Konstantinos Prokopidis
@kostasproko.bsky.social
PhD in Musculoskeletal Biology | University of Liverpool | Sarcopenia, frailty, cachexia, heart failure
https://scholar.google.com/citations?user=jrawkREAAAAJ&hl=el&authuser=1
https://scholar.google.com/citations?user=jrawkREAAAAJ&hl=el&authuser=1
Reposted by Konstantinos Prokopidis
Recruiting a comp PDRA for the lab 🚨
Working on multiple projects using integrated multi omics in bulk & single cell level
Passion for data, coding, bioinformatics & keen to lead our labs comp workflow
12 months in first instance but extendable for further 19 months
my.corehr.com/pls/coreport...
Working on multiple projects using integrated multi omics in bulk & single cell level
Passion for data, coding, bioinformatics & keen to lead our labs comp workflow
12 months in first instance but extendable for further 19 months
my.corehr.com/pls/coreport...
my.corehr.com
November 10, 2025 at 5:23 PM
Recruiting a comp PDRA for the lab 🚨
Working on multiple projects using integrated multi omics in bulk & single cell level
Passion for data, coding, bioinformatics & keen to lead our labs comp workflow
12 months in first instance but extendable for further 19 months
my.corehr.com/pls/coreport...
Working on multiple projects using integrated multi omics in bulk & single cell level
Passion for data, coding, bioinformatics & keen to lead our labs comp workflow
12 months in first instance but extendable for further 19 months
my.corehr.com/pls/coreport...
Reposted by Konstantinos Prokopidis
Top Cited Review Article: Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions
Michael D. Roberts, et al.
https://ow.ly/moMh50Xe5nU
#hypertrophy #myofiber
Michael D. Roberts, et al.
https://ow.ly/moMh50Xe5nU
#hypertrophy #myofiber
October 31, 2025 at 5:00 PM
Top Cited Review Article: Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions
Michael D. Roberts, et al.
https://ow.ly/moMh50Xe5nU
#hypertrophy #myofiber
Michael D. Roberts, et al.
https://ow.ly/moMh50Xe5nU
#hypertrophy #myofiber
The effect of bed rest, unilateral limb immobilization and head-down tilt on muscle protein synthesis: A systematic review and meta-analysis
physoc.onlinelibrary.wiley.com/doi/10.1113/...
physoc.onlinelibrary.wiley.com/doi/10.1113/...
The effect of bed rest, unilateral limb immobilization and head‐down tilt on muscle protein synthesis: A systematic review and meta‐analysis
Muscle disuse leads to muscle atrophy and a decrease in muscle function that is primarily driven by reduced muscle protein synthesis (MPS). The aim of this systematic review and meta-analysis was to ...
physoc.onlinelibrary.wiley.com
October 31, 2025 at 1:51 PM
The effect of bed rest, unilateral limb immobilization and head-down tilt on muscle protein synthesis: A systematic review and meta-analysis
physoc.onlinelibrary.wiley.com/doi/10.1113/...
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Impact of Semaglutide on fat mass, lean mass and muscle function in patients with obesity: The SEMALEAN study
dom-pubs.onlinelibrary.wiley.com/doi/10.1111/...
dom-pubs.onlinelibrary.wiley.com/doi/10.1111/...
October 14, 2025 at 3:24 AM
Impact of Semaglutide on fat mass, lean mass and muscle function in patients with obesity: The SEMALEAN study
dom-pubs.onlinelibrary.wiley.com/doi/10.1111/...
dom-pubs.onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Konstantinos Prokopidis
We are looking for an enthusiastic MD or PhD to work on a postdoc project on the molecular mechanisms underlying human hibernating myocardium and ischemic cardiomyopathy. If interested send me an email! #heart #cardiomyopathy #sarcomere
14 postdoctoral fellowships to the BRIDGE – Translational Excellence Programme
employment.ku.dk
September 29, 2025 at 11:11 AM
We are looking for an enthusiastic MD or PhD to work on a postdoc project on the molecular mechanisms underlying human hibernating myocardium and ischemic cardiomyopathy. If interested send me an email! #heart #cardiomyopathy #sarcomere
Reposted by Konstantinos Prokopidis
Little under a week left to apply for this position to come and lead some cool experiments in muscle biology in London!
🚨Hiring a 2yr postdoc in the lab work on muscle biology, genomics & ALS. Expertise in the above advantageous, but work ethic, desire to learn/develop and being a good scientist/person more important
Good collab with @droch.bsky.social so travel to CPH involved as well
www.kcl.ac.uk/jobs/126245-...
Good collab with @droch.bsky.social so travel to CPH involved as well
www.kcl.ac.uk/jobs/126245-...
