The Le Group
@leresearchgroup.bsky.social
A young research group at York University in Toronto. Specializing in synthesis and catalytic activation of fluorinated molecules.
http://leresearchgroup.com
http://leresearchgroup.com
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The Le Group
@leresearchgroup.bsky.social
· Mar 14
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🚨Paper alert!🚨 Our review on the synthesis of carbamoyl fluorides and their use in fluoride-enabled reactions was just published in @synthesis1969.bsky.social! An excellent summary of an emerging field by @maryamjabbarpoor.bsky.social www.thieme-connect.com/products/ejo...
Reposted by The Le Group
Presenting PhD #1 from the Le Group: Dr. Dusty Cadwallader! (@dustyc94.bsky.social)
Many congratulations on a successful defense 🎉
Wishing you all the best as you begin your NSERC Postdoctoral Fellowship @chem.ubc.ca with Zac Hudson!
Many congratulations on a successful defense 🎉
Wishing you all the best as you begin your NSERC Postdoctoral Fellowship @chem.ubc.ca with Zac Hudson!
September 4, 2025 at 3:59 PM
Presenting PhD #1 from the Le Group: Dr. Dusty Cadwallader! (@dustyc94.bsky.social)
Many congratulations on a successful defense 🎉
Wishing you all the best as you begin your NSERC Postdoctoral Fellowship @chem.ubc.ca with Zac Hudson!
Many congratulations on a successful defense 🎉
Wishing you all the best as you begin your NSERC Postdoctoral Fellowship @chem.ubc.ca with Zac Hudson!
Once a semester our undergrads present a named reaction at group meeting to improve their skills in literature searching/comprehension.
Today, Emily was ambitious and gave us a stellar overview of the Catellani reaction! Got a review of the mechanism and some cool emerging applications 😎
Today, Emily was ambitious and gave us a stellar overview of the Catellani reaction! Got a review of the mechanism and some cool emerging applications 😎
July 22, 2025 at 3:03 PM
Once a semester our undergrads present a named reaction at group meeting to improve their skills in literature searching/comprehension.
Today, Emily was ambitious and gave us a stellar overview of the Catellani reaction! Got a review of the mechanism and some cool emerging applications 😎
Today, Emily was ambitious and gave us a stellar overview of the Catellani reaction! Got a review of the mechanism and some cool emerging applications 😎
Reposted by The Le Group
And yes, that is a full scale Dance Dance Revolution machine in my home.
July 14, 2025 at 7:04 PM
And yes, that is a full scale Dance Dance Revolution machine in my home.
Yesterday, @christinemle.bsky.social gathered current and former group members at her home to celebrate her recent tenure and promotion to associate professor! We were so busy having fun with Lola, the baby, DDR and all the familiar faces that we forgot to take a group photo 😅
Congrats Christine!!!
Congrats Christine!!!
July 14, 2025 at 3:39 PM
Yesterday, @christinemle.bsky.social gathered current and former group members at her home to celebrate her recent tenure and promotion to associate professor! We were so busy having fun with Lola, the baby, DDR and all the familiar faces that we forgot to take a group photo 😅
Congrats Christine!!!
Congrats Christine!!!
Reposted by The Le Group
York University: NMR Specialist https://chempostingscanada.blogspot.com/2025/06/york-university-nmr-specialist.html
June 5, 2025 at 12:50 AM
York University: NMR Specialist https://chempostingscanada.blogspot.com/2025/06/york-university-nmr-specialist.html
Final group talk today from Ali! #CSC2025 in Ottawa has been a blast and we’re all taking in the final poster night and preparing for the final day tomorrow. Till next year 🫡
June 18, 2025 at 11:28 PM
Final group talk today from Ali! #CSC2025 in Ottawa has been a blast and we’re all taking in the final poster night and preparing for the final day tomorrow. Till next year 🫡
Two more talks down from @maryamjabbarpoor.bsky.social and @dustyc94.bsky.social this morning in Ottawa!
