Claudine Kraft's Lab
@kraftlabfr.bsky.social
Research group led by Claudine Kraft at the
@UniFreiburg
Our focus is on understanding the molecular mechanisms of #yeast and #mammalian #autophagy.
Profile run by Riccardo.
@UniFreiburg
Our focus is on understanding the molecular mechanisms of #yeast and #mammalian #autophagy.
Profile run by Riccardo.
Pinned
Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy - Nature Cell Biology
Licheva, Pflaum, Babic, Mancilla et al. show that low-affinity cargo–receptor interactions promote autophagy receptor mobility and condensation of the scaffold protein Atg11 to trigger initiation hub ...
nature.com
🚨 Paper Alert! We’re starting off the year with our latest publication in @naturecellbiology.bsky.social on the role of phase separation in selective autophagy initiation!
This work was a close and exciting collaboration with
@wilflinglab.bsky.social
🔗 nature.com/articles/s41...
Here's a thread👇
This work was a close and exciting collaboration with
@wilflinglab.bsky.social
🔗 nature.com/articles/s41...
Here's a thread👇
Reposted by Claudine Kraft's Lab
Online now - the Review " #Autophagy regulation by phase separation, avidity, and wetting" from @wilflinglab.bsky.social, @kraftlabfr.bsky.social and co.
#BiomolecularCondensates #PhaseSeparation #Wetting #Avidity #Theraeputics
Read it here: authors.elsevier.com/sd/article/S...
#BiomolecularCondensates #PhaseSeparation #Wetting #Avidity #Theraeputics
Read it here: authors.elsevier.com/sd/article/S...
November 21, 2025 at 5:54 PM
Online now - the Review " #Autophagy regulation by phase separation, avidity, and wetting" from @wilflinglab.bsky.social, @kraftlabfr.bsky.social and co.
#BiomolecularCondensates #PhaseSeparation #Wetting #Avidity #Theraeputics
Read it here: authors.elsevier.com/sd/article/S...
#BiomolecularCondensates #PhaseSeparation #Wetting #Avidity #Theraeputics
Read it here: authors.elsevier.com/sd/article/S...
Physical principles have redefined our understanding of autophagy.
In our new @cp-trendsbiochem.bsky.social review, we discuss how phase separation, avidity, and wetting shape autophagy at the molecular level.
Great collaboration with @wilflinglab.bsky.social
www.cell.com/trends/bioch...
In our new @cp-trendsbiochem.bsky.social review, we discuss how phase separation, avidity, and wetting shape autophagy at the molecular level.
Great collaboration with @wilflinglab.bsky.social
www.cell.com/trends/bioch...
Autophagy regulation by phase separation, avidity, and wetting
Autophagy enables cells to selectively degrade a wide range of macromolecules, and
how this process achieves spatial precision within the densely packed cytosol is an
active area of investigation. Rec...
www.cell.com
November 20, 2025 at 1:34 PM
Physical principles have redefined our understanding of autophagy.
In our new @cp-trendsbiochem.bsky.social review, we discuss how phase separation, avidity, and wetting shape autophagy at the molecular level.
Great collaboration with @wilflinglab.bsky.social
www.cell.com/trends/bioch...
In our new @cp-trendsbiochem.bsky.social review, we discuss how phase separation, avidity, and wetting shape autophagy at the molecular level.
Great collaboration with @wilflinglab.bsky.social
www.cell.com/trends/bioch...
Reposted by Claudine Kraft's Lab
Congratulations! Our SFB 1381 Principal Investigator Claudine Kraft has been awarded an esteemed ERC Synergy Grant, along with her partners in Vienna and Berkeley.
Congratulations! Claudine Kraft @kraftlabfr.bsky.social receives a prestigious ERC Synergy Grant – to find out why some protein #aggregates can be cleared by #autophagy and others not. She and her partners will harness this knowledge to improve autophagy in #ageing & #disease.
🔗 kurzlinks.de/50j8
🔗 kurzlinks.de/50j8
ERC Synergy Grant for Prof. Dr. Claudine Kraft
CIBSS speaker Prof. Dr. Claudine Kraft is part of a team receiving an ERC Synergy Grant of ten million euros for her research on how autophagy degrades large protein aggregates in health and disease.
kurzlinks.de
November 7, 2025 at 8:52 AM
Congratulations! Our SFB 1381 Principal Investigator Claudine Kraft has been awarded an esteemed ERC Synergy Grant, along with her partners in Vienna and Berkeley.
