Maria Dilia Palumbieri
@mariapalumbieri.bsky.social
Passionate about science. Interested in DNA repair and ADP ribosylation
Postdoc at the
MaxPlanck for biology of ageing
@maticlab.bsky.social
Postdoc at the
MaxPlanck for biology of ageing
@maticlab.bsky.social
Pinned
Our latest study on ADP-ribosyl-linked serine ubiquitylation in the context of PARP1 signaling and the DNA damage response is out today in Nature Chemical Biology www.nature.com/articles/s41...
Serine ADPr on histones and PARP1 is a cellular target of ester-linked ubiquitylation - Nature Chemical Biology
RNF114 is an E3 ligase that can recognize ADP-ribose (ADPr) and ubiquitin with separate domains. Using these domains, Kolvenbach and Palumbieri et al. developed a proteomics approach to map ADP-ribosy...
www.nature.com
Thrilled to share my first first-author postdoc publication — a team effort with @aklvnbch.bsky.social. We present the first MS-based evidence of ADP-ribosylation–linked ubiquitin (ADPrUb) in cells after DNA damage.
Grateful for all I’ve learned and looking forward to uncovering more about ADPrUb
Grateful for all I’ve learned and looking forward to uncovering more about ADPrUb
Reposted by Maria Dilia Palumbieri
New important opportunity for young PI recruitment at our Institute! Please spread the news. Interested candidates should carefully check their eligibility for the indicated SNSF funding schemes, before submitting their application 👍 👇
www.imcr.uzh.ch/dam/jcr:3d1f...
www.imcr.uzh.ch/en.html
www.imcr.uzh.ch/dam/jcr:3d1f...
www.imcr.uzh.ch/en.html
www.imcr.uzh.ch
September 11, 2025 at 7:58 PM
New important opportunity for young PI recruitment at our Institute! Please spread the news. Interested candidates should carefully check their eligibility for the indicated SNSF funding schemes, before submitting their application 👍 👇
www.imcr.uzh.ch/dam/jcr:3d1f...
www.imcr.uzh.ch/en.html
www.imcr.uzh.ch/dam/jcr:3d1f...
www.imcr.uzh.ch/en.html
Reposted by Maria Dilia Palumbieri
🎉 Celebrating our Amazing Women in Ageing Research! 🎉
Meet Maria, Postdoc in the Matic Lab 👩🔬 Maria studies how our cells respond to damage in their DNA — the instruction manual of life. 🧬
@mariapalumbieri.bsky.social
Meet Maria, Postdoc in the Matic Lab 👩🔬 Maria studies how our cells respond to damage in their DNA — the instruction manual of life. 🧬
@mariapalumbieri.bsky.social
October 24, 2025 at 11:23 AM
🎉 Celebrating our Amazing Women in Ageing Research! 🎉
Meet Maria, Postdoc in the Matic Lab 👩🔬 Maria studies how our cells respond to damage in their DNA — the instruction manual of life. 🧬
@mariapalumbieri.bsky.social
Meet Maria, Postdoc in the Matic Lab 👩🔬 Maria studies how our cells respond to damage in their DNA — the instruction manual of life. 🧬
@mariapalumbieri.bsky.social
Great to see research on ADPrUb, including our work, being highlighted and summarized here:
Superb News&Views on our recent paper reporting identification of ADP-ribosyl-linked serine ubiquitylation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
ADPr gets a ubiquitin upgrade - Nature Chemical Biology
MARUbylation is a hybrid post-translational protein modification in which mono-ADP-ribosylation acts as a scaffold for sequential mono- and polyubiquitylation. Recent studies illuminate its substrates...
www.nature.com
September 24, 2025 at 12:21 PM
Great to see research on ADPrUb, including our work, being highlighted and summarized here:
ADPr gets a ubiquitin upgrade:
great to see research on ADPrUb, including our work, being highlighted and summarized here:
doi.org/10.1038/s415...
great to see research on ADPrUb, including our work, being highlighted and summarized here:
doi.org/10.1038/s415...
September 24, 2025 at 8:15 AM
ADPr gets a ubiquitin upgrade:
great to see research on ADPrUb, including our work, being highlighted and summarized here:
doi.org/10.1038/s415...
great to see research on ADPrUb, including our work, being highlighted and summarized here:
doi.org/10.1038/s415...