Postdoctoral Research Associate in Muscle Biology and Genomics | King's College London
www.kcl.ac.uk
October 6, 2025 at 11:54 AM
Little under a week left to apply for this position to come and lead some cool experiments in muscle biology in London!
Reposted by Konstantinos Prokopidis
Clenbuterol induces lean mass and muscle protein accretion, but attenuates cardiorespiratory fitness and desensitizes muscle β2-adrenergic signalling
physoc.onlinelibrary.wiley.com/doi/10.1113/...
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Clenbuterol induces lean mass and muscle protein accretion, but attenuates cardiorespiratory fitness and desensitizes muscle β2‐adrenergic signalling
Abstract figure legend This randomized controlled study investigated the effect of a 2 week treatment cycle of either oral clenbuterol or placebo in healthy young men. We found that clenbuterol: (1) ...
physoc.onlinelibrary.wiley.com
September 15, 2025 at 5:35 PM
Clenbuterol induces lean mass and muscle protein accretion, but attenuates cardiorespiratory fitness and desensitizes muscle β2-adrenergic signalling
physoc.onlinelibrary.wiley.com/doi/10.1113/...
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Resistance training, but not leucine, increased basal muscle protein synthesis and reversed frailty in older women consuming optimized protein intake
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Resistance training, but not leucine, increased basal muscle protein synthesis and reversed frailty in older women consuming optimized protein intake - GeroScience
Frailty, often linked to sarcopenia, involves reduced muscle strength and mass. While sarcopenia has multiple causes, impaired muscle protein synthesis may contribute. Leucine and resistance training ...
link.springer.com
September 15, 2025 at 7:21 AM
Resistance training, but not leucine, increased basal muscle protein synthesis and reversed frailty in older women consuming optimized protein intake
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Konstantinos Prokopidis
Weighing the risk of GLP-1 treatment in older adults: Should we be concerned about sarcopenic obesity?
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Weighing the risk of GLP-1 treatment in older adults: Should we be concerned about sarcopenic obesity?
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been pivotal for obesity treatment, achieving 15–25 % weight loss over 12–24 months, but qu…
www.sciencedirect.com
August 18, 2025 at 5:35 PM
Weighing the risk of GLP-1 treatment in older adults: Should we be concerned about sarcopenic obesity?
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
In this article, we provide a rationale behind the risk of sarcopenic obesity due to weight cycling with GLP-1 receptor agonists...
"Weighing the risk of GLP-1 treatment in older adults: Should we be concerned about sarcopenic obesity?"
www.sciencedirect.com/science/arti...
"Weighing the risk of GLP-1 treatment in older adults: Should we be concerned about sarcopenic obesity?"
www.sciencedirect.com/science/arti...
August 16, 2025 at 12:37 PM
In this article, we provide a rationale behind the risk of sarcopenic obesity due to weight cycling with GLP-1 receptor agonists...
"Weighing the risk of GLP-1 treatment in older adults: Should we be concerned about sarcopenic obesity?"
www.sciencedirect.com/science/arti...
"Weighing the risk of GLP-1 treatment in older adults: Should we be concerned about sarcopenic obesity?"
www.sciencedirect.com/science/arti...
Efficacy and safety of anamorelin in patients with metastatic urothelial carcinoma receiving systemic chemotherapy: a randomized controlled study
academic.oup.com/oncolo/artic...
academic.oup.com/oncolo/artic...
July 15, 2025 at 10:24 AM
Efficacy and safety of anamorelin in patients with metastatic urothelial carcinoma receiving systemic chemotherapy: a randomized controlled study
academic.oup.com/oncolo/artic...
academic.oup.com/oncolo/artic...
Treating Sarcopenic Obesity in the Era of Incretin
Therapies: Perspectives and Challenges
diabetesjournals.org/diabetes/art...
Therapies: Perspectives and Challenges
diabetesjournals.org/diabetes/art...
Treating Sarcopenic Obesity in the Era of Incretin Therapies: Perspectives and Challenges
Sarcopenic obesity, a subtype of obesity, is marked by reduced skeletal muscle mass and function, or sarcopenia, and poses a significant health challenge t
diabetesjournals.org
July 11, 2025 at 10:12 PM
Treating Sarcopenic Obesity in the Era of Incretin
Therapies: Perspectives and Challenges
diabetesjournals.org/diabetes/art...
Therapies: Perspectives and Challenges
diabetesjournals.org/diabetes/art...
Reposted by Konstantinos Prokopidis
Microgravity accelerates skeletal muscle degeneration: Functional and transcriptomic insights from an ISS muscle lab-on-chip model
www.cell.com/stem-cell-re...
www.cell.com/stem-cell-re...
