Nic Lehrbach
@nlehrbach.bsky.social
Worm researcher at Fred Hutch
Reposted by Nic Lehrbach
#Celegans peel-1/zeel-1 is one of the best-characterized animal #toxin-antidote systems, but how does it work? @lewsiferase.bsky.social &co show that PEEL-1 co-opts the PMPL-1 to exert toxicity by creating a novel #IonChannel that leads to cell swelling @plosbiology.org 🧪 plos.io/3HfH8LN
May 27, 2025 at 6:21 PM
#Celegans peel-1/zeel-1 is one of the best-characterized animal #toxin-antidote systems, but how does it work? @lewsiferase.bsky.social &co show that PEEL-1 co-opts the PMPL-1 to exert toxicity by creating a novel #IonChannel that leads to cell swelling @plosbiology.org 🧪 plos.io/3HfH8LN
Reposted by Nic Lehrbach
Excited to share a recent preprint by Oliver Newsom, where we evaluate the functional contributions of serum for cancer cell proliferation. Inside:
A broadly applicable serum-free media,
Quantitative lipid uptake characterization,
Evidence lipid scavenging > synthesis for cancer cell proliferation.
A broadly applicable serum-free media,
Quantitative lipid uptake characterization,
Evidence lipid scavenging > synthesis for cancer cell proliferation.
Defined media reveals the essential role of lipid scavenging to support cancer cell proliferation https://www.biorxiv.org/content/10.1101/2025.02.12.637975v1
February 20, 2025 at 2:43 AM
Excited to share a recent preprint by Oliver Newsom, where we evaluate the functional contributions of serum for cancer cell proliferation. Inside:
A broadly applicable serum-free media,
Quantitative lipid uptake characterization,
Evidence lipid scavenging > synthesis for cancer cell proliferation.
A broadly applicable serum-free media,
Quantitative lipid uptake characterization,
Evidence lipid scavenging > synthesis for cancer cell proliferation.
Reposted by Nic Lehrbach
Huge congratulations @jbloomlab.bsky.social!
Congrats to Fred Hutch evolutionary biologist
@jbloomlab.bsky.social on being named a fellow of the American Academy of Microbiology, an honorific leadership group within the American Society for Microbiology! Read more: bit.ly/3EFmnb1 @hutchbasicsci.bsky.social
@jbloomlab.bsky.social on being named a fellow of the American Academy of Microbiology, an honorific leadership group within the American Society for Microbiology! Read more: bit.ly/3EFmnb1 @hutchbasicsci.bsky.social
February 15, 2025 at 4:56 PM
Huge congratulations @jbloomlab.bsky.social!
Reposted by Nic Lehrbach
In the midst of the dark ages, we MUST retain optimism—keep going, keep publishing, keep talking science, and keep doing fun experiments! Our latest paper on the fascinating TF SKN-1/NRF presents exciting new findings using our one and only #Celegans #genetics #oxidativestress #proteasome
Our latest work on the ever-fascinating skn-1 transcription factor (Nrf1 and Nrf2 for non-worm people).
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Protein sequence editing defines distinct and overlapping functions of SKN-1A/Nrf1 and SKN-1C/Nrf2
The Nrf/NFE2L family of transcription factors regulates redox balance, xenobiotic detoxification, metabolism, proteostasis, and aging. Nrf1/NFE2L1 is primarily responsible for stress-responsive upregu...
www.biorxiv.org
February 9, 2025 at 10:19 PM
In the midst of the dark ages, we MUST retain optimism—keep going, keep publishing, keep talking science, and keep doing fun experiments! Our latest paper on the fascinating TF SKN-1/NRF presents exciting new findings using our one and only #Celegans #genetics #oxidativestress #proteasome
Our latest work on the ever-fascinating skn-1 transcription factor (Nrf1 and Nrf2 for non-worm people).
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Protein sequence editing defines distinct and overlapping functions of SKN-1A/Nrf1 and SKN-1C/Nrf2
The Nrf/NFE2L family of transcription factors regulates redox balance, xenobiotic detoxification, metabolism, proteostasis, and aging. Nrf1/NFE2L1 is primarily responsible for stress-responsive upregu...
www.biorxiv.org
February 7, 2025 at 7:51 PM
Our latest work on the ever-fascinating skn-1 transcription factor (Nrf1 and Nrf2 for non-worm people).
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Nic Lehrbach
Check out a fantastic @elife.bsky.social article highlighting @yarimura.bsky.social’s MagIC #cryoEM technique - a method using specialized magnetic beads that makes it possible to study the structure of proteins from dilute samples. elifesciences.org/articles/105...
Cryogenic Electron Microscopy: MagIC beads for scarce macromolecules
Specialized magnetic beads that bind target proteins to a cryogenic electron microscopy grid make it possible to study the structure of protein complexes from dilute samples.
elifesciences.org
January 24, 2025 at 6:16 PM
Check out a fantastic @elife.bsky.social article highlighting @yarimura.bsky.social’s MagIC #cryoEM technique - a method using specialized magnetic beads that makes it possible to study the structure of proteins from dilute samples. elifesciences.org/articles/105...
Reposted by Nic Lehrbach
The best part of the week kicks off soon: Friday Afternoon Seminars!
Can’t wait to learn about the latest research from Elyse Christensen in the @nlehrbach.bsky.social Lab and Liberalis Boila in Human Biology’s Kugel Lab. For all our @FredHutch.bsky.social colleagues, join us for two great talks!
Can’t wait to learn about the latest research from Elyse Christensen in the @nlehrbach.bsky.social Lab and Liberalis Boila in Human Biology’s Kugel Lab. For all our @FredHutch.bsky.social colleagues, join us for two great talks!
November 22, 2024 at 10:28 PM
The best part of the week kicks off soon: Friday Afternoon Seminars!
Can’t wait to learn about the latest research from Elyse Christensen in the @nlehrbach.bsky.social Lab and Liberalis Boila in Human Biology’s Kugel Lab. For all our @FredHutch.bsky.social colleagues, join us for two great talks!
Can’t wait to learn about the latest research from Elyse Christensen in the @nlehrbach.bsky.social Lab and Liberalis Boila in Human Biology’s Kugel Lab. For all our @FredHutch.bsky.social colleagues, join us for two great talks!