Reposted by Maria Dilia Palumbieri
New Video: "Combining Cancer Drugs to Extend Lifespan" 📹
Watch our new video to learn how researchers at the Max Planck Institute for Biology of Ageing discovered that combining Rapamycin and Trametinib significantly extends the lifespan of mice.
youtu.be/5L-k4v1TRd0
Watch our new video to learn how researchers at the Max Planck Institute for Biology of Ageing discovered that combining Rapamycin and Trametinib significantly extends the lifespan of mice.
youtu.be/5L-k4v1TRd0
Live longer - Combination therapy with Rapamycin and Trametinib prolongs the life of mice
YouTube video by Max Planck Institute for Biology of Ageing
youtu.be
July 24, 2025 at 12:38 PM
New Video: "Combining Cancer Drugs to Extend Lifespan" 📹
Watch our new video to learn how researchers at the Max Planck Institute for Biology of Ageing discovered that combining Rapamycin and Trametinib significantly extends the lifespan of mice.
youtu.be/5L-k4v1TRd0
Watch our new video to learn how researchers at the Max Planck Institute for Biology of Ageing discovered that combining Rapamycin and Trametinib significantly extends the lifespan of mice.
youtu.be/5L-k4v1TRd0
Reposted by Maria Dilia Palumbieri
RNF114 is an E3 ligase that can recognize ADP-ribose (ADPr) and ubiquitin with separate domains. A proteomics approach is developed using these domains to map ADP-ribosyl-ubiquitylation sites
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Serine ADPr on histones and PARP1 is a cellular target of ester-linked ubiquitylation - Nature Chemical Biology
RNF114 is an E3 ligase that can recognize ADP-ribose (ADPr) and ubiquitin with separate domains. Using these domains, Kolvenbach and Palumbieri et al. developed a proteomics approach to map ADP-ribosy...
www.nature.com
July 10, 2025 at 4:56 PM
RNF114 is an E3 ligase that can recognize ADP-ribose (ADPr) and ubiquitin with separate domains. A proteomics approach is developed using these domains to map ADP-ribosyl-ubiquitylation sites
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Maria Dilia Palumbieri
An amazing paper from van der Heden and Ahel groups! They use clever chemistry to identify RNF114 as a dual ADP-ribose-Ubiquitin reader involved in the DNA damage response! Congratulations to first authors Max, @chatrin-c.bsky.social and Rishov. Happy to have a small contribution in this story
Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose - Nature Communications
Deltex E3s modify ADP-ribosylated targets with ubiquitin, creating a hybrid modification whose readers remains unknown. Here, the authors synthesise a non-hydrolysable probe that mimics the modificati...
www.nature.com
July 10, 2025 at 10:44 AM
An amazing paper from van der Heden and Ahel groups! They use clever chemistry to identify RNF114 as a dual ADP-ribose-Ubiquitin reader involved in the DNA damage response! Congratulations to first authors Max, @chatrin-c.bsky.social and Rishov. Happy to have a small contribution in this story
Thrilled to share my first first-author postdoc publication — a team effort with @aklvnbch.bsky.social. We present the first MS-based evidence of ADP-ribosylation–linked ubiquitin (ADPrUb) in cells after DNA damage.
Grateful for all I’ve learned and looking forward to uncovering more about ADPrUb
Grateful for all I’ve learned and looking forward to uncovering more about ADPrUb
Our latest study on ADP-ribosyl-linked serine ubiquitylation in the context of PARP1 signaling and the DNA damage response is out today in Nature Chemical Biology www.nature.com/articles/s41...
Serine ADPr on histones and PARP1 is a cellular target of ester-linked ubiquitylation - Nature Chemical Biology
RNF114 is an E3 ligase that can recognize ADP-ribose (ADPr) and ubiquitin with separate domains. Using these domains, Kolvenbach and Palumbieri et al. developed a proteomics approach to map ADP-ribosy...
www.nature.com
July 10, 2025 at 4:57 AM
Thrilled to share my first first-author postdoc publication — a team effort with @aklvnbch.bsky.social. We present the first MS-based evidence of ADP-ribosylation–linked ubiquitin (ADPrUb) in cells after DNA damage.
Grateful for all I’ve learned and looking forward to uncovering more about ADPrUb
Grateful for all I’ve learned and looking forward to uncovering more about ADPrUb
Reposted by Maria Dilia Palumbieri
Really happy that our paper is finally released. We show that PARP1 and histones are targets of ADP-ribosyl-linked ubiquitylation during DNA damage and describe how to detect the dual modification. Great teamwork with @mariapalumbieri.bsky.social & thanks to everyone involved @maticlab.bsky.social !
