Luke Yates
@layates.bsky.social
Assistant Professor in Genome Stability at University of Sussex, Brighton, UK. Visiting scientist at Francis Crick Institute & Imperial College London. Structural biologist investigating DNA damage checkpoints. Artist and charity trustee. Views are own.
Reposted by Luke Yates
My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social
DNA2 enables growth by restricting recombination-restarted replication - Nature
DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...
www.nature.com
September 3, 2025 at 3:59 PM
My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social
Reposted by Luke Yates
#NEW_PAPER
In this study, the Chan Lab uncover the molecular mechanisms by which human cells safeguard centromeric chromatin during mitosis, via tight dynamic control of the Bloom Syndrome complex (BTRR).
rdcu.be/eCGxF
In this study, the Chan Lab uncover the molecular mechanisms by which human cells safeguard centromeric chromatin during mitosis, via tight dynamic control of the Bloom Syndrome complex (BTRR).
rdcu.be/eCGxF
Centromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex
Nature Communications - Centromeres play an essential function in faithful chromosome segregation. Here, the authors demonstrate the mechanism by which human cells dynamically modulate the activity...
rdcu.be
August 27, 2025 at 11:16 AM
#NEW_PAPER
In this study, the Chan Lab uncover the molecular mechanisms by which human cells safeguard centromeric chromatin during mitosis, via tight dynamic control of the Bloom Syndrome complex (BTRR).
rdcu.be/eCGxF
In this study, the Chan Lab uncover the molecular mechanisms by which human cells safeguard centromeric chromatin during mitosis, via tight dynamic control of the Bloom Syndrome complex (BTRR).
rdcu.be/eCGxF
Reposted by Luke Yates
#NEW_PAPER
The Hochegger laboratory + collaborators investigate the sensitivity of cancer cells to a highly selective inhibitor of human Greatwall kinase (GWL) + the BB5alpha-to-GWL expression ratio is a predictive biomarker for the cellular reponse to Greatwall-targeted therapeutics. rdcu.be/eC4Hf
The Hochegger laboratory + collaborators investigate the sensitivity of cancer cells to a highly selective inhibitor of human Greatwall kinase (GWL) + the BB5alpha-to-GWL expression ratio is a predictive biomarker for the cellular reponse to Greatwall-targeted therapeutics. rdcu.be/eC4Hf
The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells
Nature Communications - The authors develop and characterise a selective Greatwall inhibitor, C-604, and show that its cytotoxicity stems from PP2A-B55α hyperactivation. They identify...
rdcu.be
August 29, 2025 at 2:20 PM
#NEW_PAPER
The Hochegger laboratory + collaborators investigate the sensitivity of cancer cells to a highly selective inhibitor of human Greatwall kinase (GWL) + the BB5alpha-to-GWL expression ratio is a predictive biomarker for the cellular reponse to Greatwall-targeted therapeutics. rdcu.be/eC4Hf
The Hochegger laboratory + collaborators investigate the sensitivity of cancer cells to a highly selective inhibitor of human Greatwall kinase (GWL) + the BB5alpha-to-GWL expression ratio is a predictive biomarker for the cellular reponse to Greatwall-targeted therapeutics. rdcu.be/eC4Hf
Reposted by Luke Yates
#New-Paper Rass laboratory reveal DNA2 to be a gatekeeper to homologous recombination at stalled DNA replication forks, rrequired to stave off cellular senescence. Their findings provide a molecular explanation for the association of DNA2 with primordial dwarfism and cancer.
doi.org/10.1038/s415...
doi.org/10.1038/s415...
DNA2 enables growth by restricting recombination-restarted replication - Nature
DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...
doi.org
September 3, 2025 at 3:13 PM
#New-Paper Rass laboratory reveal DNA2 to be a gatekeeper to homologous recombination at stalled DNA replication forks, rrequired to stave off cellular senescence. Their findings provide a molecular explanation for the association of DNA2 with primordial dwarfism and cancer.
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Absolute pleasure to be invited back on the @agentsoftech.bsky.social podcast to join Stephen Horn and Laila Rizvi and talk with #Nobel winner John Jumper about #AlphaFold and research at Google DeepMind. We also touch on needing experimentalists, and what he & AI will tackle next in biology
Exclusive Interview with Nobel Prize Winner John Jumper: AI's Next Frontier After AlphaFold
YouTube video by Agents of Tech
youtu.be
August 6, 2025 at 9:34 PM
Absolute pleasure to be invited back on the @agentsoftech.bsky.social podcast to join Stephen Horn and Laila Rizvi and talk with #Nobel winner John Jumper about #AlphaFold and research at Google DeepMind. We also touch on needing experimentalists, and what he & AI will tackle next in biology
Published online now in @annualreviews.bsky.social Annual Review of Biochemistry, Prof Zhang @crick.ac.uk and Prof Burgers @washu.bsky.social and I summarise current mechanistic understanding of DNA damage checkpoints, which act as a barrier to cancer in humans. www.annualreviews.org/content/jour...
DNA Damage and Replication Stress Checkpoints | Annual Reviews
DNA damage checkpoints are key regulatory signaling cascades that arrest cell cycle progression upon DNA damage or upon DNA replication stalling and allow time for repair or correction. Failure to eli...
www.annualreviews.org
June 24, 2025 at 8:42 AM
Published online now in @annualreviews.bsky.social Annual Review of Biochemistry, Prof Zhang @crick.ac.uk and Prof Burgers @washu.bsky.social and I summarise current mechanistic understanding of DNA damage checkpoints, which act as a barrier to cancer in humans. www.annualreviews.org/content/jour...
