Lucrezia Ferme
@lcferme.bsky.social
Developmental biologist interested in Morphogenesis, Tissue Patterning, Microscopy & Biophysics | postdoc-ing @ Schier lab | PhDone with @nordenlab.bsky.social 🦓🐟 | Embryology Course 2024 @mblscience.bsky.social 🦑
Reposted by Lucrezia Ferme
I am thrilled to share the main result of our work at @nordenlab.bsky.social with @liormoneta.bsky.social and @carldmodes.bsky.social . We bridged DevBiology + theoretical physics to understand how the eye becomes round #morphogenesis #devbio #biophysics #zebrafish www.biorxiv.org/content/10.1...
The Optic cup is actively shape programmed by independently patterned apical forces
During morphogenesis, initially flat tissues often must transition into complex 3D shapes, reminiscent of shape-programmable systems in physics and engineering. One key question in developmental biolo...
www.biorxiv.org
September 1, 2025 at 9:22 PM
I am thrilled to share the main result of our work at @nordenlab.bsky.social with @liormoneta.bsky.social and @carldmodes.bsky.social . We bridged DevBiology + theoretical physics to understand how the eye becomes round #morphogenesis #devbio #biophysics #zebrafish www.biorxiv.org/content/10.1...
Reposted by Lucrezia Ferme
Thrilled to share the first story from my postdoc! 🎉 A wonderful experiment + simulations collaboration. In the Drosophila wing, we find that 3D cell shapes affect signalling range and fine-tune developmental patterning www.biorxiv.org/content/10.1... Thread below ⬇️
August 11, 2025 at 1:18 PM
Thrilled to share the first story from my postdoc! 🎉 A wonderful experiment + simulations collaboration. In the Drosophila wing, we find that 3D cell shapes affect signalling range and fine-tune developmental patterning www.biorxiv.org/content/10.1... Thread below ⬇️
Reposted by Lucrezia Ferme
To better treat cancer, we need to understand its underlying biology. Despite decades of research, some fundamental questions remain unanswered. One is why certain key tumor suppressor or oncogenes lead to cancer predominantly in single tissue: e.g. Rb in the retina, or APC in the colon 1/n 🧪
July 26, 2025 at 2:11 PM
To better treat cancer, we need to understand its underlying biology. Despite decades of research, some fundamental questions remain unanswered. One is why certain key tumor suppressor or oncogenes lead to cancer predominantly in single tissue: e.g. Rb in the retina, or APC in the colon 1/n 🧪
Reposted by Lucrezia Ferme
Exciting news: our Board of Trustees has appointed @monicabettencourt.bsky.social as the CRG's new Director. Prof Bettencourt-Dias is expected to take up the post in 2026, replacing Dr. Luis Serrano, who will continue to maintain a research group at the institute.
www.crg.eu/en/news/moni...
www.crg.eu/en/news/moni...
July 1, 2025 at 8:59 AM
Exciting news: our Board of Trustees has appointed @monicabettencourt.bsky.social as the CRG's new Director. Prof Bettencourt-Dias is expected to take up the post in 2026, replacing Dr. Luis Serrano, who will continue to maintain a research group at the institute.
www.crg.eu/en/news/moni...
www.crg.eu/en/news/moni...
Reposted by Lucrezia Ferme
Reminder: Nobel-prize winning PCR (1983), used in basically all genetic tech today, was only possible because of extremophile bacterium discovered in 1964 in Yellowstone funded by a small ~$80k NSF grant with no obvious application at the time. #science 🧪
www.richmondscientific.com/how-a-discov...
www.richmondscientific.com/how-a-discov...
How a discovery in Yellowstone National Park led to the development of PCR - Richmond Scientific
A discovery in Yellowstone National Park led to the development of PCR, the gold-standard COVID-19 tests used to fight the global pandemic.
www.richmondscientific.com
June 8, 2025 at 9:09 PM
Reminder: Nobel-prize winning PCR (1983), used in basically all genetic tech today, was only possible because of extremophile bacterium discovered in 1964 in Yellowstone funded by a small ~$80k NSF grant with no obvious application at the time. #science 🧪
www.richmondscientific.com/how-a-discov...
www.richmondscientific.com/how-a-discov...
I always enjoy reading the science published in Development, but I never imagined I would be featured as a specimen in this journal! Well, this happened thanks to my very enthusiastic
fellow classmates who wrote this piece about our life-changing experience in last year's MBL Embryology course...
fellow classmates who wrote this piece about our life-changing experience in last year's MBL Embryology course...
What a fantastic essay by last year's @mblscience.bsky.social Embryology students! A perfect paean to the most wonderful science: "It's exhausting; it's exhilarating; it's Embryology."
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
Embryology 2024: a summer like no other
Each summer since 1893, a small group of scientists from around the world have convened at the Marine Biological Laboratory (MBL) in Woods Hole, Massachusetts, USA, to work on the most exciting model ...
journals.biologists.com
May 30, 2025 at 5:12 PM
I always enjoy reading the science published in Development, but I never imagined I would be featured as a specimen in this journal! Well, this happened thanks to my very enthusiastic
fellow classmates who wrote this piece about our life-changing experience in last year's MBL Embryology course...
fellow classmates who wrote this piece about our life-changing experience in last year's MBL Embryology course...