Last talk from our group is tomorrow at 4 from Ali!
Last talk from our group is tomorrow at 4 from Ali!
June 17, 2025 at 5:22 PM
Two more talks down from @maryamjabbarpoor.bsky.social and @dustyc94.bsky.social this morning in Ottawa!
Last talk from our group is tomorrow at 4 from Ali!
Last talk from our group is tomorrow at 4 from Ali!
1 #CSC2025 talk down by @jesseleblanc.bsky.social who absolutely killed it (and had a line up of questioners after his section 👀)
Be sure to check out @maryamjabbarpoor.bsky.social and @dustyc94.bsky.social who are giving talks at 8 and 9am tomorrow morning!!!
Be sure to check out @maryamjabbarpoor.bsky.social and @dustyc94.bsky.social who are giving talks at 8 and 9am tomorrow morning!!!
June 16, 2025 at 11:28 PM
1 #CSC2025 talk down by @jesseleblanc.bsky.social who absolutely killed it (and had a line up of questioners after his section 👀)
Be sure to check out @maryamjabbarpoor.bsky.social and @dustyc94.bsky.social who are giving talks at 8 and 9am tomorrow morning!!!
Be sure to check out @maryamjabbarpoor.bsky.social and @dustyc94.bsky.social who are giving talks at 8 and 9am tomorrow morning!!!
Classic pre-CSC group photo (featuring new undergraduate volunteer Emily!!)
June 12, 2025 at 1:03 PM
Classic pre-CSC group photo (featuring new undergraduate volunteer Emily!!)
Reposted by The Le Group
Carbamoyl #fluorides: an emerging frontier in organofluorine chemistry! Learn about their unique reactivity and potential in various fields.✨ Latest short review by Maryam Jabbarpoor and Christine Le
#fluorination
👉 buff.ly/lEEZIgF
#fluorination
👉 buff.ly/lEEZIgF
June 6, 2025 at 7:02 AM
Carbamoyl #fluorides: an emerging frontier in organofluorine chemistry! Learn about their unique reactivity and potential in various fields.✨ Latest short review by Maryam Jabbarpoor and Christine Le
#fluorination
👉 buff.ly/lEEZIgF
#fluorination
👉 buff.ly/lEEZIgF
Just under 1 week until #CSC2025 kicks off in Ottawa! Very excited to connect with the Canadian chemistry community. Be sure to come find our eager graduate students who will all be giving talks on their research!
June 5, 2025 at 4:04 PM
Just under 1 week until #CSC2025 kicks off in Ottawa! Very excited to connect with the Canadian chemistry community. Be sure to come find our eager graduate students who will all be giving talks on their research!
It’s a live, laugh, love/hate relationship 😬
My students really know how to hurt my feelings sometimes #chemsky @leresearchgroup.bsky.social
May 10, 2025 at 12:15 PM
It’s a live, laugh, love/hate relationship 😬
Also worth sharing that Sam started her pre-program summer research @uoft.bsky.social this week as she was accepted to their graduate program in chemistry! We’re very excited to see what she gets up to!!!
An exciting week as our undergrads defended their CHEM4000 theses! Congrats Sam and Sepi!
April 30, 2025 at 4:33 PM
Also worth sharing that Sam started her pre-program summer research @uoft.bsky.social this week as she was accepted to their graduate program in chemistry! We’re very excited to see what she gets up to!!!
Keep up with group news on our website: www.leresearchgroup.com
- @dustyc94.bsky.social wins the NSERC PDF!!
- Sam wins the CSC silver medal for top chemistry GPA at York (3rd year in a row one of our undergrads has won this award 😎)
- @christinemle.bsky.social gave an invited talk at Spring ACS
- @dustyc94.bsky.social wins the NSERC PDF!!
