Mark Pepin, MD, PhD
@markpepin.bsky.social
Cardiology Fellow and Physician-Scientist @ Stanford Medicine | HFpEF Genomics, Epigenenomics, & Metabolism | Dad x 4
Reposted by Mark Pepin, MD, PhD
Looking for a #LifeSciences postdoctoral #opportunity? 🧪 Have a look at the EMBO Postdoctoral Fellowships for internationally mobile scientists in #Europe and globally.
Apply before 11 July: www.embo.org/funding/fell...
#research #funding #postdoc
Apply before 11 July: www.embo.org/funding/fell...
#research #funding #postdoc
Fellowships, grants and career support – Postdoctoral Fellowships – EMBO
Supporting internationally mobile postdoctoral researchers in Europe and around the world
www.embo.org
July 4, 2025 at 3:19 PM
Looking for a #LifeSciences postdoctoral #opportunity? 🧪 Have a look at the EMBO Postdoctoral Fellowships for internationally mobile scientists in #Europe and globally.
Apply before 11 July: www.embo.org/funding/fell...
#research #funding #postdoc
Apply before 11 July: www.embo.org/funding/fell...
#research #funding #postdoc
Reposted by Mark Pepin, MD, PhD
Four Reviews on Metabolic alterations in heart failure, free for 1 month!
Cardiac intermediary metabolism: doi.org/10.1038/s415...
Vascular dysfunction: doi.org/10.1038/s415...
Immunometabolism: doi.org/10.1038/s415...
Mechano-energetic uncoupling: doi.org/10.1038/s415...
Cardiac intermediary metabolism: doi.org/10.1038/s415...
Vascular dysfunction: doi.org/10.1038/s415...
Immunometabolism: doi.org/10.1038/s415...
Mechano-energetic uncoupling: doi.org/10.1038/s415...
Cardiac intermediary metabolism in heart failure: substrate use, signalling roles and therapeutic targets - Nature Reviews Cardiology
In this Review, Mericskay and colleagues discuss the role of cardiac intermediary metabolism in heart failure, describing the perturbations in cardiac energy metabolism that occur in heart failure wit...
doi.org
June 27, 2025 at 11:18 AM
Four Reviews on Metabolic alterations in heart failure, free for 1 month!
Cardiac intermediary metabolism: doi.org/10.1038/s415...
Vascular dysfunction: doi.org/10.1038/s415...
Immunometabolism: doi.org/10.1038/s415...
Mechano-energetic uncoupling: doi.org/10.1038/s415...
Cardiac intermediary metabolism: doi.org/10.1038/s415...
Vascular dysfunction: doi.org/10.1038/s415...
Immunometabolism: doi.org/10.1038/s415...
Mechano-energetic uncoupling: doi.org/10.1038/s415...
Gendefekt der Maus deckt neues HFpEF-Therapiekonzept auf!
May 31, 2025 at 8:49 PM
Gendefekt der Maus deckt neues HFpEF-Therapiekonzept auf!
Reposted by Mark Pepin, MD, PhD
Job Alert: Professorship in Human Genetics
Univeristy of Cologne is searching for a new head for human genetics.
www.nature.com/naturecareer...
Univeristy of Cologne is searching for a new head for human genetics.
www.nature.com/naturecareer...
Professorship in Human Genetics (W3) (f/m/d) - Cologne, Nordrhein-Westfalen (DE) job with Faculty of Medicine // University of Cologne | 12839753
Professorship in Human Genetics (W3) (f/m/d) Faculty of Medicine University of Cologne, including the directorship of the Institute for Human Genetics
www.nature.com
May 29, 2025 at 1:58 PM
Job Alert: Professorship in Human Genetics
Univeristy of Cologne is searching for a new head for human genetics.
www.nature.com/naturecareer...
Univeristy of Cologne is searching for a new head for human genetics.
www.nature.com/naturecareer...
Reposted by Mark Pepin, MD, PhD
Just read this lovely paper in @cellpress.bsky.social by @tassimes.bsky.social and colleagues. Nice work! www.cell.com/cell/fulltex...
CXCL12 drives natural variation in coronary artery anatomy across diverse populations
Coronary dominance is a clinically important developmental phenotype that dictates
whether the left or right coronary arteries perfuse the back of the heart. Genome-wide
association studies and downst...
www.cell.com
April 27, 2025 at 4:37 PM
Just read this lovely paper in @cellpress.bsky.social by @tassimes.bsky.social and colleagues. Nice work! www.cell.com/cell/fulltex...
Despite the tragedy of his untimely passing, it is exciting to continue learning from Dr. Lopaschuk’s seasoned perspective on all things cardiac metabolism…
www.ahajournals.org/doi/10.1161/...
www.ahajournals.org/doi/10.1161/...
Impact of Cholesterol on Cardiac Mitochondrial Function | Circulation Research
www.ahajournals.org
April 27, 2025 at 9:28 PM
Despite the tragedy of his untimely passing, it is exciting to continue learning from Dr. Lopaschuk’s seasoned perspective on all things cardiac metabolism…
www.ahajournals.org/doi/10.1161/...
www.ahajournals.org/doi/10.1161/...
