Lydia Grmai, Ph.D.
@lydiagrmai.bsky.social
biologist by day • asst professor @ yalemed
drosophilist: repro, stress, inter-organ signaling
maker of music • isaiah 43:2 • she/her
drosophilist: repro, stress, inter-organ signaling
maker of music • isaiah 43:2 • she/her
Pinned
Hello fellow scientists, I'm thrilled to share with you a state of the art review that @lydiagrmai.bsky.social , the bsky-less Deepika Vasudevan and I have been working on for >1 year! Keep reading...!
febs.onlinelibrary.wiley.com/doi/full/10....
febs.onlinelibrary.wiley.com/doi/full/10....
FEBS Press
Integrated stress response (ISR), an evolutionarily conserved eukaryotic stress-adaptive program in eukaryotes, has also been implicated in homeostatic functions. This review covers a broad body of l....
febs.onlinelibrary.wiley.com
new review alert❗️
thought your neighborhood stress response pathway (ISR) only dealt in stress adaptation? well, maybe so. but many cells are apparently quite “stressed out” - even healthy ones.
see quoted thread by my phenom co-author @shyama13.bsky.social for a summary! ⬇️
thought your neighborhood stress response pathway (ISR) only dealt in stress adaptation? well, maybe so. but many cells are apparently quite “stressed out” - even healthy ones.
see quoted thread by my phenom co-author @shyama13.bsky.social for a summary! ⬇️
Save the date: our faculty job market series continues this Wed, Nov12 at 3pm ET / 12p PT!
Topic: on-site interviews + seminars
Come hear our junior faculty share our thoughts/advice! There will also be time for Q&A.
Registration link in flyer - see you soon!
Topic: on-site interviews + seminars
Come hear our junior faculty share our thoughts/advice! There will also be time for Q&A.
Registration link in flyer - see you soon!
November 10, 2025 at 7:28 PM
Save the date: our faculty job market series continues this Wed, Nov12 at 3pm ET / 12p PT!
Topic: on-site interviews + seminars
Come hear our junior faculty share our thoughts/advice! There will also be time for Q&A.
Registration link in flyer - see you soon!
Topic: on-site interviews + seminars
Come hear our junior faculty share our thoughts/advice! There will also be time for Q&A.
Registration link in flyer - see you soon!
Reposted by Lydia Grmai, Ph.D.
The Leading Edge Fellows gathered this week to celebrate Zara Weinberg, a beloved member of our community. Our 7th cohort of Leading Edge Fellows (2026) will be named in her honor.
The Zara Weinberg Leading Edge Cohort application is now open! Due Feb 2.
www.leadingedgesymposium.org/apply/
The Zara Weinberg Leading Edge Cohort application is now open! Due Feb 2.
www.leadingedgesymposium.org/apply/
November 5, 2025 at 5:48 PM
The Leading Edge Fellows gathered this week to celebrate Zara Weinberg, a beloved member of our community. Our 7th cohort of Leading Edge Fellows (2026) will be named in her honor.
The Zara Weinberg Leading Edge Cohort application is now open! Due Feb 2.
www.leadingedgesymposium.org/apply/
The Zara Weinberg Leading Edge Cohort application is now open! Due Feb 2.
www.leadingedgesymposium.org/apply/
Reposted by Lydia Grmai, Ph.D.
We built a targeted protein degradation–based system to mimic reproductive age-related aneuploidy in young eggs - revealing how chromosome errors associated with female infertility arise with age. 🧬✨
With @jiyeonleem.bsky.social and our team at Yale MCDB.
Read: www.nature.com/articles/s43...
With @jiyeonleem.bsky.social and our team at Yale MCDB.
Read: www.nature.com/articles/s43...
A versatile cohesion manipulation system probes female reproductive age-related egg aneuploidy - Nature Aging
To study pathways that lead to aneuploidy during aging, the authors provide a system that enables cohesion protein depletion in mouse oocytes, mimicking effects that occur during aging. They uncover a...
www.nature.com
November 4, 2025 at 1:17 PM
We built a targeted protein degradation–based system to mimic reproductive age-related aneuploidy in young eggs - revealing how chromosome errors associated with female infertility arise with age. 🧬✨
With @jiyeonleem.bsky.social and our team at Yale MCDB.
