Mihovil Joja
@mihojoja.bsky.social
MD, PhD student in Mahesh Desai lab in Luxembourg. Studying mucin-degrading bacteria in IBD.
Reposted by Mihovil Joja
@contamclub.bsky.social Undergraduate practical yeast plate (rich media). As well as the Saccharomyces, there's a bacterial contaminant plus unknown orange, red and green contaminants!
February 5, 2026 at 10:15 AM
@contamclub.bsky.social Undergraduate practical yeast plate (rich media). As well as the Saccharomyces, there's a bacterial contaminant plus unknown orange, red and green contaminants!
Reposted by Mihovil Joja
Another piece of the microbe-mucin interactions puzzle 🧩:
Enzyme extracts of our favourite mucin glycan degraders cleave different bonds that occur in mucins. 🍬
Expression of glycoside hydrolases also differs per species. ✂️
To each their own! 😋
#glycotime #microsky #mucin
doi.org/10.1093/glyc...
Enzyme extracts of our favourite mucin glycan degraders cleave different bonds that occur in mucins. 🍬
Expression of glycoside hydrolases also differs per species. ✂️
To each their own! 😋
#glycotime #microsky #mucin
doi.org/10.1093/glyc...
Efficient mucin O-glycan degradation by specific mucin degrading intestinal bacteria: towards understanding enzyme-glycan interactions
Abstract. Intestinal mucin glycan-degrading bacteria are important for mucus turnover, stimulating mucus production, and producing beneficial metabolites.
academic.oup.com
January 27, 2026 at 11:26 AM
Another piece of the microbe-mucin interactions puzzle 🧩:
Enzyme extracts of our favourite mucin glycan degraders cleave different bonds that occur in mucins. 🍬
Expression of glycoside hydrolases also differs per species. ✂️
To each their own! 😋
#glycotime #microsky #mucin
doi.org/10.1093/glyc...
Enzyme extracts of our favourite mucin glycan degraders cleave different bonds that occur in mucins. 🍬
Expression of glycoside hydrolases also differs per species. ✂️
To each their own! 😋
#glycotime #microsky #mucin
doi.org/10.1093/glyc...
Reposted by Mihovil Joja
MaAsLin 3: a comprehensive, flexible framework for microbiome association studies. @hutlab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
MaAsLin 3: refining and extending generalized multivariable linear models for meta-omic association discovery - Nature Methods
MaAsLin 3 is a comprehensive and flexible framework for microbiome association studies with expanded toolsets of statistical models, tests and types of inference.
www.nature.com
January 22, 2026 at 2:05 PM
MaAsLin 3: a comprehensive, flexible framework for microbiome association studies. @hutlab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Mihovil Joja
We just released #anvio v9, "eunice" 🎉
This version represents over 2,000 changes in the codebase since v8, increasing the total number of programs in the anvi'o ecosystem to 176.
Read the release notes:
github.com/merenlab/anv...
Visit our up-to-date web page:
anvio.org
This version represents over 2,000 changes in the codebase since v8, increasing the total number of programs in the anvi'o ecosystem to 176.
Read the release notes:
github.com/merenlab/anv...
Visit our up-to-date web page:
anvio.org
January 20, 2026 at 11:48 AM
We just released #anvio v9, "eunice" 🎉
This version represents over 2,000 changes in the codebase since v8, increasing the total number of programs in the anvi'o ecosystem to 176.
Read the release notes:
github.com/merenlab/anv...
Visit our up-to-date web page:
anvio.org
This version represents over 2,000 changes in the codebase since v8, increasing the total number of programs in the anvi'o ecosystem to 176.
Read the release notes:
github.com/merenlab/anv...
Visit our up-to-date web page:
anvio.org
Reposted by Mihovil Joja
New Perspective!
Navigating the duality of Akkermansia muciniphila
by Erica Grant, Elena Monzel & Mahesh Desai
#microsky #microbiomesky
www.nature.com/articles/s41...
Navigating the duality of Akkermansia muciniphila
by Erica Grant, Elena Monzel & Mahesh Desai
#microsky #microbiomesky
www.nature.com/articles/s41...
January 9, 2026 at 11:07 AM
New Perspective!
