Matteo Quartagno
@matteoq21.bsky.social
Some Italian guy who lives in London and works on statistical methods in clinical trials for a living.
Reposted by Matteo Quartagno
It’s time for another #ProudestOf Wednesday!
Today, we’re spotlighting Matteo Quartagno (@matteoq21.bsky.social), Principal Research Fellow, who’s advancing the field with innovative trial designs as part of our #Methodology research.
Here’s what Matteo is #ProudestOf from his work at the Unit 👇
Today, we’re spotlighting Matteo Quartagno (@matteoq21.bsky.social), Principal Research Fellow, who’s advancing the field with innovative trial designs as part of our #Methodology research.
Here’s what Matteo is #ProudestOf from his work at the Unit 👇
September 24, 2025 at 9:08 AM
It’s time for another #ProudestOf Wednesday!
Today, we’re spotlighting Matteo Quartagno (@matteoq21.bsky.social), Principal Research Fellow, who’s advancing the field with innovative trial designs as part of our #Methodology research.
Here’s what Matteo is #ProudestOf from his work at the Unit 👇
Today, we’re spotlighting Matteo Quartagno (@matteoq21.bsky.social), Principal Research Fellow, who’s advancing the field with innovative trial designs as part of our #Methodology research.
Here’s what Matteo is #ProudestOf from his work at the Unit 👇
Hot off the press:
bmcmedresmethodol.biomedcentral.com/articles/10....
In this we confirm empirically some theoretical results about using different summary measures in non-inferiority trials with survival outcomes. tldr: RMST beats HR.
bmcmedresmethodol.biomedcentral.com/articles/10....
In this we confirm empirically some theoretical results about using different summary measures in non-inferiority trials with survival outcomes. tldr: RMST beats HR.
Summary measures in non-inferiority clinical trials with a time-to-event outcome: an empirical comparison of power - BMC Medical Research Methodology
Background Time-to-event data is commonly used in non-inferiority clinical trials. While the hazard ratio is a popular summary measure in this context, the difference in restricted mean survival time ...
bmcmedresmethodol.biomedcentral.com
May 27, 2025 at 5:02 PM
Hot off the press:
bmcmedresmethodol.biomedcentral.com/articles/10....
In this we confirm empirically some theoretical results about using different summary measures in non-inferiority trials with survival outcomes. tldr: RMST beats HR.
bmcmedresmethodol.biomedcentral.com/articles/10....
In this we confirm empirically some theoretical results about using different summary measures in non-inferiority trials with survival outcomes. tldr: RMST beats HR.
We still have few places available for our short course on sample size calculations. If interested, book your spot by the end of this week!
The next delivery of our short course on sample size calculations will be on the 4th March 2025. We start from the basics and expand to more complex designs, eg factorial, cluster-randomised, MAMS. With Babak Oskooei, Ian White and Andrew Copas. Info&Registration here:
www.ucl.ac.uk/clinical-tri...
www.ucl.ac.uk/clinical-tri...
Sample size calculations in randomised clinical trials: beyond the basics
www.ucl.ac.uk
February 17, 2025 at 10:26 AM
We still have few places available for our short course on sample size calculations. If interested, book your spot by the end of this week!
Reposted by Matteo Quartagno
This new paper explores the best way to implement reference-based multiple imputation for longitudinal binary data in #ClinicalTrials where data are missing after participants deviate from their assigned treatment.
Read now👇
https://buff.ly/4jJtGOW
@matteoq21.bsky.social @suziecro.bsky.social
Read now👇
https://buff.ly/4jJtGOW
@matteoq21.bsky.social @suziecro.bsky.social
Reference-Based Multiple Imputation for Longitudinal Binary Data
Reference-based multiple imputation provides a practical information anchored tool for inferences about the treatment effect for a treatment policy estimand with a longitudinal binary outcome. The latent multivariate normal model is the preferred implementation.
buff.ly
February 10, 2025 at 12:00 PM
This new paper explores the best way to implement reference-based multiple imputation for longitudinal binary data in #ClinicalTrials where data are missing after participants deviate from their assigned treatment.
