Martin Kaiser
@mymkaiser.bsky.social
Haemato-oncologist and myeloma researcher; genetics, imaging and more for patient-centric care. Vice-chair UK NCRI Myeloma Trials. EHA European Affairs. Interested in access and HTA. Academic nomad.
Real-world data is a hot topic with medical regulators and payers in oncology. Here is our analysis comparing a change in induction regimens in multiple myeloma in a public healthcare system, using real-world MRD measurement.
www.clinical-lymphoma-myeloma-leukemia.com/article/S215...
www.clinical-lymphoma-myeloma-leukemia.com/article/S215...
Evaluating the real-world value of daratumumab addition to multiple myeloma induction therapy by real-world minimal residual disease assessment and extended genetic profiling
Daratumumab, bortezomib, thalidomide, and dexamethasone (Dara-VTd) is the current
standard of care in Europe based on the CASSIOPEIA study, which demonstrated improved
depth of response and progressio...
www.clinical-lymphoma-myeloma-leukemia.com
November 16, 2025 at 7:10 AM
Real-world data is a hot topic with medical regulators and payers in oncology. Here is our analysis comparing a change in induction regimens in multiple myeloma in a public healthcare system, using real-world MRD measurement.
www.clinical-lymphoma-myeloma-leukemia.com/article/S215...
www.clinical-lymphoma-myeloma-leukemia.com/article/S215...
Reposted by Martin Kaiser
Yet again, we can't afford to let LLMs become a source of epistemic grounding for society.
Largest study of its kind shows AI assistants misrepresent news content 45% of the time – regardless of language or territory
An intensive international study was coordinated by the European Broadcasting Union (EBU) and led by the BBC
www.bbc.co.uk
October 24, 2025 at 5:21 AM
Yet again, we can't afford to let LLMs become a source of epistemic grounding for society.
Very nice reflection on risk and personalisation of medicine in context of regulation
www.gov.uk/government/n...
www.gov.uk/government/n...
Sir David Spiegelhalter: Regulation in an age of personalised medicine
The internationally renowned expert in the calculation and communication of risk and statistics, Sir David Spiegelhalter, discusses the concept of a ‘preference zone’ to frame the demands of safety, e...
www.gov.uk
October 11, 2025 at 5:01 PM
Very nice reflection on risk and personalisation of medicine in context of regulation
www.gov.uk/government/n...
www.gov.uk/government/n...
Reposted by Martin Kaiser
Doesn’t sound ideal.
"We cannot control who sees what, we cannot see what users are doing, and we cannot verify that the software itself is secure," the memo says.
www.reuters.com/business/aer...
"We cannot control who sees what, we cannot see what users are doing, and we cannot verify that the software itself is secure," the memo says.
www.reuters.com/business/aer...
Anduril and Palantir battlefield communication system has deep flaws, Army memo says
The much-needed modernization of the U.S. Army's battlefield communications network being undertaken by Anduril, Palantir and others is rife with "fundamental security" problems and vulnerabilities, and should be treated as a "very high risk," according to a recent internal Army memo.
www.reuters.com
October 4, 2025 at 7:05 PM
Doesn’t sound ideal.
"We cannot control who sees what, we cannot see what users are doing, and we cannot verify that the software itself is secure," the memo says.
www.reuters.com/business/aer...
"We cannot control who sees what, we cannot see what users are doing, and we cannot verify that the software itself is secure," the memo says.
www.reuters.com/business/aer...
Reposted by Martin Kaiser
"Researchers recruited to work in the UK have to fund a £1,035 annual immigration health surcharge, which must be paid in full in advance, as well as up to £1,519 in visa fees. For a family of four, the upfront costs can total almost £30,000."
“The visa fees are so exceedingly high that it makes coming here very difficult for some people. We are fishing for the best scientists in the world. They want to come and work here because we are such an effective country at science, but if we have these high costs, they can and will go elsewhere.”
Is the UK paying the price for world’s most expensive visas? | The Observer
Competing political and economic goals on immigration are resulting in the loss of valuable skills and talent in the UK
observer.co.uk
May 12, 2025 at 10:05 AM
"Researchers recruited to work in the UK have to fund a £1,035 annual immigration health surcharge, which must be paid in full in advance, as well as up to £1,519 in visa fees. For a family of four, the upfront costs can total almost £30,000."