- Sam wins the CSC silver medal for top chemistry GPA at York (3rd year in a row one of our undergrads has won this award 😎)
- @christinemle.bsky.social gave an invited talk at Spring ACS
@leresearchgroup
We are a research group in the Department of Chemistry at York University specializing in reaction and catalyst development for the synthesis of biologically relevant small molecules.
www.leresearchgroup.com
April 30, 2025 at 4:22 PM
Keep up with group news on our website: www.leresearchgroup.com
- @dustyc94.bsky.social wins the NSERC PDF!!
- Sam wins the CSC silver medal for top chemistry GPA at York (3rd year in a row one of our undergrads has won this award 😎)
- @christinemle.bsky.social gave an invited talk at Spring ACS
- @dustyc94.bsky.social wins the NSERC PDF!!
- Sam wins the CSC silver medal for top chemistry GPA at York (3rd year in a row one of our undergrads has won this award 😎)
- @christinemle.bsky.social gave an invited talk at Spring ACS
An exciting week as our undergrads defended their CHEM4000 theses! Congrats Sam and Sepi!
April 24, 2025 at 1:19 PM
An exciting week as our undergrads defended their CHEM4000 theses! Congrats Sam and Sepi!
Congrats to our rockstar undergrad Sam for winning best organic chemistry talk this weekend at #SOUSCC53!!!
Strong YorkU representation at the 53rd SOUSCC at U of Guelph!
Congratulations to Samantha and Gracia, honors thesis students in the @leresearchgroup.bsky.social and Caputo lab, for winning outstanding oral presentation awards! 🎉
Congratulations to Samantha and Gracia, honors thesis students in the @leresearchgroup.bsky.social and Caputo lab, for winning outstanding oral presentation awards! 🎉
April 1, 2025 at 2:00 PM
Congrats to our rockstar undergrad Sam for winning best organic chemistry talk this weekend at #SOUSCC53!!!
My (person of mystery) phone tells me that it’s been 2 years to the day since @jesseleblanc.bsky.social googley-eyesed our lab 👀😳
March 27, 2025 at 6:21 PM
My (person of mystery) phone tells me that it’s been 2 years to the day since @jesseleblanc.bsky.social googley-eyesed our lab 👀😳
Reposted by The Le Group
Hello, San Diego! I’ll be presenting at #ACSSpring2025 on Tuesday at 4:25 pm in the “Chemistry Across the Border 🇨🇦/🇺🇸” symposium. Please come by and say hi 👋
March 22, 2025 at 4:57 PM
Hello, San Diego! I’ll be presenting at #ACSSpring2025 on Tuesday at 4:25 pm in the “Chemistry Across the Border 🇨🇦/🇺🇸” symposium. Please come by and say hi 👋
🚨Paper alert!🚨 Our review on the synthesis of carbamoyl fluorides and their use in fluoride-enabled reactions was just published in @synthesis1969.bsky.social! An excellent summary of an emerging field by @maryamjabbarpoor.bsky.social www.thieme-connect.com/products/ejo...
Thieme E-Books & E-Journals -
www.thieme-connect.com
March 14, 2025 at 12:50 PM
🚨Paper alert!🚨 Our review on the synthesis of carbamoyl fluorides and their use in fluoride-enabled reactions was just published in @synthesis1969.bsky.social! An excellent summary of an emerging field by @maryamjabbarpoor.bsky.social www.thieme-connect.com/products/ejo...
Some of our work features the carbofluorination of pi bonds, a strategy for rapidly increasing molecular complexity via fluorine incorporation. Ali and @dustyc94.bsky.social recently published a review on this topic. Check it out here #ICYMI! chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
Carbofluorination of π‐Bonds and Related Reactions Involving Tandem C−C/C−F Bond Formation
A review on the carbofluorination of π-bonds and related transformations involving tandem C−C/C−F bond forming reactions is presented. The application of electrophilic fluorine and nucleophilic fluor...
chemistry-europe.onlinelibrary.wiley.com
March 6, 2025 at 1:40 PM
Some of our work features the carbofluorination of pi bonds, a strategy for rapidly increasing molecular complexity via fluorine incorporation. Ali and @dustyc94.bsky.social recently published a review on this topic. Check it out here #ICYMI! chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
Some cool work from our neighbours in the Baumgartner lab featuring some involved crystallography from our grad student @jesseleblanc.bsky.social ✨
New paper from the group - if you are interested in how to “smarten up” the dyes from your clothes, this one may be for you. #ChemSky #PiSky
First big article of the year, Chemical Science!
