...
#Chemistry #Mixing #Reproducibility
🚫 Current self-driving labs (SDLs) cost >$100K, blocking access for most researchers.
💡 Enter RoboChem-Flex: A fully modular, AI-driven lab for under €5K.
Built to democratize automation in chemistry. Open, affordable, and powerful.
🔗 chemrxiv.org/engage/chemr...
💡 Enter RoboChem-Flex: A fully modular, AI-driven lab for under €5K.
Built to democratize automation in chemistry. Open, affordable, and powerful.
🔗 chemrxiv.org/engage/chemr...
July 11, 2025 at 6:09 AM
🚫 Current self-driving labs (SDLs) cost >$100K, blocking access for most researchers.
💡 Enter RoboChem-Flex: A fully modular, AI-driven lab for under €5K.
Built to democratize automation in chemistry. Open, affordable, and powerful.
🔗 chemrxiv.org/engage/chemr...
💡 Enter RoboChem-Flex: A fully modular, AI-driven lab for under €5K.
Built to democratize automation in chemistry. Open, affordable, and powerful.
🔗 chemrxiv.org/engage/chemr...
New @chemrxiv.bsky.social preprint!
RoboChem-Flex is a powerful, low-cost (<5k EUR), modular self-driving lab for chemical synthesis
We showcase 6 studies (photochemistry, biocatalysis, cross coupling, ee ...), all optimized with different configurations & ML
🔗 chemrxiv.org/engage/chemr...
RoboChem-Flex is a powerful, low-cost (<5k EUR), modular self-driving lab for chemical synthesis
We showcase 6 studies (photochemistry, biocatalysis, cross coupling, ee ...), all optimized with different configurations & ML
🔗 chemrxiv.org/engage/chemr...
July 10, 2025 at 3:06 PM
New @chemrxiv.bsky.social preprint!
RoboChem-Flex is a powerful, low-cost (<5k EUR), modular self-driving lab for chemical synthesis
We showcase 6 studies (photochemistry, biocatalysis, cross coupling, ee ...), all optimized with different configurations & ML
🔗 chemrxiv.org/engage/chemr...
RoboChem-Flex is a powerful, low-cost (<5k EUR), modular self-driving lab for chemical synthesis
We showcase 6 studies (photochemistry, biocatalysis, cross coupling, ee ...), all optimized with different configurations & ML
🔗 chemrxiv.org/engage/chemr...
🆕 Preprint out now on @chemrxiv.bsky.social!
We report a modular flow cascade for the synthesis of γ- & N-substituted γ-lactams via photochemical radical alkylation and cyclization.
Fast, scalable & broad scope!
🔗 chemrxiv.org/engage/chemr...
#FlowChemistry #Photochemistry #Lactams
We report a modular flow cascade for the synthesis of γ- & N-substituted γ-lactams via photochemical radical alkylation and cyclization.
Fast, scalable & broad scope!
🔗 chemrxiv.org/engage/chemr...
#FlowChemistry #Photochemistry #Lactams
June 19, 2025 at 9:37 AM
🆕 Preprint out now on @chemrxiv.bsky.social!
We report a modular flow cascade for the synthesis of γ- & N-substituted γ-lactams via photochemical radical alkylation and cyclization.
Fast, scalable & broad scope!
🔗 chemrxiv.org/engage/chemr...
#FlowChemistry #Photochemistry #Lactams
We report a modular flow cascade for the synthesis of γ- & N-substituted γ-lactams via photochemical radical alkylation and cyclization.
Fast, scalable & broad scope!
🔗 chemrxiv.org/engage/chemr...
#FlowChemistry #Photochemistry #Lactams
New paper in #GreenChemistry!
We developed a recyclable ionic liquid photocatalyst based on decatungstate (DT-IL) 💡
✅ Easy synthesis ✅ Broad solvent compatibility
✅ 100× higher concentrations ✅ Fully recyclable
🔗 pubs.rsc.org/en/content/a...
#Photocatalysis #FlowChemistry
We developed a recyclable ionic liquid photocatalyst based on decatungstate (DT-IL) 💡
✅ Easy synthesis ✅ Broad solvent compatibility
✅ 100× higher concentrations ✅ Fully recyclable
🔗 pubs.rsc.org/en/content/a...