Reposted by Claudine Kraft's Lab
Vier #ERCSynergyGrants für Forschende der #UniFreiburg. Insgesamt werden die vier Projekte durch den @erc.europa.eu mit rund 41 Millionen Euro über sechs Jahre gefördert; die #UniversitätFreiburg erhält davon gut neun Mio Euro.
➡️ Mehr zu den geförderten Projekten hier: ufr.link/erc-synergy-grant-25
➡️ Mehr zu den geförderten Projekten hier: ufr.link/erc-synergy-grant-25
November 6, 2025 at 12:05 PM
Vier #ERCSynergyGrants für Forschende der #UniFreiburg. Insgesamt werden die vier Projekte durch den @erc.europa.eu mit rund 41 Millionen Euro über sechs Jahre gefördert; die #UniversitätFreiburg erhält davon gut neun Mio Euro.
➡️ Mehr zu den geförderten Projekten hier: ufr.link/erc-synergy-grant-25
➡️ Mehr zu den geförderten Projekten hier: ufr.link/erc-synergy-grant-25
Reposted by Claudine Kraft's Lab
Congratulations! Claudine Kraft @kraftlabfr.bsky.social receives a prestigious ERC Synergy Grant – to find out why some protein #aggregates can be cleared by #autophagy and others not. She and her partners will harness this knowledge to improve autophagy in #ageing & #disease.
🔗 kurzlinks.de/50j8
🔗 kurzlinks.de/50j8
ERC Synergy Grant for Prof. Dr. Claudine Kraft
CIBSS speaker Prof. Dr. Claudine Kraft is part of a team receiving an ERC Synergy Grant of ten million euros for her research on how autophagy degrades large protein aggregates in health and disease.
kurzlinks.de
November 6, 2025 at 12:17 PM
Congratulations! Claudine Kraft @kraftlabfr.bsky.social receives a prestigious ERC Synergy Grant – to find out why some protein #aggregates can be cleared by #autophagy and others not. She and her partners will harness this knowledge to improve autophagy in #ageing & #disease.
🔗 kurzlinks.de/50j8
🔗 kurzlinks.de/50j8
Reposted by Claudine Kraft's Lab
Fantastic teamwork with @kraftlabfr.bsky.social and @jimhurley.bsky.social! Looking forward to exciting discoveries ahead. Many thanks to @erc.europa.eu for funding our proposal. @univie.ac.at @maxperutzlabs.ac.at @viennabiocenter.bsky.social
Big news! Group leader Sascha Martens has been awarded a prestigious @erc.europa.eu Synergy Grant for the collaborative project DegrAbility to explore how cells can better recycle harmful protein aggregates linked to diseases like Alzheimer’s ➡️ tinyurl.com/2zuz9jcf
@univie.ac.at
@meduniwien.ac.at
@univie.ac.at
@meduniwien.ac.at
November 6, 2025 at 11:12 AM
Fantastic teamwork with @kraftlabfr.bsky.social and @jimhurley.bsky.social! Looking forward to exciting discoveries ahead. Many thanks to @erc.europa.eu for funding our proposal. @univie.ac.at @maxperutzlabs.ac.at @viennabiocenter.bsky.social
Reposted by Claudine Kraft's Lab
Thrilled to join you and Claudine to study the cell's own version of Banksy's self-shredding artwork!
November 6, 2025 at 2:18 PM
Thrilled to join you and Claudine to study the cell's own version of Banksy's self-shredding artwork!
Reposted by Claudine Kraft's Lab
New #CORDIS article on work by Claudine Kraft
@kraftlabfr.bsky.social l "Autophagy: the cell’s waste disposal system" - work was result of @erc.europa.eu LS1 project "AutoClean" #H2020 #EUfunded cordis.europa.eu/article/id/4...
@kraftlabfr.bsky.social l "Autophagy: the cell’s waste disposal system" - work was result of @erc.europa.eu LS1 project "AutoClean" #H2020 #EUfunded cordis.europa.eu/article/id/4...
Autophagy: the cell’s waste disposal system
Research into how cells initiate and regulate autophagy opens the door to new ways of preventing a range of diseases.,,,European Commission
cordis.europa.eu
October 13, 2025 at 9:05 AM
New #CORDIS article on work by Claudine Kraft
@kraftlabfr.bsky.social l "Autophagy: the cell’s waste disposal system" - work was result of @erc.europa.eu LS1 project "AutoClean" #H2020 #EUfunded cordis.europa.eu/article/id/4...