Navigating the duality of Akkermansia muciniphila
by Erica Grant, Elena Monzel & Mahesh Desai
#microsky #microbiomesky
www.nature.com/articles/s41...
Navigating the duality of Akkermansia muciniphila
by Erica Grant, Elena Monzel & Mahesh Desai
#microsky #microbiomesky
www.nature.com/articles/s41...
Reposted by Mihovil Joja
Happy New Year – new role! 🎉
We’re looking for a PostDoc to join us in @halllab.bsky.social @unibirmingham.bsky.social.
Full-time, fixed-term to March 2028. Note tight closing date: 11 Jan 2026. CV + cover letter (submit via portal).
Further details 👇
edzz.fa.em3.oraclecloud.com/hcmUI/Candid...
We’re looking for a PostDoc to join us in @halllab.bsky.social @unibirmingham.bsky.social.
Full-time, fixed-term to March 2028. Note tight closing date: 11 Jan 2026. CV + cover letter (submit via portal).
Further details 👇
edzz.fa.em3.oraclecloud.com/hcmUI/Candid...
Research Fellow - Department of Microbes, Infection and Microbiomes - 106849 - Grade 7
To create and contribute to the creation of knowledge by undertaking a specified range of activities as part of an Investigator project funded by Wellcome, focusing on understanding microbial and diet...
edzz.fa.em3.oraclecloud.com
January 7, 2026 at 5:06 PM
Happy New Year – new role! 🎉
We’re looking for a PostDoc to join us in @halllab.bsky.social @unibirmingham.bsky.social.
Full-time, fixed-term to March 2028. Note tight closing date: 11 Jan 2026. CV + cover letter (submit via portal).
Further details 👇
edzz.fa.em3.oraclecloud.com/hcmUI/Candid...
We’re looking for a PostDoc to join us in @halllab.bsky.social @unibirmingham.bsky.social.
Full-time, fixed-term to March 2028. Note tight closing date: 11 Jan 2026. CV + cover letter (submit via portal).
Further details 👇
edzz.fa.em3.oraclecloud.com/hcmUI/Candid...
Reposted by Mihovil Joja
Reposted by Mihovil Joja
Please do not miss the opportunity to apply for this exciting PhD position in my lab.
The project will providefundamental insights into the coevolution of cross-feeding microbial consortia within and between species.
The deadline ends this week.
Looking forward to receiving your application.
The project will providefundamental insights into the coevolution of cross-feeding microbial consortia within and between species.
The deadline ends this week.
Looking forward to receiving your application.
I am very excited to announce that a fully funded PhD position is available in my group.
Topic: Synergistic coevolution in mono-specific and multi-species microbial consortia
Please RT or forward this information to interested candidates.
Deadline: 11.01.26
More info:
shorturl.at/f1TuF
Topic: Synergistic coevolution in mono-specific and multi-species microbial consortia
Please RT or forward this information to interested candidates.
Deadline: 11.01.26
More info:
shorturl.at/f1TuF
January 5, 2026 at 3:36 PM
Please do not miss the opportunity to apply for this exciting PhD position in my lab.
The project will providefundamental insights into the coevolution of cross-feeding microbial consortia within and between species.
The deadline ends this week.
Looking forward to receiving your application.
The project will providefundamental insights into the coevolution of cross-feeding microbial consortia within and between species.
The deadline ends this week.
Looking forward to receiving your application.
Reposted by Mihovil Joja
Hoping everyone's new year fluorescence is clear and bright. Happy #FluorescenceFriday.
January 3, 2026 at 4:52 AM
Hoping everyone's new year fluorescence is clear and bright. Happy #FluorescenceFriday.
