Maurizio De Pittà
@mdepitta.bsky.social
Quodlibetic twitter on #Neuroscience and related #Arts. Luscious #glia supporter, prone to irreverence, and curmudgeonly regarding religions | Neuron-Glial Interactions Group Leader at @KCNhub and @KBI_UHN | Assistant Professor at the University of Toronto
The first @embo.org #Astrocyte #Meeting was a success! Thanks to our excellent speakers, brilliant trainees, & DiBio @unipd.bsky.social volunteers. Looking forward to the next iteration! Laura.Civiero Matthew.Holt Olga.Sin WonSuk.Chun Keith.Murai Valentin.Nagerl @carmenfalcone.bsky.social
April 21, 2025 at 7:18 PM
The first @embo.org #Astrocyte #Meeting was a success! Thanks to our excellent speakers, brilliant trainees, & DiBio @unipd.bsky.social volunteers. Looking forward to the next iteration! Laura.Civiero Matthew.Holt Olga.Sin WonSuk.Chun Keith.Murai Valentin.Nagerl @carmenfalcone.bsky.social
@embo.org Astrocyte has been a success. Our lab at @kcnhub.bsky.social contributed by three posters and one talk in a continuous endeavor to build a #biophysical #theory of the #brain that puts #tripartite neuron #astrocytes circuits at its core @kbi-uhn.bsky.social Thanks team & brilliant peers.
April 19, 2025 at 10:05 AM
@embo.org Astrocyte has been a success. Our lab at @kcnhub.bsky.social contributed by three posters and one talk in a continuous endeavor to build a #biophysical #theory of the #brain that puts #tripartite neuron #astrocytes circuits at its core @kbi-uhn.bsky.social Thanks team & brilliant peers.
Great feedback from a galvanizing community at @embo.org #Astrocye Meeting where @zhenyangsun.bsky.social presented our data unravelling how #anatomy shapes astrocyte function @kcnhub.bsky.social @kbi-uhn.bsky.social
April 17, 2025 at 2:10 PM
Great feedback from a galvanizing community at @embo.org #Astrocye Meeting where @zhenyangsun.bsky.social presented our data unravelling how #anatomy shapes astrocyte function @kcnhub.bsky.social @kbi-uhn.bsky.social
Happy to share this work putting forth the first #computational model of #developing #embrionic cortical circuits. Phenomenal team coordination by Fernando Garcia Moreno @achucarro.bsky.social. @kbi-uhn.bsky.social @kcnhub.bsky.social
Evolutionary convergence of sensory circuits in the pallium of amniotes
The amniote pallium contains sensory circuits that are structurally and functionally equivalent, yet their evolutionary relationship remains unresolved. We used birthdating analysis, single-cell RNA a...
www.science.org
February 15, 2025 at 12:54 AM
Happy to share this work putting forth the first #computational model of #developing #embrionic cortical circuits. Phenomenal team coordination by Fernando Garcia Moreno @achucarro.bsky.social. @kbi-uhn.bsky.social @kcnhub.bsky.social
Reposted by Maurizio De Pittà
Despite carrying a genetic mutation associated with early-onset #Alzheimer’s, a man remained free of dementia symptoms for at least 2 decades longer than expected 👉 genetic variants may explain this remarkable resilience. See more here: www.nature.com/articles/d41...
A man was destined for early Alzheimer’s — these genes might explain his escape
Scientists identify nine genetic variants that could have helped a man to avoid dementia for at least two decades longer than expected.
idp.nature.com
February 14, 2025 at 3:17 PM
Despite carrying a genetic mutation associated with early-onset #Alzheimer’s, a man remained free of dementia symptoms for at least 2 decades longer than expected 👉 genetic variants may explain this remarkable resilience. See more here: www.nature.com/articles/d41...
Reposted by Maurizio De Pittà
I am excited to share the last work of my postdoc as a Swartz Fellow at NYU on the dynamic routing of large-scale cognitive networks in the neocortex! 🌐🧠 Here's a quick breakdown: 🧵
preprint: www.biorxiv.org/content/10.1...
preprint: www.biorxiv.org/content/10.1...
Cognitive networks interactions through communication subspaces in large-scale models of the neocortex
The neocortex-wide neural activity is organized into distinct networks of areas engaged in different cognitive processes. To elucidate the underlying mechanism of flexible network reconfiguration, we ...
www.biorxiv.org
December 7, 2024 at 12:22 AM
I am excited to share the last work of my postdoc as a Swartz Fellow at NYU on the dynamic routing of large-scale cognitive networks in the neocortex! 🌐🧠 Here's a quick breakdown: 🧵
preprint: www.biorxiv.org/content/10.1...
preprint: www.biorxiv.org/content/10.1...