Reposted by Martin Kaiser
🧬 Some promising novel candidates for therapeutic inhibition included:
• BAFF-R and CD39 in HL
• CD25 in MM
• CD27 in CLL
• CD80/86 in DLBCL
• CCR2 in FL and MZL
• BAFF-R and CD39 in HL
• CD25 in MM
• CD27 in CLL
• CD80/86 in DLBCL
• CCR2 in FL and MZL
April 16, 2025 at 11:52 AM
🧬 Some promising novel candidates for therapeutic inhibition included:
• BAFF-R and CD39 in HL
• CD25 in MM
• CD27 in CLL
• CD80/86 in DLBCL
• CCR2 in FL and MZL
• BAFF-R and CD39 in HL
• CD25 in MM
• CD27 in CLL
• CD80/86 in DLBCL
• CCR2 in FL and MZL
Reposted by Martin Kaiser
We are excited to announce our latest publication in #BloodCancerJournal of our Two-Sample MR analysis to investigate causal relationships between 446 immune cell traits and 6 B-cell malignancies
📄 www.nature.com/articles/s41...
#cancer #genetics #Bcell #bloodcancer #drugdiscovery #MR
📄 www.nature.com/articles/s41...
#cancer #genetics #Bcell #bloodcancer #drugdiscovery #MR
Mendelian randomization of immune cell phenotypes to discover potential drug targets for B-cell malignancy - Blood Cancer Journal
Blood Cancer Journal - Mendelian randomization of immune cell phenotypes to discover potential drug targets for B-cell malignancy
www.nature.com
April 16, 2025 at 11:52 AM
We are excited to announce our latest publication in #BloodCancerJournal of our Two-Sample MR analysis to investigate causal relationships between 446 immune cell traits and 6 B-cell malignancies
📄 www.nature.com/articles/s41...
#cancer #genetics #Bcell #bloodcancer #drugdiscovery #MR
📄 www.nature.com/articles/s41...
#cancer #genetics #Bcell #bloodcancer #drugdiscovery #MR
Reposted by Martin Kaiser
Funny how this hypothetical talk of "optimizing" never considers traits like kindness, decency, generosity of spirit... It's always "what does my baby need to get ahead?"
April 6, 2025 at 9:51 AM
Funny how this hypothetical talk of "optimizing" never considers traits like kindness, decency, generosity of spirit... It's always "what does my baby need to get ahead?"
Reposted by Martin Kaiser
Great comment by @sarahoconnorft.ft.com -- I shared some reflection at the start of the year. To me a revaluation of social status is necessary and potentially a reconfiguration of social organisation away from occupational silos.
www.trfetzer.com/generational...
www.trfetzer.com/generational...
March 25, 2025 at 1:12 PM
Great comment by @sarahoconnorft.ft.com -- I shared some reflection at the start of the year. To me a revaluation of social status is necessary and potentially a reconfiguration of social organisation away from occupational silos.
www.trfetzer.com/generational...
www.trfetzer.com/generational...
Reposted by Martin Kaiser
Peto's Paradox—that cancer does not increase with body size of mammals—was wrong.
A new, comprehensive study of 263 species documents higher cancer prevalence with increasing body mass. Some large animals (e.g. elephants) have some built-in genetic adaptations
www.pnas.org/doi/10.1073/... @pnas.org
A new, comprehensive study of 263 species documents higher cancer prevalence with increasing body mass. Some large animals (e.g. elephants) have some built-in genetic adaptations
www.pnas.org/doi/10.1073/... @pnas.org
No evidence for Peto’s paradox in terrestrial vertebrates | PNAS
Larger, longer-lived species are expected to have a higher cancer prevalence compared
to smaller, shorter-lived species owing to the greater number...
www.pnas.org
February 25, 2025 at 6:15 PM
Peto's Paradox—that cancer does not increase with body size of mammals—was wrong.
A new, comprehensive study of 263 species documents higher cancer prevalence with increasing body mass. Some large animals (e.g. elephants) have some built-in genetic adaptations
www.pnas.org/doi/10.1073/... @pnas.org
A new, comprehensive study of 263 species documents higher cancer prevalence with increasing body mass. Some large animals (e.g. elephants) have some built-in genetic adaptations
www.pnas.org/doi/10.1073/... @pnas.org
A pleasure to do this British Society of Haematology podcast on advanced imaging in myeloma for earlier diagnosis and morbidity prevention with Dr Ceri Bygrave.
open.spotify.com/episode/1JAq...
open.spotify.com/episode/1JAq...