Reposted by Mihovil Joja
This is absolutely amazing. #Science 🧪
The proteasome, cleaving proteins into antimicrobial peptides. Biology is a amazing
“There’s something that we thought is so familiar and so well understood, and then boom — something totally unexpected and exciting comes out of it.” — Medzhitov
The proteasome, cleaving proteins into antimicrobial peptides. Biology is a amazing
“There’s something that we thought is so familiar and so well understood, and then boom — something totally unexpected and exciting comes out of it.” — Medzhitov
This scientist found a new trick of the immune system by digging through cellular rubbish
Yifat Merbl is part of Nature’s 10, a list of people who shaped science in 2025.
www.nature.com
December 12, 2025 at 12:04 AM
This is absolutely amazing. #Science 🧪
The proteasome, cleaving proteins into antimicrobial peptides. Biology is a amazing
“There’s something that we thought is so familiar and so well understood, and then boom — something totally unexpected and exciting comes out of it.” — Medzhitov
The proteasome, cleaving proteins into antimicrobial peptides. Biology is a amazing
“There’s something that we thought is so familiar and so well understood, and then boom — something totally unexpected and exciting comes out of it.” — Medzhitov
Reposted by Mihovil Joja
New paper from the lab!
Led by Patrick Müller: we show that non-antibiotic compounds — but not macrolide antibiotics — can induce an efflux pump that protects Bacteroidaceae from macrolides.
A neat twist on drug–microbe interactions... www.tandfonline.com/doi/full/10....
Led by Patrick Müller: we show that non-antibiotic compounds — but not macrolide antibiotics — can induce an efflux pump that protects Bacteroidaceae from macrolides.
A neat twist on drug–microbe interactions... www.tandfonline.com/doi/full/10....
December 9, 2025 at 10:33 AM
New paper from the lab!
Led by Patrick Müller: we show that non-antibiotic compounds — but not macrolide antibiotics — can induce an efflux pump that protects Bacteroidaceae from macrolides.
A neat twist on drug–microbe interactions... www.tandfonline.com/doi/full/10....
Led by Patrick Müller: we show that non-antibiotic compounds — but not macrolide antibiotics — can induce an efflux pump that protects Bacteroidaceae from macrolides.
A neat twist on drug–microbe interactions... www.tandfonline.com/doi/full/10....
Reposted by Mihovil Joja
Akkermansia muciniphila has potential as a next-generation #probiotic, but can it claim a niche and persist in a pre-existing, complex microbial community (in vitro)? 🦠🔍
#microsky
#microbiomesky
#glycotime
link.springer.com/article/10.1...
#microsky
#microbiomesky
#glycotime
link.springer.com/article/10.1...
Probiotic Engraftment of Akkermansia muciniphila in an In Vitro Synthetic Microbial Community - Microbial Ecology
Akkermansia muciniphila is a specialist mucin glycan-degrader that is common in the human gut. A. muciniphila is associated with host health and therefore proposed as a next-generation probiotic. Howe...
link.springer.com
November 20, 2025 at 11:27 AM
Akkermansia muciniphila has potential as a next-generation #probiotic, but can it claim a niche and persist in a pre-existing, complex microbial community (in vitro)? 🦠🔍
#microsky
#microbiomesky
#glycotime
link.springer.com/article/10.1...
#microsky
#microbiomesky
#glycotime
link.springer.com/article/10.1...
Reposted by Mihovil Joja
⏰ Timing is everything 🦠 as you will appreciate listening in!
🤓Keep abreast of the literature as @kknoop.bsky.social gives a round up summary of the review that inspired the latest @mucosalimmunol.bsky.social cover and guess the disease/pathogen with @ashu-mangalam.bsky.social ‘s Med Mystery 🎧
🤓Keep abreast of the literature as @kknoop.bsky.social gives a round up summary of the review that inspired the latest @mucosalimmunol.bsky.social cover and guess the disease/pathogen with @ashu-mangalam.bsky.social ‘s Med Mystery 🎧
Time for the August episode of the #MucosalMonday MI Podcast featuring a discussion with @michael-silverman.bsky.social, @marionbrunck.bsky.social, and Agnes Garcias Lopez; Medical mystery from @ashu-mangalam.bsky.social; and MI research with @kknoop.bsky.social open.spotify.com/show/0Q4Ve1x...
Timing Exposure to Microbes
open.spotify.com
August 26, 2025 at 11:32 AM
⏰ Timing is everything 🦠 as you will appreciate listening in!
