Laura Corrales
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lauracorrales.bsky.social
Laura Corrales
@lauracorrales.bsky.social
Molecular microbiologist
Ramón y Cajal Group Leader at unisevilla
https://www.ibvf.us-csic.es/
Happy to participate in this work by Alejandro Velázquez-Cruz from Irene Díaz-Moreno lab in collaboration with Jackie Wilce and R. Fernández-Chacón:
Allosteric modulation of TIA-1 phase separation by double serine phosphorylation https://www.biorxiv.org/content/10.1101/2025.08.21.671602v1
August 27, 2025 at 10:49 AM
Tenemos un contrato disponible. Si estás interesad@ en la Biotecnología y la Microbiología, vente al @ibvf-sevilla.bsky.social ! @unisevilla.bsky.social
July 2, 2025 at 3:42 PM
Reposted by Laura Corrales
Bacterial cell envelope wonders. Always fascinating to learn about cell envelope biogenesis and see all the ingenious molecular tricks we can use to study it. Great work from the Colin Kleanthouse lab @oxfordbiochemistry.bsky.social Check at rb.gy/akaugi @pnas.org
Immobile lipopolysaccharides and outer membrane proteins differentially segregate in growing Escherichia coli | PNAS
The outer membrane (OM) of gram-negative bacteria is a robust, impermeable barrier that excludes many classes of antibiotics. Contrary to the class...
rb.gy
May 13, 2025 at 2:20 PM
New postdoc position available at IBVF!
March 19, 2025 at 1:41 PM
Reposted by Laura Corrales
Interested in the bacterial ParABS DNA segregation system? Then have a look at our latest preprint... 🧬

Thanks to the Hennig and Bange groups for the great collaboration!

doi.org/10.1101/2025...
Molecular basis of ParA ATPase activation by the CTPase ParB during bacterial chromosome segregation
DNA segregation by bacterial ParABS systems is mediated by transient tethering interactions between nucleoid-bound dimers of the ATPase ParA and centromere (parS)-associated complexes of the clamp-for...
doi.org
March 18, 2025 at 7:56 PM
Reposted by Laura Corrales
Happy to join BlueSky with new work on improving heterologous P450s in Synechocystis. Efficient thylakoid targeting makes a big difference: higher protein amounts and up to 18x more product using a fusion protein engineering approach. #lightdrivencatalysis #teamgreen
pubs.acs.org/doi/10.1021/...
Thylakoid Targeting Improves Stability of a Cytochrome P450 in the Cyanobacterium Synechocystis sp. PCC 6803
Plants produce a large array of natural products of biotechnological interest. In many cases, these compounds are naturally produced at low titers and involve complex biosynthetic pathways, which often include cytochrome P450 enzymes. P450s are known to be difficult to express in traditional heterotrophic chassis. However, cyanobacteria have shown promise as a sustainable alternative for the heterologous expression of P450s and light-driven product biosynthesis. In this study, we explore strategies for improving plant P450 stability and membrane insertion in cyanobacteria. The widely used model cyanobacterium Synechocystis sp. PCC 6803 was chosen as the host, and the well-studied P450 CYP79A1 from the dhurrin pathway of Sorghum bicolor was chosen as the model enzyme. Combinations of the P450 fused with individual elements (e.g., signal peptide, transmembrane domain) or the full length cyanobacterial, thylakoid-localized, protein PetC1 were designed. All generated CYP79A1 variants led to oxime production. Our data show that strains producing CYP79A1 variants with elements of PetC1 improved thylakoid targeting. In addition, chlorophyll-normalized oxime levels increased, on average, up to 18 times compared to the unmodified CYP79A1. These findings offer promising strategies to improve heterologous P450 expression in cyanobacteria and can ultimately contribute to advancing light-driven biocatalysis in cyanobacterial chassis.
pubs.acs.org
March 6, 2025 at 9:21 AM
I am thrilled to share that the proposal PHLAG was funded with a Consolidación Investigadora grant at IBVF!! 🙌🙌 @unisevilla.bsky.social
ℹ️ La AEI publica la propuesta de resolución provisional de la convocatoria 2024 de ayudas para incentivar la consolidación investigadora.
🔗 www.aei.gob.es/sites/defaul...
💰 41,9 M€ para consolidar la carrera de 221 investigadores/as en España.
February 1, 2025 at 11:30 AM
Reposted by Laura Corrales
ℹ️ La AEI publica la propuesta de resolución provisional de la convocatoria 2024 de ayudas para incentivar la consolidación investigadora.
🔗 www.aei.gob.es/sites/defaul...
💰 41,9 M€ para consolidar la carrera de 221 investigadores/as en España.
January 30, 2025 at 3:47 PM
Estamos buscando candidato para solicitar una beca FPU en @unisevilla.bsky.social :
January 14, 2025 at 4:27 PM