#Photocatalysis #FlowChemistry
June 4, 2025 at 12:41 PM
New paper in #GreenChemistry!
We developed a recyclable ionic liquid photocatalyst based on decatungstate (DT-IL) 💡
✅ Easy synthesis ✅ Broad solvent compatibility
✅ 100× higher concentrations ✅ Fully recyclable
🔗 pubs.rsc.org/en/content/a...
#Photocatalysis #FlowChemistry
We developed a recyclable ionic liquid photocatalyst based on decatungstate (DT-IL) 💡
✅ Easy synthesis ✅ Broad solvent compatibility
✅ 100× higher concentrations ✅ Fully recyclable
🔗 pubs.rsc.org/en/content/a...
#Photocatalysis #FlowChemistry
Our latest study presents a photocatalytic platform that enables the Minisci alkylation of heteroarenes using C1-C4 hydrocarbons under continuous-flow conditions.
No prefunctionalized reagents—just change the gas to vary the alkyl moiety!
Now at #ACSCentralScience: pubs.acs.org/doi/10.1021/...
No prefunctionalized reagents—just change the gas to vary the alkyl moiety!
Now at #ACSCentralScience: pubs.acs.org/doi/10.1021/...
May 13, 2025 at 6:00 AM
Our latest study presents a photocatalytic platform that enables the Minisci alkylation of heteroarenes using C1-C4 hydrocarbons under continuous-flow conditions.
No prefunctionalized reagents—just change the gas to vary the alkyl moiety!
Now at #ACSCentralScience: pubs.acs.org/doi/10.1021/...
No prefunctionalized reagents—just change the gas to vary the alkyl moiety!
Now at #ACSCentralScience: pubs.acs.org/doi/10.1021/...
Ni/photoredox-catalyzed methylation of (hetero)aryl bromides using air-stable DABAl-Me₃ — also flow-compatible and scalable.
Mechanistic studies reveal an unprecedented generation of a methyl radical from an organoaluminum compound.
Now
@chemrxiv.bsky.social: chemrxiv.org/engage/chemr...
Mechanistic studies reveal an unprecedented generation of a methyl radical from an organoaluminum compound.
Now
@chemrxiv.bsky.social: chemrxiv.org/engage/chemr...
March 24, 2025 at 7:44 AM
Ni/photoredox-catalyzed methylation of (hetero)aryl bromides using air-stable DABAl-Me₃ — also flow-compatible and scalable.
Mechanistic studies reveal an unprecedented generation of a methyl radical from an organoaluminum compound.
Now
@chemrxiv.bsky.social: chemrxiv.org/engage/chemr...
Mechanistic studies reveal an unprecedented generation of a methyl radical from an organoaluminum compound.
Now
@chemrxiv.bsky.social: chemrxiv.org/engage/chemr...
Our latest study presents a photocatalytic platform that enables the Minisci alkylation of heteroarenes using C1-C4 hydrocarbons under continuous-flow conditions.
No prefunctionalized reagents—just change the gas to vary the alkyl moiety!
@chemrxiv.bsky.social: chemrxiv.org/engage/chemr...
No prefunctionalized reagents—just change the gas to vary the alkyl moiety!
@chemrxiv.bsky.social: chemrxiv.org/engage/chemr...
March 20, 2025 at 5:52 AM
Our latest study presents a photocatalytic platform that enables the Minisci alkylation of heteroarenes using C1-C4 hydrocarbons under continuous-flow conditions.
No prefunctionalized reagents—just change the gas to vary the alkyl moiety!
@chemrxiv.bsky.social: chemrxiv.org/engage/chemr...
No prefunctionalized reagents—just change the gas to vary the alkyl moiety!
@chemrxiv.bsky.social: chemrxiv.org/engage/chemr...
Excited to share our latest work @angewandtechemie.bsky.social, on an efficient Ni-catalyzed electrochemical cyclopropanation in continuous flow—broad scope, ambient conditions, and scalable! ⚡
🔗: onlinelibrary.wiley.com/doi/10.1002/...