Read: www.nature.com/articles/s43...
With @jiyeonleem.bsky.social and our team at Yale MCDB.
Read: www.nature.com/articles/s43...
I can’t add much to all the beautiful reflections I’ve read about @weinberz.witchlab.org . But one of her many impacts is that she modeled how fierce advocacy and research excellence can exist in one person, neither at the others expense. I hope we can carry her legacy forward on both counts 🤍
Zara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
November 1, 2025 at 7:47 PM
I can’t add much to all the beautiful reflections I’ve read about @weinberz.witchlab.org . But one of her many impacts is that she modeled how fierce advocacy and research excellence can exist in one person, neither at the others expense. I hope we can carry her legacy forward on both counts 🤍
Reposted by Lydia Grmai, Ph.D.
Zara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
October 31, 2025 at 1:18 PM
Zara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
Reposted by Lydia Grmai, Ph.D.
greetings friends!
crowd-sourcing for a group discussion…to my fellow academics, can you reply/DM with answers to the following (either/both)?
- how is genAI (GPT, claude) helping your research/other aspects of your work?
- how are you seeing genAI misused in research/work?
please share/repost!
crowd-sourcing for a group discussion…to my fellow academics, can you reply/DM with answers to the following (either/both)?
- how is genAI (GPT, claude) helping your research/other aspects of your work?
- how are you seeing genAI misused in research/work?
please share/repost!
October 20, 2025 at 10:37 AM
greetings friends!
crowd-sourcing for a group discussion…to my fellow academics, can you reply/DM with answers to the following (either/both)?
- how is genAI (GPT, claude) helping your research/other aspects of your work?
- how are you seeing genAI misused in research/work?
please share/repost!
crowd-sourcing for a group discussion…to my fellow academics, can you reply/DM with answers to the following (either/both)?
- how is genAI (GPT, claude) helping your research/other aspects of your work?
- how are you seeing genAI misused in research/work?
please share/repost!
greetings friends!
crowd-sourcing for a group discussion…to my fellow academics, can you reply/DM with answers to the following (either/both)?
- how is genAI (GPT, claude) helping your research/other aspects of your work?
- how are you seeing genAI misused in research/work?
please share/repost!
crowd-sourcing for a group discussion…to my fellow academics, can you reply/DM with answers to the following (either/both)?
- how is genAI (GPT, claude) helping your research/other aspects of your work?
- how are you seeing genAI misused in research/work?
please share/repost!
October 20, 2025 at 10:37 AM
greetings friends!
crowd-sourcing for a group discussion…to my fellow academics, can you reply/DM with answers to the following (either/both)?
- how is genAI (GPT, claude) helping your research/other aspects of your work?
- how are you seeing genAI misused in research/work?
please share/repost!
crowd-sourcing for a group discussion…to my fellow academics, can you reply/DM with answers to the following (either/both)?
- how is genAI (GPT, claude) helping your research/other aspects of your work?
- how are you seeing genAI misused in research/work?
please share/repost!
Reposted by Lydia Grmai, Ph.D.
The Hopkins Lab (hopkins-lab.com) at the University of Florida is looking to recruit a postdoc to work on the genetics of organ function and evolution across Drosophila and beyond. Please visit tinyurl.com/vcsjpmzz or email me for more info. And please RT or send to anyone who might be interested!
October 15, 2025 at 8:42 PM
The Hopkins Lab (hopkins-lab.com) at the University of Florida is looking to recruit a postdoc to work on the genetics of organ function and evolution across Drosophila and beyond. Please visit tinyurl.com/vcsjpmzz or email me for more info. And please RT or send to anyone who might be interested!
Our faculty job market series continues today on the topic of zoom interviews! Come hear Tyler, Heather, and Duc share their thoughts/advice today at 3pm ET / 12p PT. There will also be time for Q&A.
Registration link in flyer - hope to see you there!
Registration link in flyer - hope to see you there!
October 14, 2025 at 5:34 PM
Our faculty job market series continues today on the topic of zoom interviews! Come hear Tyler, Heather, and Duc share their thoughts/advice today at 3pm ET / 12p PT. There will also be time for Q&A.
Registration link in flyer - hope to see you there!
Registration link in flyer - hope to see you there!
Reposted by Lydia Grmai, Ph.D.
