Laurie Parker
@llparker100.bsky.social
Chemical biLOLogist, proteomics enthusiast. MN 🔬🧪🧫 views expressed are my personal ones.
Reposted by Laurie Parker
The appearance of large language models caused a drastic shift in the vocabulary of academic writing, according to an analysis in #ScienceAdvances of more than 15 million biomedical abstracts published from 2010 to 2024.
Learn more:
Learn more:
Delving into LLM-assisted writing in biomedical publications through excess vocabulary
Large language models (LLMs) like ChatGPT can generate and revise text with human-level performance. These models come with clear limitations, can produce inaccurate information, and reinforce existing biases.
scim.ag
August 10, 2025 at 2:07 PM
The appearance of large language models caused a drastic shift in the vocabulary of academic writing, according to an analysis in #ScienceAdvances of more than 15 million biomedical abstracts published from 2010 to 2024.
Learn more:
Learn more:
Reposted by Laurie Parker
Reposted by Laurie Parker
Nice containerization of AlphaFold, Boltz, and Chai, and calculation of metrics (including our ipSAE score for protein-protein interactions). www.biorxiv.org/content/10.1...
August 8, 2025 at 6:11 PM
Nice containerization of AlphaFold, Boltz, and Chai, and calculation of metrics (including our ipSAE score for protein-protein interactions). www.biorxiv.org/content/10.1...
Reposted by Laurie Parker
Reposted by Laurie Parker
The National Institutes of Health’s budget, and structure, would be preserved under a Senate bill for the 2026 fiscal year.
With boost to NIH budget, Senate panel rejects Trump’s plan to slash agency
Republicans on spending committee push back against proposed reorganization and overhead cuts
scim.ag
July 31, 2025 at 9:37 PM
The National Institutes of Health’s budget, and structure, would be preserved under a Senate bill for the 2026 fiscal year.
Reposted by Laurie Parker
Russell Vought wanted to shut down all extramural grants from NIH in this current fiscal year, putting stop to ALL research across the US. Someone in the White House had better sense. But Vought is a dangerous man, who will stop at nothing to destroy science in America. www.wsj.com/politics/pol...
Trump Administration Scraps Effort to Pause Health-Research Funding
The administration halted and then restarted billions in new research grants flowing from the National Institutes of Health.
www.wsj.com
July 30, 2025 at 9:50 AM
Russell Vought wanted to shut down all extramural grants from NIH in this current fiscal year, putting stop to ALL research across the US. Someone in the White House had better sense. But Vought is a dangerous man, who will stop at nothing to destroy science in America. www.wsj.com/politics/pol...
Reposted by Laurie Parker
This NIH grant Multi-Year Funding ploy really makes you wonder what equally obscure and equally harmful stuff Vought is advancing across all the other functions of federal government, doesn’t it?
July 29, 2025 at 9:17 PM
This NIH grant Multi-Year Funding ploy really makes you wonder what equally obscure and equally harmful stuff Vought is advancing across all the other functions of federal government, doesn’t it?
Reposted by Laurie Parker
This is just so screwed up.
July 29, 2025 at 5:35 PM
This is just so screwed up.
Reposted by Laurie Parker
Researchers’ chances of winning a grant from the National Institutes of Health have dropped under a new policy. scim.ag/4f7uew2
Odds of winning NIH grants plummet as new funding policy and spending delays bite
Funding multiyear grants up front will sharply cut number of investigators receiving awards
scim.ag
July 28, 2025 at 10:10 PM
Researchers’ chances of winning a grant from the National Institutes of Health have dropped under a new policy. scim.ag/4f7uew2
Reposted by Laurie Parker
This 4th percentile funding cutoff for the NCI is so very catastrophic. Assuming a 4th percentile payline corresponds to a ~5% success rate, it would take 27 grant submissions to have an 80% chance of getting just one funded. At the current submission cap of 6 apps as PI/year that means 4.5 years
July 24, 2025 at 1:32 AM
This 4th percentile funding cutoff for the NCI is so very catastrophic. Assuming a 4th percentile payline corresponds to a ~5% success rate, it would take 27 grant submissions to have an 80% chance of getting just one funded. At the current submission cap of 6 apps as PI/year that means 4.5 years
Reposted by Laurie Parker
NIH staff are being required to fully fund ~ 50% of their grants. This means that all 4 years of an award will be paid out of this appropriation. This will help them get the appropriated funds spent, but will mean they can only fund (1/2 + 1/4*1/2) = 5/8 has many grants as they would have otherwise.