Fun fact: This marks the 20th ACIE paper from our group!
🔗: onlinelibrary.wiley.com/doi/10.1002/...
Fun fact: This marks the 20th ACIE paper from our group!
January 31, 2025 at 8:32 AM
Excited to share our latest work @angewandtechemie.bsky.social, on an efficient Ni-catalyzed electrochemical cyclopropanation in continuous flow—broad scope, ambient conditions, and scalable! ⚡
🔗: onlinelibrary.wiley.com/doi/10.1002/...
Fun fact: This marks the 20th ACIE paper from our group!
🔗: onlinelibrary.wiley.com/doi/10.1002/...
Fun fact: This marks the 20th ACIE paper from our group!
We've developed a robust photochemical alkylation method to transform secondary amides into α-substituted secondary amines. Broad functional group tolerance, scalability via #flowchemistry, and ideal for drug discovery!
🔗 @naturecomms.bsky.social: www.nature.com/articles/s41...
#photocatalysis
🔗 @naturecomms.bsky.social: www.nature.com/articles/s41...
#photocatalysis
January 23, 2025 at 11:35 AM
We've developed a robust photochemical alkylation method to transform secondary amides into α-substituted secondary amines. Broad functional group tolerance, scalability via #flowchemistry, and ideal for drug discovery!
🔗 @naturecomms.bsky.social: www.nature.com/articles/s41...
#photocatalysis
🔗 @naturecomms.bsky.social: www.nature.com/articles/s41...
#photocatalysis
Check out our new preprint on #electrophotocatalysis:
Oxidant-free amidation of aldehydes enabled by a hydrogen atom transfer - radical polar crossover sequence.
🔗ChemRXiv : chemrxiv.org/engage/chemr...
Congrats Dimitris, Elena, Jiri, Joost and @tnoel82.bsky.social
#flowchemistry
Oxidant-free amidation of aldehydes enabled by a hydrogen atom transfer - radical polar crossover sequence.
🔗ChemRXiv : chemrxiv.org/engage/chemr...
Congrats Dimitris, Elena, Jiri, Joost and @tnoel82.bsky.social
#flowchemistry
January 21, 2025 at 1:12 PM
Check out our new preprint on #electrophotocatalysis:
Oxidant-free amidation of aldehydes enabled by a hydrogen atom transfer - radical polar crossover sequence.
🔗ChemRXiv : chemrxiv.org/engage/chemr...
Congrats Dimitris, Elena, Jiri, Joost and @tnoel82.bsky.social
#flowchemistry
Oxidant-free amidation of aldehydes enabled by a hydrogen atom transfer - radical polar crossover sequence.
🔗ChemRXiv : chemrxiv.org/engage/chemr...
Congrats Dimitris, Elena, Jiri, Joost and @tnoel82.bsky.social
#flowchemistry
👏 Thrilled to share that Antonio Pulcinella has defended his PhD with brilliance and achieved the esteemed Cum Laude distinction University of Amsterdam!
🔗Photocatalytic strategies for the valorization of feedstock chemicals in batch and flow: dare.uva.nl/search?ident...
#ChemSky #PhD
🔗Photocatalytic strategies for the valorization of feedstock chemicals in batch and flow: dare.uva.nl/search?ident...
#ChemSky #PhD
January 13, 2025 at 6:03 AM
👏 Thrilled to share that Antonio Pulcinella has defended his PhD with brilliance and achieved the esteemed Cum Laude distinction University of Amsterdam!
🔗Photocatalytic strategies for the valorization of feedstock chemicals in batch and flow: dare.uva.nl/search?ident...
#ChemSky #PhD
🔗Photocatalytic strategies for the valorization of feedstock chemicals in batch and flow: dare.uva.nl/search?ident...
#ChemSky #PhD
1st paper of 2025 is a fact: Turns out, adding gas bubbles can boost photon absorption in photoreactors by scattering and intensifying light intensity.
🔗 React Chem Eng: pubs.rsc.org/en/content/a...
