Lucy Bell
@lucyckbell.bsky.social
Infection doctor and clinical lecturer at UCL, researching innate immunity and TB
Reposted by Lucy Bell
Great study in @jexpmed.bsky.social.
IFNAR1 or IFNAR2 complete deficiency leads to severe viral disease. Here, authors identify 11 mutations where heterozygosity predisposes to severe viral disease by negative dominance. 1 is common. Paper: rupress.org/jem/article/...
IFNAR1 or IFNAR2 complete deficiency leads to severe viral disease. Here, authors identify 11 mutations where heterozygosity predisposes to severe viral disease by negative dominance. 1 is common. Paper: rupress.org/jem/article/...
A common form of dominant human IFNAR1 deficiency impairs IFN-α and -ω but not IFN-β-dependent immunity | Journal of Experimental Medicine | Rockefeller University Press
This study identifies 11 IFNAR1 alleles impairing IFN-α/ω responses but sparing IFN-β, including an allele common in Southern China (P335del). Heterozygous
rupress.org
December 17, 2024 at 4:50 PM
Great study in @jexpmed.bsky.social.
IFNAR1 or IFNAR2 complete deficiency leads to severe viral disease. Here, authors identify 11 mutations where heterozygosity predisposes to severe viral disease by negative dominance. 1 is common. Paper: rupress.org/jem/article/...
IFNAR1 or IFNAR2 complete deficiency leads to severe viral disease. Here, authors identify 11 mutations where heterozygosity predisposes to severe viral disease by negative dominance. 1 is common. Paper: rupress.org/jem/article/...
Working on type I interferons in TB and would love to be added 😊
November 20, 2024 at 9:35 AM
Working on type I interferons in TB and would love to be added 😊