Makoto T Hayashi
@makotothayashi.bsky.social
Group leader at IFOM-KU joint lab is working on #chromosome biology, especially focusing on #telomere functions. Employed by IFOM ETS and running the lab at Kyoto University.
Pinned
A CPC-shelterin-BTR axis regulates mitotic telomere deprotection
Nature Communications - Here the authors reveal how telomeres signal mitotic stress. A key protein network alters their structure exposing telomere ends to signal mitotic stress, ultimately...
rdcu.be
🧵 1/10 Excited to share our latest study in @naturecomms.bsky.social
"A CPC-shelterin-BTR axis regulates mitotic telomere deprotection" t.co/VypPsLBJCR
"A CPC-shelterin-BTR axis regulates mitotic telomere deprotection" t.co/VypPsLBJCR
Thrilled to see our work published! Huge thanks to all my co-authors for the great collaboration!!
1/Out today in @naturecomms.bsky.social,
“A CPC-shelterin-BTR axis regulates mitotic telomere deprotection”.
Here we identify the mechanism that unwinds telomere-loops (t-loops) during mitotic arrest to activate the DNA damage response and signal mitotic stress.
www.nature.com/articles/s41....
“A CPC-shelterin-BTR axis regulates mitotic telomere deprotection”.
Here we identify the mechanism that unwinds telomere-loops (t-loops) during mitotic arrest to activate the DNA damage response and signal mitotic stress.
www.nature.com/articles/s41....
A CPC-shelterin-BTR axis regulates mitotic telomere deprotection - Nature Communications
Here the authors reveal how telomeres signal mitotic stress. A key protein network alters their structure exposing telomere ends to signal mitotic stress, ultimately triggering a controlled DNA damage...
www.nature.com
March 17, 2025 at 12:50 PM
Thrilled to see our work published! Huge thanks to all my co-authors for the great collaboration!!
🧵 1/10 Excited to share our latest study in @naturecomms.bsky.social
"A CPC-shelterin-BTR axis regulates mitotic telomere deprotection" t.co/VypPsLBJCR
"A CPC-shelterin-BTR axis regulates mitotic telomere deprotection" t.co/VypPsLBJCR
A CPC-shelterin-BTR axis regulates mitotic telomere deprotection
Nature Communications - Here the authors reveal how telomeres signal mitotic stress. A key protein network alters their structure exposing telomere ends to signal mitotic stress, ultimately...
rdcu.be
March 17, 2025 at 12:49 PM
🧵 1/10 Excited to share our latest study in @naturecomms.bsky.social
"A CPC-shelterin-BTR axis regulates mitotic telomere deprotection" t.co/VypPsLBJCR
"A CPC-shelterin-BTR axis regulates mitotic telomere deprotection" t.co/VypPsLBJCR