I’m excited to share our new preprint! We built a single-nucleus multiomic (snRNA-seq+snATAC-seq) atlas of leptin receptor-expressing hypothalamic neurons (LepRᴴʸᵖᵒ) and identified conserved cis-regulatory elements overlapping human obesity-linked variants and eQTLs🧠🧬
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Single-nucleus transcriptional and chromatin accessibility profiling of mouse hypothalamic LepRb neurons reveals cell type-specific cis-regulatory elements linked to human obesity
Leptin receptor-expressing hypothalamic neurons (LepRHypo) are key regulators of energy balance, yet a comprehensive, cell type-resolved, chromatin accessibility map of these neurons is lacking. We pr...
www.biorxiv.org
October 8, 2025 at 5:02 PM
I’m excited to share our new preprint! We built a single-nucleus multiomic (snRNA-seq+snATAC-seq) atlas of leptin receptor-expressing hypothalamic neurons (LepRᴴʸᵖᵒ) and identified conserved cis-regulatory elements overlapping human obesity-linked variants and eQTLs🧠🧬
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Lydia Grmai, Ph.D.
The 2025-2026 season of the Ethel Browne Harvey Postdoc Seminar kicks off Friday, September 12 at 3 pm Eastern Time with @sarahcolijn.bsky.social of Washington Univ in St. Louis and @shyama13.bsky.social of the Univ of Pittsburgh. Register today and join us. bit.ly/4649fWS #SDBPostdocSeminar
September 3, 2025 at 6:06 PM
The 2025-2026 season of the Ethel Browne Harvey Postdoc Seminar kicks off Friday, September 12 at 3 pm Eastern Time with @sarahcolijn.bsky.social of Washington Univ in St. Louis and @shyama13.bsky.social of the Univ of Pittsburgh. Register today and join us. bit.ly/4649fWS #SDBPostdocSeminar
Our faculty job market series continues today on the topic of CVs, cover letters, and LORs. Come hear myself, @brisapalikuqilab.bsky.social & @jayeperview.bsky.social share our thoughts/advice today at 3pm ET / 12p PT. There will also be time for Q&A.
Registration link in flyer - see you soon!
Registration link in flyer - see you soon!
August 13, 2025 at 2:38 PM
Our faculty job market series continues today on the topic of CVs, cover letters, and LORs. Come hear myself, @brisapalikuqilab.bsky.social & @jayeperview.bsky.social share our thoughts/advice today at 3pm ET / 12p PT. There will also be time for Q&A.
Registration link in flyer - see you soon!
Registration link in flyer - see you soon!
new review alert❗️
thought your neighborhood stress response pathway (ISR) only dealt in stress adaptation? well, maybe so. but many cells are apparently quite “stressed out” - even healthy ones.
see quoted thread by my phenom co-author @shyama13.bsky.social for a summary! ⬇️
thought your neighborhood stress response pathway (ISR) only dealt in stress adaptation? well, maybe so. but many cells are apparently quite “stressed out” - even healthy ones.
see quoted thread by my phenom co-author @shyama13.bsky.social for a summary! ⬇️
Hello fellow scientists, I'm thrilled to share with you a state of the art review that @lydiagrmai.bsky.social , the bsky-less Deepika Vasudevan and I have been working on for >1 year! Keep reading...!
febs.onlinelibrary.wiley.com/doi/full/10....
febs.onlinelibrary.wiley.com/doi/full/10....
FEBS Press
Integrated stress response (ISR), an evolutionarily conserved eukaryotic stress-adaptive program in eukaryotes, has also been implicated in homeostatic functions. This review covers a broad body of l....
febs.onlinelibrary.wiley.com
July 15, 2025 at 2:51 AM
new review alert❗️
thought your neighborhood stress response pathway (ISR) only dealt in stress adaptation? well, maybe so. but many cells are apparently quite “stressed out” - even healthy ones.
see quoted thread by my phenom co-author @shyama13.bsky.social for a summary! ⬇️
thought your neighborhood stress response pathway (ISR) only dealt in stress adaptation? well, maybe so. but many cells are apparently quite “stressed out” - even healthy ones.
see quoted thread by my phenom co-author @shyama13.bsky.social for a summary! ⬇️
Calling all future faculty! Great news: we are bringing back our EquiSciTrack series with a fantastic lineup of generous new PIs. As before, we’ll be discussing all the major points of the application process.