“Adaptive, resilient, curious, essential.” Descriptors given by our @the-asci.bsky.social panel discussing the value of physician-scientist trainees
April 26, 2025 at 2:03 PM
“Adaptive, resilient, curious, essential.” Descriptors given by our @the-asci.bsky.social panel discussing the value of physician-scientist trainees
Reposted by Mark Pepin, MD, PhD
Welcome to the 2025 AAP/ASCI/APSA Joint Meeting! We're excited to kick off an inspiring week with physician-scientist leaders, trainees & mentors. Be sure to connect, explore, and tag us along the way! Let’s make it a great one. See you around the conference!
April 24, 2025 at 11:54 PM
Welcome to the 2025 AAP/ASCI/APSA Joint Meeting! We're excited to kick off an inspiring week with physician-scientist leaders, trainees & mentors. Be sure to connect, explore, and tag us along the way! Let’s make it a great one. See you around the conference!
“Dog ate my suit,” and a day before @the-asci.bsky.social. Maybe it was time for an upgrade anyway!
April 24, 2025 at 7:00 PM
“Dog ate my suit,” and a day before @the-asci.bsky.social. Maybe it was time for an upgrade anyway!
Excited to see this in-press! Using single-nuclear RNA-seq & GWAS integration, we can implicate vascular cell types that both enrich CAD risk loci and undergo phenotypic cell state transitions. www.sciencedirect.com/science/arti...
Integrative Analysis of Single-Cell Transcriptomics and Genetic Associations Identify Cell States Associated with Vascular Disease
Vascular diseases are accompanied by alterations in cellular phenotypes which underly disease pathogenesis, with single-cell technologies aiding in th…
www.sciencedirect.com
February 4, 2025 at 11:27 PM
Excited to see this in-press! Using single-nuclear RNA-seq & GWAS integration, we can implicate vascular cell types that both enrich CAD risk loci and undergo phenotypic cell state transitions. www.sciencedirect.com/science/arti...
Going home for the holidays is such a wonderful privilege; here's a glimpse of our first time in years!
January 3, 2025 at 4:30 PM
Going home for the holidays is such a wonderful privilege; here's a glimpse of our first time in years!
One of these days I'll go... or maybe host my own PepCon.
November 28, 2024 at 9:20 PM
One of these days I'll go... or maybe host my own PepCon.
Loved reading this. Truly raising the standard, @jengreitz.bsky.social
New work on congenital heart disease genetics from @jengreitz.bsky.social & co
-regulatory mapping from developmental ❤️ tissues
-implication of valvular interstitial cells & epicardial fibroblasts in CHD pathogenesis
Hugely integrative & comprehensive analysis!
www.medrxiv.org/content/10.1...
-regulatory mapping from developmental ❤️ tissues
-implication of valvular interstitial cells & epicardial fibroblasts in CHD pathogenesis
Hugely integrative & comprehensive analysis!
www.medrxiv.org/content/10.1...
Molecular convergence of risk variants for congenital heart defects leveraging a regulatory map of the human fetal heart
Congenital heart defects (CHD) arise in part due to inherited genetic variants that alter genes and noncoding regulatory elements in the human genome. These variants are thought to act during fetal de...
www.medrxiv.org
November 24, 2024 at 11:24 PM
Loved reading this. Truly raising the standard, @jengreitz.bsky.social
Reposted by Mark Pepin, MD, PhD
O-GlcNAc modification of enzymes within the N-glycosylation pathway impacts their function, revealing a connection between these two distinct glycosylation pathways.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
O-GlcNAcylation modulates expression and abundance of N-glycosylation machinery in an inherited glycosylation disorder
Matheny-Rabun and colleagues discover that O-GlcNAc modification of rate-limiting
enzymes within the N-glycosylation pathway impacts their function, drawing a connection
between two spatially separate...
www.cell.com
November 20, 2024 at 2:02 PM
O-GlcNAc modification of enzymes within the N-glycosylation pathway impacts their function, revealing a connection between these two distinct glycosylation pathways.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by Mark Pepin, MD, PhD
Phase I results of AAV delivery of LAMP2B in Danon disease reported yesterday at #AHA24 & NEJM www.nejm.org/doi/full/10....
Phase 1 Study of AAV9.LAMP2B Gene Therapy in Danon Disease | NEJM
Danon disease is a rare, X-linked, monogenic cardiomyopathy caused by mutations in the lysosomal-associated membrane 2 gene (LAMP2), which encodes the LAMP2 protein. In male patients, the predomina...
www.nejm.org
November 19, 2024 at 6:56 PM
Phase I results of AAV delivery of LAMP2B in Danon disease reported yesterday at #AHA24 & NEJM www.nejm.org/doi/full/10....
Reposted by Mark Pepin, MD, PhD
These are remarkable results and while it is early days, this represents new hope for millions of patients worldwide with severe inherited cardiovascular disease. Congrats to the entire team of investigators.
For more on these disorders, see med.stanford.edu/familyheart
For more on these disorders, see med.stanford.edu/familyheart
November 18, 2024 at 5:36 PM
These are remarkable results and while it is early days, this represents new hope for millions of patients worldwide with severe inherited cardiovascular disease. Congrats to the entire team of investigators.
For more on these disorders, see med.stanford.edu/familyheart
For more on these disorders, see med.stanford.edu/familyheart