@kraftlabfr.bsky.social l "Autophagy: the cell’s waste disposal system" - work was result of @erc.europa.eu LS1 project "AutoClean" #H2020 #EUfunded cordis.europa.eu/article/id/4...
Back from the 8th NAS Conference in Sånga Säby, and what a wonderful experience it was! Christoph and Franzi represented the lab, and as a cherry on top, Chris won an award for his talk 🎉 Huge thanks to the NAS for organising and always creating such a warm community atmosphere!
September 26, 2025 at 2:58 PM
Back from the 8th NAS Conference in Sånga Säby, and what a wonderful experience it was! Christoph and Franzi represented the lab, and as a cherry on top, Chris won an award for his talk 🎉 Huge thanks to the NAS for organising and always creating such a warm community atmosphere!
Reposted by Claudine Kraft's Lab
The future of @cibss.bsky.social @uni-freiburg.de is about teamwork, curiosity, and collaboration across disciplines.
We are thrilled to be in this together @kraftlabfr.bsky.social @archaellum.bsky.social @kleinevehnlab.bsky.social !
We are thrilled to be in this together @kraftlabfr.bsky.social @archaellum.bsky.social @kleinevehnlab.bsky.social !
September 22, 2025 at 2:40 PM
The future of @cibss.bsky.social @uni-freiburg.de is about teamwork, curiosity, and collaboration across disciplines.
We are thrilled to be in this together @kraftlabfr.bsky.social @archaellum.bsky.social @kleinevehnlab.bsky.social !
We are thrilled to be in this together @kraftlabfr.bsky.social @archaellum.bsky.social @kleinevehnlab.bsky.social !
Reposted by Claudine Kraft's Lab
New leadership for #CIBSS!
Welcome Sonja-Verena Albers as new spokesperson & congrats to Claudine Kraft on her confirmation. Together with Jürgen Kleine-Vehn, they’ll lead CIBSS into its #NextChapter – following Wolfgang Driever & Carola Hunte.
More info: kurzlinks.de/fkv4
Welcome Sonja-Verena Albers as new spokesperson & congrats to Claudine Kraft on her confirmation. Together with Jürgen Kleine-Vehn, they’ll lead CIBSS into its #NextChapter – following Wolfgang Driever & Carola Hunte.
More info: kurzlinks.de/fkv4
September 22, 2025 at 10:01 AM
New leadership for #CIBSS!
Welcome Sonja-Verena Albers as new spokesperson & congrats to Claudine Kraft on her confirmation. Together with Jürgen Kleine-Vehn, they’ll lead CIBSS into its #NextChapter – following Wolfgang Driever & Carola Hunte.
More info: kurzlinks.de/fkv4
Welcome Sonja-Verena Albers as new spokesperson & congrats to Claudine Kraft on her confirmation. Together with Jürgen Kleine-Vehn, they’ll lead CIBSS into its #NextChapter – following Wolfgang Driever & Carola Hunte.
More info: kurzlinks.de/fkv4
Reposted by Claudine Kraft's Lab
And it's out!
I'm thrilled to share our new paper (Adriaenssens et al., Nat Cell Biol 2025).
This paper describes a new mechanism for the initiation of autophagosome biogenesis.
We found that this WIPI-ATG13-driven pathway is preferentially used by a group of transmembrane autophagy receptors.
I'm thrilled to share our new paper (Adriaenssens et al., Nat Cell Biol 2025).
This paper describes a new mechanism for the initiation of autophagosome biogenesis.
We found that this WIPI-ATG13-driven pathway is preferentially used by a group of transmembrane autophagy receptors.
July 25, 2025 at 9:43 AM
And it's out!
I'm thrilled to share our new paper (Adriaenssens et al., Nat Cell Biol 2025).
This paper describes a new mechanism for the initiation of autophagosome biogenesis.
We found that this WIPI-ATG13-driven pathway is preferentially used by a group of transmembrane autophagy receptors.
I'm thrilled to share our new paper (Adriaenssens et al., Nat Cell Biol 2025).
This paper describes a new mechanism for the initiation of autophagosome biogenesis.
We found that this WIPI-ATG13-driven pathway is preferentially used by a group of transmembrane autophagy receptors.
🎓✨ Huge congratulations to Saskia, an amazing PhD student who just successfully defended her thesis!