See flyer below for registration link/QR. We hope to see you there!
See flyer below for registration link/QR. We hope to see you there!
June 24, 2025 at 4:24 PM
Calling all future faculty! Great news: we are bringing back our EquiSciTrack series with a fantastic lineup of generous new PIs. As before, we’ll be discussing all the major points of the application process.
See flyer below for registration link/QR. We hope to see you there!
See flyer below for registration link/QR. We hope to see you there!
Reposted by Lydia Grmai, Ph.D.
⚖️🍿 Alright, let’s do it.
Live-tweeting oral arguments on a motion for preliminary injunction in APHA v NIH.
Hearing starts at 11a EDT today
This is scheduled to be an argument about whether the Court should reinstate terminated NIH grants on topics like DEI, trans health, HIV prevention. But...
Live-tweeting oral arguments on a motion for preliminary injunction in APHA v NIH.
Hearing starts at 11a EDT today
This is scheduled to be an argument about whether the Court should reinstate terminated NIH grants on topics like DEI, trans health, HIV prevention. But...
May 22, 2025 at 2:47 PM
⚖️🍿 Alright, let’s do it.
Live-tweeting oral arguments on a motion for preliminary injunction in APHA v NIH.
Hearing starts at 11a EDT today
This is scheduled to be an argument about whether the Court should reinstate terminated NIH grants on topics like DEI, trans health, HIV prevention. But...
Live-tweeting oral arguments on a motion for preliminary injunction in APHA v NIH.
Hearing starts at 11a EDT today
This is scheduled to be an argument about whether the Court should reinstate terminated NIH grants on topics like DEI, trans health, HIV prevention. But...
Reposted by Lydia Grmai, Ph.D.
They are resegregating academic science
An important point getting overlooked:
When NIH cancels "diversity" grants (e.g., diversity supplements, Fs, Ks, etc), they aren't canceling the grants based on *what* the grant studies.
They're cancelling them based on *who* is doing the research. And that disallowed "who" is anyone not white.
When NIH cancels "diversity" grants (e.g., diversity supplements, Fs, Ks, etc), they aren't canceling the grants based on *what* the grant studies.
They're cancelling them based on *who* is doing the research. And that disallowed "who" is anyone not white.
April 4, 2025 at 1:35 PM
They are resegregating academic science
Reposted by Lydia Grmai, Ph.D.
Beyond thrilled - I’ve been awarded an NSF CAREER grant! I get to continue making scientific discoveries, training the next generation of researchers, & sharing knowledge about the scientific enterprise with the general public. This support is much needed, personally & professionally…let’s GOOO!!!
February 24, 2025 at 11:26 PM
Beyond thrilled - I’ve been awarded an NSF CAREER grant! I get to continue making scientific discoveries, training the next generation of researchers, & sharing knowledge about the scientific enterprise with the general public. This support is much needed, personally & professionally…let’s GOOO!!!
Reposted by Lydia Grmai, Ph.D.
The Zwick lab has landed in the Regenerative Medicine Institute @NYU! I’m incredibly excited to build a team to study how epithelial organs are patterned and remodeled throughout life, with a major focus on the remarkable changes that occur in the maternal body during pregnancy..1/5
February 6, 2025 at 6:16 PM
The Zwick lab has landed in the Regenerative Medicine Institute @NYU! I’m incredibly excited to build a team to study how epithelial organs are patterned and remodeled throughout life, with a major focus on the remarkable changes that occur in the maternal body during pregnancy..1/5
two more days to submit for consideration in this workshop! looking forward to hearing about all your amazing science :)
Calling all fly biologists: submit your research for consideration in the “Everything you ever wanted to know about sex” workshop at #Dros25! We hope to highlight diverse science, researchers, and career stages. Email submission to rmgraze@auburn.edu by Wed, Jan 15.
January 13, 2025 at 8:10 PM
two more days to submit for consideration in this workshop! looking forward to hearing about all your amazing science :)
Reposted by Lydia Grmai, Ph.D.
Eligible? Don’t hesitate to apply for this fantabulous peer mentoring program!
We can’t wait to meet you!
We can’t wait to meet you!