Read now👇
https://buff.ly/4jJtGOW
@matteoq21.bsky.social @suziecro.bsky.social
Read now👇
https://buff.ly/4jJtGOW
@matteoq21.bsky.social @suziecro.bsky.social
Reposted by Matteo Quartagno
Hot off the press! 📣📣In this tutorial we illustrate available multiple imputation approaches for handling longitudinal data including when they are clustered within higher level clusters. A reproducible example with R and Stata code provided! #OpenAccess
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Multiple Imputation for Longitudinal Data: A Tutorial
Longitudinal studies are frequently used in medical research and involve collecting repeated measures on individuals over time. Observations from the same individual are invariably correlated and thu....
onlinelibrary.wiley.com
January 27, 2025 at 4:14 AM
Hot off the press! 📣📣In this tutorial we illustrate available multiple imputation approaches for handling longitudinal data including when they are clustered within higher level clusters. A reproducible example with R and Stata code provided! #OpenAccess
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Matteo Quartagno
📢New publication: How to implement Reference-based multiple imputation for longitudinal binary data, lead by
@suziecro.bsky.social with @matteoq21.bsky.social Ian White & James Carpenter onlinelibrary.wiley.com/doi/10.1002/...
@suziecro.bsky.social with @matteoq21.bsky.social Ian White & James Carpenter onlinelibrary.wiley.com/doi/10.1002/...
Reference‐Based Multiple Imputation for Longitudinal Binary Data
Introduction
In clinical trials, a treatment policy strategy is often used to handle treatment nonadherence. However, estimation in this context is complicated when data are missing after treatment .....
onlinelibrary.wiley.com
January 24, 2025 at 12:37 PM
📢New publication: How to implement Reference-based multiple imputation for longitudinal binary data, lead by
@suziecro.bsky.social with @matteoq21.bsky.social Ian White & James Carpenter onlinelibrary.wiley.com/doi/10.1002/...
@suziecro.bsky.social with @matteoq21.bsky.social Ian White & James Carpenter onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Matteo Quartagno
Stata users: if you want to make ‘kmunicate’-style Kaplan–Meier graphs, I’ve just released a Stata package on GitHub.
To get it:
. net from raw.githubusercontent.com/tpmorris/kmu...
User feedback welcome!
1/
To get it:
. net from raw.githubusercontent.com/tpmorris/kmu...
User feedback welcome!
1/
January 17, 2025 at 1:58 PM
Stata users: if you want to make ‘kmunicate’-style Kaplan–Meier graphs, I’ve just released a Stata package on GitHub.
To get it:
. net from raw.githubusercontent.com/tpmorris/kmu...
User feedback welcome!
1/
To get it:
. net from raw.githubusercontent.com/tpmorris/kmu...
User feedback welcome!
1/
Reposted by Matteo Quartagno
Ian White, Professor of Statistical Methods for Medicine at the MRC Clinical Trials Unit at UCL, has been awarded the 2024 Stata Journal Editor's Prize for his outstanding contributions to the journal.
Congratulations Ian! 🎉 Read more about the award 👉 https://buff.ly/3BGCUKU
Congratulations Ian! 🎉 Read more about the award 👉 https://buff.ly/3BGCUKU
January 8, 2025 at 12:00 PM
Ian White, Professor of Statistical Methods for Medicine at the MRC Clinical Trials Unit at UCL, has been awarded the 2024 Stata Journal Editor's Prize for his outstanding contributions to the journal.
Congratulations Ian! 🎉 Read more about the award 👉 https://buff.ly/3BGCUKU
Congratulations Ian! 🎉 Read more about the award 👉 https://buff.ly/3BGCUKU
Reposted by Matteo Quartagno
NEW PREPRINT
A detailed overview of 32 popular predictive performance metrics for prediction models
arxiv.org/abs/2412.10288
A detailed overview of 32 popular predictive performance metrics for prediction models
arxiv.org/abs/2412.10288
December 16, 2024 at 8:44 AM
NEW PREPRINT
A detailed overview of 32 popular predictive performance metrics for prediction models
arxiv.org/abs/2412.10288
A detailed overview of 32 popular predictive performance metrics for prediction models
arxiv.org/abs/2412.10288
Reposted by Matteo Quartagno
Do carrots or mince pies improve reindeer performance? 🦌 & how can #estimands help Santa's delivery improvement research programme? Find out in ✨All I want for Christmas… is a precisely defined research question ✨
trialsjournal.biomedcentral.com/articles/10....
trialsjournal.biomedcentral.com/articles/10....