The flower crown toss might just become our new lab tradition! @uni-freiburg.de
The flower crown toss might just become our new lab tradition! @uni-freiburg.de
July 30, 2025 at 1:50 PM
🎓✨ Huge congratulations to Saskia, an amazing PhD student who just successfully defended her thesis!
The flower crown toss might just become our new lab tradition! @uni-freiburg.de
The flower crown toss might just become our new lab tradition! @uni-freiburg.de
🧬 Excited to share this new publication! A collaborative effort within @sfb1381.bsky.social exploring the intersection of immunology and autophagy.
📖 Read it here: www.embopress.org/doi/full/10....
📖 Read it here: www.embopress.org/doi/full/10....
LRBA deficiency impairs autophagy and contributes to enhanced antigen presentation and T-cell dysregulation | EMBO reports
imageimageLRBA regulates autophagy and antigen presentation, shedding light on the mechanism
of immune dysregulation in LRBA deficiency. LRBA directly interacts with PIK3R4 and FYCO1, promoting autop...
www.embopress.org
July 1, 2025 at 8:06 AM
🧬 Excited to share this new publication! A collaborative effort within @sfb1381.bsky.social exploring the intersection of immunology and autophagy.
📖 Read it here: www.embopress.org/doi/full/10....
📖 Read it here: www.embopress.org/doi/full/10....
Reposted by Claudine Kraft's Lab
Die @dfg.de fördert drei Graduiertenkollegs „FORSCALE“, „Analysis nichtlinearer PDG“ und „ProtPath“ an der #UniFreiburg. Dieser Erfolg stärkt die #Spitzenforschung und #Nachwuchsförderung in Freiburg in #Forstwissenschaften, #Biochemie und #Mathematik. ➡️ ufr.link/dfg-grk-2025 #DFG
June 17, 2025 at 9:55 AM
Die @dfg.de fördert drei Graduiertenkollegs „FORSCALE“, „Analysis nichtlinearer PDG“ und „ProtPath“ an der #UniFreiburg. Dieser Erfolg stärkt die #Spitzenforschung und #Nachwuchsförderung in Freiburg in #Forstwissenschaften, #Biochemie und #Mathematik. ➡️ ufr.link/dfg-grk-2025 #DFG
Reposted by Claudine Kraft's Lab
Excited to share our newly published work on ATG9A — this time focusing on its role at the lysosome. Discover how ARFIP2 and ATG9A coordinate PI4P regulation during lysosomal repair!
Congrats to all the authors, and special thanks to @stedet.bsky.social & @satooze.bsky.social !!
📜 bit.ly/43EbrDo
Congrats to all the authors, and special thanks to @stedet.bsky.social & @satooze.bsky.social !!
📜 bit.ly/43EbrDo
ATG9A and ARFIP2 cooperate to control PI4P levels for lysosomal repair
Lysosome damage activates multiple pathways to prevent lysosome-dependent cell death, including a repair mechanism involving endoplasmic reticulum (ER…
bit.ly
June 3, 2025 at 6:54 AM
Excited to share our newly published work on ATG9A — this time focusing on its role at the lysosome. Discover how ARFIP2 and ATG9A coordinate PI4P regulation during lysosomal repair!
Congrats to all the authors, and special thanks to @stedet.bsky.social & @satooze.bsky.social !!
📜 bit.ly/43EbrDo
Congrats to all the authors, and special thanks to @stedet.bsky.social & @satooze.bsky.social !!
📜 bit.ly/43EbrDo
Reposted by Claudine Kraft's Lab
Celebrating our successful new excellence cluster #FutureForests @uni-freiburg.de. Thanks @dfg.de, this will enable us to substantially invest in exciting and much-needed research for the next 7 years - predicting and transforming forest systems in a changing climate uni-freiburg.de/futureforest...
May 24, 2025 at 9:48 PM
Celebrating our successful new excellence cluster #FutureForests @uni-freiburg.de. Thanks @dfg.de, this will enable us to substantially invest in exciting and much-needed research for the next 7 years - predicting and transforming forest systems in a changing climate uni-freiburg.de/futureforest...
Reposted by Claudine Kraft's Lab
🎉Ab 1. Januar 2026 fördert die @dfg.de (#DFG) zwei #Exzellenzcluster der #UniFreiburg. Der bisherige #Exzellenzcluster @cibss.bsky.social wird weitere sieben Jahre fortgesetzt. Zudem startet der neue Exzellenzcluster #FutureForests. ufr.link/exzellenzclu...