Reposted by Lucrezia Ferme
The amazing tour de force of the great @lcferme.bsky.social is now out in its final form in @ScienceAdvances (not on Bluesky???). It was hard work and all the conceptual advance was her doing. Check it out: www.science.org/doi/epdf/10....
Timely neurogenesis drives the transition from nematic to crystalline nuclear packing during retinal morphogenesis
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www.science.org
May 10, 2025 at 8:40 AM
The amazing tour de force of the great @lcferme.bsky.social is now out in its final form in @ScienceAdvances (not on Bluesky???). It was hard work and all the conceptual advance was her doing. Check it out: www.science.org/doi/epdf/10....
Reposted by Lucrezia Ferme
Hi Bluesky science community!
Rocha Lab has finally arrived!
I'm excited to introduce our team and the science we're working on in future posts. Can’t wait to connect and see what everyone has been up to!
Rocha Lab has finally arrived!
I'm excited to introduce our team and the science we're working on in future posts. Can’t wait to connect and see what everyone has been up to!
May 10, 2025 at 7:47 PM
Hi Bluesky science community!
Rocha Lab has finally arrived!
I'm excited to introduce our team and the science we're working on in future posts. Can’t wait to connect and see what everyone has been up to!
Rocha Lab has finally arrived!
I'm excited to introduce our team and the science we're working on in future posts. Can’t wait to connect and see what everyone has been up to!
Reposted by Lucrezia Ferme
Yes, that is me, for those who did not yet know. This was not planned but I am very happy to go 'home' even though I will miss a lot about Portugal. If you still want to visit, hurry, otherwise see you in Cambridge. If you want to know more contact me directly.
www.pdn.cam.ac.uk/news/dr-care...
www.pdn.cam.ac.uk/news/dr-care...
Dr Caren Norden appointed Darwin Professor of Animal Embryology at PDN | Department of Physiology, Development and Neuroscience
Dr Caren Norden has been appointed Darwin Professor of Animal Embryology, joining the Department of Physiology, Development and Neuroscience in the School of Biological Sciences, from April 2026. Her ...
www.pdn.cam.ac.uk
May 8, 2025 at 1:55 PM
Yes, that is me, for those who did not yet know. This was not planned but I am very happy to go 'home' even though I will miss a lot about Portugal. If you still want to visit, hurry, otherwise see you in Cambridge. If you want to know more contact me directly.
www.pdn.cam.ac.uk/news/dr-care...
www.pdn.cam.ac.uk/news/dr-care...
Reposted by Lucrezia Ferme
Celebrating the work of @lcferme.bsky.social ! As always with style! Congrats to the paper acceptance. More news will follow soon! Great weekend to all!
April 4, 2025 at 6:38 PM
Celebrating the work of @lcferme.bsky.social ! As always with style! Congrats to the paper acceptance. More news will follow soon! Great weekend to all!
Reposted by Lucrezia Ferme
Rita Levi-Montalcini defied fascism, which excluded her from university due to her jewish ancestry, by setting up a clandestine lab in her own bedroom. During 1940-42 she carried out experiments that set the foundations for her Nobel-prize-winning research a decade later.
nautil.us/a-lab-of-her...
nautil.us/a-lab-of-her...
February 27, 2025 at 8:58 AM
Rita Levi-Montalcini defied fascism, which excluded her from university due to her jewish ancestry, by setting up a clandestine lab in her own bedroom. During 1940-42 she carried out experiments that set the foundations for her Nobel-prize-winning research a decade later.
nautil.us/a-lab-of-her...
nautil.us/a-lab-of-her...
Yes, it’s officially PhDone! It’s being a long and adventurous journey and I feel so lucky that I got to make it with all my wonderful colleagues in the Norden lab @nordenlab.bsky.social ❤️ They even managed to design a hat out of a Panettone box! I loved it. That’s the spirit!!
February 26, 2025 at 12:24 PM
Yes, it’s officially PhDone! It’s being a long and adventurous journey and I feel so lucky that I got to make it with all my wonderful colleagues in the Norden lab @nordenlab.bsky.social ❤️ They even managed to design a hat out of a Panettone box! I loved it. That’s the spirit!!
Thank you so much Caren @nordenlab.bsky.social for all the support, technical and emotional as well! You are a great mentor :)
@lcferme.bsky.social did outstandingly at her defense and now can call herself Doctor Lucrezia! It was a pleasure and honor to be part of this journey. Congrats!
Great things will await you!
Great things will await you!
February 26, 2025 at 12:12 PM
Thank you so much Caren @nordenlab.bsky.social for all the support, technical and emotional as well! You are a great mentor :)
Reposted by Lucrezia Ferme
New NIH funded research from our group now out. We are interested in development and evolution of cell types and adult phenotypes. In this paper, postdoc Dylan Huang and collaborators asked how a pigmentary ornament of bright white cells develops on the fin of zebrafish. www.pnas.org/doi/10.1073/...
