@nadeemshaikh.bsky.social
Staff Scientist, Barts Cancer Institute QMUL
Deadline is very soon (12pm November 5th) so get those applications in for a PhD position at Barts Cancer Institute working on radiotherapy resistance , copy number alterations and chromosomal instability !
Apply to join our lab for a very cool PhD project studying radiation therapy, chromosomal instability, DNA repair and cancer evolution!
We are looking for our next PhD student to join us 🤩 www.mcclellandlab.com to understand cancer radiation therapy's impact on DNA damage repair and chromosomal instability. Prestigious funding from CRUK RadNet. Please contact me informally - deadline 5th Nov! crukradnet.colcc.ac.uk/phd-students...
November 3, 2025 at 11:06 AM
Deadline is very soon (12pm November 5th) so get those applications in for a PhD position at Barts Cancer Institute working on radiotherapy resistance , copy number alterations and chromosomal instability !
It’s time for academics and academic institutions to do the right thing
www.soas.ac.uk/about/news/s...
www.soas.ac.uk/about/news/s...
Senate statement on Gaza, Palestine
The Senate has published a ‘Senate Statement on Scholasticide in Gaza, Palestine’.
www.soas.ac.uk
October 31, 2025 at 6:31 PM
It’s time for academics and academic institutions to do the right thing
www.soas.ac.uk/about/news/s...
www.soas.ac.uk/about/news/s...
Reposted
Two back-to-back stories on mitosis led by my incredible postdoc @krunovuk.bsky.social at @institutrb.bsky.social, in which we challenge the gliding model of CENP-E-driven chromosome congression! Today in @natcomms.nature.com
doi.org/10.1038/s414...
doi.org/10.1038/s414...
doi.org/10.1038/s414...
doi.org/10.1038/s414...
October 21, 2025 at 11:14 AM
Two back-to-back stories on mitosis led by my incredible postdoc @krunovuk.bsky.social at @institutrb.bsky.social, in which we challenge the gliding model of CENP-E-driven chromosome congression! Today in @natcomms.nature.com
doi.org/10.1038/s414...
doi.org/10.1038/s414...
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Reposted
A follow-up PhD project is now available: www.findaphd.com/phds/project...
October 21, 2025 at 11:43 AM
A follow-up PhD project is now available: www.findaphd.com/phds/project...
Reposted
Are you a future black leader in cancer? Come join @mirazrahman.bsky.social and my labs @qmbci.bsky.social @kingscollegelondon.bsky.social to work on turning defective cell cycle checkpoints into innovative cancer therapies! Get in touch for more details www.colcc.ac.uk/2026-blic-ph...
October 2, 2025 at 2:59 PM
Are you a future black leader in cancer? Come join @mirazrahman.bsky.social and my labs @qmbci.bsky.social @kingscollegelondon.bsky.social to work on turning defective cell cycle checkpoints into innovative cancer therapies! Get in touch for more details www.colcc.ac.uk/2026-blic-ph...
Apply to join our lab for a very cool PhD project studying radiation therapy, chromosomal instability, DNA repair and cancer evolution!
We are looking for our next PhD student to join us 🤩 www.mcclellandlab.com to understand cancer radiation therapy's impact on DNA damage repair and chromosomal instability. Prestigious funding from CRUK RadNet. Please contact me informally - deadline 5th Nov! crukradnet.colcc.ac.uk/phd-students...
October 2, 2025 at 6:40 PM
Apply to join our lab for a very cool PhD project studying radiation therapy, chromosomal instability, DNA repair and cancer evolution!
Ultimate dream - scientific work leading to major impact on people’s lives, the researchers and Drs involved must be over the moon to treat such a difficult and horrendous disease
www.bbc.co.uk/news/article...
www.bbc.co.uk/news/article...
Huntington's disease successfully treated for first time
One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.
www.bbc.co.uk
September 24, 2025 at 4:01 PM
Ultimate dream - scientific work leading to major impact on people’s lives, the researchers and Drs involved must be over the moon to treat such a difficult and horrendous disease
www.bbc.co.uk/news/article...
www.bbc.co.uk/news/article...
Reposted
We’re excited to share that, after receiving many requests each year from the research community for Oligopaint DNA & RNA FISH probes, we’re piloting a service to design & prepare probes for labs.
Please share with colleagues who may benefit!
ericjoycelab.com/oligopaint-f...
Please share with colleagues who may benefit!
ericjoycelab.com/oligopaint-f...