Leading Edge is celebrating a milestone: 100 (actually 102!) new assistant professors!!! 🎉🥳🎊
Learn more about them:
www.leadingedgesymposium.org/fellows/
Applications are now open for the 2025 Leading Edge cohort! (Deadline Feb 3).
You do NOT need to be ready for the job market to apply.
Learn more about them:
www.leadingedgesymposium.org/fellows/
Applications are now open for the 2025 Leading Edge cohort! (Deadline Feb 3).
You do NOT need to be ready for the job market to apply.
January 6, 2025 at 5:58 PM
Eligible? Don’t hesitate to apply for this fantabulous peer mentoring program!
We can’t wait to meet you!
We can’t wait to meet you!
Reposted by Lydia Grmai, Ph.D.
Tigist Tamir PhD has joined the department as a TT Assistant Professor. Her research focuses on Cell signaling mediated regulation of metabolism & oxidative stress response in obesity and cancer. Her lab is accepting applications for RA,postdoc positions & rotation students. @phosphotig.bsky.social
January 6, 2025 at 3:52 PM
Tigist Tamir PhD has joined the department as a TT Assistant Professor. Her research focuses on Cell signaling mediated regulation of metabolism & oxidative stress response in obesity and cancer. Her lab is accepting applications for RA,postdoc positions & rotation students. @phosphotig.bsky.social
Reposted by Lydia Grmai, Ph.D.
#Mentoring is empowering our mentees with a broader network so they can experience different perspectives as they progress in their own journey.
January 4, 2025 at 2:24 AM
#Mentoring is empowering our mentees with a broader network so they can experience different perspectives as they progress in their own journey.
Reposted by Lydia Grmai, Ph.D.
If you are an #EarlyCareerResearcher (grad student, postdoc, pre-tenure faculty) using #Drosophila, consider the new mentoring initiative #FlyCROSS. Complete the survey (link and QR code in the reposts) by Jan 5 to get matched up with a mentor.
Hello #Drosophila early career scientists, this is your chance to get mentored and achieve your goals - a one of a kind opportunity!!! Complete the survey by Jan 5th !!
#holidays #genetics #AcademicTwitter
Please share @fly-eds.bsky.social @flybase.bsky.social @bdsc.bsky.social #ABRCMS24
#holidays #genetics #AcademicTwitter
Please share @fly-eds.bsky.social @flybase.bsky.social @bdsc.bsky.social #ABRCMS24
Calling #Drosophila #grad students #postdoc and #pretenure #faculty to participate in FlyCROSS and be matched by a #mentor of your preferences to gain guidance to your unique needs !
#genetics #dros25 #phdlife
@flybase.bsky.social @bdsc.bsky.social
#genetics #dros25 #phdlife
@flybase.bsky.social @bdsc.bsky.social
December 31, 2024 at 8:38 PM
If you are an #EarlyCareerResearcher (grad student, postdoc, pre-tenure faculty) using #Drosophila, consider the new mentoring initiative #FlyCROSS. Complete the survey (link and QR code in the reposts) by Jan 5 to get matched up with a mentor.
Closing out the year with a new pre-print! Here, we show that the stress response factor Atf4 is more abundant in female vs male fat (likely directly Doublesex-regulated). This dimorphism renders females more resilient to starvation-induced death. Lots of follow-up work to come!
Sexually dimorphic ATF4 expression in the fat confers female stress tolerance in Drosophila melanogaster https://www.biorxiv.org/content/10.1101/2024.12.27.630478v1
December 30, 2024 at 4:14 PM
Closing out the year with a new pre-print! Here, we show that the stress response factor Atf4 is more abundant in female vs male fat (likely directly Doublesex-regulated). This dimorphism renders females more resilient to starvation-induced death. Lots of follow-up work to come!
Calling all fly biologists: submit your research for consideration in the “Everything you ever wanted to know about sex” workshop at #Dros25! We hope to highlight diverse science, researchers, and career stages. Email submission to rmgraze@auburn.edu by Wed, Jan 15.
December 9, 2024 at 9:05 PM
Calling all fly biologists: submit your research for consideration in the “Everything you ever wanted to know about sex” workshop at #Dros25! We hope to highlight diverse science, researchers, and career stages. Email submission to rmgraze@auburn.edu by Wed, Jan 15.