All I want for Christmas…is a precisely defined research question - Trials
trialsjournal.biomedcentral.com
December 16, 2024 at 11:15 AM
Do carrots or mince pies improve reindeer performance? 🦌 & how can #estimands help Santa's delivery improvement research programme? Find out in ✨All I want for Christmas… is a precisely defined research question ✨
trialsjournal.biomedcentral.com/articles/10....
trialsjournal.biomedcentral.com/articles/10....
Asked ChatGPT to do 3 questions I prepared for various assessments in M.Sc. courses. His scores:
1) 42% (fail)
2) 45% (fail)
3) 72% (pass)
Unsure whether to be happy or worried about it.
Now the plan is to praise it for the wrong answers to train it to lead students astray if they use it.
1) 42% (fail)
2) 45% (fail)
3) 72% (pass)
Unsure whether to be happy or worried about it.
Now the plan is to praise it for the wrong answers to train it to lead students astray if they use it.
December 11, 2024 at 10:54 AM
Asked ChatGPT to do 3 questions I prepared for various assessments in M.Sc. courses. His scores:
1) 42% (fail)
2) 45% (fail)
3) 72% (pass)
Unsure whether to be happy or worried about it.
Now the plan is to praise it for the wrong answers to train it to lead students astray if they use it.
1) 42% (fail)
2) 45% (fail)
3) 72% (pass)
Unsure whether to be happy or worried about it.
Now the plan is to praise it for the wrong answers to train it to lead students astray if they use it.
The next delivery of our short course on sample size calculations will be on the 4th March 2025. We start from the basics and expand to more complex designs, eg factorial, cluster-randomised, MAMS. With Babak Oskooei, Ian White and Andrew Copas. Info&Registration here:
www.ucl.ac.uk/clinical-tri...
www.ucl.ac.uk/clinical-tri...
Sample size calculations in randomised clinical trials: beyond the basics
www.ucl.ac.uk
December 10, 2024 at 1:40 PM
The next delivery of our short course on sample size calculations will be on the 4th March 2025. We start from the basics and expand to more complex designs, eg factorial, cluster-randomised, MAMS. With Babak Oskooei, Ian White and Andrew Copas. Info&Registration here:
www.ucl.ac.uk/clinical-tri...
www.ucl.ac.uk/clinical-tri...
A similar one is leaving emails as unread in the mailbox. I feel dirty if I have just one there sitting unread for over 5 minutes. Meanwhile, my partner right now has 2435 unread emails, the first of which is probably the gmail welcome email.
This is one of those underappreciated personality differences. I don't keep any tabs open; it would make me feel like I had lost control of my life.
i am doing so good at cleaning up my tabs for the end of the year i am down to a mere 45 or 50 open tabs
December 3, 2024 at 12:19 PM
A similar one is leaving emails as unread in the mailbox. I feel dirty if I have just one there sitting unread for over 5 minutes. Meanwhile, my partner right now has 2435 unread emails, the first of which is probably the gmail welcome email.
Reposted by Matteo Quartagno
I am looking for a PhD student in Medical Statistics. This project aims to develop new methods for design of early phase trials starting from monotherapy and progressing into combinations. More details are in the link. Feel free to contact me if any questions. www.findaphd.com/phds/project...
Designs for sequences of early phase (modular) studies at University of Cambridge on FindAPhD.com
PhD Project - Designs for sequences of early phase (modular) studies at University of Cambridge, listed on FindAPhD.com
www.findaphd.com
November 26, 2024 at 11:51 AM
I am looking for a PhD student in Medical Statistics. This project aims to develop new methods for design of early phase trials starting from monotherapy and progressing into combinations. More details are in the link. Feel free to contact me if any questions. www.findaphd.com/phds/project...
Reposted by Matteo Quartagno
We pioneer new designs to make #ClinicalTrials more efficient & robust. Next up in our ‘25 at 25’ series: the Response Over Continuous Intervention (ROCI) design.