Claiming #LLM will outperform #humans in #neuroscience or #science discovery is #hallucination. LLMs may aid discovery, but producing #foundational #scientific discovery is #serendipitous, which #LLM will confuse with #noise. I see LLMs as more useful for #fact-checking a study tinyurl.com/bdsx2mxa
Large language models surpass human experts in predicting neuroscience results - Nature Human Behaviour
Large language models (LLMs) can synthesize vast amounts of information. Luo et al. show that LLMs—especially BrainGPT, an LLM the authors tuned on the neuroscience literature—outperform experts in pr...
www.nature.com
November 28, 2024 at 10:22 PM
Claiming #LLM will outperform #humans in #neuroscience or #science discovery is #hallucination. LLMs may aid discovery, but producing #foundational #scientific discovery is #serendipitous, which #LLM will confuse with #noise. I see LLMs as more useful for #fact-checking a study tinyurl.com/bdsx2mxa
Reposted by Maurizio De Pittà
My paper is out!! 🎉
"Opponent control of reinforcement by striatal dopamine and serotonin", @Nature
Here, we show that dopamine and serotonin signals form a gas-brake system for reward in the mammalian brain
THREAD ⬇️
1/n
"Opponent control of reinforcement by striatal dopamine and serotonin", @Nature
Here, we show that dopamine and serotonin signals form a gas-brake system for reward in the mammalian brain
THREAD ⬇️
1/n
November 25, 2024 at 4:31 PM
My paper is out!! 🎉
"Opponent control of reinforcement by striatal dopamine and serotonin", @Nature
Here, we show that dopamine and serotonin signals form a gas-brake system for reward in the mammalian brain
THREAD ⬇️
1/n
"Opponent control of reinforcement by striatal dopamine and serotonin", @Nature
Here, we show that dopamine and serotonin signals form a gas-brake system for reward in the mammalian brain
THREAD ⬇️
1/n
Should we just raise the issue with the #Candian equivalent...?
One of the biggest problems in science... 👇
Grant agency: "In the end, despite some initial enthusiasm, the panel was not convinced [...], and expected that the impact in the field is likely to be low."
Despite evidence to the contrary, funding bodies remain confident they can predict the success of a project.
elifesciences.org/articles/13323
Despite evidence to the contrary, funding bodies remain confident they can predict the success of a project.
elifesciences.org/articles/13323
November 25, 2024 at 12:32 AM
Should we just raise the issue with the #Candian equivalent...?
I am giving a 2-day #advanced #course on #astrocyte multiscale #models at the University of #Padua IT on April 10--11, 2025 #EMBO. An excellent opportunity to learn how to include #neuron-#glia #interactions in your models, from molecules to networks. Info & Registration: tinyurl.com/yx3m6acy
November 24, 2024 at 11:06 PM
I am giving a 2-day #advanced #course on #astrocyte multiscale #models at the University of #Padua IT on April 10--11, 2025 #EMBO. An excellent opportunity to learn how to include #neuron-#glia #interactions in your models, from molecules to networks. Info & Registration: tinyurl.com/yx3m6acy
Reposted by Maurizio De Pittà
‘A place of joy’: why scientists are joining the rush to 🦋
Just out in @natureportfolio.bsky.social 👇
www.nature.com/articles/d41...
Just out in @natureportfolio.bsky.social 👇
www.nature.com/articles/d41...
‘A place of joy’: why scientists are joining the rush to Bluesky
Researchers say the social-media platform — an alternative to X — offers more control over the content they see and the people they engage with.
www.nature.com
November 23, 2024 at 9:15 PM
‘A place of joy’: why scientists are joining the rush to 🦋
Just out in @natureportfolio.bsky.social 👇
www.nature.com/articles/d41...
Just out in @natureportfolio.bsky.social 👇
www.nature.com/articles/d41...
Reposted by Maurizio De Pittà
Sooo, there are still a few spots available if you want to give a talk at the third edition of #AstrocyteCafe 😏
#AstrocyteCafe is a FREE monthly seminars starting from January 2025!
Speakers can be of any career stage: just send us an email with your topic to astrocytecafe@gmail.com!😍
#AstrocyteCafe is a FREE monthly seminars starting from January 2025!
Speakers can be of any career stage: just send us an email with your topic to astrocytecafe@gmail.com!😍
November 19, 2024 at 11:55 PM
Sooo, there are still a few spots available if you want to give a talk at the third edition of #AstrocyteCafe 😏
#AstrocyteCafe is a FREE monthly seminars starting from January 2025!
Speakers can be of any career stage: just send us an email with your topic to astrocytecafe@gmail.com!😍
#AstrocyteCafe is a FREE monthly seminars starting from January 2025!
Speakers can be of any career stage: just send us an email with your topic to astrocytecafe@gmail.com!😍
Reposted by Maurizio De Pittà
Paper of the year 2 👉 astrocytes, glucose, lactate, IDO1 and impressive results!
👇👇👇👇👇👇👇👇👇👇👇👇👇
www.science.org/doi/10.1126/...
👇👇👇👇👇👇👇👇👇👇👇👇👇
www.science.org/doi/10.1126/...
Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologies
Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer’s disease (AD), with recent proteomic studies highlighting disrupted glial metabolism in AD. We report that inhibition of indo...
www.science.org
November 20, 2024 at 2:03 PM
Paper of the year 2 👉 astrocytes, glucose, lactate, IDO1 and impressive results!
👇👇👇👇👇👇👇👇👇👇👇👇👇
www.science.org/doi/10.1126/...
👇👇👇👇👇👇👇👇👇👇👇👇👇
www.science.org/doi/10.1126/...
Reposted by Maurizio De Pittà
I'm just learning about Starter Packs. Here's a great place to find them! blueskydirectory.com
The Ultimate Directory of tools and applications for Bluesky
A curated collection of all things relating to the Blue Sky social media platform.
blueskydirectory.com
November 20, 2024 at 11:40 AM
I'm just learning about Starter Packs. Here's a great place to find them! blueskydirectory.com