Microgravity accelerates skeletal muscle degeneration: Functional and transcriptomic insights from an ISS muscle lab-on-chip model
In this article, Parafati, Malany, and colleagues show that microgravity altered contractile
response and slow-twitch protein levels in a lab-on-chip muscle model on the ISS.
Electrical stimulation en...
www.cell.com
June 28, 2025 at 7:48 PM
Microgravity accelerates skeletal muscle degeneration: Functional and transcriptomic insights from an ISS muscle lab-on-chip model
www.cell.com/stem-cell-re...
www.cell.com/stem-cell-re...
Reposted by Konstantinos Prokopidis
Assessing the composition of myofibrillar and muscle connective protein fractions within skeletal muscle tissue
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Assessing the composition of myofibrillar and muscle connective protein fractions within skeletal muscle tissue
It has been suggested that different nutritional stimuli are required to augment myofibrillar versus muscle connective protein synthesis rates. To study such different aspects of skeletal muscle re...
www.tandfonline.com
June 26, 2025 at 5:54 PM
Assessing the composition of myofibrillar and muscle connective protein fractions within skeletal muscle tissue
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Effects of exercise with or without a hypocaloric diet on intermuscular and intramuscular fat: a systematic review
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Effects of exercise with or without a hypocaloric diet on intermuscular and intramuscular fat: a systematic review - Aging Clinical and Experimental Research
Background Intermuscular (InterMAT) and intramuscular (IntraMAT) adipose tissues are key contributors to skeletal muscle function and metabolic health. Objective In this systematic review, we aimed to...
link.springer.com
June 9, 2025 at 5:22 PM
Effects of exercise with or without a hypocaloric diet on intermuscular and intramuscular fat: a systematic review
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Konstantinos Prokopidis
The Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta-Analysis
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
The Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta‐Analysis
Introduction Sarcopenia is associated with the loss of skeletal muscle function and mass. Nicotinamide precursors, such as nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR), have rece...
onlinelibrary.wiley.com
April 25, 2025 at 9:35 PM
The Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta-Analysis
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
The Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta-Analysis
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
The Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta‐Analysis
Introduction Sarcopenia is associated with the loss of skeletal muscle function and mass. Nicotinamide precursors, such as nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR), have rece...
onlinelibrary.wiley.com
April 25, 2025 at 8:44 AM
The Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta-Analysis
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Prognostic and associative significance of malnutrition in sarcopenia: a systematic review and meta-analysis
pubmed.ncbi.nlm.nih.gov/40222723/
pubmed.ncbi.nlm.nih.gov/40222723/
Prognostic and associative significance of malnutrition in sarcopenia: a systematic review and meta-analysis - PubMed
Malnutrition is associated with a higher odds of sarcopenia and their combined presence is a better predictor of all-cause mortality compared to sarcopenia alone, further highlighting the importance o...
pubmed.ncbi.nlm.nih.gov
April 15, 2025 at 7:29 AM
Prognostic and associative significance of malnutrition in sarcopenia: a systematic review and meta-analysis
pubmed.ncbi.nlm.nih.gov/40222723/
pubmed.ncbi.nlm.nih.gov/40222723/
Reposted by Konstantinos Prokopidis
Our New study in EJSS!
2 weeks of bed rest causes ~5% leg muscle loss in healthy adults.
DXA, CT & MRI detect similar decline. MRI-based automated analysis offers a fast, reliable alternative to manual muscle quantification.
🔗 onlinelibrary.wiley.com/doi/10.1002/...
#musclehealth #MRI #research
2 weeks of bed rest causes ~5% leg muscle loss in healthy adults.
DXA, CT & MRI detect similar decline. MRI-based automated analysis offers a fast, reliable alternative to manual muscle quantification.
🔗 onlinelibrary.wiley.com/doi/10.1002/...
#musclehealth #MRI #research
Quantifying Leg Muscle Disuse Atrophy During Bed Rest Using DXA, CT, and MRI
This study evaluated whether dual-energy X-ray absorptiometry (DXA), computed tomography (CT), and magnetic resonance imaging (MRI) provide comparable outcomes in quantifying disuse-induced skeletal ...
onlinelibrary.wiley.com
April 11, 2025 at 7:18 AM
Our New study in EJSS!
2 weeks of bed rest causes ~5% leg muscle loss in healthy adults.
DXA, CT & MRI detect similar decline. MRI-based automated analysis offers a fast, reliable alternative to manual muscle quantification.
🔗 onlinelibrary.wiley.com/doi/10.1002/...
#musclehealth #MRI #research
2 weeks of bed rest causes ~5% leg muscle loss in healthy adults.
DXA, CT & MRI detect similar decline. MRI-based automated analysis offers a fast, reliable alternative to manual muscle quantification.
🔗 onlinelibrary.wiley.com/doi/10.1002/...