🤓Keep abreast of the literature as @kknoop.bsky.social gives a round up summary of the review that inspired the latest @mucosalimmunol.bsky.social cover and guess the disease/pathogen with @ashu-mangalam.bsky.social ‘s Med Mystery 🎧
🤓Keep abreast of the literature as @kknoop.bsky.social gives a round up summary of the review that inspired the latest @mucosalimmunol.bsky.social cover and guess the disease/pathogen with @ashu-mangalam.bsky.social ‘s Med Mystery 🎧
Reposted by Mihovil Joja
Our August issue is online now www.mucosalimmunology.org/current, featuring microbes that are “living on the edge” from Mahesh Desai www.mucosalimmunology.org/article/S193...
August 8, 2025 at 2:06 PM
Our August issue is online now www.mucosalimmunology.org/current, featuring microbes that are “living on the edge” from Mahesh Desai www.mucosalimmunology.org/article/S193...
Reposted by Mihovil Joja
Finally online!
Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG
Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG
Non-antibiotics disrupt colonization resistance against enteropathogens
Nature - Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens, a previously underappreciated side effect of...
rdcu.be
July 16, 2025 at 9:20 PM
Finally online!
Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG
Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG
Reposted by Mihovil Joja
Ever wondered why proton pump inhibitors raise the risk of C. diff infections? Is it due to pH shifts or direct antibacterial effects on the gut microbiome? We think it’s the pH. 🧪💡 Dive into Julia & Patrick’s new paper for the full story! 📖👇 #Microbiome #PPI
doi.org/10.1080/1949...
doi.org/10.1080/1949...
Proton-pump inhibitors increase C. difficile infection risk by altering pH rather than by affecting the gut microbiome based on a bioreactor model
Clostridioides difficile infections often occur after antibiotic use, but they have also been linked to proton-pump inhibitor (PPI) therapy. The underlying mechanism – whether infection risk is due...
doi.org
June 17, 2025 at 12:32 PM
Ever wondered why proton pump inhibitors raise the risk of C. diff infections? Is it due to pH shifts or direct antibacterial effects on the gut microbiome? We think it’s the pH. 🧪💡 Dive into Julia & Patrick’s new paper for the full story! 📖👇 #Microbiome #PPI
doi.org/10.1080/1949...
doi.org/10.1080/1949...
Reposted by Mihovil Joja
Reposted by Mihovil Joja
To celebrate this (urp 🤢) exciting new journal series, we made a mini game!
Can YOU guess which journals are Discover, MDPI, or both? No cheating! There's even the challenge mode "APC Ladder."
Share your high score with the hashtag #ResearchIntegrity
pagoba.shinyapps.io/publi_guess/
FUN!! 🤮 6/n
Can YOU guess which journals are Discover, MDPI, or both? No cheating! There's even the challenge mode "APC Ladder."
Share your high score with the hashtag #ResearchIntegrity
pagoba.shinyapps.io/publi_guess/
FUN!! 🤮 6/n
June 10, 2025 at 5:49 AM
To celebrate this (urp 🤢) exciting new journal series, we made a mini game!
Can YOU guess which journals are Discover, MDPI, or both? No cheating! There's even the challenge mode "APC Ladder."
Share your high score with the hashtag #ResearchIntegrity
pagoba.shinyapps.io/publi_guess/
FUN!! 🤮 6/n
Can YOU guess which journals are Discover, MDPI, or both? No cheating! There's even the challenge mode "APC Ladder."
Share your high score with the hashtag #ResearchIntegrity
pagoba.shinyapps.io/publi_guess/
FUN!! 🤮 6/n
Reposted by Mihovil Joja
Have you discovered the Night Science Podcast yet?
@nightsciencepod.bsky.social
@nightsciencepod.bsky.social
May 15, 2025 at 1:53 PM
Have you discovered the Night Science Podcast yet?