Oligopaint Probe Requests
In an effort to make Oligopaint FISH probes more broadly available to the research community, we offer DNA and RNA FISH probe design, synthesis, and generation. By dedicating a full-time staff memb…
ericjoycelab.com
September 16, 2025 at 5:44 PM
We’re excited to share that, after receiving many requests each year from the research community for Oligopaint DNA & RNA FISH probes, we’re piloting a service to design & prepare probes for labs.
Please share with colleagues who may benefit!
ericjoycelab.com/oligopaint-f...
Please share with colleagues who may benefit!
ericjoycelab.com/oligopaint-f...
@mcclellandlab.bsky.social hosted Prof Raksawan Deenonpoe from Thailand so she could collaborate with @mollyguscott.bsky.social & I to look for evidence of chromosomal instability in cholangiocarcinoma. Our work is now published in Journal of Pathology.
September 16, 2025 at 8:26 AM
@mcclellandlab.bsky.social hosted Prof Raksawan Deenonpoe from Thailand so she could collaborate with @mollyguscott.bsky.social & I to look for evidence of chromosomal instability in cholangiocarcinoma. Our work is now published in Journal of Pathology.
Ever more depraved , like real world Squid Games, they should be relegated to pariah status
www.bbc.co.uk/news/article...
www.bbc.co.uk/news/article...
Gaza aid site offered a 'women only' day. It didn't stop the killing
Families say mothers Mary Sheikh al-Eid and Khadija Abu Anza were shot while seeking aid from GHF station in southern Gaza.
www.bbc.co.uk
July 26, 2025 at 10:17 PM
Ever more depraved , like real world Squid Games, they should be relegated to pariah status
www.bbc.co.uk/news/article...
www.bbc.co.uk/news/article...
Reposted
New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes?
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Global inhibition of deadenylation stabilizes the transcriptome in mitotic cells
In the presence of cell division errors, mammalian cells can pause in mitosis for tens of hours with little to no transcription, while still requiring continued translation for viability. These unique...
www.biorxiv.org
July 23, 2025 at 10:57 AM
New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes?
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted
We're very proud that our recent PhD graduate (and now postdoc) Rosie Wilkins' study on RNase H2 overexpression in human cells has been published in Oncogene.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Human RNase H2 upregulation counteracts oncogene- and chemotherapy-induced replication stress - Oncogene
Oncogene - Human RNase H2 upregulation counteracts oncogene- and chemotherapy-induced replication stress
www.nature.com
July 23, 2025 at 12:39 PM
We're very proud that our recent PhD graduate (and now postdoc) Rosie Wilkins' study on RNase H2 overexpression in human cells has been published in Oncogene.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Great talk by @susanagodinho.bsky.social at London Cell Club today
July 15, 2025 at 6:08 PM
Great talk by @susanagodinho.bsky.social at London Cell Club today
Two years ago, being accused of bombing a hospital was met with horror and denials. Now, bombing children is met with a shrug
www.bbc.co.uk/news/article...
www.bbc.co.uk/news/article...
Gaza officials say children killed in strike as Israeli military admits 'error'
Six children waiting for water are among those killed in an Israeli air strike, emergency service officials say.
www.bbc.co.uk
July 13, 2025 at 7:10 PM
Two years ago, being accused of bombing a hospital was met with horror and denials. Now, bombing children is met with a shrug
www.bbc.co.uk/news/article...
www.bbc.co.uk/news/article...
Reposted
Interested in population genetics of cancer?
If so, have a look at our manuscript accepted by @genetics-gsa.bsky.social, in which we provide a theoretical assessment of the genetic makeup of cancers before and after treatment!
If so, have a look at our manuscript accepted by @genetics-gsa.bsky.social, in which we provide a theoretical assessment of the genetic makeup of cancers before and after treatment!
Very happy that @alexsteinresearch.bsky.social manuscript on the patterns of genetic heterogeneity before and after treatment is out now:
academic.oup.com/genetics/adv...
We build on and expand the population genetics theory of gITH.
Very worth a read if you are interested in somatic evolution.
academic.oup.com/genetics/adv...
We build on and expand the population genetics theory of gITH.
Very worth a read if you are interested in somatic evolution.
On the patterns of genetic intra-tumour heterogeneity before and after treatment
Abstract. Genetic intra-tumour heterogeneity (gITH) is a universal property of all cancers. It emerges from the interplay of cell division, mutation accumu
academic.oup.com
May 29, 2025 at 3:22 PM
Interested in population genetics of cancer?
