Nischal Ranganath
@nischalr3.bsky.social
ID physician and hospitalist at Mayo Clinic, Rochester
@ofidjournal.bsky.social
Take a read of our recent study assessing use of mcfDNA-NGS relative to standard testing in the workup of FUO. Molecular testing offered earlier time to diagnosis and some interesting non-hypothesis driven diagnoses.
academic.oup.com/ofid/article...
Take a read of our recent study assessing use of mcfDNA-NGS relative to standard testing in the workup of FUO. Molecular testing offered earlier time to diagnosis and some interesting non-hypothesis driven diagnoses.
academic.oup.com/ofid/article...
From Chart Biopsy to Liquid Biopsy: Evaluating the Diagnostic Yield and Clinical Impact of Plasma Microbial Cell-Free DNA Next-Generation Sequencing in the Management of Fever of Unknown Origin
Microbial cell-free DNA next-generation sequencing (mcfDNA-NGS) had a positive diagnostic impact in 30% of patients with fever of unknown origin (FUO). Pre
academic.oup.com
February 13, 2025 at 9:42 AM
@ofidjournal.bsky.social
Take a read of our recent study assessing use of mcfDNA-NGS relative to standard testing in the workup of FUO. Molecular testing offered earlier time to diagnosis and some interesting non-hypothesis driven diagnoses.
academic.oup.com/ofid/article...
Take a read of our recent study assessing use of mcfDNA-NGS relative to standard testing in the workup of FUO. Molecular testing offered earlier time to diagnosis and some interesting non-hypothesis driven diagnoses.
academic.oup.com/ofid/article...
Reposted by Nischal Ranganath
Concordance of non-invasive plasma cell-free DNA with invasive diagnostics for diagnosis of invasive fungal disease
✅ Just Accepted
✅ Just Accepted
Concordance of non-invasive plasma cell-free DNA with invasive diagnostics for diagnosis of invasive fungal disease
Mold plasma cell-free DNA (cfDNA) PCR is a promising non-invasive diagnostic modality for early diagnosis of invasive mold disease (IMD) in immunocompromised patients. Although mold cfDNA PCR has been shown to be highly accurate, the value of invasive procedures to collect specimens for conventional fungal diagnostics following plasma cfDNA testing remains unclear.
buff.ly
January 23, 2025 at 11:49 PM
Concordance of non-invasive plasma cell-free DNA with invasive diagnostics for diagnosis of invasive fungal disease
✅ Just Accepted
✅ Just Accepted
Reposted by Nischal Ranganath
Wow,timely!
Spinal implant infections are a serious complications of instrumented spinal fusion surgeries,carrying high morbidity & complex management challenges
🆕️🔥State-of-the-Art Review: Diagnosis and Management of Spinal Implant Infections #idsky #EMIMCC #medsky
academic.oup.com/cid/article/...
Spinal implant infections are a serious complications of instrumented spinal fusion surgeries,carrying high morbidity & complex management challenges
🆕️🔥State-of-the-Art Review: Diagnosis and Management of Spinal Implant Infections #idsky #EMIMCC #medsky
academic.oup.com/cid/article/...
December 17, 2024 at 9:08 PM
Wow,timely!
Spinal implant infections are a serious complications of instrumented spinal fusion surgeries,carrying high morbidity & complex management challenges
🆕️🔥State-of-the-Art Review: Diagnosis and Management of Spinal Implant Infections #idsky #EMIMCC #medsky
academic.oup.com/cid/article/...
Spinal implant infections are a serious complications of instrumented spinal fusion surgeries,carrying high morbidity & complex management challenges
🆕️🔥State-of-the-Art Review: Diagnosis and Management of Spinal Implant Infections #idsky #EMIMCC #medsky
academic.oup.com/cid/article/...
Reposted by Nischal Ranganath
🆕️✨️The largest study to date of patients with Bacteroides spp. bacteremia in ISAC Journal, IJAA.
#IDsky
#IDsky
🆕️✨️The largest study to date of patients with Bacteroides spp. bacteremia
Metronidazole 500mg q12h dosing was not associated with worse outcomes compared to metronidazole 500mgq8h
Metro:500mgq12h must be used for most types of infections #idsky #medsky #EMIMCC
www.sciencedirect.com/science/arti...
