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longweibai.bsky.social
Longwei Bai
@longweibai.bsky.social
51 followers 100 following 6 posts
PhD student @Leulier's lab @igfl @ENS de Lyon
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Reposted by Longwei Bai
francoisleulier.bsky.social
Latest from the lab. MS previously preprinted (see below) and finally published in print @dev-journal.bsky.social
journals.biologists.com/dev/article/...

Review process via @reviewcommons.org and @dev-journal.bsky.social
1/3
January 26, 2026 at 12:44 PM
Reposted by Longwei Bai
drosostalis.bsky.social
📣First preprint of the lab📣 Did that really happen?😅

Enteric neurons, aka somatic postmitotic cells, must hold on to their sex identity tight, to deliver a tuned response to signals from the ovary that instruct the animal to engage sex-matched behavioural programmes.
www.biorxiv.org/content/10.6...
Genetic sex of enteric neurons enables ovarian relaxin to gate maternal gut plasticity
Animals must align intestinal plasticity and feeding with reproductive state, yet the checkpoint that gates these adaptations is unknown. Here we show that an ovary-to-enteric-neuron axis gates the on...
www.biorxiv.org
January 11, 2026 at 3:32 PM
Reposted by Longwei Bai
bardinlab.bsky.social
Happy 2026 everyone- the time has come to apply!
Registration for this exciting Dev Bio conference is until the end of January!
bardinlab.bsky.social Bardin Lab @bardinlab.bsky.social · Dec 3
Come join us in beautiful Roscoff for this Conference Jacques Monod on Developmental regulation: from molecular to ecological niches
May 18-22, 2026 Roscoff, France
Abstract deadline: January 31, 2026
Apply here: cjm.sb-roscoff.fr/en
January 3, 2026 at 3:47 PM
Reposted by Longwei Bai
francoisleulier.bsky.social
Revised refereed preprint:
www.biorxiv.org/content/10.1...
Revision work lead by @longweibai.bsky.social