🙌: @jhaschuurmans.bsky.social, Stefan, Arnab, Miguel, John & @tnoel82.bsky.social
#flowchemistry
🔗 React Chem Eng: pubs.rsc.org/en/content/a...
🙌: @jhaschuurmans.bsky.social, Stefan, Arnab, Miguel, John & @tnoel82.bsky.social
#flowchemistry
January 6, 2025 at 7:57 AM
1st paper of 2025 is a fact: Turns out, adding gas bubbles can boost photon absorption in photoreactors by scattering and intensifying light intensity.
🔗 React Chem Eng: pubs.rsc.org/en/content/a...
🙌: @jhaschuurmans.bsky.social, Stefan, Arnab, Miguel, John & @tnoel82.bsky.social
#flowchemistry
🔗 React Chem Eng: pubs.rsc.org/en/content/a...
🙌: @jhaschuurmans.bsky.social, Stefan, Arnab, Miguel, John & @tnoel82.bsky.social
#flowchemistry
🎄✨What a year for @noelgroupuva.bsky.social!✨🎄
From festive fun to unforgettable scientific moments, 2024 was amazing:
Secret Santa with Père Noël @tnoel82.bsky.social & his elves:
@morganregnier.bsky.social & Clara!
A fantastic Xmas dinner to wrap it all up.
Here’s to 2025! 🥂
#Chemsky #Xmas
From festive fun to unforgettable scientific moments, 2024 was amazing:
Secret Santa with Père Noël @tnoel82.bsky.social & his elves:
@morganregnier.bsky.social & Clara!
A fantastic Xmas dinner to wrap it all up.
Here’s to 2025! 🥂
#Chemsky #Xmas
December 20, 2024 at 8:31 AM
🎄✨What a year for @noelgroupuva.bsky.social!✨🎄
From festive fun to unforgettable scientific moments, 2024 was amazing:
Secret Santa with Père Noël @tnoel82.bsky.social & his elves:
@morganregnier.bsky.social & Clara!
A fantastic Xmas dinner to wrap it all up.
Here’s to 2025! 🥂
#Chemsky #Xmas
From festive fun to unforgettable scientific moments, 2024 was amazing:
Secret Santa with Père Noël @tnoel82.bsky.social & his elves:
@morganregnier.bsky.social & Clara!
A fantastic Xmas dinner to wrap it all up.
Here’s to 2025! 🥂
#Chemsky #Xmas
Stefan Zondag defended his PhD –"Design, characterization and application of continuous-flow photoreactors"– with flying colors.
Innovative reactors, solar-powered systems, and clog-free solutions – a bright future for photochemistry!
Congrats, Stefan!
#PhDone #CumLaude #Photochemistry #ChemSky
Innovative reactors, solar-powered systems, and clog-free solutions – a bright future for photochemistry!
Congrats, Stefan!
#PhDone #CumLaude #Photochemistry #ChemSky
December 17, 2024 at 4:16 PM
Stefan Zondag defended his PhD –"Design, characterization and application of continuous-flow photoreactors"– with flying colors.
Innovative reactors, solar-powered systems, and clog-free solutions – a bright future for photochemistry!
Congrats, Stefan!
#PhDone #CumLaude #Photochemistry #ChemSky
Innovative reactors, solar-powered systems, and clog-free solutions – a bright future for photochemistry!
Congrats, Stefan!
#PhDone #CumLaude #Photochemistry #ChemSky
Check out our new preprint: flow electroreductive nickel-catalyzed cyclopropanation of olefins using gem-dichloroalkanes.
Out now @chemrxiv.bsky.social: chemrxiv.org/engage/chemr...
Great work by @morganregnier.bsky.social, Clara, Dimitris and @tnoel82.bsky.social!
#ChemSky #electrochemistry
Out now @chemrxiv.bsky.social: chemrxiv.org/engage/chemr...
Great work by @morganregnier.bsky.social, Clara, Dimitris and @tnoel82.bsky.social!
#ChemSky #electrochemistry
December 11, 2024 at 7:04 AM
Check out our new preprint: flow electroreductive nickel-catalyzed cyclopropanation of olefins using gem-dichloroalkanes.