Metronidazole 500mg q12h dosing was not associated with worse outcomes compared to metronidazole 500mgq8h
Metro:500mgq12h must be used for most types of infections #idsky #medsky #EMIMCC
www.sciencedirect.com/science/arti...
Clinical outcomes of a twice daily metronidazole dosing strategy for Bacteroides bloodstream infections
The optimal metronidazole dose for the treatment of Bacteroides spp. has not been well-defined.This study was a multicenter, retrospective chart revie…
www.sciencedirect.com
December 11, 2024 at 9:18 AM
🆕️✨️The largest study to date of patients with Bacteroides spp. bacteremia in ISAC Journal, IJAA.
#IDsky
#IDsky
Reposted by Nischal Ranganath
🆕🔥Clinical Insights #JAMAInternalMed
When Can a MRSA Nares Swab Guide Antibiotic Stewardship?
What the Nose Knows #idsky #medsky #AMSsky #EMIMCC
jamanetwork.com/journals/jam...
When Can a MRSA Nares Swab Guide Antibiotic Stewardship?
What the Nose Knows #idsky #medsky #AMSsky #EMIMCC
jamanetwork.com/journals/jam...
When Can a MRSA Nares Swab Guide Antibiotic Stewardship?
This Clinical Insights discusses how the methicillin-resistant Staphylococcus aureus (MRSA) nares swab may be used alongside disease prevalence and clinical factors to determine when MRSA coverage is ...
jamanetwork.com
December 9, 2024 at 4:21 PM
🆕🔥Clinical Insights #JAMAInternalMed
When Can a MRSA Nares Swab Guide Antibiotic Stewardship?
What the Nose Knows #idsky #medsky #AMSsky #EMIMCC
jamanetwork.com/journals/jam...
When Can a MRSA Nares Swab Guide Antibiotic Stewardship?
What the Nose Knows #idsky #medsky #AMSsky #EMIMCC
jamanetwork.com/journals/jam...
Reposted by Nischal Ranganath
December 1, 2024 at 5:17 PM
Reposted by Nischal Ranganath
New in @cidjournal.bsky.social
State-of-the-Art Review: Ocular Infections
Miriam Barshak and multidisciplinary team
#IDSky #OphthoSky #MedSky @nottheogdrv.bsky.social
academic.oup.com/cid/article/...
State-of-the-Art Review: Ocular Infections
Miriam Barshak and multidisciplinary team
#IDSky #OphthoSky #MedSky @nottheogdrv.bsky.social
academic.oup.com/cid/article/...
November 22, 2024 at 2:52 AM
New in @cidjournal.bsky.social
State-of-the-Art Review: Ocular Infections
Miriam Barshak and multidisciplinary team
#IDSky #OphthoSky #MedSky @nottheogdrv.bsky.social
academic.oup.com/cid/article/...
State-of-the-Art Review: Ocular Infections
Miriam Barshak and multidisciplinary team
#IDSky #OphthoSky #MedSky @nottheogdrv.bsky.social
academic.oup.com/cid/article/...
Reposted by Nischal Ranganath
If you have access listen to #IDweek presentation in the Era of shorted is better. @maricarmalinis.bsky.social #TxID #IDSky
November 19, 2024 at 8:38 PM
If you have access listen to #IDweek presentation in the Era of shorted is better. @maricarmalinis.bsky.social #TxID #IDSky
Reposted by Nischal Ranganath
#ShorterIsBetter in immunocompromised hosts?
Short treatments are feasible in early responders without source control issues.
A significant number of observational studies serve as proof-of-concept on the feasibility of short courses in selected patients (see ⚠️)
#AMSsky #IDOnc #TxID #IDsky
Short treatments are feasible in early responders without source control issues.
A significant number of observational studies serve as proof-of-concept on the feasibility of short courses in selected patients (see ⚠️)
#AMSsky #IDOnc #TxID #IDsky
November 19, 2024 at 7:05 PM
#ShorterIsBetter in immunocompromised hosts?
Short treatments are feasible in early responders without source control issues.
A significant number of observational studies serve as proof-of-concept on the feasibility of short courses in selected patients (see ⚠️)
#AMSsky #IDOnc #TxID #IDsky
Short treatments are feasible in early responders without source control issues.