A fantastic and very pleasant collaboration with our friends from the @tbaumlab.bsky.social, York University of Toronto, Canada.
It is so exciting to collaborate with such outstanding scientists! 🤗🤗
@uclm.es
pubs.rsc.org/en/content/a...
A fantastic and very pleasant collaboration with our friends from the @tbaumlab.bsky.social, York University of Toronto, Canada.
It is so exciting to collaborate with such outstanding scientists! 🤗🤗
@uclm.es
pubs.rsc.org/en/content/a...
February 5, 2025 at 3:54 PM
Some cool work from our neighbours in the Baumgartner lab featuring some involved crystallography from our grad student @jesseleblanc.bsky.social ✨
Want to get to know us better? All of our talented graduate students will be attending #CSC2025!! Submit your abstract before tomorrow and come meet us and a ton of other amazing Canadian chemists!
✨ A great way to start a Friday is by announcing that...📣 THE #CSC2025 ABSTRACT SUBMISSION DEADLINE HAS BEEN EXTENDED UNTIL FEB. 6, 2025 AT 11:59 PM ET! Don't delay, submit your abstract today! Start planning your Ottawa conference experience ASAP! ☺️ ☝️ buff.ly/4gk9ksS
February 5, 2025 at 3:21 PM
Want to get to know us better? All of our talented graduate students will be attending #CSC2025!! Submit your abstract before tomorrow and come meet us and a ton of other amazing Canadian chemists!
If you haven’t heard of us, we are a Canadian research group who work with fluorinated molecules 🤓 We love catalysis, and we don’t discriminate! (1/2)
BF3-Catalyzed Intramolecular Fluorocarbamoylation of Alkynes via Halide Recycling
A BF3-catalyzed atom-economical fluorocarbamoylation reaction of alkyne-tethered carbamoyl fluorides is reported. The catalyst acts as both a fluoride source and Lewis acid activator, thereby enabling...
pubs.acs.org
February 5, 2025 at 3:09 PM
If you haven’t heard of us, we are a Canadian research group who work with fluorinated molecules 🤓 We love catalysis, and we don’t discriminate! (1/2)
Hello #chemsky!! We’re so happy to have successfully migrated! You may know us as the carbamoyl fluoride people, but we opened the new year with a report on acyl fluorides. Check it out an follow us for Le Lab updates 😎⚗️
Our first paper of 2025 is now online in Org Lett. Congrats, Ali, Yuriko, and Namrata! #ChemSky
Be sure to follow @leresearchgroup.bsky.social for more updates on science & other shenanigans.
pubs.acs.org/doi/full/10....
Be sure to follow @leresearchgroup.bsky.social for more updates on science & other shenanigans.
pubs.acs.org/doi/full/10....
Intramolecular Fluoroacylation Enabled by TrBF4-Catalyzed Fluoride Recycling
Alkyne- and alkene-tethered acyl fluorides undergo intramolecular carbofluorination via fluoride recycling using catalytic TrBF4. Excellent stereoselectivity is observed for the alkyne addition, enabling access to novel fluorinated indan-2-ones (all ≥95:5 E/Z) and cyclopentan-2-ones (85:15 E/Z). Fluorinated chroman-2-ones and tertiary alkyl fluorides can also be synthesized using this method, comparing favorably to previously reported protocols that employ expensive metal catalysts under harsher conditions.
pubs.acs.org
February 5, 2025 at 2:54 PM
Hello #chemsky!! We’re so happy to have successfully migrated! You may know us as the carbamoyl fluoride people, but we opened the new year with a report on acyl fluorides. Check it out an follow us for Le Lab updates 😎⚗️