Out now @chemrxiv.bsky.social: chemrxiv.org/engage/chemr...
Great work by @morganregnier.bsky.social, Clara, Dimitris and @tnoel82.bsky.social!
#ChemSky #electrochemistry
Out now @chemrxiv.bsky.social: chemrxiv.org/engage/chemr...
Great work by @morganregnier.bsky.social, Clara, Dimitris and @tnoel82.bsky.social!
#ChemSky #electrochemistry
We’ve conducted extensive research on the photocatalytic activation of volatile alkanes, publishing a series of papers showcasing diverse synthetic applications.
Stay tuned for insights and updates on this topic! #ChemSky
Stay tuned for insights and updates on this topic! #ChemSky
November 25, 2024 at 1:40 PM
We’ve conducted extensive research on the photocatalytic activation of volatile alkanes, publishing a series of papers showcasing diverse synthetic applications.
Stay tuned for insights and updates on this topic! #ChemSky
Stay tuned for insights and updates on this topic! #ChemSky
The protocol is straightforward:
Load a cartridge with CsF, pump the appropriate precursor through, collect your desired reagent, and let it react with your chosen electrophile.
The power of #FlowChemistry 🪄
Load a cartridge with CsF, pump the appropriate precursor through, collect your desired reagent, and let it react with your chosen electrophile.
The power of #FlowChemistry 🪄
November 25, 2024 at 1:28 PM
The protocol is straightforward:
Load a cartridge with CsF, pump the appropriate precursor through, collect your desired reagent, and let it react with your chosen electrophile.
The power of #FlowChemistry 🪄
Load a cartridge with CsF, pump the appropriate precursor through, collect your desired reagent, and let it react with your chosen electrophile.
The power of #FlowChemistry 🪄
In #Science, we presented a flow method to prepare CF3-X anions on demand using organic precursors and CsF, avoiding #PFAS use in the process.
🔗https://www.science.org/doi/10.1126/science.adq2954
This allows for precise introduction of these groups at any stage!
#flowchemistry meets #fluorine!
🔗https://www.science.org/doi/10.1126/science.adq2954
This allows for precise introduction of these groups at any stage!
#flowchemistry meets #fluorine!
November 25, 2024 at 1:25 PM
In #Science, we presented a flow method to prepare CF3-X anions on demand using organic precursors and CsF, avoiding #PFAS use in the process.
🔗https://www.science.org/doi/10.1126/science.adq2954
This allows for precise introduction of these groups at any stage!
#flowchemistry meets #fluorine!
🔗https://www.science.org/doi/10.1126/science.adq2954
This allows for precise introduction of these groups at any stage!
#flowchemistry meets #fluorine!
One of our 2024 highlights was our robotic platform, #RoboChem, which has been published in #Science!
🔗https://www.science.org/doi/10.1126/science.adj1817
#RoboChem can carry out your substrate scope and provide tailored reaction conditions for every entry. 🤖
#FlowChemistry #photocatalysis
🔗https://www.science.org/doi/10.1126/science.adj1817
#RoboChem can carry out your substrate scope and provide tailored reaction conditions for every entry. 🤖
#FlowChemistry #photocatalysis
November 25, 2024 at 1:19 PM
One of our 2024 highlights was our robotic platform, #RoboChem, which has been published in #Science!
🔗https://www.science.org/doi/10.1126/science.adj1817
#RoboChem can carry out your substrate scope and provide tailored reaction conditions for every entry. 🤖
#FlowChemistry #photocatalysis
🔗https://www.science.org/doi/10.1126/science.adj1817
#RoboChem can carry out your substrate scope and provide tailored reaction conditions for every entry. 🤖
#FlowChemistry #photocatalysis
We’re excited to share we’re now on Bluesky! If you’re interested in following our journey at the intersection of synthetic organic chemistry and technology, follow us here! #FlowChemistry #OrganicChemistry #science
November 19, 2024 at 2:22 PM
We’re excited to share we’re now on Bluesky! If you’re interested in following our journey at the intersection of synthetic organic chemistry and technology, follow us here! #FlowChemistry #OrganicChemistry #science