Reposted by Luke Yates
Dear all,
Postdoc positions are available to work on (1) the role of DNA strand break repair proteins during DNA replication and (2) the molecular/structural biology of XRCC1 protein complexes, as part of our work on genetic diseases & cancer. Contact me if interested: k.w.caldecott@sussex.ac.uk
Postdoc positions are available to work on (1) the role of DNA strand break repair proteins during DNA replication and (2) the molecular/structural biology of XRCC1 protein complexes, as part of our work on genetic diseases & cancer. Contact me if interested: k.w.caldecott@sussex.ac.uk
February 10, 2025 at 2:45 PM
Dear all,
Postdoc positions are available to work on (1) the role of DNA strand break repair proteins during DNA replication and (2) the molecular/structural biology of XRCC1 protein complexes, as part of our work on genetic diseases & cancer. Contact me if interested: k.w.caldecott@sussex.ac.uk
Postdoc positions are available to work on (1) the role of DNA strand break repair proteins during DNA replication and (2) the molecular/structural biology of XRCC1 protein complexes, as part of our work on genetic diseases & cancer. Contact me if interested: k.w.caldecott@sussex.ac.uk
I have a funded PhD position in my lab in @gdsc-sussex.bsky.social (UK fees only).
This is an exciting new project using structural biology to investigate proteins involved in ovarian cancer, with opportunities for drug discovery and collaborations with clinicians. Application link below.
This is an exciting new project using structural biology to investigate proteins involved in ovarian cancer, with opportunities for drug discovery and collaborations with clinicians. Application link below.
Life Sciences PhD Genome Stability - Molecular basis for DNA damage checkpoint termination : University of Sussex
www.sussex.ac.uk
February 11, 2025 at 9:57 AM
I have a funded PhD position in my lab in @gdsc-sussex.bsky.social (UK fees only).
This is an exciting new project using structural biology to investigate proteins involved in ovarian cancer, with opportunities for drug discovery and collaborations with clinicians. Application link below.
This is an exciting new project using structural biology to investigate proteins involved in ovarian cancer, with opportunities for drug discovery and collaborations with clinicians. Application link below.
Reposted by Luke Yates
I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication, with 8 years of funding at the Francis Crick Institute.
Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now!
3 postdoc positions advertised soon.
Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now!
3 postdoc positions advertised soon.
December 11, 2024 at 1:53 PM
I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication, with 8 years of funding at the Francis Crick Institute.
Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now!
3 postdoc positions advertised soon.
Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now!
3 postdoc positions advertised soon.
Reposted by Luke Yates
The Genome Damage and Stability Centre at the University of Sussex has now joined BlueSky! Follow us here, for news, views and publications.
December 6, 2024 at 9:25 AM
The Genome Damage and Stability Centre at the University of Sussex has now joined BlueSky! Follow us here, for news, views and publications.
Reposted by Luke Yates
Online today @science.org 👀Molecular basis of FIGNL1 in dissociating RAD51 from #DNA and #chromatin by @alexcarver.bsky.social @layates.bsky.social et al. in @imperialcollegeldn.bsky.social @mskcancercenter.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
NEW in @science.org, so happy to contribute to our understanding of the molecular machine, Fidgetin-like 1 (FIGNL1), and elucidating the mechanism of why cells cannot survive when it is lost! #ScienceResearch science.org/doi/10.1126/... (1/7)
Molecular basis of FIGNL1 in dissociating RAD51 from DNA and chromatin
Maintaining genome integrity is an essential and challenging process. RAD51 recombinase, the central player of several crucial processes in repairing DNA and protecting genome integrity, forms filamen...
science.org
December 5, 2024 at 9:11 PM
Online today @science.org 👀Molecular basis of FIGNL1 in dissociating RAD51 from #DNA and #chromatin by @alexcarver.bsky.social @layates.bsky.social et al. in @imperialcollegeldn.bsky.social @mskcancercenter.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
The Equal Dose podcast by @websedgetv.bsky.social covered a topic very close to my heart - organ donation. And it was wonderful to share my story and very humbling to hear about Billy Moon’s legacy. Episode available here: youtu.be/9UAruhx2vk0?...
Celebrating 70 Years of Organ Transplants: Inspiring Stories of Legacy, Innovation, and Hope
YouTube video by WebsEdgeMedicine
youtu.be
November 24, 2024 at 10:16 PM
The Equal Dose podcast by @websedgetv.bsky.social covered a topic very close to my heart - organ donation. And it was wonderful to share my story and very humbling to hear about Billy Moon’s legacy. Episode available here: youtu.be/9UAruhx2vk0?...
It was a pleasure to be invited on the ‘Agents of Tech’ podcast from @websedgetv.bsky.social to talk about how AlphaFold3 is transforming structural biology and biomedical research. Link to the episode below: youtu.be/ohKGM6A9vhQ
Building Blocks of Life, AlphaFold and AI Drug Development
YouTube video by WebsEdge
youtu.be
November 15, 2024 at 8:57 PM
It was a pleasure to be invited on the ‘Agents of Tech’ podcast from @websedgetv.bsky.social to talk about how AlphaFold3 is transforming structural biology and biomedical research. Link to the episode below: youtu.be/ohKGM6A9vhQ