Lucy Bell
@lucyckbell.bsky.social
Infection doctor and clinical lecturer at UCL, researching innate immunity and TB
Reposted by Lucy Bell
Post-TB lung disease - the impact of TB on patients does not end with the course of antibiotics, characterised by substantial long-term pulmonary impairment.
Proposed case definition to support assessments and interventions in research studies 👇
#TBSky #IDSky @thelancetinfdis.bsky.social
Proposed case definition to support assessments and interventions in research studies 👇
#TBSky #IDSky @thelancetinfdis.bsky.social
Post-tuberculosis lung disease: a case definition for use in research studies
Despite growing awareness of the substantial burden of long-term pulmonary impairment
among tuberculosis survivors, marked variability in how post-tuberculosis lung disease
is defined across research ...
www.thelancet.com
November 17, 2025 at 8:47 AM
Post-TB lung disease - the impact of TB on patients does not end with the course of antibiotics, characterised by substantial long-term pulmonary impairment.
Proposed case definition to support assessments and interventions in research studies 👇
#TBSky #IDSky @thelancetinfdis.bsky.social
Proposed case definition to support assessments and interventions in research studies 👇
#TBSky #IDSky @thelancetinfdis.bsky.social
Reposted by Lucy Bell
Great study in @jexpmed.bsky.social.
IFNAR1 or IFNAR2 complete deficiency leads to severe viral disease. Here, authors identify 11 mutations where heterozygosity predisposes to severe viral disease by negative dominance. 1 is common. Paper: rupress.org/jem/article/...
IFNAR1 or IFNAR2 complete deficiency leads to severe viral disease. Here, authors identify 11 mutations where heterozygosity predisposes to severe viral disease by negative dominance. 1 is common. Paper: rupress.org/jem/article/...
A common form of dominant human IFNAR1 deficiency impairs IFN-α and -ω but not IFN-β-dependent immunity | Journal of Experimental Medicine | Rockefeller University Press
This study identifies 11 IFNAR1 alleles impairing IFN-α/ω responses but sparing IFN-β, including an allele common in Southern China (P335del). Heterozygous
rupress.org
December 17, 2024 at 4:50 PM
Great study in @jexpmed.bsky.social.
IFNAR1 or IFNAR2 complete deficiency leads to severe viral disease. Here, authors identify 11 mutations where heterozygosity predisposes to severe viral disease by negative dominance. 1 is common. Paper: rupress.org/jem/article/...
IFNAR1 or IFNAR2 complete deficiency leads to severe viral disease. Here, authors identify 11 mutations where heterozygosity predisposes to severe viral disease by negative dominance. 1 is common. Paper: rupress.org/jem/article/...
The dynamics of interferon-stimulated gene expression in COVID-19 depends on their underlying epigenetics in specific cell types, with impacts on their utility as blood RNA biomarkers. Great to contribute to this study bringing insights into diagnostics from immune cell epigenetics
#IDSky #ImmunoSky
#IDSky #ImmunoSky
Also out now.. after peer review, our analysis of blood transcriptional biomarkers of acute respiratory viral infection leveraging the SARS-CoV-2 human challenge model: www.nature.com/articles/s41...
SARS-CoV-2 human challenge reveals biomarkers that discriminate early and late phases of respiratory viral infections - Nature Communications
It’s not always clear whether blood biomarkers are differentially expressed in the time course of viral infections. In this SARS-CoV-2 human challenge study, the authors identify distinct single-gene ...
www.nature.com
December 2, 2024 at 11:04 AM
The dynamics of interferon-stimulated gene expression in COVID-19 depends on their underlying epigenetics in specific cell types, with impacts on their utility as blood RNA biomarkers. Great to contribute to this study bringing insights into diagnostics from immune cell epigenetics
#IDSky #ImmunoSky
#IDSky #ImmunoSky
Reposted by Lucy Bell
Also out now.. after peer review, our analysis of blood transcriptional biomarkers of acute respiratory viral infection leveraging the SARS-CoV-2 human challenge model: www.nature.com/articles/s41...
SARS-CoV-2 human challenge reveals biomarkers that discriminate early and late phases of respiratory viral infections - Nature Communications
It’s not always clear whether blood biomarkers are differentially expressed in the time course of viral infections. In this SARS-CoV-2 human challenge study, the authors identify distinct single-gene ...
www.nature.com
November 30, 2024 at 2:50 PM
Also out now.. after peer review, our analysis of blood transcriptional biomarkers of acute respiratory viral infection leveraging the SARS-CoV-2 human challenge model: www.nature.com/articles/s41...
Reposted by Lucy Bell
This is a great thread on #UnionConf2024, and useful for anyone who like me was not able to attend.
Thank you for putting together. #TBSky #IDSky
Thank you for putting together. #TBSky #IDSky
#UnionConf2024 has wrapped up, and what a conference! Some fascinating talks and great discussions. Seems to me that there are more questions than answers right now in #TBSky but its an exciting time..
Some personal highlights (in no particular order):
1/10
Some personal highlights (in no particular order):
1/10
November 19, 2024 at 10:07 AM
This is a great thread on #UnionConf2024, and useful for anyone who like me was not able to attend.
Thank you for putting together. #TBSky #IDSky
Thank you for putting together. #TBSky #IDSky
Reposted by Lucy Bell
Results 10 yrs metagenomic sequencing for CNS infections www.nature.com/articles/s41...
Impressive.
Key take homes for me.
1) Time to result still long - addressable but a barrier currently.
2) 10% contamination.
3) Despite using cutting edge tests a "causative" organism found in only 15%.
Impressive.
Key take homes for me.
1) Time to result still long - addressable but a barrier currently.
2) 10% contamination.
3) Despite using cutting edge tests a "causative" organism found in only 15%.
November 13, 2024 at 5:15 PM
Results 10 yrs metagenomic sequencing for CNS infections www.nature.com/articles/s41...
Impressive.
Key take homes for me.
1) Time to result still long - addressable but a barrier currently.
2) 10% contamination.
3) Despite using cutting edge tests a "causative" organism found in only 15%.
Impressive.
Key take homes for me.
1) Time to result still long - addressable but a barrier currently.
2) 10% contamination.
3) Despite using cutting edge tests a "causative" organism found in only 15%.
Looks like a fabulous resource! #IDsky
First paper to share here
Delightful to have been part of the all new UK guidelines on the diagnosis of and management of eosinophilia!
www.journalofinfection.com/article/S016...
Delightful to have been part of the all new UK guidelines on the diagnosis of and management of eosinophilia!
www.journalofinfection.com/article/S016...
UK guidelines for the investigation and management of eosinophilia in returning travellers and migrants
Eosinophilia is a common finding in returning travellers, migrants and other travelling
groups. In this setting it often indicates an underlying helminth infection. Infections
associated with eosinoph...
www.journalofinfection.com
November 12, 2024 at 11:16 PM
Looks like a fabulous resource! #IDsky