A significant number of observational studies serve as proof-of-concept on the feasibility of short courses in selected patients (see ⚠️)
#AMSsky #IDOnc #TxID #IDsky
Reposted by Nischal Ranganath
🌟 ABX Pearl of the Day: Duration of treatment in intra-abdominal infections (IAI)! 💊
💡 Q: How long should I treat IAI after source control?
🔍 A: While STOP-IT trial calls for 4 days post-source control, there are notable exceptions. See infographic for details 👇
#IDsky #AMSsky #MedSky #Pharmsky
💡 Q: How long should I treat IAI after source control?
🔍 A: While STOP-IT trial calls for 4 days post-source control, there are notable exceptions. See infographic for details 👇
#IDsky #AMSsky #MedSky #Pharmsky
November 22, 2024 at 6:07 PM
Join us in Hawaii (or via livestream) on Feb. 3-7 for Infectious Diseases Practice Updates 2025! Our outstanding @MayoClinicINFD faculty will cover updates on best practices and new developments in the field. Register here: tinyurl.com/2d7tkz6x
tinyurl.com
November 22, 2024 at 5:36 PM
Join us in Hawaii (or via livestream) on Feb. 3-7 for Infectious Diseases Practice Updates 2025! Our outstanding @MayoClinicINFD faculty will cover updates on best practices and new developments in the field. Register here: tinyurl.com/2d7tkz6x
Reposted by Nischal Ranganath
🆕 Just published in NEJM!
The BALANCE trial definitively establishes 7-day treatments as the standard of care for uncomplicated BSIs, with more than 3,600 randomized patients.
Fantastic work! @drtoddlee.bsky.social
www.nejm.org/doi/full/10.... #AMSsky #IDSky #ShorterIsBetter
The BALANCE trial definitively establishes 7-day treatments as the standard of care for uncomplicated BSIs, with more than 3,600 randomized patients.
Fantastic work! @drtoddlee.bsky.social
www.nejm.org/doi/full/10.... #AMSsky #IDSky #ShorterIsBetter
Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections | NEJM
Bloodstream infections are associated with substantial morbidity and mortality. Early, appropriate antibiotic therapy is important, but the duration of treatment is uncertain. In a multicenter, non...
www.nejm.org
November 20, 2024 at 3:24 PM
🆕 Just published in NEJM!
The BALANCE trial definitively establishes 7-day treatments as the standard of care for uncomplicated BSIs, with more than 3,600 randomized patients.
Fantastic work! @drtoddlee.bsky.social
www.nejm.org/doi/full/10.... #AMSsky #IDSky #ShorterIsBetter
The BALANCE trial definitively establishes 7-day treatments as the standard of care for uncomplicated BSIs, with more than 3,600 randomized patients.
Fantastic work! @drtoddlee.bsky.social
www.nejm.org/doi/full/10.... #AMSsky #IDSky #ShorterIsBetter
Reposted by Nischal Ranganath
Congratulations to @nischalr3.bsky.social and his team for their paper being selected as the @thetxidjournal.bsky.social 2024 Bob Rubin Clinical Impact Awardee - this award selects the paper felt to have the biggest impact on clinical care in #TxID!
#IDSky
onlinelibrary.wiley.com/doi/10.1111/...
#IDSky
onlinelibrary.wiley.com/doi/10.1111/...
Evaluating antimicrobial duration for Gram‐negative bacteremia in patients with neutropenia due to hematologic malignancy or hematopoietic stem cell transplantation
In the management of immunocompromised patients with neutropenia and Gram-negative bloodstream infection, short antimicrobial courses (≤10 days) had comparable propensity score-adjusted 90-day outcom...
onlinelibrary.wiley.com
November 18, 2024 at 3:17 PM
Congratulations to @nischalr3.bsky.social and his team for their paper being selected as the @thetxidjournal.bsky.social 2024 Bob Rubin Clinical Impact Awardee - this award selects the paper felt to have the biggest impact on clinical care in #TxID!
#IDSky
onlinelibrary.wiley.com/doi/10.1111/...
#IDSky
onlinelibrary.wiley.com/doi/10.1111/...