@nightsciencepod.bsky.social
@nightsciencepod.bsky.social
Reposted by Mihovil Joja
Very happy that HiBC is out: rdcu.be/ekSCO 🔥 @natcomms.nature.com Excellent team spirit, and, as always, great driving factor by @tcahitch.bsky.social ⭐⭐⭐⭐ We hope that these bacterial isolates from the human gut will facilitate many studies by others... 😀
HiBC: a publicly available collection of bacterial strains isolated from the human gut
Nature Communications - Here, the authors present and characterise a collection of human gut bacteria including novel taxa associated with health conditions and a large diversity of plasmids. All...
rdcu.be
May 6, 2025 at 1:14 PM
Very happy that HiBC is out: rdcu.be/ekSCO 🔥 @natcomms.nature.com Excellent team spirit, and, as always, great driving factor by @tcahitch.bsky.social ⭐⭐⭐⭐ We hope that these bacterial isolates from the human gut will facilitate many studies by others... 😀
Reposted by Mihovil Joja
Here are our ideas on developing tools and technologies for anaerobic bacteria! We hope you enjoy the read as much as we enjoyed brainstorming on the topic...
Here we share thoughts on next-gen cultivation: rdcu.be/ejPSb. Hope it helps 😄 Was fun to write with great colleagues @lisamaierlab.bsky.social @jselkrig.bsky.social @baerboletta.bsky.social @typaslab.bsky.social @mmmicrobiomelab.bsky.social @leibniz-dsmz.bsky.social @westermannlab.bsky.social
Enabling next-generation anaerobic cultivation through biotechnology to advance functional microbiome research
Nature Biotechnology - Overcoming key hurdles for the development of next-generation anaerobic cultivation methods could have major impacts on microbial community research and applications.
rdcu.be
April 30, 2025 at 6:53 AM
Here are our ideas on developing tools and technologies for anaerobic bacteria! We hope you enjoy the read as much as we enjoyed brainstorming on the topic...
Reposted by Mihovil Joja
Our "Guide to communicating microbiomes in the media", created in collaboration @lindsaybroadbent.bsky.social aims to help navigate the complexities of communicating microbiome research. Click the link in our bio to read and download the guide.
April 11, 2025 at 10:05 AM
Our "Guide to communicating microbiomes in the media", created in collaboration @lindsaybroadbent.bsky.social aims to help navigate the complexities of communicating microbiome research. Click the link in our bio to read and download the guide.
Reposted by Mihovil Joja
Out now! Live bacteria can translocate to other tissues via Colonic goblet cell-associated passages which may be beneficial to the host!
#MicroSky #MicrobiomeSky 🦠
www.nature.com/articles/s41...
#MicroSky #MicrobiomeSky 🦠
www.nature.com/articles/s41...
Colonic goblet cell-associated antigen passages mediate physiologic and beneficial translocation of live gut bacteria in preweaning mice - Nature Microbiology
Colonic goblet cell-associated passages allow translocation of live bacteria to other organs in early life, potentially leading to beneficial impacts.
www.nature.com
April 4, 2025 at 2:09 AM
Out now! Live bacteria can translocate to other tissues via Colonic goblet cell-associated passages which may be beneficial to the host!
#MicroSky #MicrobiomeSky 🦠
www.nature.com/articles/s41...
#MicroSky #MicrobiomeSky 🦠
www.nature.com/articles/s41...
Reposted by Mihovil Joja
My colleague Sjoerd van der Post just quietly dropped a preprint defining the interaction of the #ETEC SPATE family enzyme EatA with intestinal Muc2, providing some fascinating insights into host specific #mucus degradation 🤯. Check it out: www.biorxiv.org/content/10.1...
Degradation of the intestinal mucus layer by the ETEC protease EatA is species specific determined by the structure of the MUC2 mucin
Enterotoxigenic Escherichia coli (ETEC) infections are a leading cause of diarrheal illness, responsible for an estimated 100,000 deaths annually. ETEC pathogenesis is driven by various virulence fact...
www.biorxiv.org
March 22, 2025 at 12:48 AM
My colleague Sjoerd van der Post just quietly dropped a preprint defining the interaction of the #ETEC SPATE family enzyme EatA with intestinal Muc2, providing some fascinating insights into host specific #mucus degradation 🤯. Check it out: www.biorxiv.org/content/10.1...
Reposted by Mihovil Joja
A very helpful read on tackling procrastination @naturebiotech.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
An open letter to graduate students and other procrastinators: it’s time to write - Nature Biotechnology
Nature Biotechnology - An open letter to graduate students and other procrastinators: it’s time to write
www.nature.com
March 19, 2025 at 1:41 PM
A very helpful read on tackling procrastination @naturebiotech.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...