February 18, 2025 at 8:59 PM
New NIH funded research from our group now out. We are interested in development and evolution of cell types and adult phenotypes. In this paper, postdoc Dylan Huang and collaborators asked how a pigmentary ornament of bright white cells develops on the fin of zebrafish. www.pnas.org/doi/10.1073/...
Reposted by Lucrezia Ferme
Divide and conquer. Or don’t divide but still conquer.
@kkukreja.bsky.social & co. looked into the role of cell division in forming all major cell types during early zebrafish 🐟development, and found something they didn't expect. Read the story behind the paper:
@kkukreja.bsky.social & co. looked into the role of cell division in forming all major cell types during early zebrafish 🐟development, and found something they didn't expect. Read the story behind the paper:
Divide and conquer. Or don't divide but still conquer. - the Node
Behind the paper story for "Cell state transitions are decoupled from cell division during early embryo development" As embryos develop, their cells
thenode.biologists.com
January 27, 2025 at 12:04 PM
Divide and conquer. Or don’t divide but still conquer.
@kkukreja.bsky.social & co. looked into the role of cell division in forming all major cell types during early zebrafish 🐟development, and found something they didn't expect. Read the story behind the paper:
@kkukreja.bsky.social & co. looked into the role of cell division in forming all major cell types during early zebrafish 🐟development, and found something they didn't expect. Read the story behind the paper:
Reposted by Lucrezia Ferme
Highly-respected non-profit journals like @dev-journal.bsky.social support scientific communities
But after rejection at glam journals, it is tempting to avoid re-review by sliding through commercial ecosystems
BUT WAIT! LOOK! “We will consider papers with reviewer reports from other journals” 😍
But after rejection at glam journals, it is tempting to avoid re-review by sliding through commercial ecosystems
BUT WAIT! LOOK! “We will consider papers with reviewer reports from other journals” 😍
December 3, 2024 at 9:33 AM
Highly-respected non-profit journals like @dev-journal.bsky.social support scientific communities
But after rejection at glam journals, it is tempting to avoid re-review by sliding through commercial ecosystems
BUT WAIT! LOOK! “We will consider papers with reviewer reports from other journals” 😍
But after rejection at glam journals, it is tempting to avoid re-review by sliding through commercial ecosystems
BUT WAIT! LOOK! “We will consider papers with reviewer reports from other journals” 😍
Reposted by Lucrezia Ferme
By definition, enhancers can activate from a distance. But with increased distance between enhancer and promoter, the activation drops. To study this systematically, we build a synthetic locus: www.cell.com/molecular-ce... 1/12
Redirecting
doi.org
December 2, 2024 at 4:44 PM
By definition, enhancers can activate from a distance. But with increased distance between enhancer and promoter, the activation drops. To study this systematically, we build a synthetic locus: www.cell.com/molecular-ce... 1/12
Reposted by Lucrezia Ferme
To mark Black Friday, we are excited to share our latest work, "Planar polarized force propagation integrates cell behavior with tissue shaping during convergent extension." Now online in Current Biology. authors.elsevier.com/a/1kATd3QW8S...
November 30, 2024 at 3:32 AM
To mark Black Friday, we are excited to share our latest work, "Planar polarized force propagation integrates cell behavior with tissue shaping during convergent extension." Now online in Current Biology. authors.elsevier.com/a/1kATd3QW8S...
I’m very grateful to be part of the Norden lab 🤩 ze best
I just leave this here…with the only thing noting is that I am happy and blessed to have worked, do work and will work with this incredible group of individuals and independent thinkers! Also… I love tiaras! Thank you!
November 28, 2024 at 9:03 AM
I’m very grateful to be part of the Norden lab 🤩 ze best
Reposted by Lucrezia Ferme
This week I’m giving thanks for the Sling-Jaw Wrasse, and it’s amazing jaw #biomechanics!
🐟🦑🧪🌿
🐟🦑🧪🌿
November 27, 2024 at 3:32 PM
This week I’m giving thanks for the Sling-Jaw Wrasse, and it’s amazing jaw #biomechanics!
🐟🦑🧪🌿
🐟🦑🧪🌿
🟦 First post on bluesky and first first-author pre-print! It is was a long journey and I am so grateful for all the opportunities I got to grow as a scientist, thanks to @nordenlab.bsky.social. Come cantava Rino Gaetano: il cielo è sempre più blu! 🟦
And it is finally there! The heroic effort by @lcferme.bsky.social paid off. Not always easy but resilience and stamina got us there. Thanks also to our collaborators Carl Modes and @haesleinhuepf.bsky.social for support! Check it out and let us know what you think!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Timely neurogenesis enables increased nuclear packing order during neuronal lamination
The coordination of cell proliferation, migration, and differentiation is crucial for organogenesis in many tissues, including the CNS and other organs that arise from pseudostratified epithelia (PSE)...
www.biorxiv.org
November 16, 2024 at 9:50 PM
🟦 First post on bluesky and first first-author pre-print! It is was a long journey and I am so grateful for all the opportunities I got to grow as a scientist, thanks to @nordenlab.bsky.social. Come cantava Rino Gaetano: il cielo è sempre più blu! 🟦