Find out how ROCI trials can help researchers avoid choosing arbitrary treatment options 👇 https://buff.ly/3OhgGll
Find out how ROCI trials can help researchers avoid choosing arbitrary treatment options 👇 https://buff.ly/3OhgGll
25 at 25: Optimising treatments using the ROCI design
Over the 25-year history of the MRC Clinical Trials Unit at UCL, our methodology researchers have pioneered several innovative designs to make randomised cli...
youtu.be
November 21, 2024 at 12:45 PM
We pioneer new designs to make #ClinicalTrials more efficient & robust. Next up in our ‘25 at 25’ series: the Response Over Continuous Intervention (ROCI) design.
Find out how ROCI trials can help researchers avoid choosing arbitrary treatment options 👇 https://buff.ly/3OhgGll
Find out how ROCI trials can help researchers avoid choosing arbitrary treatment options 👇 https://buff.ly/3OhgGll
Grant rejections are tough, but can be fun as well:
Reviewer 1: You should have focused more on A!
Rev. 2: You should have focused less on A!
Rev. 3: I don't like A. Why didn't you apply for a project on B?
Decision letter: we won't give you feedback, figure out by yourself why we're rejecting.
Reviewer 1: You should have focused more on A!
Rev. 2: You should have focused less on A!
Rev. 3: I don't like A. Why didn't you apply for a project on B?
Decision letter: we won't give you feedback, figure out by yourself why we're rejecting.
October 30, 2024 at 11:25 AM
Grant rejections are tough, but can be fun as well:
Reviewer 1: You should have focused more on A!
Rev. 2: You should have focused less on A!
Rev. 3: I don't like A. Why didn't you apply for a project on B?
Decision letter: we won't give you feedback, figure out by yourself why we're rejecting.
Reviewer 1: You should have focused more on A!
Rev. 2: You should have focused less on A!
Rev. 3: I don't like A. Why didn't you apply for a project on B?
Decision letter: we won't give you feedback, figure out by yourself why we're rejecting.
We are advertising a new PhD project to work alongside Michelle Clements, Ian White and myself on methods for non-inferiority trials with sparse outcome data. Funding through TMRP available for both UK and international students, please get in touch with me for more info. Deadline: Jan 13th.
Improving Design and Analysis of Non-Inferiority Trials with sparse outcome data at University College London on FindAPhD.com
PhD Project - Improving Design and Analysis of Non-Inferiority Trials with sparse outcome data at University College London, listed on FindAPhD.com
www.findaphd.com
October 23, 2024 at 1:28 PM
We are advertising a new PhD project to work alongside Michelle Clements, Ian White and myself on methods for non-inferiority trials with sparse outcome data. Funding through TMRP available for both UK and international students, please get in touch with me for more info. Deadline: Jan 13th.
Kind of a wasted opportunity to have all 9 digits exactly once in the exponent of 2.
2¹³⁶²⁷⁹⁸⁴¹−1 is the new largest prime discovered to date. Reset the counter!
This is a Mersenne prime, which is a Mersenne number that is also prime. A Mersenne number is of the form
M_n = 2^n-1.
Most of these are not prime. To be prime, n must itself be a prime, but that's not sufficient.
🧪 #🧮
This is a Mersenne prime, which is a Mersenne number that is also prime. A Mersenne number is of the form
M_n = 2^n-1.
Most of these are not prime. To be prime, n must itself be a prime, but that's not sufficient.
🧪 #🧮
October 22, 2024 at 12:29 PM
Kind of a wasted opportunity to have all 9 digits exactly once in the exponent of 2.
My first Bluesky post, and my first blog in ~4 years (!): this is about the unlikely mashup of an Aesop fable and a paper from @timpmorris.bsky.social, @maartenvsmeden.bsky.social and Tra Pham.
The donkey and the load of marginality
Aesop, Marginality Principle, Interactions and Children's Books. In the past few months / years I unfortunately found myself reading less and less. There are only two categories of books that I still ...
theupperquartile.wixsite.com
September 30, 2024 at 12:41 PM
My first Bluesky post, and my first blog in ~4 years (!): this is about the unlikely mashup of an Aesop fable and a paper from @timpmorris.bsky.social, @maartenvsmeden.bsky.social and Tra Pham.