#musclehealth #MRI #research
Resistance and Impact Training During Weight Loss Improves Physical Function and Body Composition in Older Adults With Obesity
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Resistance and Impact Training During Weight Loss Improves Physical Function and Body Composition in Older Adults With Obesity
Background Weight loss achieved via energy restriction leads to significant losses in muscle and bone mass, potentially increasing risk for sarcopenia and osteoporosis. High-intensity resistance and...
onlinelibrary.wiley.com
April 10, 2025 at 9:27 AM
Resistance and Impact Training During Weight Loss Improves Physical Function and Body Composition in Older Adults With Obesity
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Reposted by Konstantinos Prokopidis
Length of stay and prior heart failure admission in frailty and heart failure: A systematic review and meta‐analysis - Prokopidis - ESC Heart Failure - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...
April 10, 2025 at 9:20 AM
Length of stay and prior heart failure admission in frailty and heart failure: A systematic review and meta‐analysis - Prokopidis - ESC Heart Failure - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...
Metformin and physical performance in older people with probable sarcopenia and physical prefrailty or frailty in England (MET-PREVENT): a double-blind, randomised, placebo-controlled trial
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Metformin and physical performance in older people with probable sarcopenia and physical prefrailty or frailty in England (MET-PREVENT): a double-blind, randomised, placebo-controlled trial
Metformin did not improve 4-m walk speed and was poorly tolerated in this population.
www.thelancet.com
April 6, 2025 at 3:03 PM
Metformin and physical performance in older people with probable sarcopenia and physical prefrailty or frailty in England (MET-PREVENT): a double-blind, randomised, placebo-controlled trial
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Reposted by Konstantinos Prokopidis
Out in this month's issue of Aging Cell. Motor neurons do better in the presence of primary human muscle cells from older exercisers vs non-exercisers.
🙏to @lundbeckfonden.bsky.social for the Ascending Investigator grant 4 years ago to see this work through
doi.org/10.1111/acel...
🙏to @lundbeckfonden.bsky.social for the Ascending Investigator grant 4 years ago to see this work through
doi.org/10.1111/acel...
Muscle fibroblasts and stem cells stimulate motor neurons in an age and exercise‐dependent manner
Muscle biopsies were taken from males and females differing in age and exercise habits. Mononucleated cells were isolated and purified into muscle stem cells (MuSC) and muscle fibroblasts (FIB). Neur....
doi.org
March 20, 2025 at 2:35 PM
Out in this month's issue of Aging Cell. Motor neurons do better in the presence of primary human muscle cells from older exercisers vs non-exercisers.
🙏to @lundbeckfonden.bsky.social for the Ascending Investigator grant 4 years ago to see this work through
doi.org/10.1111/acel...
🙏to @lundbeckfonden.bsky.social for the Ascending Investigator grant 4 years ago to see this work through
doi.org/10.1111/acel...
Reposted by Konstantinos Prokopidis
SR: Impact of #deprescribing on sarcopenia:
- no effect on skeletal muscle mass
- some studies find ⬆️ in strength, phys. perf. & nutritional status.
Pairing DeRx with nutrition & exercise therapies may further prevent sarcopenia. More research needed:
bmcgeriatr.biomedcentral.com/articles/10....
- no effect on skeletal muscle mass
- some studies find ⬆️ in strength, phys. perf. & nutritional status.
Pairing DeRx with nutrition & exercise therapies may further prevent sarcopenia. More research needed:
bmcgeriatr.biomedcentral.com/articles/10....
The evidence and impact of deprescribing on sarcopenia parameters: a systematic review - BMC Geriatrics
Background Polypharmacy (concomitant prescription of ≥ 5 medications) affects a third of older people, and evidence suggests an association with sarcopenia (loss of skeletal muscle mass/quality, muscl...
bmcgeriatr.biomedcentral.com
March 18, 2025 at 2:26 PM
SR: Impact of #deprescribing on sarcopenia:
- no effect on skeletal muscle mass
- some studies find ⬆️ in strength, phys. perf. & nutritional status.
Pairing DeRx with nutrition & exercise therapies may further prevent sarcopenia. More research needed:
bmcgeriatr.biomedcentral.com/articles/10....
- no effect on skeletal muscle mass
- some studies find ⬆️ in strength, phys. perf. & nutritional status.
Pairing DeRx with nutrition & exercise therapies may further prevent sarcopenia. More research needed:
bmcgeriatr.biomedcentral.com/articles/10....
Reposted by Konstantinos Prokopidis
Assessing the link of #malnutrition with #diabetes and mortality risk in #heartfailure patients
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
March 13, 2025 at 12:52 PM
Assessing the link of #malnutrition with #diabetes and mortality risk in #heartfailure patients
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....