Mark McCarthy
LightNews LightNews
banner
markmccarthy985.bsky.social
Mark McCarthy
@markmccarthy985.bsky.social
660 followers 420 following 4 posts

Bluesky newbie. Twitter exile. Previously Professor of Diabetes in Oxford, now heading human genetics at Genentech. Living the California dream. Views my own. #YNWA

Videos
Biology 83%
Medicine 10%
Posts Replies Media Videos

Reposted by Mark I. McCarthy

method1.bsky.social
Jason / Method One @method1.bsky.social · Apr 29
MOGWAI - San Francisco, April 28, 2025

Because sometimes you just want to atomize yourself in a wave of guitar feedback
Mogwai performing at the Regency Ballroom, San Francisco, 4/28/25

markmccarthy985.bsky.social
Mark McCarthy @markmccarthy985.bsky.social · Apr 29
It’s never a bad day when Mogwai shows up in town. First saw them in 1999. Love them more than ever…..

Reposted by Mark I. McCarthy

wafoli.bsky.social
Jane Natoli 🥑🚲🍍 @wafoli.bsky.social · Apr 29
Spending tonight with everyone’s favorite Glaswegians, Mogwai

markmccarthy985.bsky.social
Mark McCarthy @markmccarthy985.bsky.social · Jan 15
Exactly! Continues to amaze/frustrate me to find so many still place confidence in the value of differential expression/proteomics/methylation analyses of case control samples as a basis for causal inference.

Reposted by Mark I. McCarthy

gbart.bsky.social
Giacomo Bartolucci (he) @gbart.bsky.social · Jan 4
1/n Some time ago my colleague, excellent cook, and friend Ivan told me: "Cacio e pepe is the recipe that I screw up more often. Let's make a project studying systematically the physics of that sauce".

Prepare to get cheesy, I'm glad to share the Cacio e paper preprint:

arxiv.org/abs/2501.00536

Reposted by Mark I. McCarthy

kihear.bsky.social
Kimmo Aro @kihear.bsky.social · Dec 4
Long awaited peer review finally completed!! Our paper comparing quantitative metabolomics disease risk prediction with PGS is accepted in Nature Comms!! 🥳🥳
@nightingalehealth.com #riskprediction #metabolomics #nmr #genomics #polygenicscore

www.nature.com/articles/s41...
Metabolomic and genomic prediction of common diseases in 700,217 participants in three national biobanks - Nature Communications
Identifying individuals at high risk for chronic diseases can improve prevention. Here, the authors show that blood metabolomics scores effectively stratify disease risk and compare favorably to genet...
www.nature.com

Reposted by Mark I. McCarthy

wiringthebrain.bsky.social
Kevin Mitchell @wiringthebrain.bsky.social · Nov 28
A wonderful paper from @tonyzador.bsky.social and colleagues: Encoding innate ability through a genomic bottleneck www.pnas.org/doi/10.1073/...
Encoding innate ability through a genomic bottleneck | PNAS
Animals are born with extensive innate behavioral capabilities, which arise from neural circuits encoded in the genome. However, the information ca...
www.pnas.org

markmccarthy985.bsky.social
Mark McCarthy @markmccarthy985.bsky.social · Nov 25
Love this

Reposted by Mark I. McCarthy, Kerry Carrington, Martina Topić

scalzi.com
John Scalzi @scalzi.com · Nov 23
Others have noted it but I will too: The big reason Bluesky is so hot right now is that the people who add value to social media - the frequent posters in specific fields - are here now, talking to each other and creating the "spectator value" that draws users and attention.
Twitter’s heir apparent isn’t X or Threads — it’s Bluesky
The blue bird is dead. Long live the blue sky.
www.theverge.com

markmccarthy985.bsky.social
Mark McCarthy @markmccarthy985.bsky.social · Nov 18
It’s fantastic to find so many friends already here. As others have noted, this feels like the early days of science twitter (RIP).

Reposted by Mark I. McCarthy

alexisbattle.bsky.social
Alexis Battle @alexisbattle.bsky.social · Nov 14
Check out our new work led by @ashton_omdahl discussing matrix factorization across GWAS, accounting for sample overlap. Factors with varying polygenicity, enrichment for cell type / developmental stage... Ashton is speaking at #biodata24 today! www.biorxiv.org/content/10.1...
Sparse matrix factorization of GWAS summary statistics robust to sample sharing improves detection and interpretation of factors with diverse genetic architectures
Complex trait-associated genetic variation is highly pleiotropic. This extensive pleiotropy implies that multi-phenotype analyses are informative for characterizing genetic variation, as they facilita...
www.biorxiv.org

Reposted by Mark I. McCarthy

Reposted by Mark I. McCarthy

Reposted by Mark I. McCarthy

Reposted by Mark I. McCarthy

Reposted by Mark I. McCarthy

Reposted by Mark I. McCarthy

Reposted by Mark I. McCarthy

Reposted by Mark I. McCarthy

Reposted by Mark I. McCarthy

Reposted by Mark I. McCarthy