Our latest study on ADP-ribosyl-linked serine ubiquitylation in the context of PARP1 signaling and the DNA damage response is out today in Nature Chemical Biology www.nature.com/articles/s41...
Serine ADPr on histones and PARP1 is a cellular target of ester-linked ubiquitylation - Nature Chemical Biology
RNF114 is an E3 ligase that can recognize ADP-ribose (ADPr) and ubiquitin with separate domains. Using these domains, Kolvenbach and Palumbieri et al. developed a proteomics approach to map ADP-ribosy...
www.nature.com
July 9, 2025 at 2:17 PM
Really happy that our paper is finally released. We show that PARP1 and histones are targets of ADP-ribosyl-linked ubiquitylation during DNA damage and describe how to detect the dual modification. Great teamwork with @mariapalumbieri.bsky.social & thanks to everyone involved @maticlab.bsky.social !
Reposted by Maria Dilia Palumbieri
A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th.
my.corehr.com/pls/uoxrecru...
my.corehr.com/pls/uoxrecru...
'
my.corehr.com
May 24, 2025 at 5:29 AM
A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th.
my.corehr.com/pls/uoxrecru...
my.corehr.com/pls/uoxrecru...
Thrilled to have presented our latest work at FEBS PARP 2025! A fantastic joint effort with @aklvnbch.bsky.social . I really enjoyed sharing our results and discussing with experts in the field—looking forward to what’s next!
Many thanks to the organizers for making this great meeting possible!
Many thanks to the organizers for making this great meeting possible!
May 19, 2025 at 10:25 AM
Thrilled to have presented our latest work at FEBS PARP 2025! A fantastic joint effort with @aklvnbch.bsky.social . I really enjoyed sharing our results and discussing with experts in the field—looking forward to what’s next!
Many thanks to the organizers for making this great meeting possible!
Many thanks to the organizers for making this great meeting possible!
Reposted by Maria Dilia Palumbieri
Exciting PhD project available in our lab (time sensitive)! 👇
May 7, 2025 at 12:10 PM
Exciting PhD project available in our lab (time sensitive)! 👇
Reposted by Maria Dilia Palumbieri
Online now - the Spotlight "Modifying the modifiers: ubiquitination of ADP-ribosylation in human cells" from @kfeijszaja.bsky.social and colleagues.
#ADPribosylation #ubiquitination #MARUbylation #crosstalk
authors.elsevier.com/sd/article/S...
#ADPribosylation #ubiquitination #MARUbylation #crosstalk
authors.elsevier.com/sd/article/S...
April 25, 2025 at 3:41 PM
Online now - the Spotlight "Modifying the modifiers: ubiquitination of ADP-ribosylation in human cells" from @kfeijszaja.bsky.social and colleagues.
#ADPribosylation #ubiquitination #MARUbylation #crosstalk
authors.elsevier.com/sd/article/S...
#ADPribosylation #ubiquitination #MARUbylation #crosstalk
authors.elsevier.com/sd/article/S...
Reposted by Maria Dilia Palumbieri
🎥We're excited to share the new film about our graduate programme. Get a glimpse of our faculty & PhD students and explore your research opportunities. Join us as we dive into the world of ageing research and discover what makes the CGA truly unique.👩🔬🧑🎓 www.ageing-grad-school.de/about-us/cal...
Discover the CGA film
Get to know our people & programme
www.ageing-grad-school.de
March 20, 2025 at 3:49 PM
🎥We're excited to share the new film about our graduate programme. Get a glimpse of our faculty & PhD students and explore your research opportunities. Join us as we dive into the world of ageing research and discover what makes the CGA truly unique.👩🔬🧑🎓 www.ageing-grad-school.de/about-us/cal...
Reposted by Maria Dilia Palumbieri
We’ve uploaded a bioRxiv preprint on new antibodies specific for poly-ADP-ribosylation (PARylation). These modular tools were developed and validated through novel applications of our Serine ADP-ribosylation-based technology. www.biorxiv.org/content/10.1...
February 9, 2025 at 9:52 AM
We’ve uploaded a bioRxiv preprint on new antibodies specific for poly-ADP-ribosylation (PARylation). These modular tools were developed and validated through novel applications of our Serine ADP-ribosylation-based technology. www.biorxiv.org/content/10.1...