July 22, 2025 at 6:02 PM
NIH staff are being required to fully fund ~ 50% of their grants. This means that all 4 years of an award will be paid out of this appropriation. This will help them get the appropriated funds spent, but will mean they can only fund (1/2 + 1/4*1/2) = 5/8 has many grants as they would have otherwise.
Reposted by Laurie Parker
Multi-year funding at NIH: The Quickening drugmonkey.wordpress.com/2025/07/23/m...
Multi-year funding at NIH: The Quickening
I have apparently missed some major NIH moves that are related to my thoughts about the Multi-Year Funded Research Project Grant (RF1) mechanism. It turns out that this strategy of multi-year fundi…
drugmonkey.wordpress.com
July 23, 2025 at 11:01 PM
Multi-year funding at NIH: The Quickening drugmonkey.wordpress.com/2025/07/23/m...
Reposted by Laurie Parker
"NIH has ..implemented a new policy requiring that at least one-half of the remaining funds for competing research project grants (RPGs) in FY 2025 be used to upfront fund RPG competing awards. Upfront funding provides the funding for all years of the approved project period .. from one fiscal year"
If anyone is interested NCI posted their FY25 funding strategy today www.cancer.gov/grants-train...
Reasonable to assume other NIH institutes will follow the same guidelines
Reasonable to assume other NIH institutes will follow the same guidelines
Funding Policy - Research Grants
NCI funding policy for research project grant (RPG) awards reflects the funding goals of the institute, NIH, and HHS.
www.cancer.gov
July 23, 2025 at 11:15 PM
"NIH has ..implemented a new policy requiring that at least one-half of the remaining funds for competing research project grants (RPGs) in FY 2025 be used to upfront fund RPG competing awards. Upfront funding provides the funding for all years of the approved project period .. from one fiscal year"
Reposted by Laurie Parker
Talk about your grant lotteries. Earn a 4%ile for a chance at a four year award....or bupkis. whee.
July 23, 2025 at 11:22 PM
Talk about your grant lotteries. Earn a 4%ile for a chance at a four year award....or bupkis. whee.
Reposted by Laurie Parker
There is a rally on MONDAY at 4:30 PM to stand up for NIH. Please join.
Many NIH employees signed the Bethesda Declaration, objecting to the destruction of NIH. The Trump NIH Director asked the signers to meet. The rally follows that meeting, in support.
actionnetwork.org/ev...
Many NIH employees signed the Bethesda Declaration, objecting to the destruction of NIH. The Trump NIH Director asked the signers to meet. The rally follows that meeting, in support.
actionnetwork.org/ev...
July 19, 2025 at 3:30 PM
There is a rally on MONDAY at 4:30 PM to stand up for NIH. Please join.
Many NIH employees signed the Bethesda Declaration, objecting to the destruction of NIH. The Trump NIH Director asked the signers to meet. The rally follows that meeting, in support.
actionnetwork.org/ev...
Many NIH employees signed the Bethesda Declaration, objecting to the destruction of NIH. The Trump NIH Director asked the signers to meet. The rally follows that meeting, in support.
actionnetwork.org/ev...
Had such a good time at aps2025.org, so good to see everyone! A real community.
APS2025 – Peptides Rising
aps2025.org
June 20, 2025 at 6:24 AM
Had such a good time at aps2025.org, so good to see everyone! A real community.
Reposted by Laurie Parker
I started reading DrugMonkey when I was NIGMS Director. I will impressed with his command of NIH policies and practices and his clear, direct voice to scientists and to NIH.
We started the NIGMS Feedback
Loop blog (the first IC director-written blog) in large parts because of his example.
1/n
We started the NIGMS Feedback
Loop blog (the first IC director-written blog) in large parts because of his example.
1/n
You are not alone in this NIH grant game drugmonkey.wordpress.com/2025/05/21/y...
You are not alone in this NIH grant game
Many years ago I started blogging about the NIH system of extramural grant award because of my own frustrations with the system, as it appeared to be to me. Over time, I realized that there were a …
drugmonkey.wordpress.com
May 23, 2025 at 4:22 AM
I started reading DrugMonkey when I was NIGMS Director. I will impressed with his command of NIH policies and practices and his clear, direct voice to scientists and to NIH.