Advanced imaging for earlier diagnosis and morbidity prevention in multiple myeloma: A British Society of Haematology and UK Myeloma Society Good Practice Paper
The BSH Guidelines Official Podcast · Episode
open.spotify.com
February 24, 2025 at 10:08 PM
A pleasure to do this British Society of Haematology podcast on advanced imaging in myeloma for earlier diagnosis and morbidity prevention with Dr Ceri Bygrave.
open.spotify.com/episode/1JAq...
open.spotify.com/episode/1JAq...
Reposted by Martin Kaiser
The inverse correlation between articles bemoaning the existential plight of the German economy, and its stock market, is a wonder to behold
February 18, 2025 at 3:16 PM
The inverse correlation between articles bemoaning the existential plight of the German economy, and its stock market, is a wonder to behold
Amazing historical quote in the Economist: 'In part owing to the East German government’s industrial policy in the 1980s, ..., the region (Saxony) has become Europe’s largest maker of microelectronics'
Fantastic DLF podcast on similar topic ('Neuland')
www.economist.com/finance-and-...
Fantastic DLF podcast on similar topic ('Neuland')
www.economist.com/finance-and-...
Can Germany’s economy stage an unexpected recovery?
The situation is dire, but there are glimmers of hope
www.economist.com
January 31, 2025 at 9:21 AM
Amazing historical quote in the Economist: 'In part owing to the East German government’s industrial policy in the 1980s, ..., the region (Saxony) has become Europe’s largest maker of microelectronics'
Fantastic DLF podcast on similar topic ('Neuland')
www.economist.com/finance-and-...
Fantastic DLF podcast on similar topic ('Neuland')
www.economist.com/finance-and-...
Reposted by Martin Kaiser
China wants in on the pedestrian and cyclist crushing game too.
Why this China-made BYD Shark pickup is drawing attention in the global truck market
BYD has not announced plans to sell the Shark in the U.S., but it has entered countries such as Mexico, where GM, Ford and Toyota sell pickup trucks.
www.cnbc.com
January 26, 2025 at 8:00 AM
China wants in on the pedestrian and cyclist crushing game too.
Reposted by Martin Kaiser
If there's something we don't understand I assume transposons are responsible unless proven otherwise
January 18, 2025 at 6:23 PM
If there's something we don't understand I assume transposons are responsible unless proven otherwise
Reposted by Martin Kaiser
Nah, it was dumb as balls. Congress relabeled French fries "freedom fries" because they were mad at France for not joining the war. The justification for attacking Iraq was that they had aluminum tubes. The war had a slogan and the slogan was "Let's Roll!"
There was a sort of tragic grandeur to the War on Terror that the Trump years lack, I think. There’s only so much you can make out artistically of a country shitting itself in a Walmart to own the libs on a national scale.
We got the amazing Battlestar Galactica reboot from the over reaction to 9/11
What amazing SciFi will be inspired by trump's nonsense?
What amazing SciFi will be inspired by trump's nonsense?
January 7, 2025 at 6:25 AM
Nah, it was dumb as balls. Congress relabeled French fries "freedom fries" because they were mad at France for not joining the war. The justification for attacking Iraq was that they had aluminum tubes. The war had a slogan and the slogan was "Let's Roll!"
Reposted by Martin Kaiser
Word of the Day is ‘uhtcearu’ [ucht-kay-aru, with the 'ch' as in the Scottish ‘loch']:
Old English for ‘the sorrow before dawn', when you lie awake in the darkness and worries crowd your mind.
Old English for ‘the sorrow before dawn', when you lie awake in the darkness and worries crowd your mind.
January 10, 2025 at 7:56 AM
Word of the Day is ‘uhtcearu’ [ucht-kay-aru, with the 'ch' as in the Scottish ‘loch']:
Old English for ‘the sorrow before dawn', when you lie awake in the darkness and worries crowd your mind.
Old English for ‘the sorrow before dawn', when you lie awake in the darkness and worries crowd your mind.
Reposted by Martin Kaiser
So many replies like this
January 3, 2025 at 11:42 PM
So many replies like this
Reposted by Martin Kaiser
This session should be considered required viewing for anyone who takes care of myeloma patients -- Audience Member reacts to High Risk Disease session #IMS24
September 26, 2024 at 4:26 PM
This session should be considered required viewing for anyone who takes care of myeloma patients -- Audience Member reacts to High Risk Disease session #IMS24
Reposted by Martin Kaiser
Friendly reminder
December 17, 2023 at 9:33 AM
Friendly reminder