Nature Biomedical Engineering, Published online: 06 February 2026; doi:10.1038/s41551-025-01608-0Prima is an AI foundation model for neuroimaging based on clinical magnetic resonance imaging that offers accurate and explainable diagnostics, worklist priority for radiologists and clinical referral recommendations with equitable performance on diverse groups.

Nature Biomedical Engineering, Published online: 05 February 2026; doi:10.1038/s41551-025-01602-6Spatial multi-modal data analysis using embeddings from diverse foundation models (spEMO) represents a transformative approach that unifies embeddings from pathology foundation models with those from large language models to advance spatial multi-omics research.

Nature Biomedical Engineering, Published online: 03 February 2026; doi:10.1038/s41551-026-01624-8Author Correction: Steric stabilization-independent stealth cloak enables nanoreactors-mediated starvation therapy against refractory cancer

Nature Biomedical Engineering, Published online: 03 February 2026; doi:10.1038/s41551-025-01609-zA bioresorbable microneedle sensor array provides continuous, wireless and multimodal monitoring of organ metabolism, oxygenation and electrophysiology for up to 7 days in postoperative kidney ischaemia and gut disorders.

Nature Biomedical Engineering, Published online: 28 January 2026; doi:10.1038/s41551-025-01607-1A suite of TadA-derived cytosine base editors was optimized to improve efficiency, reduce sequence bias, expand PAM compatibility and minimize artefacts, enabling precise genetic interrogation of variants of uncertain significance (VUS) in zebrafish.

Nature Biomedical Engineering, Published online: 28 January 2026; doi:10.1038/s41551-025-01601-7A disc device integrating chromatography, centripetal liquid transfer and bead-based vesicle capture enables extracellular vesicle isolation and labelling, achieving high accuracy in cancer detection and tumour classification.

Nature Biomedical Engineering, Published online: 26 January 2026; doi:10.1038/s41551-025-01586-3Limited human data, needed to train artificial intelligence (AI) models, has constrained the development of hyperspectral imaging (HSI) for surgical applications. We developed xeno-learning, an AI method that harnesses shared biological responses found across species, allowing experimental data from animals to be used in training AI models for HSI applications in humans.

Nature Biomedical Engineering, Published online: 26 January 2026; doi:10.1038/s41551-025-01605-3A soft robotic probe enables continuous in utero monitoring of fetal physiological parameters, including heart rate, blood oxygen saturation, temperature and electrocardiogram data, during open or fetoscopic surgery to provide real-time information on fetal condition and distress.

Nature Biomedical Engineering, Published online: 26 January 2026; doi:10.1038/s41551-025-01585-4Xeno-learning uses preclinical data from one species to boost the performance of neural networks applied to another species when exploring physiological responses.

Nature Biomedical Engineering, Published online: 23 January 2026; doi:10.1038/s41551-025-01553-yIn vitro models using tissue-specific progenitors recapitulate the lumen with gland-like structures and functional characteristics of the human stomach epithelium in a patient-specific disease model.

Nature Biomedical Engineering, Published online: 22 January 2026; doi:10.1038/s41551-025-01562-xA droplet solution for wrapping thin bioelectronics onto complex 3D surfaces

Nature Biomedical Engineering, Published online: 22 January 2026; doi:10.1038/s41551-025-01568-5The AI sycophant

About the Editors

An artistic depiction of retinal imaging to detect and predict cerebrovascular diseases, including silent brain infarction and future stroke events. A...

An iontronic tip-sensing guidewire measures haemodynamic and contact pressure in animal stenosis models and can be integrated with commercial workhorse guidewires.

Cut-seq1, Cut-seq2, DeepCut and CLOVE-seq methods find optimized single-guide RNAs to detect a large number of rare variants in cells.

A vesicular nanoreactor has increased crosslinks between the constituent polyions for longer blood circulation, and is shown to sensitize solid tumours to asparagine starvation therapy.