Mauriz Lichtenstein
@mlichtenstein.bsky.social
PhD student Winter lab @ AITHYRA/ CeMM Vienna | interested in using structural and synthetic biology to engineer cellular decision making | previously Baker lab @ IPD and Taylor lab @ mpiib-berlin
Pinned
Bottom-up reconstruction of functional death fold signalosomes reveals a requirement for polymer stability and avidity
Protein polymer scaffolds composed of death fold (DF) proteins are critical to the formation of signalosomes in immune signaling. The biophysical properties that these polymeric scaffolds require for ...
www.science.org
Excited to share our paper out now in @science.org . We (@mpiib-berlin.mpg.de ) engineered single-component signalosomes to dissect the biophysical properties required for signaling. Read on for a cool story on using #synthetic-biology to study #signaling. 1/10
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Mauriz Lichtenstein
1️⃣ @mmbronstein.bsky.social (@aithyra.bsky.social Scientific Director of AI) spoke with @mlichtenstein.bsky.social (@georgwinter.bsky.social's group) about the value of taking on ambitious projects & the key role of collaboration in science.
October 8, 2025 at 8:45 AM
1️⃣ @mmbronstein.bsky.social (@aithyra.bsky.social Scientific Director of AI) spoke with @mlichtenstein.bsky.social (@georgwinter.bsky.social's group) about the value of taking on ambitious projects & the key role of collaboration in science.
Reposted by Mauriz Lichtenstein
Phosphorylation on tyrosines control key pathways in immunity, cancer, and metabolism. For the first time, we can now design proteins that specifically recognize individual phosphotyrosines, even in disordered regions. (1/8)
Preprint: www.biorxiv.org/content/10.1...
Preprint: www.biorxiv.org/content/10.1...
September 30, 2025 at 9:55 PM
Phosphorylation on tyrosines control key pathways in immunity, cancer, and metabolism. For the first time, we can now design proteins that specifically recognize individual phosphotyrosines, even in disordered regions. (1/8)
Preprint: www.biorxiv.org/content/10.1...
Preprint: www.biorxiv.org/content/10.1...
Reposted by Mauriz Lichtenstein
I'm thrilled to join the Stowers Institute to explore how molecular complexity arises during evolution and how it can be designed! If you are a young scientist interested in questions related to protein design and evolution, feel free to e-mail me to learn more about opportunities!
Investigator Announcement: @arvindspillai.bsky.social, PhD, joins the Stowers Institute as our newest Assistant Investigator! His lab will explore how new protein structures emerge during evolution—and how to design novel proteins for future therapies. #SciSky
Read more: bit.ly/3SCZQiM
Read more: bit.ly/3SCZQiM
May 15, 2025 at 10:48 PM
I'm thrilled to join the Stowers Institute to explore how molecular complexity arises during evolution and how it can be designed! If you are a young scientist interested in questions related to protein design and evolution, feel free to e-mail me to learn more about opportunities!
Excited to share our paper out now in @science.org . We (@mpiib-berlin.mpg.de ) engineered single-component signalosomes to dissect the biophysical properties required for signaling. Read on for a cool story on using #synthetic-biology to study #signaling. 1/10
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Bottom-up reconstruction of functional death fold signalosomes reveals a requirement for polymer stability and avidity
Protein polymer scaffolds composed of death fold (DF) proteins are critical to the formation of signalosomes in immune signaling. The biophysical properties that these polymeric scaffolds require for ...
www.science.org
April 25, 2025 at 7:10 AM
Excited to share our paper out now in @science.org . We (@mpiib-berlin.mpg.de ) engineered single-component signalosomes to dissect the biophysical properties required for signaling. Read on for a cool story on using #synthetic-biology to study #signaling. 1/10
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Mauriz Lichtenstein
We did this crazy project where we tried to see if proteins could interact with their mirror image ligand. Seems impossible when proteins need to form 3D structures to interact. But what about if the interaction remains disordered???
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Stereochemistry in the disorder–order continuum of protein interactions - Nature
Studies on protein–protein interactions using proteins containing d- or l-amino acids show that stereoselectivity of binding varies with the degree of disorder within the complex.
www.nature.com
November 27, 2024 at 8:31 PM
We did this crazy project where we tried to see if proteins could interact with their mirror image ligand. Seems impossible when proteins need to form 3D structures to interact. But what about if the interaction remains disordered???
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Mauriz Lichtenstein
@mlichtenstein.bsky.social and I also used facilitated dissociation to make biosensors which are just as modular as those built previously with our LOCKR platform, but which respond 70 times faster.
November 20, 2024 at 8:26 AM
@mlichtenstein.bsky.social and I also used facilitated dissociation to make biosensors which are just as modular as those built previously with our LOCKR platform, but which respond 70 times faster.
Reposted by Mauriz Lichtenstein
Also, if you have ideas for how these switchable cytokines can modulate biological systems in new ways, we would love to discuss/collaborate! We envision these tools could open up a whole new way to explore the biology of transient cytokine signaling.
November 20, 2024 at 8:26 AM
Also, if you have ideas for how these switchable cytokines can modulate biological systems in new ways, we would love to discuss/collaborate! We envision these tools could open up a whole new way to explore the biology of transient cytokine signaling.
Check out this great work by @adambroerman.bsky.social. We describe a general way to control and sense ppi with fast kinetics using #proteindesign. Congrats!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 20, 2024 at 4:50 PM
Check out this great work by @adambroerman.bsky.social. We describe a general way to control and sense ppi with fast kinetics using #proteindesign. Congrats!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...