We started the NIGMS Feedback
Loop blog (the first IC director-written blog) in large parts because of his example.
1/n
We started the NIGMS Feedback
Loop blog (the first IC director-written blog) in large parts because of his example.
1/n
Drugmonkey is one of the people who helped me feel not alone when I was starting out. NIH funding is a tough game (even tougher now?) but it’s normal for it to feel hard!
You are not alone in this NIH grant game drugmonkey.wordpress.com/2025/05/21/y...
You are not alone in this NIH grant game
Many years ago I started blogging about the NIH system of extramural grant award because of my own frustrations with the system, as it appeared to be to me. Over time, I realized that there were a …
drugmonkey.wordpress.com
May 21, 2025 at 10:27 PM
Drugmonkey is one of the people who helped me feel not alone when I was starting out. NIH funding is a tough game (even tougher now?) but it’s normal for it to feel hard!
Reposted by Laurie Parker
This is the way we recommend everyone make targeted proteomics assays. We've been doing it this way for 6-7 years now but only recently got around to putting a manuscript together. We use it for everything from SRM to PRM. Great work by @deannaplubell.bsky.social
Data Independent Acquisition to Inform the Development of Targeted Proteomics Assays Using a Triple Quadrupole Mass Spectrometer pubs.acs.org/doi/10....
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#proteomics #prot-paper
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#proteomics #prot-paper
May 11, 2025 at 4:05 PM
This is the way we recommend everyone make targeted proteomics assays. We've been doing it this way for 6-7 years now but only recently got around to putting a manuscript together. We use it for everything from SRM to PRM. Great work by @deannaplubell.bsky.social
Reposted by Laurie Parker
👇🏼👇🏼👇🏼
Every week @lizneeley.bsky.social’s newsletter manages to pull coherence & moral clarity out of the wreckage of the news around science and higher ed. This week it feels particularly impressive (and more critical than ever!) to have pulled off.
buttondown.com/liminalcreat...
buttondown.com/liminalcreat...
Week 16
Figuring out what to focus on now & next in science and higher ed
buttondown.com
May 10, 2025 at 7:56 PM
👇🏼👇🏼👇🏼
Reposted by Laurie Parker
The NIH firings, and the grant cuts that pushed out scientists at universities, have already had DEVASTATING effects on US science.
Research labs are precious and fragile things. Taking one key person out can break it.
ICYMI, we pub’d an essay on this:
altnih4science.subst...
Research labs are precious and fragile things. Taking one key person out can break it.
ICYMI, we pub’d an essay on this:
altnih4science.subst...
It takes years to build a science lab
Productive science requires a great team, and that team develops together. That's one reason chaotic interference is dangerous for science.
altnih4science.substack.com
April 27, 2025 at 1:14 PM
The NIH firings, and the grant cuts that pushed out scientists at universities, have already had DEVASTATING effects on US science.
Research labs are precious and fragile things. Taking one key person out can break it.
ICYMI, we pub’d an essay on this:
altnih4science.subst...
Research labs are precious and fragile things. Taking one key person out can break it.
ICYMI, we pub’d an essay on this:
altnih4science.subst...
Reposted by Laurie Parker
UPDATE: The NIH has made this move official — publishing the draft we reported on this morning
www.statnews.com/2025/04/21/t...
www.statnews.com/2025/04/21/t...
April 21, 2025 at 7:13 PM
UPDATE: The NIH has made this move official — publishing the draft we reported on this morning
www.statnews.com/2025/04/21/t...
www.statnews.com/2025/04/21/t...
Reposted by Laurie Parker
“Instead of cutting red tape, they are strangling grantees with it,”
DOGE is killing NIH. They froze the panels that determine funding. Then they froze funding announcements. Then they cancelled 100s of funded grants. Now they're freezing the remaining funded grants by making it impossible to actually access the funds
www.washingtonpost.com/politics/202...
www.washingtonpost.com/politics/202...
DOGE begins to freeze health-care payments for extra review
DOGE is putting new curbs on billions of dollars in federal grants, requiring officials to manually review and approve payments that were previously routine.
www.washingtonpost.com
April 18, 2025 at 12:49 PM
“Instead of cutting red tape, they are strangling grantees with it,”
This guy is doing his best
April 7, 2025 at 2:25 PM
This guy is doing his best