Our work reveals how the #microbiota helps buffer #malnutrition: L. plantarum sustains intestinal activity of the steroid hormone ecdysone, expanding the midgut and supporting systemic growth.
November 23, 2025 at 6:19 AM
longweibai.bsky.social
Thank you so much, Dafni😀😀
November 9, 2025 at 10:53 AM
longweibai.bsky.social
Thank you, Julie 😀😀
November 9, 2025 at 10:17 AM
Reposted by Longwei Bai
francoisleulier.bsky.social
Latest from the lab by @longweibai.bsky.social
www.biorxiv.org/content/10.1...
1/6
A nutrient-sensitive enterokine coordinates developmental plasticity through inter-organ signalling
Animal survival in fluctuating environments depend on the ability to modulate their developmental pace in response to nutrient availability, a phenomenon known as developmental plasticity. In Drosophi...
www.biorxiv.org
November 8, 2025 at 2:44 PM
longweibai.bsky.social
Congratulations🥳🥳
October 9, 2025 at 5:22 PM
Reposted by Longwei Bai
colombani-lab.bsky.social
Excited to share our last paper describing how intestinal stem cell migration promotes gut regeneration!
www.nature.com/articles/s41...
Pvf1-Pvr-mediated crosstalk between trachea and gut guides intestinal stem cell migration to promote gut regeneration - Nature Communications
Adult stem cells often reside in specialized niches that they exit upon injury. Here they show that in Drosophila, after damage the gut-associated trachea produces the PDGF-VEGF-related ligand Pvf1, which acts as a guidance cue directing ISC migration toward injury sites.
www.nature.com
September 29, 2025 at 8:04 PM
longweibai.bsky.social
Thank you, bro🙈🙈
September 17, 2025 at 5:05 PM
longweibai.bsky.social
Huge thanks to the whole Leulier's team for their support over the past four years😘😘
September 17, 2025 at 7:43 AM
Reposted by Longwei Bai
corderolab.bsky.social
Very happy and proud to share the latest work from our lab.
Neuroendocrine control of intestinal regeneration through the vascular niche.
www.sciencedirect.com/science/arti...
Neuroendocrine control of intestinal regeneration through the vascular niche in Drosophila
Robust and controlled intestinal regeneration involves reciprocal interactions between the intestinal epithelium and its microenvironment. Here, we id…
www.sciencedirect.com
July 21, 2025 at 6:19 PM
Reposted by Longwei Bai
bardinlab.bsky.social
Very happy to share our latest lab publication!
The hard work of @bboumard.bsky.social, Gwenn Le Meur and collaborators!
Cell-type-specific nucleotide sharing through gap junctions impacts sensitivity to replication stress in Drosophila: Developmental Cell
authors.elsevier.com/a/1lDFi_Yv6z...
Cell-type-specific nucleotide sharing through gap junctions impacts sensitivity to replication stress in Drosophila
Boumard et al. demonstrate gap-junction-dependent tissue-scale nucleotide sharing, which impacts cellular sensitivity to perturbation of nucleotide homeostasis and replication stress. Drosophila wing ...
www.cell.com
June 5, 2025 at 4:47 PM
longweibai.bsky.social
Lastest work from Zhai's lab. mTORC1-mediated nutrient sensing orchestrates metabolic processes to maintain physiological homeostasis and influences organismal ageing in Drosophila.
www.biorxiv.org/content/10.1...
An Adipose mTORC1 Effector Links Nutrient-induced Ribosomal Protein Translation to Lifespan in Drosophila
Mechanistic target of rapamycin complex 1 (mTORC1) senses nutrient availability to orchestrate metabolic processes critical for physiological homeostasis and organismal ageing. While mTORC1 preferenti...
www.biorxiv.org
May 31, 2025 at 1:14 PM
Reposted by Longwei Bai
iatsenkolab.bsky.social
Happy to share our new preprint! We explored the mechanisms underlying differences between male and female #Drosophila in susceptibility to intestinal #infection. #symbiosky
#immunity #AcademicSky #insect #symbiosis
Sex Differences in Drosophila Intestinal Metabolism Contribute to Sexually Dimorphic Infection Outcome and Alter Gut Pathogen Virulence
Sexual dimorphism in infection outcomes is a pervasive phenomenon, the underlying mechanisms of which remain incompletely understood. Here, utilizing Pseudomonas entomophila intestinal infection in Dr...
www.biorxiv.org
May 28, 2025 at 7:46 PM
Reposted by Longwei Bai
erictopol.bsky.social
Discovery of a gut hormone that regulates protein intake, sleep, and influences lifespan
www.nature.com/articles/s42... (open-access) @natmetabolism.nature.com
www.nature.com/articles/s42... in mice and flies
April 14, 2025 at 2:41 PM
Reposted by Longwei Bai
iatsenkolab.bsky.social
Happy to share our latest minireview on
Drosophila symbionts in infection: when a friend becomes an enemy | Infection and Immunity journals.asm.org/doi/10.1128/...
#immunity #infection #antimicrobialpeptides #microbiome #Drosophila #AcademicSky #insect #endosymbiont #symbiosis
Drosophila symbionts in infection: when a friend becomes an enemy | Infection and Immunity
Occupying the interface between host and environment, host-associated microbes play essential roles in interactions with pathogens and influence disease progression (1–4). Considering that most entry ...
journals.asm.org
April 4, 2025 at 1:07 PM
Reposted by Longwei Bai
alexgouldlab.bsky.social
Our latest preprint…Adrien Franchet, Yuhong Jin et al @crick.ac.uk show that circulating glutamine drives brain sparing during nutrient restriction. Great collab with labs of Yaël Grosjean and Ian Gilmore.
#metabolism #Drosophila #neuralstemcells

www.biorxiv.org/content/10.1...
Glutamine-glutamate intercellular relay model for brain sparing
April 4, 2025 at 7:51 AM
Reposted by Longwei Bai
francoisleulier.bsky.social
The lab will be represented at #Dros25.
@longweibai.bsky.social presenting in the Physiology session on Friday at 5pm after I give the intro to his talk in a plenary Thursday morning 😉.
#Drosophila #microbiome friends, let’s catch up and go see Longwei ´s talk he has a really cool story to share.
March 17, 2025 at 2:27 PM
Reposted by Longwei Bai
iatsenkolab.bsky.social
And enjoyed it even more when highlighting it in Cell Host Microbe
Free access link here:
authors.elsevier.com/a/1kbY9_hwRX...
authors.elsevier.com
February 14, 2025 at 4:05 PM
Reposted by Longwei Bai
francoisleulier.bsky.social
Latest preprint from the Lab, co-led by Cathy Ramos, lecturer in the team and pushed to the final line by Longwei Bai, Ph’d candidate.

Deals with microbiome (what else… 😉), guts and steroid hormone in flies.

#MicroSky #MicrobiomeSky #SymbioSky #DevBio #Drosofeed
www.biorxiv.org/content/10.1...
Drosophila larval gut transcriptome reveals a microbe-mediated intestinal tissue growth via Ecdysone during adaptive growth
Juvenile growth is an adaptive trait since chronic undernutrition leads to reduced growth rate and delayed maturation. Using Drosophila and mouse gnotobiotic models, we previously established the evol...
www.biorxiv.org
February 8, 2025 at 1:25 PM