May 22, 2025 at 5:23 PM
🎉Ab 1. Januar 2026 fördert die @dfg.de (#DFG) zwei #Exzellenzcluster der #UniFreiburg. Der bisherige #Exzellenzcluster @cibss.bsky.social wird weitere sieben Jahre fortgesetzt. Zudem startet der neue Exzellenzcluster #FutureForests. ufr.link/exzellenzclu...
Thrilled to announce that our Cluster of Excellence CIBSS – Centre for Integrative Biological Signalling Studies @cibss.bsky.social will continue to receive funding for another seven years! We’re happy to be part of such a great team!
May 23, 2025 at 8:35 AM
Thrilled to announce that our Cluster of Excellence CIBSS – Centre for Integrative Biological Signalling Studies @cibss.bsky.social will continue to receive funding for another seven years! We’re happy to be part of such a great team!
Reposted by Claudine Kraft's Lab
We are thrilled to have just found out: CIBSS has secured continued funding under the #ExcellenceStrategy! This major boost will enable us to accelerate our research into biological signalling and lay the groundwork for next-generation insights from 2026 to 2032!
May 22, 2025 at 3:20 PM
We are thrilled to have just found out: CIBSS has secured continued funding under the #ExcellenceStrategy! This major boost will enable us to accelerate our research into biological signalling and lay the groundwork for next-generation insights from 2026 to 2032!
Reposted by Claudine Kraft's Lab
From May 5–8, 2025, the Cryo EM facility of #unifreiburg hosted an introductory workshop supported by SFB 1381 to learn how to access and use this cutting-edge technology. Hands-on sessions covered everything from sample prep to data analysis. Big thanks to the facility!
May 15, 2025 at 9:32 AM
From May 5–8, 2025, the Cryo EM facility of #unifreiburg hosted an introductory workshop supported by SFB 1381 to learn how to access and use this cutting-edge technology. Hands-on sessions covered everything from sample prep to data analysis. Big thanks to the facility!
Reposted by Claudine Kraft's Lab
📆Join us this Wednesday, May 14th at 10:00 AM EST (NY Time) as Drs. Licheva, Babic, and Mancilla present their recent work:
"Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy"
🔗Zoom Info: Contact wiajournalclub@gmail.com
We look forward to seeing you there!
"Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy"
🔗Zoom Info: Contact wiajournalclub@gmail.com
We look forward to seeing you there!
May 12, 2025 at 5:33 PM
📆Join us this Wednesday, May 14th at 10:00 AM EST (NY Time) as Drs. Licheva, Babic, and Mancilla present their recent work:
"Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy"
🔗Zoom Info: Contact wiajournalclub@gmail.com
We look forward to seeing you there!
"Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy"
🔗Zoom Info: Contact wiajournalclub@gmail.com
We look forward to seeing you there!
Reposted by Claudine Kraft's Lab
Our 'SFB 1381's Female Minds' series has officially kicked off! Visit our website to read the first feature, introducing our SFB 1381 Principal Investigator Claudine Kraft:
www.sfb1381.uni-freiburg.de/sfb-1381s-fe...
@kraftlabfr.bsky.social
www.sfb1381.uni-freiburg.de/sfb-1381s-fe...
@kraftlabfr.bsky.social
April 24, 2025 at 9:11 AM
Our 'SFB 1381's Female Minds' series has officially kicked off! Visit our website to read the first feature, introducing our SFB 1381 Principal Investigator Claudine Kraft:
www.sfb1381.uni-freiburg.de/sfb-1381s-fe...
@kraftlabfr.bsky.social
www.sfb1381.uni-freiburg.de/sfb-1381s-fe...
@kraftlabfr.bsky.social
Women in Autophagy is hosting their 6th Annual Symposium Webinar. Highly recommended for anyone interested in autophagy. #Autophagy #WomenInScience
April 15, 2025 at 7:53 AM
Women in Autophagy is hosting their 6th Annual Symposium Webinar. Highly recommended for anyone interested in autophagy. #Autophagy #WomenInScience
Happy to have participated in the #FCQC2025 in Frankfurt last week. Great to connect with others in the field and hear about exciting work. Thanks to the organizers for putting it together.
April 2, 2025 at 8:28 AM
Happy to have participated in the #FCQC2025 in Frankfurt last week. Great to connect with others in the field and hear about exciting work. Thanks to the organizers for putting it together.