If so, have a look at our manuscript accepted by @genetics-gsa.bsky.social, in which we provide a theoretical assessment of the genetic makeup of cancers before and after treatment!
If so, have a look at our manuscript accepted by @genetics-gsa.bsky.social, in which we provide a theoretical assessment of the genetic makeup of cancers before and after treatment!
Reposted
We have a new study out - Distinct functions of PAXX and MRI during chromosomal end joining: iScience www.cell.com/iscience/ful...
Distinct functions of PAXX and MRI during chromosomal end joining
A key step of Canonical-Nonhomologous End Joining is synapsis of DNA double strand
break (DSB) ends, which appears to be mediated by both the DNA-PKcs dimer and XLF
homodimer. We have examined this pr...
www.cell.com
May 22, 2025 at 1:19 PM
We have a new study out - Distinct functions of PAXX and MRI during chromosomal end joining: iScience www.cell.com/iscience/ful...
Reposted
Delighted to share that the results of my main postdoc project are now published in @nature.com
🔗 doi.org/10.1038/s415...
🔗 doi.org/10.1038/s415...
Multigenerational cell tracking of DNA replication and heritable DNA damage - Nature
A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early even...
doi.org
May 21, 2025 at 3:27 PM
Delighted to share that the results of my main postdoc project are now published in @nature.com
🔗 doi.org/10.1038/s415...
🔗 doi.org/10.1038/s415...
Reposted
Hi all, my team institut-curie.org/team/fachine... @institutcurie.bsky.social is looking for a Bioinformatician.
You can find more details about the position here: euraxess.ec.europa.eu/jobs/344508 Is anyone looking for a job in the lovely Paris?
You can find more details about the position here: euraxess.ec.europa.eu/jobs/344508 Is anyone looking for a job in the lovely Paris?
May 21, 2025 at 9:36 AM
Hi all, my team institut-curie.org/team/fachine... @institutcurie.bsky.social is looking for a Bioinformatician.
You can find more details about the position here: euraxess.ec.europa.eu/jobs/344508 Is anyone looking for a job in the lovely Paris?
You can find more details about the position here: euraxess.ec.europa.eu/jobs/344508 Is anyone looking for a job in the lovely Paris?
Reposted
📰 New research shows women of African and South Asian ancestry tend to develop and die of breast cancer at a younger age.
🎥 Prof Claude Chelala at BCI @qmul.ac.uk discusses why we must rethink screening and research to ensure no one is left behind as cancer care advances.
🧪 #medsky #oncosky
🎥 Prof Claude Chelala at BCI @qmul.ac.uk discusses why we must rethink screening and research to ensure no one is left behind as cancer care advances.
🧪 #medsky #oncosky
May 20, 2025 at 11:22 AM
📰 New research shows women of African and South Asian ancestry tend to develop and die of breast cancer at a younger age.
🎥 Prof Claude Chelala at BCI @qmul.ac.uk discusses why we must rethink screening and research to ensure no one is left behind as cancer care advances.
🧪 #medsky #oncosky
🎥 Prof Claude Chelala at BCI @qmul.ac.uk discusses why we must rethink screening and research to ensure no one is left behind as cancer care advances.
🧪 #medsky #oncosky
Reposted
Reposted
If you were shocked by my film on Israeli settlers in the West Bank, you haven’t been paying attention | Louis Theroux
If you were shocked by my film on Israeli settlers in the West Bank, you haven’t been paying attention | Louis Theroux
The response to The Settlers has been humbling. But the ongoing displacement and intimidation of Palestinians is more severe than we could capture, says documentary presenter Louis Theroux
www.theguardian.com
May 10, 2025 at 6:26 AM
If you were shocked by my film on Israeli settlers in the West Bank, you haven’t been paying attention | Louis Theroux
Reposted
Opinion from the FT's Editorial Board: 'The US and European countries that tout Israel as an ally that shares their values have issued barely a word of condemnation. They should be ashamed of their silence, and stop enabling Netanyahu to act with impunity.' www.ft.com/content/f5fd...
May 7, 2025 at 3:16 PM
Opinion from the FT's Editorial Board: 'The US and European countries that tout Israel as an ally that shares their values have issued barely a word of condemnation. They should be ashamed of their silence, and stop enabling Netanyahu to act with impunity.' www.ft.com/content/f5fd...